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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 60 Documents
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Search results for , issue "JPS Volume 6 Nomor 4 (2023)" : 60 Documents clear
Pembuatan mikrokristalin selulosa dari ubi jalar (Ipomoea batatas (L.) Lamk.) dengan Avicel PH 102 sebagai pembanding dan evaluasi mutu fisik Shinta Mida Ariani Harahap; Gabena Indrayani Dalimunthe; Minda Sari Lubis; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.297

Abstract

Microcrystalline cellulose is an excipient used in the manufacture of directly felt tablets, namely as a filler, binder, and crushing agent and can be isolated from fibrous plants. One of the abundant fibrous plants in Indonesia is sweet potato (Ipomoea batatas L.). The main chemical composition of sweet potatoes includes carbohydrates, namely dietary fibre (hemicellulose, cellulose), starch, and several types of sugar. The objective of this research was to make microcrystalline cellulose from sweet potato (Ipomoea batatas L.) and see the comparison of physical quality evaluation of microcrystalline cellulose results from sweet potato (Ipomoea batatas L.) with Avicel PH 102. This research used the hydrolysis method of HCl 2.5 N acid by heating at a temperature of 105ºC for 10-15 minutes with the ratio of alpha-cellulose and acid used is (1: 20). Then, evaluated the physical quality of microcrystalline cellulose from sweet potatoes by organoleptic tests, identification, pH determination, solubility of substances in water and drying loss. The results of this research show that sweet potato cellulose can be used as microcrystalline cellulose, namely with the results of a physical quality evaluation that meets the requirements when compared to Avicel PH 102; each includes organoleptic where both are in powder form, do not have the same smell and taste, but there are differences in colour where Avicel PH 102 is white. In contrast, microcrystalline sweet potato cellulose is yellowish-white. On identification, both produce violet blue; pH 5.2 and pH 6.5; solubility of substances in water 0.2% and 0.1%; drying shrinkage of 0.71% and 2.53%; And in the starch test, both did not produce a violet-blue solution.
Pembuatan mikrokristalin selulosa dari wortel (Daucus carota L.) dengan avicel PH 102 sebagai pembanding dan evaluasi mutu fisik Chairina Milda; Gabena Indrayani Dalimunthe; Minda Sari Lubis; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.298

Abstract

Carrots (Daucus carota L.) are vegetable types of annuals because they only produce once and then die. Carrot tubers are reddish-yellow due to the high content of carotene. Microcrystalline cellulose is one of the excipients (additives) in tablet preparations, namely as a filler, which is considered a binding agent because it can increase the compactness ability of tablets from compression mixtures. Microcrystalline cellulose comes from natural resources containing lignocellulose fibers such as wood and non-wood. One of the abundant fibrous plants in Indonesia is carrots (Daucus carota L.). The main chemical composition of carrots includes carbohydrates, namely dietary fiber (hemicellulose, cellulose), starch, and several types of sugar. This research aimed to determine whether carrot cellulose (Daucus carota L.) can be made into microcrystalline cellulose and compare the physical quality of carrot cellulose microcrystalline results with Avicel PH 102. Microcrystalline cellulose is made by a delignification process using 15% NaOH, followed by a bleaching process using 3.5% NaOCl, and then continued with a hydrolysis process with HCl 2.5N. Then, microcrystalline cellulose is carried out a physical quality evaluation, which includes organoleptic, identification, pH, solubility of substances in water, shrinkage of dryers, and starch. The results of the research showed that carrots can be made into microcrystalline cellulose, namely with the results of physical quality evaluation compared to Avicel PH 102, organoleptic powder, odorless, tasteless, and yellowish white (microcrystalline cellulose) and white (Avicel PH 102); identification, each of which produces a blue-violet color; pH 5.67 and 6.5; the solubility of substances in water is 0.1% each; drying shrinkage 4.70% and 2.53%; and starch, respectively not formed violet blue solution.
Skrining fitokimia dan isolasi senyawa flavonoid dari ekstrak etanol kulit buah menteng (Baccaurea racemosa (Reinw.) Müll.Arg) Muhammad Ari Mukhtizar; Haris Munandar Nasution; M. Pandapotan Nasution; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.299

Abstract

The menteng plant, which belongs to the Euphorbiaceae family, is a subtropical plant worldwide. Flavonoids are one of the groups of phenolic compounds found in plant tissues that can act as antioxidants. This research aimed to determine the class of chemical compounds found in the Menteng fruit peel and determine the characteristics of fruit peel flavonoids by UV Spectrophotometry and IR Spectrophotometry. %. Phytochemical screening showed positive for alkaloids, flavonoids, and steroids/triterpenoids, while tannins, saponins, and glycosides were negative from 400 grams of simplisia produced 39.1 grams of viscous extract. Characterization of crystal isolates of UV spectrophotometry showed a wavelength of 280 nm, inferred to be a flavanoid. The results of IR spectrophotometry show the O-H, C-H aliphatic, C=C aromatic, C=O, C-H, and C-O groups.
Efektivitas penyembuhan luka bakar menggunakan salep ekstrak etanol daun ciplukan (Physalis angulata L.) pada kelinci Cindy Marlina Tambunan; Gabena Indrayani Dalimunthe; Minda Sari Lubis; Rafita Yuniarti
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.300

Abstract

Indonesian people have long used plants as medicine and for health maintenance, which is inherited from generation to generation. One plant that can be used in traditional medicine is the ciplukan plant (Physalis angulata L.), which is a small plant that can grow anywhere. It turns out not only has a unique taste but is also beneficial for health; ciplukan can be used to treat flu and sore throat, whooping cough, bronchitis, mumps, ulcers, and also Ayan or epilepsy. Empirically, the use of ciplukan plants functions as a cure for smallpox, which has been used by the community by bathing. Smallpox is shaped like a blistered burn and will be shaped like an ulcer. So, researchers are interested in developing in the form of ointment because it is more effective to use and can be taken anywhere. This research was conducted to determine that ethanol extract of ciplukan leaves can be formulated on the basis of absorbent ointment and to determine the healing effect of burns in rabbits from the preparation of ethanol extract ointment of ciplukan leaves (Physalis angulata L.). Ciplukan leaf extract is made from simplicial ciplukan leaves by maceration method and then tested for the effectiveness of healing burns on rabbits using ointment. The ointment is made in 4 formulations, namely F0, F1 (10%), F2 (15%), and F3 (20%) using white Vaseline as the ointment base. Evaluation of ointment preparations includes physical stability (shape, smell and colour, homogeneity, pH, dispersion, adhesion and viscosity. All formulas of ointment preparations are good in storage. In ointment preparations in the homogeneity test, all formulas are homogeneous. In pH inspection, dispersion, adhesion and viscosity all meet requirements according to predetermined or established standards. Ciplukan leaf extract can be formulated into an ointment dosage form. Ointment preparations with a high concentration are most effective in healing burns in rabbits.
Penetapan kadar fenolik total ekstrak etanol, fraksi etil asetat dan n-heksan daun kopi robusta (Coffea canephora Pierre ex A. Froehner) dengan metode spektrofotometri Uv-Vis Yulia Nanda Putri; Muhammad Amin Nasution; Ridwanto Ridwanto; Anny Sartika Daulay
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.301

Abstract

Phenolic compounds have various biological effects, such as antioxidant activity, can reduce the risk of cancer, coronary heart disease, stroke and other neurodegenerative diseases. Robusta coffee leaves (Coffea canephora Pierre ex A. Froehner) have activity as antioxidants because they contain abundant phenolic compounds. This study aims to determine the ratio of total phenolic levels between ethanol extract, ethyl acetate fraction and n-hexane fraction from robusta coffee leaves. In this study, the first step taken was a characterization test on simplicial powder and robusta coffee leaves macerated with 70% ethanol solvent. The maserat obtained is further fractionated with n-hexane and ethyl acetate. Followed by phytochemical screening on coffee leaf samples. Furthermore, the extract, n-hexane fraction and ethyl acetate determined total phenolic levels using visible spectrophotometry at a wavelength of 749 nm. Determination of total phenolic levels using the Folin-Ciocalteu method with gallic acid standards. Total phenolic levels are expressed in mg gallic acid equivalent (GAE) per gram of simplicial. The results showed that 70% ethanol extract of robusta coffee leaves had a total phenolic content of 25.9438± 0.0889 mg GAE/g. From the fractionation results show that the ethyl acetate fraction of robusta coffee leaves has a greater total phenolic content compared to the n-hexan fraction of 28.048 ± 0.3692 mg GAE / g and followed by the n-hexane fraction of 15.5231 ± 0.7213mg GAE / g. This is because the fractionation method can increase the desired compound content by removing or separating unwanted compounds, thus making the compound results in the use of fractions purer.
Penetapan kadar fenolik total ekstrak kayu bajakah (Spatholobus littolaris Hassk.) berdasarkan perbedaan konsentrasi etanol dengan metode spektrofotometri Uv-Vis Indah Triutami Harahap; Anny Sartika Daulay; Fathur Rahman; Haris Munandar Nasution
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.302

Abstract

The root of the Bajakah tampala (Spatholobus littolaris Hassk.) is one of the plants that is empirically used by the people of the interior of Central Kalimantan as a traditional medicine. According to the preliminary tests conducted, Bajakah Tampala contains phenolics. Phenolic compounds are compounds that have antioxidant activity. The objective of this research was to determine the class of compounds contained in the macerated extract and the total phenolic content and yield of the macerated extract in Bajakah roots. The stages of this research included the processing of plant materials, preparation of macerated and pirated root extracts, characterization examination, phytochemical screening, and the effect on the yield of total phenolic content of Bajakah roots using the UV-Vis spectrophotometry method. The results showed that the simplicia powder of the root of the Bajakah wood contained alkaloids, glycosides, steroids and triterpenoids, flavonoids, phenolics, saponins, and tannins, while the ethanol extract of the roots of the Bajakah wood showed the presence of alkaloids, steroids and triterpenoids, tannins, saponins, flavonoids, and phenolic compounds. The determination of total phenolic content was carried out by determining the maximum wavelength of gallic acid and calculating the total phenolic content based on the difference in ethanol concentration using the UV-Vis spectrophotometry method. The results for determining total phenolic content in 96% ethanol extract were 33.872 ± 0.0420 mg GAE/g, 70% ethanol extract was 29.345 ± 0.2149 mg GAE/g, and 50% ethanol extract was 18.512 ± 0.1355 mg GAE/g. So it can be concluded that the total phenolic content of 96% ethanol extract is higher than that of 70% ethanol extract and 50% ethanol extract.
Skrining fitokimia dan isolasi senyawa flavonoid dari ekstrak etanol biji buah menteng (Baccaurea racemosa (Reinw.) Müll.Arg). Sarmadansyah Sarmadansyah; Haris Munandar Nasution; Anny Sartika Daulay; Daeng Elysa Putri Mambang
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.304

Abstract

Menteng or kepundung is a fruit-producing tree. At first glance, Menteng or kepundung fruit resembles duku fruit with a variety of tastes (sour) and sweet. Menteng originates from Malaysia, Sumatra, Java and Bali. The purpose of this study was to determine the class of chemical compounds found in Menteng fruit seeds and to determine the characteristics of the fruit seed extract isolates by UV spectrophotometry and IR spectrophotometry. This research includes several processes, namely manufacturing simplicia from menteng fruit seeds, phytochemical screening, and simplicia characterisation. The process of making extracts from menteng fruit seed Simplicia, after that extract analysis using paper chromatography (KKt) method, then separation (isolation) of the extract with preparative paper chromatography (KKt) method, tested the purity of isolates by two-way paper chromatography (KKt), and characterisation of isolate crystals by UV spectrophotometry and IR spectrophotometry. The results of the simplicial characterisation of Menteng fruit seeds (Baccaurea racemose (Reinw.) Müll. Arg) are 4% water content, 36.81% seawater content, 8.79% ethanol soluble extract, 1.26% ash content, 1.26% ash content. Insoluble 0.5% acid. Phytochemical screening showed positive alkaloids, flavonoids, steroids/triterpenoids and glycosides, while tannins and saponins were negative. From 400 grams of simplicia, 93.3 grams of condensed extract was produced. Characterisation of isolate crystals UV spectrophotometry showed a wavelength of 280 nm, which is suspected to be a flavonoid. The results of the IR spectrophotometry showed aliphatic O-H, C-H, C=O, C-H, C-O and C=C groups.
Penetapan kadar flavonoid total ekstrak kayu raru (Cotylelobium lanceolatum Craib) berdasarkan perbedaan konsentrasi etanol dengan metode spektrofotometri Uv-Vis Elma Natasya; Anny Sartika Daulay; Ridwanto Ridwanto; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.305

Abstract

The utilization of traditional medicinal plants for healing is the oldest form of medicine in the world. One of the plants that have many benefits and contain secondary metabolite compounds is raru bark (Cotylelobium lanceolatum Craib), used as a traditional medicine for diseases such as malaria, diarrhea, and diabetes. This study aims to determine what groups of compounds are contained in raru bark extract and the value of total flavonoid levels contained in raru bark extract in differences in ethanol concentrations (96%, 70%, 50%). The stages of this research include processing plant materials, making ethanol extracts of raru bark extract, characterization examination, phytochemical screening, and determining the total flavonoid content of raru bark ethanol extract. The section of raru bark was made by maceration method using 96%, 70%, and 50% ethanol. Then, the extract obtained was concentrated with a rotary evaporator, and the determination of total flavonoid content was carried out based on differences in ethanol concentration using the UV-Vis spectrophotometric method. The results showed that the ethanol extract of raru bark contained alkaloids, flavonoids, saponins, tannins, and steroid compounds. Determination of total flavonoid content by determining the maximum wavelength of quinine and calculating entire flavonoid content by UV-Vis spectrophotometric method. The results of the decision of complete flavonoid content of raru bark ethanol extract at 96% concentration are 1.9915 ± 0.0139 mg QE/g, 70% is 1.12492 ± 0.01532 mg QE/g, and for 50% is 0.95197 ± 0.01516 mg QE/g. So, the best ethanol concentration to produce flavonoid levels is 96%, which is higher than other ethanol concentrations.
Penetapan kadar fenolik total ekstrak kayu raru (Cotylelobium lanceolatum Craib) berdasarkan perbedaan konsentrasi etanol dengan metode spektrofotometri UV-Vis Lastri Afni; Anny Sartika Daulay; Ridwanto Ridwanto; Yayuk Putri Rahayu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.306

Abstract

Many Indonesian people use or use plants as traditional medicine; one plant that has many benefits is raru bark (Cotylelobium lanceolatum Craib), which is used as a traditional medicine in various diseases such as diarrhea, malaria, and diabetes. This study aims to find out what classes of compounds are found in raru bark extract and to determine the value of total phenolic levels contained in raru bark extract in various concentrations (96%, 70%, 50%). The stages of this research include processing plant materials, making raru bark ethanol extract, characterization examination, phytochemical screening, and determining total phenolic levels of raru bark extract based on differences in ethanol concentration by UV-Vis spectrophotometry method. The results showed that raru bark ethanol extract contains compounds, flavonoids, tannins, saponins, steroids, and phenolics. Determination of total phenolic content by determining the maximum wavelength of gallic acid and calculation of entire phenolic content by UV-Vis spectrophotometry method. Results of selecting the whole phenolic content of raru bark ethanol extract at a concentration of 96%; 28,6544±0,1548 mgGAE/g, 70%; 23,9682±0,1270 mgGAE/g, 50%; 20,5825±0,1993 mgGAE/g, then the phenolic content that best produces total phenolic levels is raru bark ethanol extract (Cotylelobium lanceolatum Craib) concentration of 96%.
Review : Metode Peningkatan Kelarutan Dengan Dispersi Padat Elpa Giovana Zola; Salman Umar; Erizal Zaini
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.307

Abstract

One or more active chemicals are dispersed in a matrix or carrier in an inert state using a solid dispersion technique. The term "solid dispersion" describes the solid state in which a material is mixed with another material. Solid dispersions have many benefits over other traditional compositions and can be manufactured in a variety of ways. A combination of a hydrophobic matrix and a hydrophilic medication is called a solid dispersion. Drugs in solid dispersions can be dispersed in the form of molecules, amorphous solids, or crystals. The carrier used in solid dispersion systems is a polymer. The drug fills the gaps between the chains of polymers and increases their relative flexibility when the medication and polymer contact. Low rates of solubility and absorption are caused by chemicals that are powerful but not very soluble in water, thus affecting the effectiveness of therapy. Therefore, solubility is a crucial factor to consider while creating high-quality, safe, and effective preparations. A common technique to improve dissolution and solubility is the solid dispersion of active drug ingredients. Solid dispersions can be made in several methods to improve solubility and dissolving rate such as Dropping Method, Spray Drying Co-grinding, Lyophilization Technique, Fusion Method, Kneading, and Solvent Evaporation. Various types of carrier polymers that can be used to make solid dispersions are also covered in this study. The results of the review article show that the dissolution and solubility rate of active drug ingredients can be increased using the solid dispersion method compared to pure active ingredients.

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