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Jurnal Penyakit Dalam Indonesia
Published by Universitas Indonesia
ISSN : 24068969     EISSN : 25490621     DOI : https://doi.org/10.7454/
Core Subject : Health,
Medicine & Pharmacology
Jurnal Penyakit Dalam Indonesia contains the publication of scientific papers that can fulfill the purpose of publishing this journal, which is to disseminate original articles, case reports, evidence-based case reports, and literature reviews in the field of internal medicine for internal medicine and general practitioners throughout Indonesia. Articles should provide new information, attract interest and be able to broaden practitioners insights in the field of internal medicine, as well as provide alternative solutions to problems, diagnosis, therapy, and prevention.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 9 Documents
 1 
Search results for , issue "Vol. 9, No. 2" : 9 Documents clear
Proportion of Depression Symptoms and Its Relationship with ARV Therapy: A Study at the VCT Clinic, Dr. Kariadi General Hospital Sofro, Muchlis Achsan Udji; Raharja, Tommy; Haidati, Titis; Sari, Linda Kartika; Jusup, Innawati
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 2
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Introduction. Indonesia has the second largest HIV burden in Asia. The prevalence of depression in HIV/AIDS is 2-10 times higher than the general population, influenced by biological, environmental, psychological, and demographic factors. Data on the proportion of depression symptoms in HIV/AIDS patients and their relationship to biological factors are still limited, which needed for better treatment of HIV/AIDS. This study aimed to determine the prevalence of depression and its relationship to the biologic factors of ARV therapy (ART) in HIV/AIDS patients.Methods. Cross-sectional study was conducted among 142 HIV/AIDS patients undergoing ARV treatment at RSUP. Dr. Kariadi in January – March 2021. Demographic data, ART, ART type, side effects, ARV use duration, viral load, and CD4 cell count were obtained from medical records. The incidence of depression was assessed by the Beck Depression Inventory II (BDI-II).Results. The proportion of depression symptoms was 48.6%, consisting of mild depression (26.1%), moderate depression (17.6%), and severe depression (4.9%). Multivariate analysis resulted a significant relationship between the incidence of depression and biological factors, consisting of ART side effects, ART use duration, and CD4 cell count. Meanwhile, there was no significant relationship between the incidence of depression with the ART type and viral load. Conclusion. The proportion of depression symptoms in HIV patients undergoing ART is 48.6%. It is concluded that biological factors can affect the proportion of depression in patients with ART.
The Association between Type 2 Diabetes Mellitus and The Outcome of COVID-19 Patients at Sanglah Hospital in 2020-2022 Upadhana, Putu Sayakumara; Sastrawan, I Gede Gita; Rahmautami, I Gita Dewi; Merry, Merry; Daradila, Ni Putu Kostarika Melia; Sutanto, Derian Adiguna; Pertiwi Manuaba, Ida Ayu Santhi; Hartadi, Putu Ardy; Ratna Kinasih, Komang Vika Nariswari; Sudarmika, Putu
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 2
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Introduction.People with type 2 diabetes mellitus (T2DM) are at a higher risk of mortality from COVID-19. This study aimed to identify the relationship between T2DM and the outcome of COVID-19 patients in Sanglah Hospital Denpasar, Bali. Methods. An observational analytic study with a cross-sectional approach was conducted among COVID-19 patients. We used secondary data from the records of confirmed COVID-19 patients who were treated at Sanglah Hospital on 1 August 2020 – 28 February 2022. Sample were selected with total sampling technique. Results. There were 1,056 patients involved in this study. Most of the patients were male (n=571; 54.1%), with a median age of 59 years old. Most of the patients were categorized as severe COVID-19 (n=641; 60.7%). A total of 275 patients had T2DM (26.0%). Chi-square analysis showed a significant association of T2DM with mortality (PR=1.422; 95%CI=1.162-1.742; p=0.001), severe COVID-19 (PR=1.726; 95%CI=1.365-2.184; p<0.001), ventilator usage (PR=1.334; 95%CI=1.093-1.791; p=0.045), and longer hospitalization duration (PR=1.340; 95%CI=1.083-1.658; p=0.006) with T2DM. Logistic regression analysis showed significant association of T2DM with mortality (PR=1.536; 95%CI=1.110-2.125; p=0.010), severe COVID-19 (PR=1.704; 95%CI=1.233-2.356; p<0.001), and longer hospitalization duration (PR=1.615; 95%CI=1.191-2.190; p=0.002).
Atherogenic Index of Plasma is Correlated with Prolonged Length of Stay in COVID-19 Patients with Type 2 Diabetes Mellitus in RSUP Sanglah Denpasar Sastrawan, I Gede Gita; Upadhana, Putu Satyakumara; Handayani, Putu Novi; Laela, Tika Rizki Nur; Dewi, Kadek Aprilia Sukma; Wiguna, I Nyoman Bayu Andika; Trisna, Cindy Gracia; Putri, Komang Anjani; Agrasidi, Komang Adya Data; Sudarmika, Putu
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 2
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Introduction. Atherogenic index of plasma (AIP) is a logarithmic calculation of the ratio of triglycerides to HDL cholesterol as a marker of lipid profile abnormalities. In COVID-19 patients with comorbid type 2 diabetes mellitus (T2DM), higher AIP tend to worsen the patient conditions. This study aims to assess the correlation between AIP and length of stay (LOS) in COVID-19 patients with T2DM.Methods. An analytical observational study with a cross-sectional approach was conducted among COVID-19 patients with comorbid T2DM. Data were collected from online medical records of confirmed COVID-19 patients with comorbid T2DM who were treated at Sanglah Hospital Denpasar during the period August 1-December 31, 2021. Patients who were <18 years old and did not have lipid profile data during>treatment, were excluded from this study.Results. There were 83 data samples that met the study criteria. The median age of the patients was 64 (23- 91) years, the majority were male (59%; n=49), and 30 patients died during treatment (36.1%). The median LOS for all patients was 10 (1-26) days. Patients with prolonged LOS (≥10 days) had higher triglyceride levels (171.8 vs. 120 mg/dL; p<0.001) and AIP values (0.442 vs. 0.286; p=0.02). There was a strong relationship between AIP and LOS values in COVID-19 patients with T2DM (r=0.632; p<0.001). The AIP value can well-discriminated in prolonged LOS conditions (AUC=0.883; 95%CI 0.792-0.974) with the optimal cut-off value of 0.3045 (sensitivity 75.9% and specificity 83.3%).Conclusion. AIP is correlated with prolonged LOS in COVID-19 patients with T2DM. Holistic management of COVID-19 patients with T2DM is urgently needed, including lipid profile control.
Effectivity of Opioid Rotation Compared to Opioid Combination for Cancer Pain: An Evidence Case Report Faisal, Edward; Puspadina, Shafira; Puranto, Rudi; Shatri, Hamzah
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 2
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Pain is the main symptom in cancer patients that needs to be addressed immediately because it can reduce the quality of life. Concern or the ineffectiveness of using one type of opioid makes it necessary for clinicians to understand how to rotate opioids. Therefore, this evidence-based case report was conducted to identify the effectiveness of opioid rotation and combined opioids for the cancer pain management through a literature search on three databases. Literature searching was performed by using Pubmed, Cochrane library, and EBSCO according to clinical inquiries. Of the 24 studies obtained, only one study met the criteria and was then critically assessed. The study found that pain score in both opioid rotation group (fentanyl transdermal) and combined opioids group (oral oxycodone and fentanyl transdermal) was decreased from 2.9 to 2.0 (p=0.22) and 3.0 to 1.8 (p<0.06), respectively. In addition, therapeutic success was achieved in 11 patients in the opioid rotation group and 12 patients in the combined opioids group (p=0.98). Based on the study, it can be concluded that opioid rotation is as effective as combined opioids in managing pain in cancer patients.
SARS-CoV-2 Infection Complicated by Acute Pericarditis Concurrent with Malaria Infection Hocin, Kevin; Kusuma, Yudha; Dewi, Atit Puspitasari
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 2
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Coronavirus disease 19 (COVID-19) can present as various symptoms, which range from asymptomatic to severe symptoms. We report a case of COVID-19 female patient with malaria co-infection who developed pericarditis complication. In this pandemic era, it is mandatory to rule out COVID-19. Coinfection with malaria will result in higher cytokine levels which lead to atypical complication, such as pericarditis. Prompt identification of atypical COVID-19 complications is essential as it can lower the mortality rate and reduce the duration of hospitalization.
Update in Laboratory Diagnosis of Urinary Tract Infection Rinawati, Weny; Aulia, Diana
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 2
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Urinary tract infection (UTI) is an infection caused by the entry of pathogens into the urinary tract. Symptoms of a UTI are not always obvious, and some are asymptomatic or atypical. Urinary tract infections must be distinguished from other diseases that have a similar clinical appearance. Many UTIs resolve spontaneously, but often cause significant morbidity and mortality. With the unpredictable nature of the disease, laboratory tests are required for accurate diagnosis and identification of the cause of infection. Thus, it is necessary to understand the interpretation and limitations of urinalysis and urine culture results. To assist in the diagnosis of urinary tract infections, flowcytometry is currently being developed. With the ability to detect bacteria, this tool can be used for UTI screening in the pre-analytic phase of urine culture
Revaksinasi COVID-19 pada Kelompok Lansia dengan Frailty Fitriana, Ika
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 2
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The Correlation Between MIR-146A and Platelet to Lymphocyte Ratio to Liver Fibrotic on Hepatitis B S.R, Brillian Van Fito; Budi S, R. Satriyo; Pramana, Triyanta Yuli
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 2
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Introduction. Liver fibrosis is a pathological condition as a recovery tissue respond, characterized by excessive extracellular matrix deposit. MicroRNA (miRNA or miR) has a pivotal role on progression of hepatic cirrhosis. Platelet to lymphocyte ratio (PLR) could be as a good predictor of liver fibrosis. This study aimed to find the correlation between miR-146a and PLR with liver fibrosis in Hepatitis B.Method. The cross sectional study conducted in Gastroenterohepatology Clinic of Internal Medicine Department RSUD Dr. Moewardi Surakarta in Januari – Juli 2020, involving 26 Hepatitis B naïve patients. Complete blood count, serum creatinine, liver enzyme, HBsAg, miR-146a, elastography measurement using FibroScan were performed.Results. The average age of patients was 49 (SD 11) years, mainly men (n : 17, 66%). The results from bivariate analysis demonstrated that miR-146a was significantly associated with liver fibrosis (r = 0,639 dan p < 0,001). PLR was also significantly associated with liver fibrosis (r = -0,455 dan p = 0,020). Conclusion. There was a significant correlation between miR-146a and PLR with liver fibrosis on Hepatitis B.
Clinical Profile of COVID-19 Older Patients Hospitalized in Immanuel Teaching Hospital Bandung Vera, Vera; Suprana, Yossie Guventri Eka
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 2
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Introduction. It was reported that 11.2% out of the 78,572 confirmed cases of COVID-19 in Indonesia was foundinolder people with a high mortality rate. There is no available data regarding functional and frailty status of these COVID-19 older patients. This study aimed to describe clinical profile of older COVID-19 patients in terms of geriatric aspect, in order to design better hospital policy for older patients in the COVID-19 isolation ward.Methods. This was a retrospective cohort study of confirmed COVID-19 patients aged >60 years which were admitted to Immanuel Teaching Hospital Bandung during the period of October 2020 - January 2021. Clinical characteristic data, frailty status, mode of oxygen therapy, functional status (activity of daily living – ADL) during and after hospitalization, as well as patient hospitalization outcomes were recorded from the medical record.Results. There were 100 COVID-19 older patients, more than half were aged 60-70 years, most with not frail status. This study found that 74% of older patients had decreased ADL scores, once they got infected with COVID-19. We also found that 43% of COVID-19 older patients died during hospitalization, dominated by frail patients. Among COVID-19 older survivor, 55%had increased ADL score when discharged. A month later, only 25%patients had better ADL scores.Conclusion. Typical symptoms of COVID-19 are not always found in older patients. Apart from its deadly consequence and prolonged hospitalization, the impact of COVID-19 on older patients is decreased functional status, so special management policy for older COVID-19 patients should be considered.

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