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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 60 Documents
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Search results for , issue "JPS Volume 6 Nomor 4 (2023)" : 60 Documents clear
Penetapan kadar flavonoid total ekstrak etanol, fraksi etil asetat dan n-heksan pada daun kakao (Theobroma cacao L.) dengan metode spektrofotometri uv-vis Zikra Maqfirah; Muhammad Amin Nasution; M. Pandapotan Nasution; Haris Munandar Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.43

Abstract

Cocoa (Theobroma cacao L.)  is a plant that is cultivated on plantations in Indonesia. One part of the cacao plant that has the potential to be developed as a traditional medicine is the cacao leaf because it contains secondary metabolites of flavonoids. Flavonoids have many properties, including acting as antioxidants, protecting cell structures, anti-inflammatories, preventing osteophoresis, and antibiotics. The purpose of this study is to determine the content of secondary metabolites and total flavonoid levels in ethanol extract, ethyl acetate fraction and n-hexane in cocoa leaves. In this study, the initial steps taken are sample collection, sample processing into simplicia, simplicia characterization test then preparation of cocoa leaf ethanol extract by maceration method using 70% ethanol solvent, followed by partitioning process with liquid-liquid extraction method to obtain ethyl acetate fraction and n-hexane and phytochemical screening is carried out. Determination of total flavonoid levels using the UV-vis spectrophotometric method at a wavelength of 437 nm with quercetin as a comparison.The results of this study showed that a cocoa leaf ethanol extract contains alkaloid compounds, flavonoids, tannins, saponins, steroids and glycosides, the ethyl acetate fraction contains alkaloid compounds, flavonoids, tannins, steroids and glycosides, while the n-hexan fraction contains alkaloid compounds, flavonoids and steroids. Total flavonoid levels in cocoa leaves from an ethanol extract amounted to 39.1422±0.0540 mg QE/g, ethyl acetate fraction 45.274±0.0629 mg QE/g and n-hexane fraction 21.4812±0.7048 mg QE/g. The highest flavonoid levels are obtained in the ethyl acetate fraction.
Pola terapi pengobatan glaukoma di RSUD Hasri Ainun Habibie Kabupaten Gorontalo Dizky Ramadani Putri Papeo; Ahmad Rifly Suleman; Kadaria Toana; Chinta Suryaningrum; Intan Nusi; Erika Dami; Fhigra Marfiah
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.191

Abstract

Background: Glaucoma is an eye condition that damages the optic nerve, causing loss of vision and even blindness. Damage to the optic nerve is often associated with high intraocular pressure (IOP), but in some cases, glaucoma can occur with normal IOP levels. There are several types of glaucoma, one of which is primary angle closure glaucoma. Angle-closure glaucoma can cause sudden and severe symptoms such as eye pain, headache, nausea, and blurred vision. Objective: This study aims to determine the pattern of glaucoma treatment therapy in one of the hospitals in Gorontalo District. Methods: Using patient medical record data, the SOAP method, and several literature studies. Results: Obtained some medical record data. From medical records, it found that the most widely used drugs to reduce intraocular pressure were tim ophthal eye drops 0.25% and glauceta 250 mg oral drug. Timolol maleate is the most commonly used beta adreno-receptor blocker, especially in the treatment of glaucoma. Glauceta 250 is a drug that contains Acetazolamide indicated to reduce the fluid that accumulates in the eyeball and reduce eyeball tension. Conclusion: From the results of the study, it can conclude that the treatment pattern of most glaucoma patients used the 0.25% tim ophthal drug with the results of 5 times the ophthal 0.25% team administration and the administration of 3 eye drops, namely HPMC + dextran 70 + glycerin, Potassium iodide + sodium iodide dan HPMC + dextran.
Uji aktivitas antibakteri ekstrak n-heksana daun sawo (Manilkara zapota L) terhadap pertumbuhan bakteri Staphylococcus aureus dan Escherichia coli Manuppak Irianto Tampubolon; Rani Erlianti Br. Hutabarat
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.225

Abstract

Sapodilla leaves have active compounds which are often referred to as secondary metabolites, which include alkaloids, flavonaids, saponins, tannins, glycosides, steroids. This study aims to determine the antibacterial activity of sapodilla leaf n-hexane extract (Manilkara zapota L) against Staphylococcus aureus and Escherichia coli bacteria. Tests were carried out through the stages of collecting materials, preparing simplicia, making sapodilla leaf n-hexane extract and testing the inhibition of sapodilla leaves against Staphylococcus aureus and Escherichia coli bacteria. The preparation of sapodilla leaf n-hexane extract was carried out by maceration method using n-hexane. Antibacterial activity testing was carried out by the agar diffusion method using disc paper. The results of the study based on the results of the phytochemical screening showed that the simplicia and n-hexane extract of sapodilla leaves contain alkaloids, flavonoids, saponins, tannins. Meanwhile, in the antibacterial activity test of the sapodilla leaf n-hexane extract, it had antibacterial or inhibition zones on the bacteria with different concentrations, namely concentrations of 35%, 45%, 55%, 65%, and 75%. The positive control used chloramphenicol and the negative control used sterile aquadest. Sapodilla leaf n-hexane extract has antibacterial activity of Staphylococcus aureus and Escherichia coli.
Uji aktivitas antibakteri fraksi n-heksana dan etil asetat daun kecombrang (Etlingera elatior) terhadap Staphylococcus aureus dan Escherichia coli Alfi Wahyudi Nasution; Haris Munandar Nasution; Minda Sari Lubis; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.228

Abstract

Infectious diseases caused by microorganisms are diseases that are commonly found in society. The therapy used to treat infections today by administering antibiotics. However, many cases of bacterial resistance to antibiotics are caused by the irrational use of antibiotics, so is necessary to develop alternatives to antibiotics derived from plants. glycosides that can function as antimicrobials. This study aims to determine the activity of the n-hexane and ethyl acetate fractions from kecombrang leaves against Staphylococcus aureus and Escherichia coli. This research was conducted experimentally, the independent variables consisted of the ethanol extract of kecombrang leaves, n hexane and ethyl acetate fractions. The dependent variable consisted of simplicia characteristic test, kecombrang leaf phytochemical screening, antibacterial activity test of kecombrang leaf fraction against S.aureus and E.coli. Antibacterial test using n-hexane and ethyl acetate fractions made with concentrations of 10%, 30%, 50% and 70%. the positive control used the antibiotic chloramphenicol and the negative control used DMSO, and the method used was agar diffusion using paper discs.The results of the antibacterial test showed that kecombrang leaves had an inhibitory effect on Staphylococcus aureus and Escherichia coli bacteria. The inhibition power of the ethyl acetate fraction was stronger than n hexane. The strongest inhibition was found in the ethyl acetate fraction with a concentration of 30.50 and 70% against Staphylococcus aureus, namely 10.9 mm, 12.6 mm and 14.15 mm. whereas in Escherichia coli bacteria, namely 10.5 mm, 12.3 mm. and 13.9mm. and based on the CLSI inhibition zone category, 2020, the concentration fraction of 70% is in the intermediate category, concentrations of 50, 30, and 10% are in the resistant category. While the positive control is categorized as sensitive to both bacteria.  
Faktor-faktor yang berhubungan dengan status gizi pada anak balita di Puskesmas Tandun 1 Kabupaten Rokan Hulu Provinsi Riau Tuty Hertati Purba; Prita Delvia Yollanda; Wanda Lestari; Athira Demitri
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.231

Abstract

Introduction; Toddlers need balanced nutrition so that their nutritional status is good, and the growth process is not hampered. The nutritional status of toddlers can be measured anthropometrically, anthropometric indices that are often used, namely: (weight/age), (height/age), and (weight/height). Objective; This study aimed to determine what factors are associated with the nutritional status of toddlers at Tandun 1 Health Center in Rokan Hulu Regency of Riau Province. Methode ;This is an observational research with a cross sectional study approach. The sampling was done by means of the Stratified Random Sampling Method. The population of this study was mothers who had toddlers aged 0-60 months and the sample in this study was mothers who had toddlers aged 24-60 months. The results of this study indicated that from the variable knowledge with a p value of 0.01 and food intake with a p value of 0.00 there was a significant relationship with a p value <0.05, while for the variable exclusive breastfeeding with a p value of 0.08 and a history of diarrhea with a p value of 0.74 there was no significant relationship with a p value> 0.05 in toddlers at Tandun 1 Health Center, Rokan Hulu Regency, Riau Province. It is expected that the health workers of the Health Center increase efforts to prevent nutritional status problems in toddlers which can be done such as providing information about good nutrition for toddlers and providing additional food to toddlers whose nutritional status is lacking.
Analisis faktor-faktor yang mempengaruhi perilaku kader terhadap penemuan suspek TB paru di Puskesmas Panombeian Panei Kabupaten Simalungun tahun 2020 Patrice Armando Sipayung; Asriwati Asriwati; Tengku Moriza
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.232

Abstract

Introduction: According Global TB Report in 2018, there were 842,000 new cases of pulmonary TB (319/100,000 people) and 116,000 fatalities from pulmonary TB (44/100,000 people), including those who were HIV-positive. Objective: The stuay aimed to determine the most important characteristics that will affect the detection of TB suspects at Panombeian Panei Health Centre in 2020, including age, education, occupation, knowledge, attitudes, distance, family support, counseling, and cadre compensation. Method: This stuay was analytic study. The sample was 132 health centre cadres from population of 196 by using proportional and random sampling methods. Univariate, bivariate with chi-square test, and multivariate with logistic regression test were utilized in the data analysis. The Result: The p-value of age (0.059 OR 1.426), occupation (0.008 OR 0.055), knowledge (0.026 OR 2.899), attitude (0.821 OR 1.756), distance (0.041 OR 2.593), family support (0.038 OR 2.617), counseling (0.620 OR 1.297), compensation (0.004 OR 6,475). Conclusion: The findings showed that identification of TB suspects was influenced by employment, knowledge, distance, family support, and compensation but not by age, education, attitude, or counseling. It is advised that the local government improve the dedication to collaboration with connected parties such health agencies, sub-districts, business sector, non-governmental organizations, health and religious groups.
Kejadian stunting pada balita usia 12-59 bulan di Desa Serule Kecamatan Bintang Kabupaten Aceh Tengah Neni Ekowati Januariana; Tuty Hertati Purba; Agnes Sry Vera Nababan; Simah Bengi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.233

Abstract

Stunting is a condition of toddlers with less length or height compared to age as measured by length or height that is more than <-2 SD of child growth, according to the World Health Organization (WHO). This study aimed to determine the factors affecting stunting in children aged 12-59 months in Serule Village, Bintang District, Central Aceh Regency. This is analytic observational research with a cross-sectional approach. The statistical test used the chi-square test. The population was 48 toddlers, all sampled by total sampling technique. I indicated a relationship between maternal knowledge and the occurrence of stunting in toddlers with a p-value = .002. There was a relationship between infectious diseases and the occurrence of stunting toddlers with a p-value = .001. There was a relationship between sanitation and the occurrence of stunting toddlers with p = .004. There was a relationship between LBW and the occurrence of stunting toddlers with a p-value = 0.000. There is a relationship between exclusive breastfeeding and stunting in toddlers with p = 0.000. There was a relationship between food intake and the occurrence of stunting in toddlers with p = .001. Conclusion of this study It is expected that mothers of toddlers pay more attention to their health, maintain environmental hygiene, fulfill their food intake, and only give breast milk when they are 0-6 months old.
Uji aktivitas antibakteri formulasi sediaan sabun padat transparan ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) terhadap bakteri Cutibacterium acnes Siti Aisyah Jamil; Yayuk Putri Rahayu; Minda Sari Lubis; Haris Munandar Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.234

Abstract

Acne is a skin disease that begins with an increase in sebum production which is exacerbated by an attack by the Cutibacterium acnes bacteria. Currently, there are many anti-acne preparations, one of which is in the form of soap, but only a few contain natural herbs. One plant that has an active substance or agent that has the potential to prevent and treat acne leaves belimbing wuluh (Averrhoa bililmbi L.) with its antibacterial properties. Besides having the potential to prevent and treat acne, this plant is also very easy to find in Indonesia. This research was conducted to see whether starfruit leaf extract could be formulated as soap preparation and whether it had antibacterial properties against Cutibacterium acnes. The research method for fresh starfruit leaves was made into Simplicia and extracted using 96% ethanol, phytochemical screening was carried out on fresh starfruit leaves and extracts. Transparent solid soap formulation with belimbing wuluh leaf extract with concentrations of 2.5%, 5%, and 7.5%. Evaluation preparations included physical quality tests, pH tests, foam height and stability tests, skin moisture tests, irritation tests, Panelist preference tests, and antibacterial activity against Cutibacterium acnes. The results and conclusions show that fresh starfruit leaves and extracts contain compounds belonging to class alkaloids, flavonoids, saponins, tannins, steroids/triterpenoids, and glycosides. Belimbing wuluh leaf extract can be formulated into transparent solid soap preparation, has a distinctive aroma extract, is homogeneous, pH 9-11, with spreadability 26-29mm. Antibacterial activity included the insensitive category at all concentrations. The panelist's preferred formula was preparation with a concentration of 2.5%
Sediaan krim ekstrak jeruk nipis (Citrus aurantifolia S.) Sebagai Obat luka sayat pada mencit jantan (Mus musculus) Madani Sirait; Gabena Indrayani Dalimunthe; Minda Sari Lubis; D. Elysa Putri Mambang
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.235

Abstract

Indonesia is a country that is rich in plant diversity. One of them is lime, which is used as a traditional wound medicine. Lime contains essential oil compounds, flavonoids, saponins, tannins, alkaloids, citric acid, amino acids, vitamin B1, and vitamin C. Based on previous research, flavonoids, tannins, and saponins can heal wounds. Making simplicia using an oven at 50oC  and characterizing simplicia Extraction using the maceration method with 96% ethanol is then concentrated using a rotary evaporator. Orientation on the preparation of the cream was carried out until a good cream texture was found, and a cream preparation test was carried out to comply with the requirements in the literature. The test animals used were 24 male mice, which were divided into six treatment groups. The first group was treated with betadine, the second group was treated with cream without extract, the third group was treated with 2 grams of extract cream, the fourth group was treated with 3 grams of extract cream, the fifth group was treated with 4 grams of extract cream, and the sixth group was untreated. Each group was given a 10-mm wound. Based on the treatment carried out for 14 days, the best formulation was a 4-gram lime extract cream, and the wound healed on day 9, which was the same as the comparison used, namely betadine.
Uji Toksisitas Akut ekstrak Etanol Bunga Turi Putih (Sesbania grandiflora (L.) Pers.) Terhadap Parameter SGOT dan SGPT pada Organ Hati Tikus Putih Jantan (Rattus norvegicus) Galur Wistar Fikih Putri Ayu Nabila; Jamilatur Rohmah
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.244

Abstract

Turi plants contain phenolic compounds, tannins, flavonoids, alkaloids, and glycosides. In addition, Turi plants also contain potentially toxic compounds such as pyrrolizidine compounds. This study aimed to determine the acute toxicity of ethanol extract of white turi flowers on toxic symptoms, macroscopic observation of liver organs, and measurement of SGOT and SGPT levels. This type of research is a laboratory experimental study using the Post Test Only Control Group Design research design. Rats were divided into four groups: standard control, 10,000, 15,000, and 20,000 mg/kgBB, then observed for toxic symptoms, liver macroscopic, and SGOT-SGPT levels. Phytochemical test results showed that turi flowers contain alkaloid, saponin, tannin, steroid, and triterpenoid compounds. Macroscopic observation of the liver showed normal condition. The results of the One-way ANOVA test on SGOT and SGPT levels showed significant differences in each group. Based on the results of the study, it can be concluded that there is toxicity of ethanol extract of white turi flower to rats seen from toxic symptoms that appear but have not caused death in rats. Besides that, white turi flower extract can affect increasing SGPT and SGPT levels

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