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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 75 Documents
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Search results for , issue "JPS Volume 8 Nomor 3 (2025)" : 75 Documents clear
Studi Molecular Docking Luteolin dan Turunannya untuk Mengidentifikasi Potensi Inhibitor ER-α pada Kanker Payudara Atwon, Fasha Jamil; Da'I , Muhammad
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1022

Abstract

Breast cancer remains one of the leading causes of cancer-related mortality worldwide, with estrogen receptor alpha (ER-α) serving as a primary therapeutic target in hormone-dependent subtypes. Resistance to current endocrine therapies underscores the need for alternative compounds with improved efficacy and safety. Luteolin, a naturally occurring flavonoid, has gained attention as a potential anticancer agent, but its structural modifications may alter biological activity. This study evaluated the binding affinity and interaction profiles of luteolin and its glycosylated derivatives (luteolin 7-glucuronide and luteolin 7-O-glucoside) against ER-α using molecular docking (PDB ID: 7UJ8). The results revealed that luteolin consistently exhibited stronger binding affinity (−7.2 to −8.0 kcal/mol) and stable RMSD values compared to its derivatives, though it remained significantly weaker than the reference drug 4-hydroxytamoxifen (−8.9 to −9.4 kcal/mol). Structural analysis demonstrated that luteolin’s superiority arises from its ability to maintain extensive hydrophobic and π–π stacking interactions within the ER-α binding pocket. In contrast, glycosylation introduced bulky polar substituents that disrupted hydrophobic contacts and reduced binding affinity. These findings highlight luteolin as the most promising scaffold among the tested compounds and underscore the structural basis for why glycoside derivatization diminishes ER-α binding. Future work should focus on enhancing luteolin’s bioavailability without compromising its key hydrophobic interactions to advance its potential as a lead candidate for breast cancer therapy.
Faktor-Faktor yang Berhubungan Dengan Kejadian Stunting pada Anak Usia Dini di Wilayah Kerja Puskesmas Buhit Kecamatan Pangururan Kabupaten Samosir Tahun 2024 Sinurat , Arni Wetty; Manurung , Kesaktian; Sembiring, Rinawati; Rochadi, Kintoko; Sinaga, Janno
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1024

Abstract

Background: Stunting is a health problem resulting from chronic malnutrition over a long period. Although it serves as the district capital, Pangururan Sub-District still has a relatively high stunting prevalence, with 154 out of 2,460 measured toddlers (6.26%) affected. Identifying associated factors is necessary to design targeted interventions. Objective: This study aims to analyse the factors associated with the incidence of stunting in early childhood children in the working area of Buhit Community Health Centre, Pangururan Sub-District, Samosir Regency. Methods: This study used a cross-sectional design conducted in the working area of Buhit Community Health Centre. The study population consisted of mothers with toddlers in the area, with a sample size of 96 mothers selected using accidental sampling. Data were collected through questionnaires and anthropometric measurements and analysed using the Chi-Square test and logistic regression. Results: Bivariate analysis results showed significant relationships between maternal nutritional status (p=0.000), parenting patterns (p=0.000), maternal education level (p=0.000), family income level (p=0.003), and exclusive breastfeeding (p=0.029) with the incidence of stunting. Multivariate analysis indicated that maternal education level was the most dominant variable (p=0.013; OR=12.814), meaning that mothers with low education levels had a 12.8 times higher risk of having stunted children. Conclusion: Maternal nutritional status, parenting patterns, maternal education, family income, and exclusive breastfeeding were significantly associated with stunting, with maternal education level being the dominant factor. Therefore, stunting prevention efforts in this region should prioritise health education targeting mothers with low educational backgrounds.
Eksplorasi Kualitas Hidup dan Kepercayaan Obat terhadap Ketidakpatuhan Pasien Hemodialisis Suryaman, Sulistia; Cholisoh, Zakky
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1029

Abstract

Background: Poor medication adherence is common among hemodialysis patients and is associated with adverse clinical outcomes. However, factors such as health-related quality of life (QoL) and medication beliefs remain underexplored as determinants of non-adherence in this population. Objective: This systematic review aims to synthesise the evidence regarding the relationship between QoL, medication beliefs, and pharmacological non-adherence in patients undergoing hemodialysis (HD). Methods: A comprehensive literature search was conducted using electronic databases (PubMed, Scopus, and Google Scholar) for observational studies published between January 2015 and July 2, 2025. Studies were included if they involved adult hemodialysis patients and examined QoL and/or medication beliefs concerning pharmacological non-adherence. Results: Six observational studies, encompassing 1,698 hemodialysis patients from various countries, met the inclusion criteria. The synthesised evidence indicated that poorer QoL (particularly depression and poor sleep quality), higher burden of physical symptoms, and specific medication beliefs (e.g., concerns about side effects and low perceived necessity of medications) were significantly associated with increased non-adherence. Conclusion: Non-adherence among hemodialysis patients is influenced by the complex interaction of psychosocial factors, including QoL and individual medication beliefs. To improve adherence, interventions should be developed to target these factors through health education, psychological support, and patient-centred care. Further integrative and contextual research is needed to strengthen understanding and develop more effective interventions.
Korelasi Kadar Vitamin C, Cholecalciferol dan Kadar Malondialdehid Antara Kejadian Abortus Dengan Kehamilan Normal : Studi Observasional Manila, Hartati Deri; Yona Amir , Aprima; Meysetri , Fafelia Rozyka
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1032

Abstract

Introduction: Abortion is a pregnancy complication that contributes significantly to maternal morbidity and mortality. Approximately 73 million abortions occur annually worldwide, with the estimated abortion rate in Padang city in 2024 reaching 58.7%. Abortion remains a challenge in obstetrics. The relationship between vitamin C deficiency, cholecalciferol, and elevated MDA levels and abortion remains debated, given the complex pathophysiological mechanisms. Objective: to determine the correlation between vitamin C, cholecalciferol, and malondialdehyde levels between abortion and normal pregnancy. Method: This study is a comparative study of two unpaired groups with a cross-sectional approach to analyze the average levels of Vitamin C, cholecalciferol, and MDA. The population in this study was pregnant women diagnosed with abortion and all women with normal pregnancies with a gestational age of ≤ 20 weeks who were treated in the delivery room of RSUD dr. M. Zein, RS. dr. Reksodiwiryo Padang, RSUP M. Djamil Padang, RS. Rasidin Padang with a sample size of 30. Data analysis was carried out using an Independent Samples T-test. Results: The results of this study showed that Vitamin C levels were lower in the abortion group than in the control group, a significant difference (p = 0.001). Cholecalciferol deficiency was more pronounced in the abortion group, a significant difference compared to normal pregnancies (p = 0.002). MDA levels were very high in the abortion group, a significant difference (p = 0.001). Conclusion: There is a significant correlation of Vitamin C and cholecalciferol levels between the occurrence of abortion and normal pregnancy, and there is a significant correlation of malondialdehyde levels between normal pregnancy and the occurrence of abortion.
Bioaktivitas dan Efek Kesehatan Bawang Hitam terhadap Enzim Reduktase Hidroksi Metilglutaril-KoA Pada Tikus Putih Jantan Obesitas Ibrahim, Ibrahim; Yerizel , Eti; Endrinaldi, Endrinaldi; Revilla, Gusti
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1039

Abstract

Obesity is a condition of abnormality or excess fat accumulation in adipose tissue. HMG-CoA reductase is an enzyme that can catalyse HMG-CoA into mevalonate, which is needed in cholesterol biosynthesis. Inhibition of the HMG-CoA reductase enzyme is an effective drug target mechanism to overcome dyslipidemia. Black garlic, which is high in antioxidants such as SAC, flavonoids, and polyphenols, is an effective mechanism. This study tested the bioactivity and health effects of black garlic on the activity of HMG-CoA reductase enzyme. This type of experimental study on male rats uses a post-test control-only group design. The sample in this study was 25 experimental animals divided into five groups, group negative control with a regular diet, group positive control with a high-fat diet, group treatment 1 with a high-fat diet and black garlic dose of 200 mg/rats, group treatment 2 with a high-fat and black garlic diet dose of 400 mg/rats, and group treatment given a high-fat diet and black garlic dose of 800 mg/rats. The results of the study showed that the average value and standard deviation of HMG-CoA in the negative control group were 1,044 and 0.088, the positive control group 2,136 and 0.487, the 1 group treatment 1,292 and 0.194, the 2 group treatment 1,296 and 0.206 and the three treatment group 1,201 and 0.201 nmol/min/mg protein. Based on the results of the hypothesis test, the significance level for the five groups was 0.004, indicating a significant difference in the average HMG-CoA levels in groups K1, K2, P1, P2, and P3. Black garlic significantly decreased HMG-CoA reductase activity in rats fed a high-fat diet, supporting its potential as a natural therapeutic agent for dyslipidemia management.
Evaluasi Penggunaan Eritropoetin (EPO) yang dikaitkan dengan Clinical Outcome pada Pasien Hemodialisis di RSUP Prof. R. D . Kandou Manado. Rambi, Firly Kartika Yuni; Ramatillah , Diana Laila
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1043

Abstract

Background: Chronic kidney disease (CKD) is a health issue that occurs in almost all parts of the world, and the number of patients continues to increase. CKD patients undergoing hemodialysis often experience anemia, which affects their quality of life and increases the risk of morbidity and mortality. Erythropoietin (EPO) is used to treat anemia, but its effectiveness can be affected by nutritional status, combination therapy, and other factors. Objective: To determine the profile of EPO therapy in CKD patients at the Dahlia Hemodialysis Unit at RSUP Prof. Dr. R.D. Kandou. Methods: An observational study with a retrospective cohort design (January–December 2020 with follow-up until December 2024) and a prospective design (October–December 2024). Patient medical records were processed and analyzed descriptively and analytically using Independent T-Tests, ANOVA, ANCOVA, and Kaplan-Meier survival analysis. Results: 209 patients undergoing therapy, 109 male (52.15%) and 100 female (47.85%). The average increase in post-treatment hemoglobin levels (Hb Post) compared to pre-treatment levels (Hb Pre) was 16.28%. Independent T-Test showed no significant difference in Hb levels between males and females (p>0.05). ANOVA Test showed a significant difference in Hb Post levels between age groups (F(7,201)=3.517; p=0.001). ANCOVA analysis showed that Hb Pre was the primary predictor of Hb Post (F=161.151; p<0.001). Conclusion: EPO therapy increases hemoglobin levels in CKD patients, with the response influenced by age and Hb Pre, but not by gender. Hb Pre levels are the primary predictor of treatment success.
Pengaruh Pemberian Teh Bevuzingiber (Beta vulgaris dan Zinger officinale) pada Pasien Hipertensi Tingkat I di Wilayah Kerja UPT Puskesmas Way Kandis Tahun 2025 Janah , Widya Miftakhul; Astuti, Dewi Woro; Hervidea, Radella
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1054

Abstract

Background: Hypertension is a major global health issue characterized by a persistent increase in arterial blood pressure, leading to severe complications. Stage I hypertension is defined as systolic blood pressure of 140-159 mmHg and diastolic pressure of 90-99 mmHg. The high prevalence of hypertension in the work area of UPT Puskesmas Way Kandis necessitates effective and accessible non-pharmacological interventions, such as the use of local ingredients like beetroot (Beta vulgaris) and ginger (Zingiber officinale). Objective: This study aimed to analyze the effect of consuming Bevuzingiber tea (a combination of Beta vulgaris and Zingiber officinale) on reducing blood pressure in patients with stage I hypertension. Methods: This study used a quantitative quasi-experimental design with a pretest-posttest control group approach. The sample consisted of 36 stage I hypertension patients selected through purposive sampling. They were divided into two groups: an intervention group (n=18) given Bevuzingiber tea and a control group (n=18) given antihypertensive medication. The intervention was conducted for 7 days. Blood pressure was measured before and after the intervention. Data were analyzed using the Wilcoxon Signed-Rank Test. Results: The results showed a significant reduction in blood pressure in the intervention group. The average systolic blood pressure decreased from 152.00 mmHg to 113.89 mmHg, and diastolic pressure decreased from 91.50 mmHg to 74.17 mmHg. Statistical analysis confirmed a significant difference with a p-value of 0.000 (<0.05). The intervention group also showed more consistent reductions compared to the control group. Conclusion: Bevuzingiber tea is effective in reducing blood pressure in patients with stage I hypertension and can be recommended as a complementary non-pharmacological therapy. It is suggested that future researchers focus on patients under 65 years of age and directly observe respondents' activities and other factors influencing blood pressure.
Determinan Kejadian Hipertensi pada Masyarakat Pedesaan di Wilayah Kerja Puskesmas Simarmata Kecamatan Simanindo Kabupaten Samosir 2024 Sibarani , Melda; Siagian, Mindo Tua; Anita , Surya; Dachi , Rahmat Alyakin; Tarigan, Frida Lina
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1057

Abstract

Background: Hypertension is a major global health issue and a significant risk factor for cardiovascular and renal diseases. Data from the Samosir Regency Health Office in 2022 indicated a high prevalence of hypertension (30%) among adults in Simanindo District, highlighting a critical local public health concern. Objectives: This study aimed to identify the determinants associated with the incidence of hypertension in the working area of the Simarmata Public Health Center, Simanindo District, Samosir Regency. Methods: A quantitative study with a cross-sectional design was conducted. A sample of 95 respondents was selected proportionally from four villages. Data on Body Mass Index (BMI), alcohol consumption, smoking habits, and dietary patterns were collected through interviews and measurements. Data analysis employed the Chi-square test and multivariate logistic regression. Results: The study revealed significant relationships between hypertension and BMI (p=0.000), alcohol consumption (p=0.000), smoking habits (p=0.000), and dietary patterns (p=0.018). Multivariate analysis identified smoking habit as the most dominant factor, with smokers having 9.758 times higher odds of developing hypertension (Exp(B) = 9.758; 95% CI: 2.697–35.303). Conclusion: Smoking habit is the most dominant determinant of hypertension in this community. It is recommended that the head of the Simarmata Public Health Center enhance the role of health workers in providing health education, particularly on the dangers of smoking and its impact on hypertension, to reduce its incidence.
Isolasi dan Karakterisasi Nano Hemiselulosa dari Tandan Kosong Kelapa Sawit (Elaeis guineensis Jacq.) Ritonga , Septi Ani; Dalimunthe , Gabena Indrayani; Lubis , Minda Sari; Yuniarti, Rafita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1058

Abstract

Background: Empty Fruit Bunches (EFB) of oil palm (Elaeis guineensis Jacq.) are a significant agricultural waste from the palm oil industry, currently underutilized. EFB contains lignocellulosic components, including hemicellulose (22.84%), which has potential applications in the pharmaceutical sector as a hydrophilic polymer. Objective: This study aimed to isolate and characterize hemicellulose and nano-hemicellulose from oil palm EFB using an environmentally friendly green chemistry method with low-concentration reagents. Methods: This experimental research began with the purposive sampling of EFB. Hemicellulose was isolated using a sequential process with 0.1 N NaOH, 0.1 N HCl, and 70% ethanol. The resulting hemicellulose was then nano-sized using a ball mill technique. Characterization included organoleptic tests, solubility tests, Fourier Transform Infrared (FTIR) spectroscopy, Particle Size Analyzer (PSA), and Scanning Electron Microscope (SEM). Results: The isolation process from 500 g of EFB powder yielded 16.7 g of hemicellulose, with a yield of 3.34%. FTIR analysis identified key functional groups (O-H, C-H, C=O, C-O, C=C) in both hemicellulose and nano-hemicellulose, confirming their chemical similarity. SEM analysis at 500x magnification revealed a more regular particle structure with distinct cavities, indicating a swelling effect from the alkali treatment. PSA confirmed the nano-scale size of the processed particles. Conclusion: Hemicellulose and nano-hemicellulose were successfully isolated from oil palm EFB using a simple green chemistry method. The characterized nano-hemicellulose showed properties suitable for potential development as a carrier in pharmaceutical formulations.
Kombinasi Formulasi Simplisia Serbuk Daun Seroja (Nelumbo nucifera Gaertn.) Dengan Serbuk Rimpang Jahe (Zingiber officinale) Dalam Sediaan Teh Celup Sebagai Minuman Kesehatan Fitri , Khairani; Khairani , Tetty Noverita; Tarigan , Rida Evalina; Ananda , Sheila Rizka; Arista , Eni
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1078

Abstract

Introduction: Indonesia is a tropical country with high humidity that supports the growth of various plants, including medicinal herbs such as lotus leaves and ginger. Objective: This study aims to formulate a combination of powdered lotus leaves (Nelumbo nucifera Gaertn.) and powdered ginger rhizome (Zingiber officinale) into tea bag preparations and to evaluate their quality. Methods: The study employed an experimental method. Testing was conducted based on the Indonesian National Standard (SNI) parameters for tea bags, including organoleptic evaluation, moisture content test, total ash content test, acid-insoluble ash test, water-soluble extractive test, and hedonic test. Results: The concentrations of lotus leaf powder and ginger powder formulated were 100:0 (F0), 90:10 (F1), 80:20 (F2), 70:30 (F3), 60:40 (F4), and 50:50 (F5). The hedonic test results indicated that formula F5 (50:50) was the most preferred by the panelists compared to other formulas, with the highest average score. However, overall, the commercial tea (positive control) still obtained a higher preference score. Conclusion: The combination of lotus leaf powder and ginger rhizome powder was successfully formulated into tea bag preparations. Formula F5 (50:50) was selected as the best among all tested formulations, although its preference level remained lower than that of commercial tea.

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