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Journal of General Procedural Dermatology and Venereology Indonesia
Published by Universitas Indonesia
ISSN : -     EISSN : 24607991     DOI : https://doi.org/10.19100/jdvi.v1i1.8
Core Subject : Health,
Medicine & Pharmacology
Journal of General-Procedural Dermatology & Venereology Indonesia is an open access and peer-reviewed journal that focuses on dermatology and venereology. This journal publishes original articles, reviews, case reports, and brief communications which contain short features of medicine, current developments in diagnostic procedures, treatments, or other health issues that are relevant and important.
Arjuna Subject : Kedokteran - Dematologi
Articles 9 Documents
 1 
Search results for , issue "Vol. 6, No. 1" : 9 Documents clear
Comparison between oral pentoxifylline + corticosteroid andoral corticosteroid alone for severe erythema nodosum leprosum Martinus, Martinus; Rihatmadja, Rahadi; Menaldi, Sri Linuwih
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
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Background: Severe erythema nodosum leprosum (ENL) is common but difficult to treat. Long term use of systemic corticosteroid causes side effects. This study compares the use of a combination of pentoxifylline + oral corticosteroids with a single oral corticosteroid in leprosy patients with severe ENL reactions. Parameters measured include skin RSA score, systemic RSA, total corticosteroid dose, resolution time of skin lesions, improvement of pain VAS and treatment side effects.Methods: 29 subjects with severe ENL reactions are allocated randomly into two groups which receive oral pentoxifylline + methylprednisolone, and oral placebo + methylprednisolone for 12 weeks. The starting dose of pentoxifylline are 400 mg thrice daily for 4 weeks, tapered to 400 mg daily every 4 weeks. Methylprednisolone is based on WHO guideline. Results: In the end, the median of cutaneous RSA score in pentoxifylline vs placebo group is 4 (0-5) vs 3 (0-5). The median of systemic RSA score in pentoxifylline vs placebo group is 0 (0-6) vs 0 (0-5). The median of total corticosteroid doses in pentoxifylline vs placebo group is 156 (120-200) mg vs 136 (96-200) mg. The median of resolution time in pentoxifylline vs placebo group is 6 (0-12) weeks vs 6 (0-12) weeks. The median of change of pain VAS score in pentoxifylline vs placebo group is 5 (0-6) vs 3 (-3-6). No statistically significant difference (p>0,05) are found in all parameters, including side effects. Conclusion: Combination of oral pentoxifylline + corticosteroid is not proven to be more effective. Both are safe.
Combined use of CROSS TCA and modified subcision with PRP administration for acne scars Fiqri, Ahmad; Mochtar, Moerbono; Zulfikar, Dendy
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
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Background: Acne vulgaris is a skin disease that can cause permanent scarring. Various therapeutic options are available to treat atrophic scars, but combination therapy is still the best choice according to different types of scars in a single patient. Chemical reconstruction of skin scars (CROSS) trichloroacetic acid (TCA), modified subcutaneous incisionless (subcision), and platelet-rich plasma (PRP) can be used as a combination therapy to treat acne scars. Case Illustration: A 25-year-old man complained of acne scars on both sides of his face. Dermatologic findings were blackheads, icepick, boxcar, and rolling scars. Clinically he had moderate to severe acne scores. He was treated with a combination of CROSS TCA for icepick-type acne scars, modified subcision, and PRP injection for rolling and boxcar-type acne scars on both sides of the face. During treatment, the patient was given oral and topical antibiotics. The patient was followed-up after one month. It resulted in a good therapeutic response, which showed 25%-49% of Goodman and Baron’s classification, and a visual analog scale of 6.Discussion: CROSS TCA is a therapeutic choice for icepick-type acne scars with a simple, practical technique and provides a significant effect. Modified subcision is modified therapies from the previous Khunger subcision technique and a new alternative that can be applied to damaged tissue. This can maximally repair scarring, facilitate surgeon, provide avenues, and increase maximum PRP penetration.Conclusion: CROSS TCA with subcision and PRP are simple procedures that can be applied as an alternative therapy to acne scars with good therapeutic response.
Bacterial sensitivity pattern to antibiotics in acne vulgaris at Universitas Sumatera Utara Hospital Medan, Indonesia in 2019 Sari, Lovena; Jusuf, Nelva Karmila; Putra, Imam Budi
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
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Background: The association between psoriasis and metabolic syndrome is appealing as the two may share a similar cross-linking systemic inflammation process. The inflammation processes occurring in obesity and psoriasis may aggravate one another. This raised the question of whether a low-calorie diet would possibly reverse the aforementioned process. This study aims to determine whether calorie restriction reduces psoriasis area and severity index (PASI) in obese patients with moderate-to-severe psoriasis receiving conventional treatment compared to no calorie restriction.Methods: We searched Pubmed/Pubmed Central, ScienceDirect, Cochrane library, EBSCOhost, and Scopus databases using keywords derived from our clinical question. The inclusion criteria were randomized clinical trial (RCT) or systematic review, published in English, and available in full-text.Results: We obtained 2 systematic reviews with meta-analyses by Ko et al. and Upala et al. Ko et al. included 6 RCTs which found that the inclusion of a low-calorie diet shows significant improvement in PASI 75 compared to standard therapy (RR 1.66; 95%CI 1.07, 2.58). Upala et al. also found significant improvement in PASI 75 in a meta-analysis of 7 RCTs (Pooled OR 2.92; 95%CI 1.39, 6.13), but shows moderately high heterogeneity between studies. Other secondary outcomes have also shown significant improvements, such as quality of life and metabolic parameters.Conclusion: The intervention of a low-calorie diet may significantly reduce PASI, improve quality of life and reduce comorbidities in obese patients with moderate-to-severe psoriasis, and thus can be recommended in psoriasis management.
Allergen profile of facial ACD to cosmetics among patients at Tertiary Referral Hospital in Yogyakarta Alfieri, Alessandro; Indrastuti, Niken; Febriana, Sri Awalia; Pudjiati, Satiti Retno; Waskito, Fajar
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
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Background: Cosmetics are a part of life for most of the population and may cause allergic contact dermatitis (ACD), especially on the face, as the primary exposure of cosmetics is on the face area.Methods: This research was conducted retrospectively using secondary data. The research subjects and demographic data were taken from the registered list of patients at Dermatology and Venereology Outpatient Clinic Dr. Sardjito General Hospital with a clinical picture of facial ACD due to cosmetics. Patch tests were carried out from January 2017 to December 2020.Results: From three years period, 26 patients were diagnosed with suspected facial ACD due to cosmetics and underwent patch tests. Of the total 26 patients, 3 patients did not show any reaction to the patch test. On the 23 patients who had reactions on the patch test, there were 66 points on the skin that showed a reaction to allergens. Of the 66 points, 37 points gave a positive reaction picture, with the most common allergen causing the reaction being cobalt(II) chloride hexahydrate (n=4, 10.8%). Then, from 29 points that gave doubtful reactions, the allergen that caused the most reactions was potassium dichromate 0.5% (n=4, 13,8%).Conclusion: The allergens that most often give a positive or doubtful reaction on the patch test of this study are metal compounds (cobalt and potassium dichromate). This study only looks at the patch test that gives a reaction without looking at the clinical relevance related to cosmetics use.
The relationship between increased body mass index with transepidermal water loss: a comparative study Yudhistira, Muhammad Yurizar; Kusumawardani, Arie; Widhiati, Suci; Mulianto, Nurachmat
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
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Background: Obesity affect significant populations on all ages. The relationship between obesity and metabolic diseases is known but a dermatological link is rarely explained. Transepidermal water loss (TEWL) is one of the measurement tools used to define the skin’s barrier function by measuring the amount of water that evaporates through the skin in aspecific amount of time. Although several studies on TEWL are available but discussion about the correlation between TEWL and body mass index (BMI) is still limited. This study aims to evaluate the correlation between TEWL and BMI. Methods: This research is a single-center study with analytical cross-sectional design that includes healthy subjects among medical students aged 18 to 23 years old in Universitas Sebelas Maret. A questionnaire was used to ensure that all subjects met the criteria. Chi-square and Pearson were used to analyze the observed variables.Results: The total sample in this study was 62 participants, with a majority of female (59.7%) and ranged from 21 to 23 years (74.2%). The ratio of normoweight and overweight/obese was 1:1. The results demonstrated significant difference and positive correlation between increased BMI with TEWL (pConclusion: This study showed a significant correlation between increased body mass index and transepidermal water loss. Overweight participants tend to develop high values of TEWL which reflect a disruption of skin barrier. Further research on other influencing factors with larger samples and more study centers are needed.
Cutaneous manifestation of thyroid carcinoma in a 64-year-old Filipino woman: a case report Linata, Andrean; Carpio, Benedicto dL; Regalado-Morales, Eileen
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
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Background: Cutaneous metastasis is a rare phenomenon of thyroid carcinoma. Several mechanisms regarding cutaneous metastasis from internal malignancies have been proposed. Various treatment options are available, including surgical procedures, radioiodine therapy, thyroid hormone therapy, and other possible therapies. The prognosis of thyroid carcinoma with cutaneous manifestation is poor.Case Illustration: We presented a case of 64-year-old female patient with previously diagnosed thyroid carcinoma admitted with enlarged and tender nodules on the right side of the anterior neck. No surgical intervention was done and patient was treated with chemotherapy using doxorubicin 80 mg as the agent of choice. Levothyroxine 100 mcg was also administered every 24 hours. Chemotherapy was given, however the patient eventually died due to respiratory failure.Discussion: The patient initially presented with a slow-growing neck mass, which rapidly developed into larger mass with multiple erythematous to violaceous papules, firm tender nodules, and patches on the thoracic area, indicating slow and rapid progression of the disease. According to histopathologic examination, the patient had papillary thyroid carcinoma. However, the patient poorly responded to the chemotherapy regimen with doxorubicin, which indicated that this malignancy is associated with poor prognosis.Conclusion: Cutaneous metastasis is a rare complication of thyroid carcinoma. Typically, it initially develops as a slow-growing tumor that subsequently progresses into multiple malignant lesions. It is an indicator of poor prognosis in thyroid carcinoma, and further studies are warranted to improve the prognosis of this disease
Microneedling and platelet-rich plasma (PRP) treatment for mixed melasma Wulandari, Puteri; Jusuf, Nelva Karmila; Nasution, Khairina
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
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Background: Melasma, or chloasma, is an acquired pigmentary disorder caused by increased melanin in the epidermal and dermal layers, characterized by brown or gray patches on the face and neck. There are many treatment options available; however, the difficulties in treating melasma are frequent recalcitrants, high recurrence rate, irregularity in treatment, and the tendency of the patients to self-medicate.Case Ilustration: We report a case of mixed melasma treated by microneedling and topical PRP administration. Thirteen weeks following the therapy, the patient showed a favorable response brighter skin and substantial disappearance of brown patches.Discussion: Studies assessing the efficacy of microneedling and platelet-rich plasma (PRP) treatment for melasma are still lacking. However, melasma improvement has been reported in patients treated with microneedling and PRP. In this study, we provided a study of a patient with mixed melasma treated by microneedling and PRP, which showed a favorable improvement.Conclusion: Microneedling and PRP treatment showed a favorable response in a patient with melasma, with substantial disappearance of brown patches and a decrease in MASI (Melasma Area and Severity Index) score.
Recent progress in immunotherapy for skin cancer Mughni, Fadhli Aulia; Astriningrum, Rinadewi; Hoemardani, Aida SD; Bramono, Kusmarinah; Sampurna, Adhimukti T.; Sutarjo, Agassi Suseno
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
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Skin cancer is a global health concern due to its growing incidence and high mortality rate. The most common therapeutic modalities in skin cancer include surgery, radiotherapy, and chemotherapy. However, those therapies do not specifically target cancer cells and may damage healthy tissues. Cancer induces immune response by releasing soluble antigens and danger signals caused by tumor cellular stress or death, while the immune system continuously monitor and control malignant proliferation through cancer immunoediting. Therefore, targeting this mechanism is a promising approach to manage cancer, especially those unresponsive to conventional therapies. Immunotherapy is a specific therapy that manipulates the immune system to fight the disease. Previous studies have shown promising results in its clinical use in melanoma and non-melanoma skin cancer (NMSC). However, its potential toxicity and tolerability may pose significant obstacles in developing effective cancer immunotherapy. Biomedical, immunological, and clinical research in skin cancer is still needed to elaborate further on its pathogenesis and design safe and effective therapy for each skin cancer.
The vaginal microbiota Kencana, Indah; Yenny, Satya Wydya
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
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The vagina is an ecosystem consisting of various species of microorganisms (microbiota) that play important role in maintaining vaginal health. The vaginal ecosystem includes a variety of species classified into aerobic and anaerobic microorganisms which are vaginal microbiota (VMB). In the vagina of a healthy woman, 70% of normal microbiota is dominated by the Lactobacillus species. Lactobacillus is a Gram-positive, anaerobic bacterium, and belongs to the group of lactic acid bacteria (LAB). LAB produces lactic acid which plays a role in maintaining vaginal acidity at pH

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