cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Salman
Contact Email
salman.kimia@gmail.com
Phone
+6285277011177
Journal Mail Official
admin@journal-jps.com
Editorial Address
Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123
Location
Kota medan,
Sumatera utara
INDONESIA
Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 55 Documents
 2   3   4   5   6 
Search results for , issue "JPS Volume 8 Nomor 1 (2025)" : 55 Documents clear
Optimasi Formulasi Cleansing Balm Minyak Biji Tomat (Solanum lycopersicum) dengan Simplex Lattice Design: Karakteristik Fisik dan Efek Anti-Aging Suryani , Arman; Cahyaningsih , Tri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.561

Abstract

This study aims to optimize the formulation of tomato (Solanum lycopersicum) seed oil-based cleansing balm with a Simplex Lattice Design (SLD) approach and evaluate its physical characteristics for facial cleansing and potential anti-aging effects. The research method used was formulation with the main component variables of shea butter, beeswax, caprylic/capric triglycerides, and tween 20, which were analyzed using SLD to obtain the optimal combination. The optimization results showed that the formulation with concentrations of shea butter (4.97996 %), beeswax (1.88189 %), caprylic/capric triglycerides (42.1382 %), and tween 20 (1 %) provided a good quality preparation with a semi-solid texture, typical beeswax aroma, and bone white color. The physical characteristics of the product, such as melting temperature stabilized at 38.67 °C ± 0.58, spreadability of 5.43 cm ± 0.12, and pH of 5.03 ± 0.06, showed that the product was safe and ideal for the skin. The product stability test for seven days of storage showed no significant changes in melting temperature and spreadability, although there was a slight increase in pH. In addition, the product showed good antioxidant activity with 46.51% free radical inhibition and an IC50 value of 21.46 ppm, indicating potential protection against oxidative stress-induced skin damage. In conclusion, the tomato seed oil cleansing balm optimized through SLD has stable, safe, and effective performance as a skincare product with anti-aging benefits.
Gambaran Kepatuhan Minum Obat Pada Pasien Hipertensi di Salah Satu Puskesmas Semarang Barat Jawa Tengah Dewi, Rissa Maharani; Widiya , Hartika; Farizi , Gilang Rizki Al
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.563

Abstract

Introduction: Hypertension is a medical condition characterised by blood pressure that is higher than usual and persistent. Based on previous studies, it was found that the low level of compliance in taking medication was related to a decrease in the quality of life for hypertensive patients. This study aimed to determine the compliance of hypertensive patients with taking medicines at one of the West Semarang Community Health Centres, Central Java. Methods: Analytic descriptive research. This type of research is observational with cross-sectional techniques, with respondents being hypertensive patients at one of the Puskesmas in West Semarang, Central Java, in 2023. Data analysis was conducted by looking at whether or not drug compliance affected patient characteristics using the chi-square Morisky Medication Adherence Scale 8 (MMAS-8) test. Results: female gender is higher than male, age 36 years to 45 years and 56 years to 65 years have high adherence, diploma and undergraduate education have high adherence values, occupation of housewives and civil servants / TNI / POLRI have high adherence to taking medication and long suffering above 2 years of moderate drug compliance, hypertension therapy with 2 to 3 drugs moderate adherence rather than one drug, other disease characteristics are equally high in adherence.Conclusion: Adherence to the use of antihypertensive medications in one Puskesmas in West Semarang, Central Java, was in the high and medium categories. Men have a moderate adherence category, and women have a high adherence category.
Potensi hepatoprotektif ekstrak daun Euphorbia heterophylla L. dalam menurunkan kadar bilirubin pada tikus Wistar yang diinduksi INH dan rifampisin Kurniasih, Khamdiyah Indah; Fauziah, Fauziah; Ratna, Uki Septi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.592

Abstract

Hepatitis is a liver damage disorder characterized by inflammation caused by various factors, one of which is medication use. Liver damage due to medication, or drug-induced liver injury (DILI), has a relatively high prevalence. Isoniazid (INH) + Rifampicin is a combination of drugs that poses a risk of DILI by causing liver damage. One parameter for assessing liver damage is through the measurement of total serum bilirubin levels. Katemas herb (Euphorbia heterophylla L) is a plant known to contain flavonoids, tannins, and saponins, with strong antioxidant properties. The high incidence of liver damage due to drug-induced liver injury (DILI) necessitates the exploration of alternative therapies to manage liver disorders. Katemas is a wild grass that grows abundantly but remains underutilized.The objective of this study is to evaluate the hepatoprotective activity of katemas herb leaves. The method used in this research involves maceration to obtain extracts, with ethanol 96% as the solvent. Testing was conducted on five groups of rats, with total serum bilirubin levels measured across all groups. All groups were induced using INH and RMP. The results showed that Groups III and IV, which were the dose variation groups, exhibited hepatoprotective activity. Group V, which received the highest dose of 200 mg/kg BW, demonstrated the greatest reduction in total bilirubin levels, with the largest mean decrease (-0.226) and a small standard deviation (±0.043).
Dampak Kualitas Pelayanan Berbasis Nilai Syariah di Apotek Karya Sehat Purwokerto Terhadap Kepuasan Konsumen Rizki, Inesya Febrianing; Hardiyanti , Annisa Mufidah; Rismayanti , Rismayanti
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.618

Abstract

Sharia-based services can improve consumer satisfaction. The four main principles of Islamic teachings on service are Rabbaniyyah, service, Waqi'iyyah, and Insaniyyah. The high and low quality of service can be determined by consumer behavior, namely Rabbaniyyah, Akhlaqiyyah, Waqi'iyyah, and Insaniyyah. The high and low quality of service can be determined by consumer behavior. The purpose is to determine how the quality of sharia-based services influences customer behavior. This research method is a cross-sectional design that is included in descriptive observation. The results showed that sharia-compliant pharmaceutical services positively impact customer satisfaction, as the significant value exceeds a t-value of 0.05. In conclusion, the quality of sharia-based services affects customer satisfaction.
Uji efektivitas antidiabetes nanoherbal dan ekstrak etanol daun toppaspara (Mikania micrantha Kunth) Pada Tikus Putih Jantan (Rattus Norvegicus) yang diinduksi streptozotosin Indah Setyarini, Putri Ayu; Gunawan , Muhammad; Safriana, Safriana; Fatimah , Cut
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.697

Abstract

Diabetes mellitus is a metabolic disease characterised by hyperglycemia caused by insufficient insulin production, insulin resistance, or both. The use of natural ingredients as a treatment option for diabetes mellitus can be developed as an alternative treatment, one of which is the toppaspara plant (Mikania micrantha Kunth.). The very small particle size in nano form is used to increase antidiabetic activity. Toppaspara leaves (Mikania micrantha Kunth.) have been empirically used as an antidiabetic, but this has not been scientifically proven. This research aims to determine the effectiveness of nanoherbal and ethanol extract of toppaspara leaves. This research was carried out experimentally, including the manufacture of simplicia, characterisation of simplicia, characterisation of nanoherbals and testing of antidiabetic effectiveness. Male white mice were induced with 2.5% streptozotocin intraperitoneally. Administration of 0.5% CMC suspension, nanoherbal and ethanol extract of toppaspara leaves at 50 mg/kgBB, 100 mg/kgBB, 200 mg/kgBB, metformin 45 mg/kgBB. The number of decreases in blood glucose levels is calculated; from the number of decreases in blood glucose levels, the percentage decrease in blood glucose levels is calculated. This analysis test uses One-way ANOVA followed by the Tukey test. The results of phytochemical screening of fresh leaves, simplicia ethanol extract and nano herbal toppaspara leaves contain secondary metabolite compounds such as alkaloids, tannins, flavonoids, saponins, steroids and glycosides. The results of the One Way ANOVA test and the Tukey test showed that nanoherbal 100 mg/kgBW and ethanol extract of toppaspara leaves 200 mg/kgBW were the best as antidiabetics and were not significantly different from metformin 45 mg/kgBW as a comparison.
Formulasi liniment kombinasi jahe merah (Zingiber officinale var. rubrum Theilade) dan atsiri daun peppermint (Menthae piperitae L.) sebagai aromaterapi Limbong, Yulia Safitri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.728

Abstract

Pendahuluan: Minyak atsiri dapat digunakan dalam penggunaan obat luar, seperti lulur, minyak pijat, lotion, pengharum ruangan dan sebagainya. Minyak atsiri dapat digunakan secara langsung. Tujuan: Penelitian ini bertujuan untuk mengetahui kombinasi minyak atsiri Jahe Merah (Zingiber officinale var. rubrum Theilade) dan daun peppermint (Mentha piperita L.) dapat diformulasikan menjadi sediaan liniment sebagai aromaterapi. Metode: Penelitian ini dilakukan secara eksperimental yaitu untuk mengetahui suatu gejala atau pengaruh yang timbul sebagai akibat dari adanya perlakuan tertentu, meliputi penyiapan sampel, formulasi sediaan, evaluasi terhadap mutu fisik sediaan seperti uji organoleptis, uji homogenitas, uji pH, uji iritasi dan uji kesukaan (hedonik). Hasil: dari penelitian ini menunjukkan Pemeriksaan organoleptis sediaan liniment dari minyak atsiri jahe Merah dan daun Peppermint berbentuk cairan jernih, beraroma jahe merah dan mint, berwarna kuning. Sediaan homogen dan sesuai syarat pH yang baik. Tidak menimbulkan iritasi. Konsentrasi terbaik yang digunakan dalam pembuatan formulasi sediaan liniment kombinasi minyak atsiri Jahe Merah dan minyak atsiri daun peppermint aromaterapi adalah (20% : 20%) kerena memiliki aroma dan rasa yang nyaman terhadap panelis.. Kesimpulan: menunjukkan Minyak atsiri Jahe Merah kombinasi daun peppermint dapat diformulasikan menjadi sediaan liniment sebagai aromaterapi dengan Konsentrasi terbaik yaitu F3 (20% : 20%).
Analisis docking tanaman meniran (Phyllanthus niruri L.) terhadap penghambatan asetilkolinesterase penyakit alzheimer Silalahi , Ali Affan; Shufyani , Fahma; Siregar , Syati Manaharawan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.731

Abstract

Meniran plants (Phyllanthus niruri L.) are plants of the Phyllanthus genus. It is known that Phyllanthus genus plants contain astragaline, phyllanthine, hypopyllanthin compounds. Which is a flavonoid derivative that can function as an inhibitor of acetylcholinesterase enzyme against Alzheimer's disease. Based on the results of molecular docking, astragaline compounds have the best binding affinity compared to other compounds, namely -8.4 kcal/mol while the nativ ligand is -5.8 or in other words astragaline compounds derived from meniran plants (Phyllanthus niruri L.) can react when the drug binds to the target receptor in Alzheimer's disease. This type of research aims to determine the potential of compounds from the meniran plant (Phylanthus niruri L.) by inhibiting acetylcholinesterase in Alzheimer's disease. This study used molecular docking method with autodock vina program and visualized with discovery studio program. The conclusion of the study can be seen from the results of docking visualization which shows the form of hydrogen conventional that dominates the hydropobic bond. The interaction that occurs on the active side of the protein indicates that the compound has the ability. In other words, the compound can react as a drug when it binds to the target receptor in Alzheimer's disease.
Gambaran budaya keselamatan pasien di rumah sakit Izza Karawang Tahun 2024 Dewi, Marhindayani; Damayanti, Rita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.737

Abstract

This study was conducted to describe the patient safety environment developed by Izza Hospital, Karawang, using the Hospital Survey on Patient Safety Culture (HSOPSC) instrument developed by the Agency for Healthcare Research and Quality (AHRQ). The research method used a quantitative descriptive design with a survey approach, involving 326 respondents from medical and non-medical personnel who were directly related to patient care. The sampling technique was accidental sampling, and data were analyzed using univariate analysis for the frequency distribution of the 12 dimensions of patient safety culture. The findings showed that most respondents were nurses (62.9%) with 1-5 years of service (38%) and working hours >40 hours per week (64%). The assessment of the work unit showed the majority in the “good” category (56%), while the most patient safety reports were 1-2 reports per year (35%). Most indicators of patient safety culture showed positive responses, such as teamwork (97%) and open communication (66-81%). However, there were challenges in indicators such as response to errors and staff courage to ask critical questions. In conclusion, the patient safety culture at Izza Hospital is in the “good” category but needs specific improvements in certain dimensions to support more optimal patient safety. These results provide insights for the hospital in formulating strategies for continuous improvement of patient safety culture.
Efektivitas sediaan spray ekstrak etanol Gracilaria sp. sebagai penolak nyamuk Aedes aegypti Puspita, Wana; Pratami, Gina Dania; Setyaningrum, Endah; Nurcahyani, Nuning
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.753

Abstract

Dengue Hemorrhagic Fever or commonly known as DHF is a disease that is transmitted through the bite of female Aedes aegypti mosquitoes which carry the Dengue virus so that it can cause Extraordinary Events (KLB). Prevention of dengue fever is generally carried out using refills containing the chemical DEET (N,N-diethyl-meta-toluamide) which is dangerous for the skin. Gracilaria sp. It is known to contain compounds that are toxic to mosquitoes, such as alkaloids, flavonoids, steroids, saponins, tannins and triterpenoids. This research aims to see the effectiveness of the ethanol extract of Gracilaria sp. as a repellent for Ae. aegypti, Effective Concentration 50% (EC50), irritating effects, and physical properties of the ethanol extract spray preparation of Gracilaria sp. The research was carried out with methodology in accordance with the recommendations of the World Health Organization Pesticides Evaluation (WHOPES) using a Completely Randomized Design (RAL). The protective power provided by the ethanol extract of Gracilaria sp. analyzed using Oneway ANOVA, followed by the Least Significant Difference (LSD) test. Probit analysis was carried out to determine the effectiveness of the ethanol extract concentration of Gracilaria sp. as a repellent. The research results show that concentration levels of 5%, 10%, 15%, and 20% provide protective power capabilities of 14.40%, 31.81%, 47.76%, and 61.17% respectively with an EC50 value of 18.86%. The spray is homogeneous and does not cause skin irritation. Conclusion, spray preparations containing ethanol extract of Gracilaria sp. potential as a repellent for Ae. aegypti. Using this repellent can help reduce the risk of dengue fever which is transmitted by mosquitoes. Further research is needed on the effectiveness of Gracilaria sp. as a repellent with a concentration above 20% and an irritation test was carried out on > 10 probands for > 15 minutes by spraying the preparation repeatedly.
Formulasi orally disintegrating tablet dari serbuk kembang kol (Brassica oleracea var. botrytis L.) dengan variasi konsentrasi sari tapai sebagai disintegrant Lestari, Sri Indah; Dalimunthe, Gabena Indrayani; Lubis, Minda Sari; Nasution, Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.773

Abstract

Cauliflower (Brassica oleracea var. botrytis L.) has a nutritional content consisting of calcium, magnesium, potassium, phosphorus, and low saturated fat. It has vitamin C, which helps increase body immunity. Orally Disintegrating Tablet preparations can dissolve quickly when placed on the tongue, formulated for ease of use of drugs for patients who have difficulty swallowing. Therefore, disintegrants are very important in ODT preparations. Tapai extract has a sweet, slightly sour taste and disintegrates immediately when placed on the tongue. This research aimed to determine whether cauliflower powder with tapai extract disintegrants can be formulated into ODT preparations and which formulation is the best.  This research included characterization of simplicia, making pre-formulation by mixing all ingredients, evaluating pre-formulation, and tablet printing by direct compression method. Then, the tablet evaluation was carried out. The disintegrant was tapai extract with 5%, 7.5%, and 10% concentrations. Data were analyzed using the One Way ANOVA method. The results of the formulation evaluation, the flow time test obtained <10 seconds, which is easy to flow; the angle of repose test obtained 26˚, the category is very good; and the compressibility test obtained 18-20%, which is quite good. The results of the tablet evaluation in the organoleptic test obtained round tablets, sweet taste, brownish-white color, and distinctive odor. The weight uniformity test on all formulas did not have any deviating weights; the size uniformity test met the requirements, the hardness test obtained 1-3 kg, the friability test obtained 0.4-0.7%, the petri dish disintegration time test obtained 44.07-52.48 seconds, and the mouth disintegration time test obtained 53.07-57.78 seconds and the wetting time test obtained 53.21-54.87 seconds. The best formula is formula 3, with a 10% tapai extract concentration.

Page 4 of 6 | Total Record : 55

 2   3   4   5   6 

Filter by Year

2025 2025


Reset
Filter By Issues
All Issue JPS Volume 9 Nomor 1 (2026) JPS Volume 8 Nomor 4 (2025) JPS Volume 8 Nomor 3 (2025) JPS Volume 8 Nomor 2 (2025) JPS Volume 8 Nomor 1 (2025) JPS Volume 7 Nomor 4 (2024) JPS Volume 7 Nomor 3 (2024) JPS Volume 7 Nomor 2 (2024) JPS Volume 7 Nomor 1 (2024) JPS Volume 6 Nomor 4 (2023) JPS Volume 6 Nomor 3 (2023) JPS Volume 6 Nomor 2 (2023) JPS Volume 6 Nomor 1 (2023) Suppl. 1, No. 1 (2023) JPS Volume 1 Nomor 1 (2018) More Issue