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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Pengaruh Ekstrak Daun Nanas Terhadap Pertumbuhann Candida albicans Dan Malassezia furfur Dalam Bentuk Sediaan Shampo Herbal Abadi , Hafizhatul; Khairani , Tetty Noverita; Fitri, Khairani; Diana, Vivi Eulis; Leny, Leny; Hasibuan, Amalia Juliani
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1181

Abstract

Background: Dandruff is a common scalp problem often caused by the overgrowth of fungi such as Candida albicans and Malassezia furfur. Pineapple leaves (Ananas comosus (L.) Merr.) are known to contain active antifungal compounds, such as alkaloids, flavonoids, saponins, and tannins, making them a potential active ingredient for anti-dandruff preparations. Objective: This study aimed to formulate an herbal anti-dandruff shampoo using pineapple leaf ethanol extract and to evaluate its effectiveness in inhibiting the growth of Candida albicans and Malassezia furfur. Methods: This experimental research used the disc diffusion method with PDA and SDA media to test antifungal inhibition. The shampoo preparations were formulated with varying extract concentrations (10%, 20%, 30%). The evaluation of the preparations included organoleptic tests, homogeneity, pH, foam height, viscosity, stability (cycling test), skin irritation, and hedonic tests. Results: The resulting shampoo preparation had a blackish-brown color, liquid form, and a menthol odor. Evaluation results showed the preparation was homogeneous, with pH values (5.0-5.8), foam height, and viscosity meeting the requirements. The preparation was also stable during the cycling test and did not cause irritation. The antifungal activity test showed that increasing the extract concentration increased the inhibitory power. The formula with a 30% concentration (F3) provided the greatest inhibition against Candida albicans (average 15.76 mm) and Malassezia furfur (average 15.9 mm), which is categorized as strong. Conclusion: Pineapple leaf ethanol extract was successfully formulated into an effective herbal anti-dandruff shampoo preparation, with the 30% concentration being the most optimal. It is recommended that further research investigate the antifungal activity of this extract against other types of fungi and in different dosage forms.
Review Artikel: Karakterisasi Dan Uji Efektivitas Antikanker Nanopartikel Emas (AuNPs) Dan Nanopartikel Perak (AgNPs) Dengan Ekstrak Kunyit (Curcuma spp.) Sebagai Bioreduktor Haura, Izmi; Mulki, Munir Alinu
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.678

Abstract

Cancer is one of the leading causes of death in the world with major challenges in the form of therapeutic side effects, poor selectivity, and drug resistance. Nanotechnology, particularly the use of gold (AuNPs) and silver (AgNPs) nanoparticles, offers a promising alternative to improve the effectiveness of cancer therapy. This article reviews recent developments in the synthesis of AuNPs and AgNPs using turmeric as a natural, environmentally friendly bioreductor. Characterization of nanoparticles through UV-Vis, TEM, SEM, and FT-IR methods showed particle sizes ranging from 1-100 nm, spherical or hexagonal morphology, and the presence of functional groups such as -OH and C=O that support stability and bioactivity. Anticancer studies show that these nanoparticles are effective against various types of cancer cells, including breast (MCF-7, MDA-MB-231), lung (A549, NCI-H661, NCI-H1975, NCI-H1573, NCI-H1563), cervical (HeLa), and epithelial (Hep-2) cancers.
Pengaruh Perlindungan Propolis Terhadap Tukak Lambung Tikus Putih (Rattus norvegicus) Jantan Galur Wistar yang Diinduksi Ibuprofen Yasli , Afifah Salsabila; Rahayu , Mulyati Sri; Siregar , Sarah Rahmayani
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.934

Abstract

Background: The use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) such as ibuprofen often associated with gastric mucosal damage commonly referred to as gastric ulcer. This damage occurs due to the inhibition of the cyclooxygenase (COX) enzyme, which plays a cytoprotective role. Propolis, a natural product from honeybees, is known to contain flavonoids with anti-inflammatory, antioxidant, and anti-ulcer activities that can protect the gastric mucosa. Objective: This study aimed to determine the protective effect of propolis against gastric ulcers in male Wistar rats (Rattus norvegicus) induced by ibuprofen. Methods: True Experimental method with a Post-Test Only Control Group Design. The sample consisted of 30 male Wistar rats divided into five groups: a control group without treatment, a negative control group treated with ibuprofen 400 mg/kg, and three treatment groups administered propolis doses of 0.13 ml, 0.26 ml, and 0.52 ml. The treatment was conducted for the first seven days, followed by ibuprofen induction at 400 mg/kg for the next seven days. Results: The lowest mean number and severity of ulcers were found in the P3 group (3.1 ± 0.75; 2.4 ± 0.48). The Kruskal Wallis test results indicated a significant difference in the number and severity of ulcers between the control and treatment groups (p < 0.05). However, the post hoc Mann Whitney test revealed no significant differences among the treatment groups (p > 0.05). Conclusion: Propolis administration reduced the number and severity of ulcers caused by ibuprofen induction. Nevertheless, the dose of propolis used in this study have not yet achieved optimal efficacy
Ektstrak Kulit Jeruk Nipis dengan Minyak Serai Wangi Stick Balm sebagai Aromaterapi dan Repellent Nyamuk Aedes aegypti Wulandari, Septi; Riandiani , Evelyne; Romdani , Ayu Nadiyah Permatasari; Elena , Felicitas; Salsabila , Frisya Nutia; Amanda , Savira Intan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.959

Abstract

Lime (Citrus aurantifolia) is a plant that has been empirically recognized to possess insecticidal and repellent properties. Citronella oil (Cymbopogon nardus) is an essential oil with antidepressant properties and is commonly used as aromatherapy. The purpose of this study was to determine the physical properties and mosquito-repellent activity of a stick balm preparation formulated from lime peel extract (Citrus aurantifolia) as a repellent, with the addition of citronella oil (Cymbopogon nardus) as aromatherapy. This study employed an experimental research method. Stick balm preparations were made in four formulations with extract concentrations of 0%, 5%, 10%, and 15%. The formulations were evaluated for organoleptic characteristics, pH, homogeneity, spreadability, smearability, hedonic acceptance, irritation, and the presence of steroids and terpenoids, as well as tested for mosquito-repellent activity against Aedes aegypti. The evaluation results showed that all formulations met the established physical quality standards, indicating good stability and safety. The mosquito-repellent effectiveness test demonstrated that formulation F3 (15% lime peel extract) provided the highest protection at 94.74%, followed by F2 (84.21%), F1 (74.68%), and F0 (42.11%). Thus, stick balm preparations containing lime peel extract and citronella oil are physically stable, safe, and effective as mosquito-repellent aromatherapy, with F3 being the most effective formulation.  
Gel Ekstrak Daun Sirsak (Annona muricata L.): Formulasi dan Efektivitas terhadap Microsporum canis Rahmawati, Juwita; Nastiti, Amaranggana Lalita; Setiyadi , Gunawan; Maulana , Farrel
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1132

Abstract

Soursop (Annona muricata  L.) leaves contain genistein, steroids, and coumarins, which exhibit potential as natural antifungal agents against Microsporum canis, the causative agent of ringworm. This study aimed to formulate a soursop leaf extract gel using Na-CMC and carbopol 940 as gelling agents, optimized through the Simplex Lattice Design (SLD) with DE version 13, and to evaluate its physical characteristics and antifungal activity. Extraction was carried out by maceration with 96% ethanol. The optimum formula was obtained with 4.3% Na-CMC and 1.7% carbopol 940. The optimized gel exhibited homogeneous texture, characteristic soursop odor, greenish-brown semi-solid appearance, pH of 6.56 ± 0.17, viscosity of 326 ± 16.73 dPas, spreadability of 3.96 ± 0.43 cm², and adhesiveness of 1.58 ± 0.71 seconds. Antifungal testing using the well diffusion method showed an inhibition zone of 15.33 mm, classified as strong activity. ANOVA analysis revealed a significance value of 0.000 (< 0.05), indicating significant differences among the positive control, negative control, optimized gel, and soursop leaf extract. The antifungal activity of the optimum formula was not significantly different from that of the soursop leaf extract (p = 0.795). These results indicate the potential of soursop leaf extract gel as an effective antifungal alternative.
Hubungan Pengetahuan Ibu Nifas Dengan Pelaksanaan Bounding Attachment Pada Bayi Baru Lahir Sihotang, Siti Mangaranap Mustika Sari Br; Ginting, Theresia Perbina Br; Ramadhani , Tiara Suci; Hulu, Yudika; Saragih, Elv. Feedia Mona
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1136

Abstract

Background: The puerperium is a crucial period after childbirth that lasts for 6 weeks. During this time, the mother's body undergoes physical changes such as the return of the uterus to its original size, the release of lochea, and other hormonal changes. During this postpartum period, the mother can build closer affection. It is the cornerstone of the child's psychological development because of the significance of emotional bonding (bounding attachment) between mother and child. However, a lot of mothers continue to overlook this. Some factors that can influence the implementation of bounding attachment are through good maternal knowledge. Objective: to ascertain how postpartum mothers' understanding and the use of bounding attachment in infants at Pratama Sunggal Clinic relate to one another. Methods: 33 respondents were given questionnaires or had in-person interviews as part of this quantitative study, which uses a cross-sectional design and an analytical survey approach. To determine the link between variables, univariate and bivariate data analysis were employed, along with the chi-square test. Results: The chi-square test revealed a p-value of 0.002 for the association between postpartum moms' knowledge and the application of bounded attachment. Thus, the results indicate that the independent and dependent variables have a substantial association.
Validasi Metode Analisis dan Penetapan Kadar Encapsulated Retinol Dengan Metode Spektrofotometri UV Istiqomah, Dewi Aulia; Fauzi, Ahmad
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1140

Abstract

Retinol is a widely used active anti-aging ingredient in cosmetic products, but it is unstable to light and oxidation. Encapsulation technology enhances its stability and reduces skin irritation, yet complicates its quantitative analysis. This study aims to validate a UV spectrophotometric method for determining the concentration of encapsulated retinol in BPOM-labeled commercial serum preparations. Validation was carried out for linearity, accuracy, intraday precision and interday precision, LOD, and LOQ according to AOAC (2002) and ICH Q2(R1) guidelines. Sample preparation involved sonication to release retinol from its encapsulating matrix prior to measurement. The maximum wavelength was observed at 325 nm using ethanol as solvent. The calibration curve yielded the equation y = 0.139x + 0.0033 with R2 = 0.998, indicating excellent linearity. Recovery ranged from 92-105%, while precision showed %RSD < 2%, confirming high reproducibility. LOD and LOQ were 0.01 ppm and 0.03 ppm, respectively. Specificity evaluation demonstrated that both the standard and sample solution exhibited a maximum peak at 325 nm, whereas the blank serum matrixs showed a distinct peak at 280 nm with no absorbance at the analytical wavelength, confirming the selectivity of the method. Thus, the UV spectrophotometric method was validated and proven suitable for the routine quantification of free retinol released from encapsulated system in commercial skincare serums.
Potensi Antidiabetes Fraksi Etil Asetat dari Ekstrak Etanol Batang Ubi Yakon (Smallanthus sonchifolius) Secara in Vivo Efendi, Alvira; Haryoto, Haryoto
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1150

Abstract

Diabetes mellitus is one of the global health problems that requires alternative therapies based on natural products. The stem of yacon (Smallanthus sonchifolius) is known to contain various secondary metabolites with potential antidiabetic effects. This study aimed to identify the secondary metabolites in the ethyl acetate fraction of yacon stem, evaluate its antidiabetic activity in alloxan-induced male Wistar rats, and determine the lowest effective dose. Phytochemical screening revealed the presence of flavonoids, terpenoids, steroids, tannins, and alkaloids. The in vivo test was conducted by administering the ethyl acetate fraction at doses of 25, 50, and 100 mg/kgBW to Wistar rats, with negative and positive control groups using metformin. The results showed that all treatment doses significantly reduced blood glucose levels compared to the negative control, with hypoglycemic effects observed from day 7 and becoming more pronounced until day 21. The 25 mg/kgBW dose was the lowest dose that produced effects comparable to metformin and thus can be considered the lowest effective dose. These findings indicate that yacon stem has the potential to be developed as a natural agent for antidiabetic therapy.
Deteksi Cemaran Bakteri Coliform dan Escherichia coli pada Minuman Es Teh di Kota X Pangesti, Adel Hening; Indrayudha, Peni
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1155

Abstract

Iced tea is a popular and refreshing beverage commonly sold by street vendors. However, because the production process utilizes water and relies on the level of hygiene during processing, there remains a risk of bacterial contamination. This study aims to determine the level of bacterial contamination, specifically Coliform and Escherichia coli, in iced tea samples sold in X City, in accordance with food safety standards. This study was conducted using the Most Probable Number (MPN) method with three dilution series. The presence of Coliform was identified using a presumptive test with Lactose Broth (LB) media and a confirmatory test with Brilliant Green Lactose Bile Broth (BGLB) media. The presence of Escherichia coli was identified using Eosin Methylene Blue Agar (EMBA) media and biochemical tests using Triple Sugar Iron Agar (TSIA) media. Samples were taken from 10 different locations spread across 5 subdistricts in X City, with 2 samples taken from each subdistrict. The results showed that there was Coliform bacterial contamination in 10 samples and Escherichia coli bacterial contamination in 6 of the 10 iced tea samples in X City with MPN values ranging from 3-460 MPN/100 mL. Based on the Mann-Whitney test, a p-value of 0.004 (p < 0.05) was obtained, indicating a significant difference in MPN values between Escherichia coli-positive and negative samples. These results indicate that all samples did not meet the microbiological quality requirements based on Peraturan Menteri Kesehatan Republik Indonesia No. 2 of 2023, which stipulates that the maximum allowable levels of total Coliform and Escherichia coli in drinking water is 0 MPN/100 mL.
Efektivitas Ekstrak Kulit Jeruk Berastagi (Citrus Sinensis L.) Yang Diberikan Secara Topikal terhadap Kadar Serum C-reactive Protein pada Luka Sayat Tikus Jantan (Rattus Norvegicus) Siregar, Yohana Putri Jelita; Natali, Oliviti; Lubis, Adhayani; Sumantri , Dinda Triana; Perangin-Angin, Eka Lestari Br
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1159

Abstract

Introduction: Cutaneous wounds in male rats (Rattus norvegicus) are widely used as models for wound-healing research. C-reactive protein (CRP) is an inflammatory biomarker that increases in response to injury. Berastagi orange peel extract (Citrus sinensis L.) is known for its anti-inflammatory properties; however, its effectiveness in reducing serum CRP levels in cutaneous wounds has not been extensively studied. Objective: This study aimed to evaluate the effectiveness of topically administered Berastagi orange peel extract on serum CRP levels in male rats with cutaneous wounds. Methods: A total of 25 male rats were divided into three groups: control, treatment with orange peel extract, and treatment with a standard ointment. Wounds were inflicted on the rats' backs, and treatments were administered for a few days. Serum CRP levels were measured using the ELISA method. Results: Results indicated that the group receiving Berastagi orange peel extract exhibited a significant reduction in CRP levels compared to the control group (p < 0.05). The standard ointment group also showed a reduction, but not as effectively as the orange peel extract. Conclusion: Berastagi orange peel extract significantly reduces serum C-reactive protein levels in male rats with cutaneous wounds. These findings support the use of natural extracts as alternatives in wound healing therapy.

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