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Pengurus Pusat Ikatan Apoteker Indonesia Jalan Wijayakusuma No. 17 Tomang, Jakarta Barat Jakarta 11430
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INDONESIA
Jurnal Farmasi Indonesia
Published by Ikatan Apoteker Indonesia
ISSN : 14121107     EISSN : 2355696X     DOI : https://doi.org/10.35617/jfionline
Core Subject : Health,
Medicine & Pharmacology
Jurnal Farmasi Indonesia adalah jurnal nasional (peer-reviewed) yang diterbitkan oleh Ikatan Apoteker Indonesia dua kali dalam setahun sebagai sarana diseminasi ilmu pengetahuan di bidang farmasi, yaitu: farmasi klinis, farmasi masyarakat/komunitas, kimia farmasi, biologi farmasi/famakognosi, farmakologi, pengembangan obat/kimia medisinal, formulasi dan bidang terkait. Artikel yang dipublikasi berupa hasil penelitian dan mini-review. JFIOnline telah mulai diterbitkan sejak tahun 2009 dalam edisi cetak. Pada tahun 2014 mulai dibuat edisi online. Akses artikel pada jurnal tidak berbayar, tetapi dikenakan biaya proses publikasi untuk penulis (open access journal). Mulai bulan Juli 2019 jurnal ini dapat diakses di alamat yang baru yaitu www.jfi-online.org dari alamat sebelumnya www.jfionline.org.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 162 Documents
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Evaluasi Waktu Tunggu Resep Elektronik Pasien Rawat Jalan di Rumah Sakit X Kota Tangerang Rangka, Febbyasi Megawaty; Laila, Zanatul; Novia, Jessica; Andriyani, Andriyani
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 2 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i2.180

Abstract

Resep elektronik merupakan permintaan obat dari dokter untuk pasien dengan memanfaatkan teknologi perangkat lunak ke farmasi. Pelayanan resep memiliki Standar Pelayanan Minimal (SPM) Rumah Sakit yaitu waktu tunggu obat non racikan ≤ 30 menit dan obat racikan ≤ 60 menit. SPM waktu tunggu di Rumah Sakit X Kota Tangerang untuk obat non racikan ≤ 8 menit dan obat racikan ≤ 30 menit. Tujuan penelitian untuk mengevaluasi waktu tunggu obat resep elektronik dan faktor yang mempengaruhinya. Metode penelitian deskriptif secara prospektif dengan pengambilan data sampel menggunakan teknik random sampling pada resep elektronik pasien rawat jalan periode April – Mei 2022. Total populasi resep Januari 2022 adalah 750 lembar dan perhitungan sampel menggunakan rumus slovin berjumlah 261 lembar resep.   Hasil penelitian waktu tunggu obat non racikan berjumlah 213 lembar resep dengan waktu ≤ 8 menit adalah 87 lembar resep (40,85 %), sedangkan obat racikan berjumlah 48 lembar resep dengan waktu ≤30 menit adalah 19 lembar resep (39,58%). Faktor yang menyebabkan tidak tercapainya SPM waktu tunggu obat adalah tahap pengambilan obat non racikan (rata-rata 3,11 menit).
Potensi Ekstrak Kelopak Bunga Rosela (Hibiscus sabdariffa L.) dalam Menghambat Denaturasi Protein secara In Vitro Vikasari, Suci Nar; Septiani, Vina; Rahajeng, Dea Julianti
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 2 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i2.216

Abstract

Inflammation is a normal response to injury, which is characterized by protein and fluid leakage from blood vessels, causing pain and swelling. This study was conducted to determine the in vitro protein denaturation inhibition activity of roselle calyx extract (Hibiscus sabdariffa L.). Roselle flowers were extracted in stages by maceration with n-hexane, ethyl acetate, and 96% ethanol. The comparator used was diclofenac sodium. Several concentration series of extracts and comparators were prepared, and protein denaturation inhibition experiments on bovine serum albumin (BSA) were conducted. The parameters measured were the inhibition value of protein denaturation at each concentration and the value of 50% inhibition (IC50). The results of the study indicated that n-hexane extract, roselle calyx ethyl acetate, and roselle calyx ethanol (96%) could inhibit protein denaturation. Roselle calyx n-hexane extract exhibited an IC50 46.6748g/mL, ethyl acetate extract exhibited an IC50 225.8391g/mL, and 96% ethanol extract exhibited an IC50 191.5105g/mL, whereas diclofenac sodium exhibited an IC50 8.5437g/mL. The conclusion revealed that roselle calyx extracts in n-hexane, ethyl acetate, and 96% ethanol display potentials as anti-inflammatory potential agents by inhibiting protein denaturation.
Analisis Hubungan Penggunaan Antibiotik dengan Lama Terapi Pasien Anak Diare Akut di RSUD Soedirman Ainni, Ayu Nissa; Khuluq , Muh. Husnul; Nisa, Isnaeni Al Khoerotun
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 2 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i2.219

Abstract

Acute diarrhea remains a major problem causing the second highest mortality rate for children in Indonesia. One of the therapies used for acute diarrhea with infection is the administration of antibiotics. If the use of antibiotics is not rational, it will cause high side effects, longer patient treatment, affecting the high cost of hospitals and decreasing the quality of hospital services. The purpose of this study is to analyze the relationship between antibiotic use and treatment duration in order to reduce irrationality and shorten treatment duration in hospitals. The research method used is qualitative research with a correlation study design, with retrospective data collection from January to December 2022. Medical record data of patients, including the type of antibiotic and length of treatment for acute diarrhea in children with bacterial infections in the inpatient ward of RSUD dr. Soedirman, were used as research material. The data obtained were then analyzed using the Gamma correlation test using SPSS version 20. The results of this study showed that almost all patients (100%) received antibiotics and Ceftriaxone (54.29%) was the most prescribed antibiotic, both in single and combination forms. The longest treatment duration for acute diarrhea in children with antibiotics was 4 to 5 days (58.57%). The Gamma correlation test showed that the use of antibiotics and treatment duration had a significance value of 0.000 (<0.005). The use of antibiotics given to children with acute diarrhea has a significant relationship with treatment duration at RSUD dr. Soedirman.
Pengembangan Kuesioner PTFKP untuk Mengevaluasi Pelayanan Telefarmasi Berupa Kepuasan Pasien Berdasarkan Mutu Pelayanan WHO Kusumawardani, Larasati Arrum; Puspasari, Annisa; Achmad, Reza Fadillah; Wati, Azizah
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 2 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i2.221

Abstract

Telepharmacy is one of pharmaceutical service that is currently growing and widely used by community and healthcare facility in the digital era. To ensure the quality, it should meet the dimensions of healthcare service quality. According to WHO, the dimensions of healthcare service quality include effective, efficient, timely, people-centered, equitable, and safe. However, instruments to assess the quality of telepharmacy services are still very limited. This study aims to develop a PTFKP questionnaire to evaluate the quality of telepharmacy services based on WHO quality health services from the perspective of patient satisfaction. Content validation was conducted in two stages by three experts consisting of academicians and community pharmacists. Face validity, construct validity, and reliability testing were conducted on 30 respondents who met the criteria of being over 18 years old and having used telepharmacy services in the last 2 years. Content validity testing showed an I-CVI value of 0.71 (first round) and 1.00 (second round). In construct validity testing using the CITC (corrected item-total correlation) method, 10 questions did not meet the requirements initially. After revision, the r value for each question met the criteria, ranging from r= 0.378-0.857 (rtable = 0.361). Reliability testing using the internal consistency method showed a Cronbach’s alpha value of 0.805-0.900 for each dimension of service quality. The number of valid and reliable questions was 5 for each dimension of effective, efficient, people-centered, and safe, and 4 for each dimension of timely and equity. The questionnaire meets the validity and reliability requirements to be used.
Faktor-Faktor yang Mempengaruhi Intensi Masyarakat Untuk Mengikuti Vaksinasi Covid-19 Dosis Lengkap di Kota Makassar Harnas, Risman; Saud, Anshar; Bahar, Muh. Akbar
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 2 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i2.224

Abstract

The control of the COVID-19 pandemic is influenced by the effective acceptance of vaccines. This study aims to identify the factors affecting the willingness of the public to receive the complete dose of COVID-19 vaccine in the city of Makassar. A cross-sectional research approach was employed, utilizing a questionnaire consisting of demographic information, perceptions of the severity and vulnerability to COVID-19, as well as barriers and benefits of COVID-19 vaccination, which were distributed online in Makassar City. Multivariate logistic regression analysis was used to identify independent factors influencing the intention of the public to receive the full dose (two doses) of the vaccine. A total of 310 respondents participated in this study. Respondents who perceived a high level of disease severity (aOR= 3.39; 95% CI: 1.41 – 8.14) had a higher likelihood of receiving full COVID-19 vaccination, while respondents with a perception of high access barriers to vaccination had a lower likelihood of receiving full COVID-19 vaccination (aOR= 0.18; 95% CI: 0.07 – 0.45). In this study, the intention to accept full COVID-19 vaccination was influenced by perceptions of disease severity and perceived access barriers to vaccination. The implementation of the COVID-19 immunization program by healthcare providers and local governments should incorporate various vaccination education strategies tailored to patients' health beliefs.
Pengaruh Diet Tinggi Fruktosa Terhadap Resistensi Insulin Pada Tikus Jantan Putih (Rattus norvegicus) Galur Wistar Susilawati, Elis; Levita, Jutti; Susilawati, Yasmiwar; Sumiwi, Sri Adi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 2 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i2.274

Abstract

Asupan tinggi fruktosa dapat menyebabkan gangguan metabolisme terhadap timbulnya sindrom metabolik dan diabetes melitus tipe 2. Dalam penelitian ini akan disampaikan beberapa dampak yang di dari konsumsi fruktosa. Penelitian ini bertujuan untuk membuat pemodelan hewan uji dengan pemberian fruktosa 60% terhadap resistensi insulin. Metode penelitian menggunakan 8 ekor tikus putih jantan galur Wistar yang dikelompokkan menjadi 2 kelompok yaitu kelompok normal dan kelompok fruktosa 60%. Parameter yang diamati terhadap bobot badan, kadar glukosa darah, Konstanta Tes Toleransi Insulin (KTTI), kadar adiponektin dan kadar TNF-α serta histologi jaringan adiposa. Hasil penelitian menunjukkan bahwa pemberian fruktosa 60% selama 60 hari menunjukan adanya perbedaan untuk kadar glukosa darah yang dumulai pada hari 30-60, Nilai KTTI kelompok fruktosa lebih kecil dibandingkan kelompok normal, kadar adiponektin kelompok fruktosa lebih kecil dibandingkan kelompok normal , sedangkan  kadar TNF-α kelompok fruktosa lebih besar dibandingkan kelompok normal  dan terjadi pembesaran diameter jaringan adiposa putih dan pengecilan adiposa cokelat  pada kelompok fruktosa, namun belum terjadi perbedaan pada bobot badan. Dapat disimpulkan bahwa pemberian fruktosa 60% selama 60 hari dapat digunakan sebagai pemodelan hewan uji resistensi insulin.
Hubungan Pengetahuan Keluarga dengan Kepatuhan Minum Obat Pasien Skizofrenia di Unit Rawat Jalan Rumah Sakit Jiwa Mutiara Tahun 2023 Qiyaam, Nurul; Isnaini, Marlinda; Nopitasari, Baiq Leny; Anjani, Baiq lenysia Puspita
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 2 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i2.218

Abstract

Schizophrenia is a brain disorder that affects thoughts, perceptions, emotions, movements, and behaviors, leading to peculiar and dependent behavior. Patients with schizophrenia may be more likely to adhere to their drug regimens if their families know and support them. This study aims to ascertain how family awareness and medication adherence relate to schizophrenia patients at Mutiara Sukma Mental Hospital's outpatient unit in 2023. The study used a cross-sectional strategy and a correlational research design. It was carried out in March 2023, involved 112 relatives of schizophrenia patients, and was chosen using selective sampling. The results showed that families of patients had good knowledge (38.4%), moderate knowledge (39.3%), and poor knowledge (22.3%). Among the patients, 72.3% were adherent to medication, while 27.7% were non-adherent. The statistical analysis revealed a significant relationship between family knowledge and medication adherence of schizophrenia patients (p=0.000, p<0.05).
Analisis Hubungan Polifarmasi dengan Interaksi Obat Antihipertensi pada Pasien Gagal Ginjal Kronik dengan Hemodialisis di RSUD Sleman Yogyakarta Febriyani, Ghesa; Padmasari, Siwi
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 16 No. 2 (2024): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v16i2.231

Abstract

Chronic Kidney Disease (CKD) is a condition of kidney damage lasting more than 3 months, resulting in both structural and functional impairment. According to Riskesdas data from 2018, the number of CKD patients aged ≥15 years in Indonesia increased from 0.2% in 2013 to 0.38%. CKD patients undergoing hemodialysis therapy in outpatient settings generally receive more than one type of medication (polypharmacy), which can increase the risk of drug interactions. This study aims to determine the relationship between polypharmacy and the potential for antihypertensive drug interactions in CKD patients undergoing hemodialysis at RSUD Sleman Yogyakarta in 2022. The study used a retrospective observational analytic design with purposive sampling technique, involving 107 outpatient samples who met the inclusion criteria. Drug interactions were analyzed using a website-based tool from drugs.com, and the data were analyzed univariately and bivariately using the chi-square test. The study results showed that the majority of CKD patients undergoing outpatient hemodialysis were aged 45–54 years (34.57%), male (57.00%), had comorbid conditions (86.91%), used single antihypertensive drugs (53.27%), and used less than 5 types of drugs (61.68%). Of the total patients, 57.94% experienced drug interactions, with a moderate severity level (90.37%) and a pharmacodynamic interaction mechanism (73.33%). The conclusion of this study indicates a significant relationship between polypharmacy and the potential for drug interactions (p=0.001).
Analisis Faktor-Faktor yang Mempengaruhi Kejadian Potentially Inappropriate Medications (PIMs) pada Pasien Geriatri Rawat Inap RSUD Dr. Soedomo Trenggalek Widyaningrum, Esti Ambar; Rizky, Fara Nikhmatul; Irawati, Renny Nur Satya; Fajriyah, Shofiatul; Rilawati, Fentyana Dwi; Kurniawati, Evi; Lestari, Tri Puji
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.271

Abstract

Background: Geriatric patients are elderly patients with multiple diseases. Geriatric patients have more comorbidities and often receive polypharmacy prescriptions. PIMs have been identified in many elderly patients. One of the explicit criteria that can be used to identify the incidence of PIMs in geriatric patients is the Beers Criteria. Objective: To determine the frequency of PIMs and the factors that can influence the occurrence of PIMs based on the Beers Criteria in hospitalized geriatric patients at RSUD Dr. Soedomo Trenggalek. Method: This research uses a type of research with a retrospective observational analytical approach. The sampling technique used was purposive sampling with a total sample of 312 medical records.  Inclusion criteria: age ≥ 65 years and exclusion: incomplete medical record data. Results: The most common characteristic profiles were male gender (62%), elderly (65-74 years) 69%, type of BPJS service (87%), main disease with the cardiovascular system (31%), number of diseases 2 (43%) and the number of drugs 6-10 drugs (50%). There was an incidence of PIMs of 78.53%. The factors gender, age, type of service, main diagnosis have a p value ≥ 0.05, while the number of diseases and medications have a p value ≤ 0.05. Conclusion: There is an incidence of PIMs in hospitalized geriatric patients of 78.53% with the number of diseases and number of medications influencing the incidence of PIMs in hospitalized geriatric patients.
Uji Aktivitas Antiinflamasi Ekstrak Etanol, Etil Asetat, dan N-heksan Tangkai Daun Kemumu (Colocasia gigantea Hook.f) secara in vitro terhadap Sel Makrofag Peritoneum Rosi, Devahimer Harsep; Qalbi, Abrar Hafidz; Afriani, Tika
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.396

Abstract

Kemumu leaf stalks (Colocasia Gigantea Hook.F) are a plant that has many benefits for society, one of which is anti-inflammatory. Inflammation is process in the body to respond to infection or tissue damage. This study aims to test the anti-inflammatory effectiveness of ethanol extract, n-hexane, and ethyl acetate of kemumu leaf stalks in vitro. Kemumu leaf stalks contain flavonoids, alkaloid and tannin which have anti-inflammatory properties. Anti-inflammatory effectiveness testing was carried out on peritoneal macrophage cells to determine the inhibition of NO production in LPS-stimulated peritoneal macrophage cells by quantifying nitrite accumulation in the culture medium using Griess reagent. This research is an experimental study with 5 dose treatments for each extract with 3 replications. The parameters observed included NO production and the percentage of peritoneal macrophage cell inhibition. The results of statistical tests using One Way Anova showed a significant difference in NO levels between the sample group given the extract and the control sample (p=0.000). From the results of the percentage inhibition of NO production in peritoneal macrophage cells, it shows that ethanol extract of kemumu leaf stalks with concentrations of 50 and 100 µg/ml has the best anti-inflammatory effect, namely with NO production of 4.67 and 1.44 µg/ml respectively, and with respective inhibition 80.32% and 89.01% respectively.

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