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INDONESIA
Jurnal Sains dan Kesehatan
Published by Universitas Muhammadiyah Manado
ISSN : 25808362     EISSN : 29621569     DOI : 10.57214
Core Subject : Health,
Health Professions Public Health
publikasi ilmiah dalam konten kesehatan dan sains yang memuat hasil penelitian, kajian pustaka, analisis kritis dan pengembangan.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 171 Documents
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Hubungan Riwayat Berat Badan Lahir Rendah Dengan Kejadian Stunting Pada Anak Balita Usia 2-5 Tahun Di Puskesmas Bandarharjo Semarang Amanda Wahyu Afriani; Rita Kartikasari
Jurnal Sains dan Kesehatan Vol. 10 No. 1 (2026): Juni : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jusika.v10i1.1120

Abstract

Stunting remains a significant nutritional issue because it can impact a child's long-term growth and development. A history of low birth weight (LBW) is suspected to play a role, reflecting the condition of fetal growth during pregnancy. This study aimed to determine the relationship between a history of LBW and the incidence of stunting in children aged 2–5 years at the Bandarharjo Community Health Center in Semarang in 2025. This study used an analytical design with a case-control approach. The study sample consisted of 203 toddlers selected using consecutive sampling. Data were obtained from the KIA book and height measurements based on WHO standards. Analysis was performed using the Chi-Square test and Odds Ratio (OR) calculation. The proportion of LBW was 10.8% and stunting was 31.0%. There was a significant relationship between a history of LBW and the incidence of stunting (p = 0.012). Toddlers with a history of LBW had approximately a threefold greater risk of experiencing stunting compared to toddlers born with normal weight (OR = 3.059). There is a relationship between a history of low LBW and the incidence of stunting in toddlers aged 2-5 years at the Bandarharjo Community Health Center, Semarang in 2025.
Gambaran Ct Value pada Swab Pertama dan Swab Kedua Covid 19 pada Anak di Indramayu Warih Kuncoro Mukti; Indriani Silvia; Donny Nauphar
Jurnal Sains dan Kesehatan Vol. 10 No. 1 (2026): Juni : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jusika.v10i1.1124

Abstract

Corona Virus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The first case was identified in Wuhan, China, in December 2019. The World Health Organization declared COVID-19 a Public Health Emergency of International Concern (PHEIC) on January 30, 2020, and a pandemic on March 11, 2020. This study aimed to determine the results of CT Value images on the first and second swab tests of children with COVID-19 in Indramayu. A descriptive design was used with total sampling, involving 54 respondents. Secondary data were analyzed using univariate analysis. On the first swab test, 27 children (50.0%) had a strong positive Ct Value, 26 children (48.1%) were positive, and 1 child (1.9%) had a weak positive Ct Value. On the second swab test, 23 children (71.9%) were positive, 6 children (18.8%) were strong positive, and 3 children (9.4%) were weak positive. All children tested positive on the first swab, while 32 (59.3%) remained positive and 22 (40.7%) became negative on the second swab. Most children showed decreased infection severity, although some remained positive.
Pengaruh Usia, Gender dan Kedekatan Tempat Tinggal dengan Landfill terhadap Kejadian Diabetes Melitus Tipe 2 Nabilla Tita Saputri; Yusuf Alam Romadhon
Jurnal Sains dan Kesehatan Vol. 10 No. 1 (2026): Juni : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jusika.v10i1.1134

Abstract

Diabetes Mellitus is a non-communicable disease with an increasing prevalence and has become a major public health concern globally and nationally. The incidence of diabetes mellitus is influenced by various individual and environmental factors. This study aimed to analyze the relationship between age, gender, and residential proximity to landfill areas and the incidence of diabetes mellitus in Bendosari District. A quantitative analytic observational design with a cross-sectional approach was employed. The study population consisted of 1,890 patient visit records recorded in the Management Information System of Bendosari Public Health Center in 2025. A total of 363 respondents were selected using proportionate stratified random sampling. Data were analyzed through univariate analysis, bivariate analysis using the Chi-Square test, and multivariate analysis using multiple logistic regression. The findings showed that age was significantly associated with diabetes mellitus incidence (p=0.000; OR=79.790; 95% CI=53.511–118.974). Gender was also significantly related to diabetes mellitus incidence (p=0.000; OR=0.298; 95% CI=0.203–0.435), indicating that females had a higher risk than males. In contrast, residential proximity to landfill areas was not significantly associated with diabetes mellitus incidence (p=0.308; OR=1.247; 95% CI=0.439–3.540). Multivariate analysis revealed that age and gender were the dominant factors influencing diabetes mellitus incidence, with the model explaining 56.1% of the variation. The study concludes that age and gender are significant determinants of diabetes mellitus incidence, whereas residential proximity to landfill areas has not been proven to significantly affect its occurrence.
Prevalensi Rinosinusitis Kronik di Poliklinik THT-KL RSUD dr. Doris Sylvanus Kota Palangka Raya Tahun 2023 dan 2024 Ariska Agustina; Margaretha Yayu Indah Anugerahny; Indria Augustina; Angeline Novia Toemon; Nuch Sabunga
Jurnal Sains dan Kesehatan Vol. 10 No. 1 (2026): Juni : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jusika.v10i1.1138

Abstract

Chronic rhinosinusitis (CRS) is a long-term inflammatory condition affecting the nasal mucosa and paranasal sinuses, which significantly impacts patients’ quality of life due to persistent and recurrent symptoms. Limited epidemiological data regarding CRS are available in Central Kalimantan, particularly at RSUD dr. Doris Sylvanus in Palangka Raya, prompting this study to determine its prevalence and patient distribution characteristics. This research employed a quantitative descriptive design with a cross-sectional approach. Data were collected from medical records of patients diagnosed with CRS in 2023 and 2024. Univariate analysis was conducted, and results were presented in tables and diagrams illustrating frequency distributions by year, gender, age, and main complaints. The findings showed a total of 118 CRS patients, with 53 cases in 2023 and 65 cases in 2024. The prevalence of CRS increased from 4.91% in 2023 to 10.83% in 2024. Based on gender, males accounted for 50.8% (60 patients), while females represented 49.2% (58 patients). The age group most affected was 46–55 years (31%), indicating a predominance among individuals of productive age. Nasal congestion was the most frequent primary complaint, reported by 35% of patients. The study concludes that the prevalence of CRS at RSUD dr. Doris Sylvanus increased notably from 2023 to 2024, with a slightly higher incidence among males in the productive age group. These findings highlight the need for enhanced preventive measures and early diagnosis to manage CRS more effectively in the local population.
Faktor-Faktor yang Berhubungan dengan Kesiapan Kader Posyandu ILP di Wilayah Kerja Puskesmas Penusupan Kabupaten Tegal Tahun 2026 Valentina Ayumy Fortunita Mia Amrillah; Lely Wahyuniar; Dwi Nastiti Iswarawanti; Mamlukah Mamlukah
Jurnal Sains dan Kesehatan Vol. 10 No. 1 (2026): Juni : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jusika.v10i1.1140

Abstract

The Integrated Primary Care Posyandu (ILP) program requires cadres to assume a much broader role compared to conventional Posyandu services. In the working area of Puskesmas Penusupan, ILP achievement reached only 20% in 2025, while merely 25 out of 225 cadres (11%) had received related training. This condition indicates that cadre readiness needs to be examined more comprehensively before the program can be implemented optimally. This study aimed to analyze the factors associated with the readiness of ILP Posyandu cadres using a descriptive-analytic method with a cross-sectional approach. The study involved 144 cadres selected proportionally from a population of 225 using the Slovin formula. Data were collected through structured interviews using a validated questionnaire and analyzed using univariate, bivariate (Spearman Rank), and multivariate (ordinal logistic regression) analyses. The results showed that among the eight variables examined, only skills (r = 0.171; p = 0.040) and resource availability (r = 0.225; p = 0.007) were significantly associated with cadre readiness. In the multivariate analysis, resource availability emerged as the most influential factor with an OR = 2.839 (95% CI: 1.311–6.149), indicating that cadres supported by adequate resources were 2.8 times more likely to demonstrate good readiness. In conclusion, resource availability was identified as the dominant factor associated with the readiness of ILP Posyandu cadres in the working area of Puskesmas Penusupan. Therefore, improving the availability of facilities and infrastructure, providing practice-based training, and strengthening operational support should become priority programs in the future.
Association of Circulating Tumor DNA (ctDNA) to Monitoring Treatment Response in Urothelial Carcinoma: A Comprehensive Systematic Review Muhammad Rizki Fadil; Fabian Gamal Sutrisno; Siti Fira Rahmawaty; Archie Fontana Iskandar
Jurnal Sains dan Kesehatan Vol. 10 No. 1 (2026): Juni : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jusika.v10i1.1141

Abstract

Circulating tumor DNA (ctDNA) has emerged as a promising liquid biopsy biomarker for real-time monitoring of tumor dynamics. In urothelial carcinoma (UC), effective monitoring of treatment response remains a clinical challenge due to the limitations of conventional imaging and invasive procedures. This systematic review aims to synthesize the existing evidence on the association between ctDNA dynamics and treatment response monitoring across various stages and therapeutic settings. A comprehensive systematic review was conducted. We included cohort studies, randomized controlled trials, and meta-analyses that evaluated ctDNA in UC patients undergoing treatment. Data were extracted on patient population, methodology, treatment, sampling strategy, clinical outcomes, and statistical associations. The review encompassed 80 studies. Baseline ctDNA positivity was strongly prognostic, associated with a 4- to 6-fold increased risk of recurrence or death (HR 4.23-6.56). Dynamic ctDNA clearances or significants reduction during treatment, were strongly associated with improved outcomes. Showing hazard ratios for adverse events as low as 0.10-0.31. ctDNA demonstrated time advantages of 53-90 days over radiographic detection. ctDNA is a potent tool for monitoring treatment response in urothelial carcinoma. It provides superior prognostic and offers a significant lead time for detecting treatment failure. Future research must focus on standardizing methodologies and validating ctDNA-guided therapeutic.
Analisis Faktor Risiko Indeks Massa Tubuh, Riwayat Hipertensi, dan Riwayat Preeklampsia terhadap Kejadian Preeklampsia pada Ibu Hamil Tia Tahnia; Defrin Defrin; Firdawati Firdawati; Rima Semiarty; Roza Sriyanti; Lusiana El Sinta Bustami
Jurnal Sains dan Kesehatan Vol. 10 No. 1 (2026): Juni : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jusika.v10i1.1142

Abstract

Preeclampsia is a pregnancy complication that significantly contributes to maternal and neonatal morbidity and mortality worldwide. Globally, it affects approximately 3–8% of pregnancies and causes more than 70,000 maternal deaths each year. In Indonesia, preeclampsia accounts for around 30% of the 4,151 maternal deaths reported in 2024. In Padang City, there were 254 cases in 2023 and 129 cases in 2024, with Puskesmas Bungus having the highest prevalence (7.2% and 3.77%). This study aimed to analyze the association between body mass index (BMI), history of hypertension, and history of preeclampsia with the incidence of preeclampsia among pregnant women at Puskesmas Bungus, Padang. This study used a quantitative case-control design involving 50 cases and 50 controls. Data were analyzed using chi-square and logistic regression tests. The results showed significant associations between obesity (p=0.031; OR=2.897), history of preeclampsia (p=0.006; OR=13.821), and history of hypertension (p=0.002; OR=17.216) with the incidence of preeclampsia. Multivariate analysis identified history of hypertension as the most dominant factor associated with preeclampsia. This study concludes that obesity, history of hypertension, and history of preeclampsia are significant risk factors for preeclampsia among pregnant women. Strengthening early detection and routine antenatal care for high-risk pregnancies is necessary to reduce maternal complications associated with preeclampsia.
Hubungan Hipertofi Adenoid Berdasarkan Rasio Adenoid-Nasofaring Dengan Kejadian Otitis Media Salsabila Salsabila; Prima Maharani Putri; Luhur Dewantoro; Nurrizki Haitamy
Jurnal Sains dan Kesehatan Vol. 10 No. 1 (2026): Juni : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jusika.v10i1.1143

Abstract

Background: Adenoid hypertrophy is a condition characterized by enlargement of the adenoid tissue which can cause nasopharyngeal obstruction and potentially affect the function of the Eustachian tube. Dysfunction of the Eustachian tube may disrupt middle ear ventilation and increase the risk of otitis media. The degree of adenoid hypertrophy can be objectively assessed using a lateral nasopharyngeal radiograph by calculating the adenoid–nasopharyngeal ratio (A/N ratio). Objective: This study aimed to determine the relationship between adenoid hypertrophy based on the adenoid–nasopharyngeal ratio and the incidence of otitis media. Methods: This study was a quantitative research with an analytic observational design using a cross-sectional approach. Data were obtained from the medical records of patients with adenoid hypertrophy who underwent lateral nasopharyngeal radiographic examination at RSI Purwokerto from 2022 to 2025. The sample consisted of 31 patients who met the inclusion and exclusion criteria. Data analysis was performed using the Spearman correlation test because the data were not normally distributed based on the Shapiro–Wilk test. Results: The results showed that most of the subjects were male (17 subjects, 54.8%) and female (14 subjects, 45.2%). The median age of the subjects was 7 years with an age range of 4–9 years. The median adenoid–nasopharyngeal ratio was 0.90 with a range of 0.68–0.99. Otitis media was found in 11 subjects (35,5%), while 20 subjects (64,5%) did not experience otitis media. The Spearman correlation test showed a correlation coefficient of r = 0.015 with a p-value of 0.936 (p > 0.05), indicating that there was no significant relationship between the adenoid–nasopharyngeal ratio and the incidence of otitis media. Conclusion: There was no statistically significant relationship between adenoid hypertrophy based on the adenoid–nasopharyngeal ratio and the incidence of otitis media.
Pentingnya Asupan Gizi Seimbang untuk Meningkatkan Performa Atlet Muda: Perspektif dan Edukasi bagi Orang Tua Atlet di SSB Kancil Mas Riska Anastasya Wijaya Kusuma; Linda Riski Sefrina; Milliyantri Elvandari
Jurnal Sains dan Kesehatan Vol. 10 No. 1 (2026): Juni : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jusika.v10i1.1145

Abstract

Balanced nutrition intake is an important factor in supporting the performance of young athletes, especially during the growth period that requires optimal nutrition for intense physical activity. However, the lack of nutritional knowledge among parents of young athletes often leads to nutritional imbalances that have a negative impact on athlete health and performance. This study aims to measure the effect of balanced nutrition education on improving the knowledge and attitudes of parents of athletes at the Kancil Mas Football School (SSB), Karawang. The method used was a quasi-experiment with a pre-test and post-test design involving 20 respondents who were parents of U-13 athletes. Education was provided in the form of direct counseling sessions and group discussions, which were supplemented with supporting materials such as leaflets. The Wilcoxon signed rank test was used to analyze changes in parental knowledge and attitude scores before and after the intervention. The results of the analysis showed a significant increase in parents' understanding and positive attitudes towards balanced nutrition after education (p < 0.05). The results showed a significant increase in the level of parents' understanding and positive attitudes towards nutrition after the education intervention. These findings highlight the importance of active parental involvement in ensuring that young athletes' nutritional needs are met, as well as providing a basis for developing nutrition education programs in other sports schools.
Eksplorasi Senyawa dan Efek Ekstrak Daun Sirsak (Annona muricata L.) terhadap Viabilitas dan Ekspresi Gen BCL2 pada Sel HeLa Jasmin Ayla Fitri Daulay; Hanifa Tasya Kamila; Rahma Yulia; Nadila Ananda Putri
Jurnal Sains dan Kesehatan Vol. 10 No. 1 (2026): Juni : Jurnal Sains dan Kesehatan (JUSIKA)
Publisher : Universitas Muhamadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jusika.v10i1.1149

Abstract

Human Papillomavirus (HPV) infection is typically the cause of cervical cancer, one of the cancers with a high death rate among women. Despite their widespread use, conventional therapeutic approaches still have drawbacks, such as the emergence of cancer cell resistance and severe side effects. Natural compounds are now used as safer alternative treatments as a result. Soursop leaves (Annona muricata L.) are one plant that has been shown to have anticancer potential. Through phytochemical screening, compound identification using GC-MS, cell viability testing using the MTT Assay, and BCL2 gene expression analysis using qPCR, this study attempts to examine the potential of soursop leaf extract as an anticancer agent against cervical cancer cells (HeLa cells). The results of the phytochemical examination showed that steroids, phenolics, and alkaloids were present. Ostole, bisacumol, and ricinoleic acid were found to be the predominant components when the active chemicals were identified by GC-MS. With an IC²₀ value of 5.01 μg/mL, the MTT experiment demonstrated that soursop leaf extract could decrease cell viability as the concentration rose. Furthermore, BCL2 gene expression was significantly reduced, especially in treatments with doses of 500 and 1000 μg/mL, according to the results of qPCR gene expression analysis. The overall findings suggest that soursop leaf extract may be used as a natural anticancer treatment against HeLa cells by lowering the expression of the BCL2 gene.

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