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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 60 Documents
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Search results for , issue "JPS Volume 6 Nomor 3 (2023)" : 60 Documents clear
Uji aktivitas antibakteri ekstrak daun ceremai (Phyllanthus acidus (L.) Skeels) terhadap Staphylococcus aureus Alya Nafis; Dia Septiani; Jekmal Malau
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.192

Abstract

Staphylococcus aureus is a bacterium capable of causing pneumonia. However, the frequent occurrence of antibiotic resistance necessitates the exploration of alternative plant-based antibiotics as natural antibacterial agents. This study aims to analyse the antibacterial activity and chemical compound classes in the ethanol and methanol extracts of Phyllanthus acidus (L.) Skeels leaves, commonly known as ceremai leaves, exhibit antibacterial properties. Chemical compound classes were determined using the TLC method. The 96% ethanol extract of ceremai leaves contained flavonoids, alkaloids, triterpenoids, steroids, and phenols. On the other hand, the methanol extract contained flavonoids, alkaloids, steroids, and phenols. The antibacterial activity was evaluated using the Kirby-Bauer agar diffusion method. The testing revealed that ethanol and methanol extracts of ceremai leaves at concentrations of 15%, 20%, 25%, 30%, 40%, and 50% exhibited antibacterial activity against Staphylococcus aureus bacteria. The 50% concentration showed the highest inhibition zone value, with the ethanol extract (96%) measuring 3.86 ± 0.11 mm and the methanol extract measuring 2.73 ± 0.24 mm falling into the weak category
Profil penggunaan analgesik oral pasien ERACS salah satu rumah sakit swasta kota Semarang tahun 2022 Rissa Maharani Dewi; Nindita Sari Nastiti; Risa Wuriana Mawardi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.193

Abstract

Enhanced Recovery After Caesarean Surgery (ERACS), the new Sectio Caesarea (SC) delivery protocol, is considered to reduce pain and speed up recovery. Oral analgesics are used to relieve post-ERACS pain. The purpose of this study was to determine the profile of the use of oral analgesics in ERACS patients at a private hospital in the city of Semarang in 2022. This study has an observational descriptive design. Data were collected retrospectively from the medical records of ERACS patients in 2022 who used oral analgesics. The results of this study analysed the use of oral analgesics in the form of the percentage of groups and types of oral analgesics used. The study data included the patient's age, gestational age, and socioeconomic status. The results showed the profile of oral analgesic use of 809 non-opioid drugs (91.93%), 43 opioid drugs (4.89%) and Fixed Dose Combination (FDC) opioid/non-opioid 28 drugs (3.18%). The types of analgesics used were Mefenamic Acid 328 (37.27%), Paracetamol 205 (23.30%), Diclofenac Sodium 192 (21.82%), Tramadol 43 (4.89%), FDC Paracetamol/Tramadol 28 (3.18%), Celecoxib 27 (3.07%), Dexketoprofen 22 (2.50%), Ibupro fen 20 (2.27%), Etoricoxib 14 (1.59%) and Ketoprofen 1 (0.11%).
Uji aktivitas diuretik ekstrak etanol daun sirih merah (Piper crocatum Ruiz & Pav) terhadap tikus putih jantan (Rattus novergicus) Muhammad Yunus; Jefri Naldi; Muhammad Andry
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.195

Abstract

Background: According to the World Health Organization (WHO), the prevalence of hypertension in the world reached over 1.13 billion people in 2015, implying that one out of every three persons was diagnosed with hypertension. Flavonoids found in red betel leaves (Piper crocatum Ruiz & Pav) serve as antifungals, diuretics, antihistamines, antihypertensives, insecticides, bactericidal, antiviral, and enzyme inhibitors. The study aimed to find the best dose of red betel leaves extract as a diuretic in male white rats. The study was experimental laboratory. Alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids are among the phytochemicals tested. A total of 25 male white rats were separated into five groups. Red betel leaves extract was administered to groups 1, 2, and 3 at dosages of 250mg/kg, 350 mg/kg, and 650mg/kg, respectively. Group 4 received a 0.5% Na CMC suspension as a negative control, while Group 5 received a furosemide suspension as a positive control. The average urine volume at 1-6 hours and the buildup of urine were used to calculate the rat urine volume. The results showed the accumulation of urine volume for 6 hours. The treatment group of red betel leaf ethanol extract at a dose of 250mg/kgBW obtained 0.57mL, a dose of 350mg/kgBW obtained 2.38mL, and a dose of 650mg/kgBW obtained 4.29mL, negative control (CMC 0.5%) obtained 0.2mL, positive control obtained 27.52mL. The study concluded that red betel leaves extract has diuretic action and that the ethanol extract of red betel leaves at a dosage of 650 mg/kgBW is the most effective dose.
Kualitas Daging Domba Berdasarkan Keragaman, Jumlah Dan Cemaran Bakteri Di Pasar Tradisional Desa Klambir V Kecamatan Hamparan Perak Kabupaten Deli Serdang Alfath Rusdhi; Tengku Gilang Pradana; Muhammad Sadiqulamin
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.196

Abstract

Meat is an essential food ingredient in meeting nutritional needs. The purpose of this research is to detect the total plate count and bacterial contamination in lamb meat. The research method used in this study is descriptive because it describes the characteristics of a population or a phenomenon that is being studied in a trial and error manner. From the observation data, 6 samples of lamb meat obtained from the traditional market in Kampung Lalang were analyzed using descriptive methods, which revealed the presence of Escherichia coli and Salmonella sp bacteria. The highest TPC analysis value was found in vendor 2 and vendor 3, sample 2, with a count of 6.55x106 cfu/g and 7.15x106 cfu/g, respectively, while the lowest contamination was found in vendor 1, sample 2, with a count of 4.57x105 cfu/g. These values are in accordance with the permissible limits of Escherichia coli (1 x 101 colonies/gram) and Salmonella sp (negative/25 grams) as set by the Indonesian National Standards (SNI). The results of the study indicate that 6 samples of lamb meat were not contaminated with Escherichia coli and Salmonella sp bacteria, demonstrating that the lamb meat sold in the traditional market of Klambir V Village complies with the Indonesian National Standards (SNI) and is suitable for consumption.
Analisis senyawa acetaminophen dalam sampel biologis dengan berbagai macam metode Lina Nurfadhila; Marsah Rahmawati; Nur Komala fitri; Salsabila Granadha Nibullah; Welly Windari
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.197

Abstract

Acetaminophen or Paracetamol is a compound that has pharmacological effects as an analgesic and antipyretic. The purpose of this journal review is to identify and understand the various methods that can be used to analyze biological samples of patients when taking paracetamol through their biological samples. The initial process for carrying out the analysis is to carry out sample preparation, samples are prepared by various suitable methods such as liquid-liquid extraction methods, solid phase extraction (SPE) and protein precipitation methods, then samples will be analyzed using appropriate methods. instruments such as GC-MS, LLE, LC-MS, HPLC-MS, or UHPLC-MS. Of the several instruments used the HPLC-MS method is the most effective method for analyzing biological samples, because HPLC-MS is considered fast, selective and sensitive and has the lowest LLOQ quantification value or lower limit.
Formulasi dan evaluasi sediaan hand cream ekstrak etanol brokoli (Brassica oleracea L.) Silvy Aldila; Veronica Bellacaesa; Tunik Saptawati; Rissa Maharani Dewi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.198

Abstract

Broccoli (Brassica oleracea L.) extract contains flavonoid compounds and vitamin C. Vitamin C has a protective role against free radicals, brightens skin tone, and enhances sensitivity to keep skin moist. The content of broccoli is very suitable for preparation in hand cream preparations with moisturizing function for dry skin, especially hand skin, because hand skin only has endocrine sweat glands, so it is easy to water. to handle. evaporation (transepidermal water loss) occurs. In this study, three formulations of hand cream were made with three concentration variants of broccoli extract, namely F1 (2g), F2 (3g) and F3 (4g). In addition, tests for the physical properties of the composition include sensory testing, homogeneity, pH, dispersion, adhesion and viscosity. The results showed that the formulas F1, F2 and F3 met the requirements of testing the mechanical and physical parameters of the preparation. The conclusion of this study was that the hand cream composition produced had an average pH value of 6, a dispersion of 5 cm, a adhesion of 3 s and a viscosity of 32000 cPs and was concluded to meet the requirements for physical characteristics.
Tata cara sertifikasi pemenuhan aspek cara pembuatan obat tradisional yang baik (CPOTB) bertahap dalam rangka kemudahan bagi usaha mikro kecil (UMK) di Bandung Jawa Barat Ivanna Fauziyah Kusnadi; Patihul
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.202

Abstract

Traditional medicine products continue to grow rapidly, both produced by UMOT, UKOT, IOT, IEBA, and the pharmaceutical industry. With the development of the use of traditional medicine, UMK such as UKOT and UMOT are becoming more formed. However, the high number of UMK present was not followed by the fulfillment of provisions related to the inspection of the facilities carried out. Based on the BBPOM Annual Report in Bandung, inspection of UMOT/UKOT facilities was carried out on 21 facilities and 33.33% did not meet the requirements (TMK). One of the results of inspection of facilities that did not meet these requirements was because they did not meet CPOTB aspects, both sanitation hygiene and documentation (42.86%). This can be caused by the lack of awareness of business actors regarding the basics in making a traditional medicinal product starting from the establishment of the facility and also the ignorance of business actors regarding the legal basis that must be adhered to. This article aims to explain the procedure for certifying the fulfillment of CPOTB aspects in order to make it easier for UMK to register their places with Balai POM.
Regulasi pengawasan iklan obat tradisional yang berlaku di Indonesia Taqiyyah Qothrunnadaa; Ade Zuhrotun
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.203

Abstract

The economic growth of the pharmaceutical industry is in line with the growing growth of the Indonesian herbal or traditional medicine industry. People's interest in buying a product is influenced by several factors. One of them is the way the product is promoted, such as advertising. The increasing circulation of traditional medicines has led to an increase in the use of excessive advertising or unscrupulous producers who do not meet the requirements, so a system is needed that can protect the public and ensure that the advertisements promoted are in accordance with applicable regulations. Therefore, a search of primary and secondary literature related to regulations regarding Advertising was carried out. The regulation governing advertising, especially for Traditional Medicines, is Keputusan Menteri Kesehatan No. 386/MENKES/SK/IV/1994 mengenai Pedoman Periklanan: Obat Bebas, Obat Tradisional, Alat Kesehatan, Kosmetika, Perbekalan Kesehatan Rumah Tangga dan Makanan-Minuman.
Analisis cemaran bakteri Staphylococcus aureus pada daging ayam krispy pinggir jalan dan fast food di daerah Teladan kota Medan Adelia Ramadani; Yayuk Putri Rahayu; M. Pandapotan Nasution; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.205

Abstract

Chicken meat is a highly nutritious food containing protein, fat, minerals and other substances. Chicken meat is easily contaminated with the pathogen Staphylococcus aureus which can cause Staph Food Poisoning (SFP) or food poisoning due to contamination from unhygienic traders, processing, and the environment. The purpose of this study was to identify the presence of S. aureus pathogenic bacteria in roadside crispy fried chicken meat and well-known fast food brands in the Teladan area of Medan city and to analyze the contamination value of S. aureus bacteria whether it meets the Indonesian National Standard (SNI) < 1X102 CFU/ml. The research method was to determine the presence of S. aureus in the sample using Baird Parker Agar Base (BPA) and Egg Yolk media. Specific identification using Gram stain test, coagulase test, and catalase test. Calculation of contamination value of S. aureus with Total Plate Count (TPC). The results on roadside crispy fried chicken were positive for the presence of S. aureus with a contamination value exceeding the threshold above 1X102 CFU/ml so it did not meet SNI standards. Fast food crispy fried chicken meat is known to be negative in the absence of S. aureus pathogenic bacteria so that it meets SNI standards.
Analisis Cemaran Bakteri Coliform pada Saus Jajanan di Sekitar Sekolah Menengah Kejuruan di Kota Medan Lisda Mayanti; Yayuk Putri Rahayu; Minda Sari Lubis; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.206

Abstract

The sauce is a type of food additive prepared from the main ingredients of chilies and tomatoes, served as a complement to food and often served in snack foods. Nowadays, sauces are in great demand by all groups, but many traders need to pay more attention to their wares, both in terms of presentation and how to process them, for example diluting sauces with unclean water so they are contaminated with pathogenic microbes. One form of biological contamination that can occur in the sauce is the presence of coliform bacteria. This group of coliform bacteria includes Escherichia coli (E. coli), Gram-negative bacteria that are rod-like and do not form spores. Normally, E. coli is part of the normal intestinal flora, but it can cause illnesses such as diarrhea when opportunistic. The purpose of this study was to test the level of bacterial contamination as measured by the Total Plate Count (ALT), as well as to determine the presence of coliform bacteria and identify E. coli bacteria in the sauces used in various types of snacks around SMKs in the city of Medan. Methods The research approach involves the use of two methods, namely the Total Plate Number (ALT) and the Most Probable Number (MPN). Based on the determination of the value of ALT < 1 x104 coli/g and MPN < 100/g. The results of the study from 5 samples of various snack sauces around one of Medan City Vocational Schools were not suitable for consumption because they did not meet SNI No.7388:2009 with the amount of microbial contamination in chili sauce that is above 1x10⁴ colonies/g and exceeding the maximum MPN coliform limit in chili sauce, i.e., above 100 colonies/g.

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