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Farmasains : Jurnal Farmasi dan Ilmu Kesehatan
Published by Universitas Muhammadiyah Malang
ISSN : 20863373     EISSN : 2620987X     DOI : 10.22219
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Farmasains publishes articles that cover textual and fieldwork studies with various perspectives of pharmacy science including: Pharmaceutical Technology Pharmaceutical Chemistry Biology Pharmacy and Natural Products Pharmacology and Toxicology Clinical Pharmacy Community Pharmacy Pharmacoepidemiology Pharmacogenomic and Pharmacogenetic Pharmacoeconomic Health-related topics
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 170 Documents
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Formulation and evaluation of hand sanitizer gel containing infused of binahong leaf (Anredera cordifolia) as antibacterial preparation Dyah Rahmasari; Esti Hendradi; Uswatun Chasanah
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 1 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i1.13008

Abstract

Hand sanitizer gel is one of the alternative methods for hand hygiene when soap and water are not available. Binahong leaf (Anredera cordifolia) is a natural herb that has phenolic, flavonoids, saponins, and the steroid-terpenoids compound, which is potentially used as the active ingredient in the hand sanitizer gel. The primary purpose of this research was to determine the antibacterial potential and physicochemical properties of a hand-sanitizer gel containing binahong leaves’ infusion against Staphylococcus aureus. The efficacy of this formulation was tested against a bacterial strain using the disc diffusion method and determined by measuring the inhibition zone of each preparation. The testing of physicochemical properties includes the organoleptic test, pH, viscosity, and gel spreadability. The physicochemical characteristics of the gel showed excellent properties for all formulas. The antibacterial test showed that hand sanitizer gel containing an infusion of binahong’s leaves has an inhibition zone (6.02 mm; 6.24 mm; 6.55 mm), almost close to a positive control (9.15 mm). In conclusion, the formulated hand sanitizer gel possesses the antibacterial potential to inhibit S. aureus.
In vitro testing of emulgel with a combined extract of Sansevieria trifasciata Prain. and Curcuma longa Linn. against the Candida albicans Uswatun Chasanah; Ayudya Rizky Permatasari
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 1 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i1.13185

Abstract

Content of flavonoids in Sansevieria trifasciata Prain. and curcumonoids in Curcuma Longa Linn. can inhibit the growth of the fungi Candida albicans in the wound. An innovative formulation was made that form a combination of antifungal extracts S. trifasciata and C. longa in the form of emulgel, which is easy to absorb and can moisturize the skin. The purpose is to determine the effect of antifungal activity of emulgel preparations using S. trifasciata extract with a concentration of 0%; 5%; and 10%, and C. longa 10% against C. albicans. S. trifasciata and C. longa extracts are formulated into emulgel in three formulas, F1 (C. longa 10%); F2 (S. trifasciata 5%; C. Longa 10%); and F3 (S. trifasciata 10%; C. Longa 10%). Antifungal activity was tested using the diffusion well method. The results of antifungal activity research showed inhibition zone diameter, inhibitory activity, and effectiveness. There were no significant differences in formula 1, formula 2, formula 3, but there were significant differences with positive controls. Variation the concentration of S. trifasciata 5% and 10% has no significant effect on the inhibitory zone of the C. albicans, but the three emulgel of S. trifasciata and C. Longa extract had antifungal activity on the growth of C. albicans.
Analysis of the effect of tofu industrial waste on dug well water quality Sara Antoneta Atakari; Zakarias Mautuka; Martasiana Karbeka; Loth Botahala
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 2 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i2.13298

Abstract

The industrial tofu factory located in Lautingara Kelurahan Kalabahi Tengah, where the remaining liquid waste is channeled directly into the reservoir without prior treatment, can affect water quality in the dug wells. The purpose of this study was to determine the quality and feasibility of dug well water as drinking water-based on parameters of pH, BOD, COD, nitrite, and nitrate of dug well water, which is suspected to be contaminated by the presence of tofu waste. The results showed that the pH value and nitrite value (NO2-) of the three dug well water samples in Lautingara met the drinking water quality standards, while the BOD, COD, and nitrate (NO3-) values in the three dug well water samples in Lautingara did not meet the values quality standards and not suitable for drinking water.
Studies on antioxidant activity of red, white, and black pomegranate (Punica granatum L.) peel extract using DPPH radical scavenging method Uswatun Chasanah
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 2 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i2.13472

Abstract

Pomegranate (Punica granatum L.) has high antioxidant activity. In Indonesia, there are red pomegranate, white pomegranate, and black pomegranate. The purpose of this study was to determine the antioxidant activity of red pomegranate peel extract, white pomegranate peel extract, and black pomegranate peel extract. The extracts prepared by ultrasonic maceration in 96% ethanol, then evaporated until thick extract was obtained and its antioxidant activity was determined using the DPPH radical scavenging method. This study showed that all pomegranate peel extract varieties have potent antioxidant activity and the black pomegranate peel extract has the highest antioxidant power.
Knowledge-attitude about toward sunlight exposure and lung function in construction workers Amelia Lorensia; Rivan Virlando Suryadinata; Try Suryandi
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 2 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i2.13927

Abstract

The primary source of Vitamin D is sunlight, which plays a role in improving respiratory health. The level of knowledge and attitudes regarding sun exposure can affect daily lifestyle, thus affecting lung function. The research design was cross-sectional and, from April to June 2018, was conducted in Rungkut District, Surabaya. The construction workers were divided into with and without respiratory problems. The variables were knowledge and attitudes towards sun exposure related to vitamin D deficiency risk, with data collection using a questionnaire. The result showed that the level of knowledge (98.31%) and attitude (100%) was low. There was no significant difference in the level of knowledge p-value (0.161 > 0.05) between with and without respiratory problems. The correlation test of knowledge and attitudes towards sun exposure related to the risk of vitamin D deficiency cannot be carried out because there was no excellent attitude. Knowledge and attitudes towards sun exposure related to the risk of vitamin D deficiency tend to be low in construction workers. However, knowledge and attitude were not the main factors affecting lung function.
Postoperative antibiotic therapy patterns in Benign Prostatic Hyperplasia (BPH) patients Aghnia Fuadatul Inayah; Rizki Lisya Nugraha; Didik Hasmono
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 2 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i2.13942

Abstract

Benign Prostatic Hyperplasia (BPH) is an enlarged prostate disease benign or a condition when the cells are present the prostate gland has an increased proliferation rate. There are several treatment options, including conservative (watchful waiting), medical, and surgery. Antibiotics in BPH cases can be prophylactic antibiotics or empiric antibiotics. This study was  an observational study. The samples were BPH patients who received antibiotics for period January - November 2019. The pattern of prophylactic antibiotic use shows that most of the patients received ceftriaxone therapy. Operation on BPH patients is TURP which is an operation classified into surgery with a clean-contaminated category so that prophylactic antibiotics are required. There are two patterns of use for empiric antibiotics in BPH patients: single (88%) and combination (12%). The pattern of single or combined use is given to patients depending on the complications of the disease and the patient's clinical condition. BPH cases occur in men mostly occurs at the age of 60-74 years. Prophylactic antibiotic therapy in BPH patients, namely ceftriaxone 1 gr IV once daily was 48 patients (90.6%), a broad spectrum. Meanwhile, the most use of empirical antibiotics with a single pattern is Ceftriaxone 1 gr IV twice daily (35.6%).
Evaluation of variations in the response of hypertensive patients in the outpatient installation of the UPT Puskesmas, Babat Lamongan District Primanitha Ria Utami; Riana Prastiwi Handayani; Sheila Sheila
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 1 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i1.13956

Abstract

Hypertension has long been a health problem that can have severe impacts on society. Measurement of blood pressure is one of the determinants of antihypertensive treatment's success, which can be seen from the reduction in the patient's blood pressure towards achieving the target blood pressure. Less than optimal blood pressure control is the most common risk factor for CVD and cerebrovascular disease. The role of the selection of antihypertensive therapy in each patient's condition is individual. Each patient will vary in response to various types of antihypertensive treatment. The research design carried out was retrospective descriptive with the observation of variations in answer to the use of antihypertensives in outpatient hypertension patients at the Babat Health Center with an examination period from January to December 2019. The study was divided into two groups, namely the positive and negative response groups. Patient characteristics data (age, sex, and treatment regimen) were statistically tested with the chi-square test to see whether there was a difference in eating or not between the two groups. It is said a positive response if the patient's blood pressure has decreased after three months of using antihypertensives. Harmful if after three months of antihypertensive use, there is no change in blood pressure or increased blood pressure. The evaluation was carried out on patients with negative responses, what factors were the causes. The results of patient characteristics, p> 0.05, were not significant differences between the two groups. There are variations in the negative response caused by the therapy regimen that is not optimal, lifestyle, and metabolism of antihypertensive drugs that are different for each individual.
Treatment pattern and precision evaluation of diabetes mellitus therapy complications of chronic renal failure at RSUD Undata Palu Dian Rahmawati
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 2 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i2.14078

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease or disorder characterized by high blood sugar levels accompanied by disorders of carbohydrate, protein, and lipid metabolism, which can produce chronic complications due to the inability to function insulin. Uncontrolled DM can be a risk factor for kidney failure. Abnormalities that occur in the kidneys of people with diabetes are characterized by microalbuminuria. This study aimed to determine the pattern and treatment of DM patients with Chronic renal failure or Chronic Kidney Disease (CKD) at Undata Hospital Palu, whether it is following the standard. This research is a descriptive cross-sectional study with retrospective data collection on medical records. Sampling was done using a total sampling technique with medical record data of thirty patients based on inclusion criteria. Based on the results of the study, the use of drugs in patients with DM complications of CKD was fast-acting insulin as many as twenty three people (79.3%) because insulin is the leading choice for DM patients with complications of CKD, especially in patients undergoing hemodialysis. Evaluation of treatment in patients with DM complications of CKD follows the standard treatment used as a reference. Insulin is the primary choice for diabetes mellitus patients with chronic renal failure complications, especially in patients undergoing hemodialysis.
Behavioral factor analysis of accuracy in using diarrhea medicines at Arjuno Health Center, Malang City with the Health Belief Model (HBM) approach Laras Hadyaning Tias; Liza Pristianty; Ika Ratna Hidayati
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 5 No. 2 (2020)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v5i2.14094

Abstract

Diarrhea is a bowel movement that can occur in adults and children, with a frequency of three or more times a day, accompanied by stool to liquid changes, with mucus and blood. The Health Belief Model is a theory used to help identify factors that influence individual health behavior. This study aims to analyze patient behavior factors that influence the accuracy in using diarrhea medication at Arjuno Health Center Malang City, according to the HBM approach. This study used a cross-sectional method with the sampling technique used, namely a non-probability sample with an accidental method. This study uses an approach to the theory of the Health Belief Model (HBM). The research instrument used was a valid and reliable questionnaire. There are two variables used, namely the independent variable (the factors of the Health Belief Model theory) with five constructs, namely Perceived susceptibility, perceived severity, perceived barrier, perceived benefits, self-efficacy. Furthermore, the dependent variable with one indicator is the accuracy of using diarrhea medication. The number of samples used was 80 respondents. The T-test with a significance value for each HBM component is 0.000 < p-value (alpha = 0.05), which means an influence between each HBM component and the accuracy of drug use in patients with diarrhea. F test with a significant value for all HBM components 0.000 < p-value (alpha = 0.05), which means that there is an effect of all HBM components on drug use accuracy in patients with diarrhea. 
Health-related quality of life: chronic kidney disease patients in Riau Ferdy Firmansyah; Tiara Tri Agustini
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 6 No. 1 (2021)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v6i1.14806

Abstract

Chronic Kidney Disease (CKD) can have an impact on quality of life which affects physical, mental health, functional status, and independence. The high prevalence of CKD will have an impact on the quality of life. The purpose of this study was to see the effect of the characteristics of CKD patients on the utility index score and to determine the dimensional correlation to the utility value measured using the SF-6D questionnaire. The study was conducted with an observational approach using a cross-sectional design in the CKD population in the city of Pekanbaru. The SF-6D questionnaire was administered to 122 patients to measure utility index scores. The difference in utility index scores based on patient characteristics was tested using Mann Whitney and Kruskal Wallis, while the correlation between domains and utility scores was used Pearson Correlation 0.61 ± 0.07. Score utility measured using the SF-6D instrument can distinguish utility values ​​based on education and comorbidities. There is a strong correlation (> 0.797) between vitality and mental domains with the SF-6D utility index.

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