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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Review Sistematis: Pengaruh Kondisi Penyimpanan Terhadap Stabilitas Tablet Vitamin C Dan Aspirin Ramadhany, Arifa Salsabilla; Utami, Marsah Rahmawati; Ramadhani , Dwi Arifa; Lismawan , Gita Novianti
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1165

Abstract

This study aims to determine the most optimal storage conditions for maintaining the stability of vitamin C and aspirin tablets by considering key environmental factors such as temperature, humidity, light exposure, and storage duration. The review was conducted using a systematic review approach based on the PRISMA guidelines. Literature searches were performed through three main sources, namely PubMed, ScienceDirect, and Google Scholar, covering publications from 2015 to early 2025. The search through Google Scholar was carried out to complement the findings and minimize publication bias. A total of 14 research articles that met the inclusion criteria were analyzed in depth. The results indicate that vitamin C tablets exhibit the highest stability at low to room temperature (<30°C), under dry conditions with relative humidity below 75% RH, and protected from direct light exposure. In contrast, aspirin tablets show optimal stability at room temperature (around 25°C), under moderate humidity (<60% RH), and when stored in tightly sealed, light-resistant containers. The degradation of vitamin C is primarily driven by oxidation induced by heat, light, and moisture, whereas aspirin undergoes hydrolysis under humid and high-temperature conditions. Therefore, storing both tablets in a cool, dry place away from direct light is the most effective approach to preserve their stability and therapeutic efficacy throughout their shelf life.
Analisis Efektivitas Biaya Penggunaan Antibiotik Pada Pasien BPJS Dengan Pneumonia Di Instalasi Rawat Inap Rumah Sakit X Alfi Syahiroh, Wafa; Harlianti , Mariska Sri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1166

Abstract

Pneumonia is a lower respiratory tract infection that remains a major challenge to public health worldwide. The use of antibiotics as primary therapy is often irrational in terms of indications, dosage, and drug selection, which can impact clinical effectiveness and treatment costs. This study aims to assess the rationality and analyze the cost-effectiveness of antibiotic therapy for BPJS patients with pneumonia in the inpatient unit of Hospital X. This study is a non-experimental study with a descriptive observational method using the payer perspective (BPJS) approach. Data were collected retrospectively from the medical records of pneumonia patients from January 2023 to June 2025. Rationality was analyzed using the 4T method. Cost-effectiveness analysis was performed using the CEA method through ACER and ICER calculations. Based on the results of the rationality evaluation, it shows that the rationality of antibiotic use based on the 4T approach includes appropriate indications (100%), appropriate drugs (100%), appropriate patients (97.7%), appropriate dose (97.1%), appropriate frequency (100%), appropriate duration (98.8%), and appropriate route (100%). The total direct medical costs of patients with cefoperazone therapy were Rp 6,073,156, while those with ceftriaxone therapy were Rp 5,474,146. The ACER value of cefoperazone was Rp 65,614 per 1% clinical effectiveness, the ACER value of ceftriaxone was Rp 57,900 per 1% clinical effectiveness, while the ICER value was Rp 866,667 per additional 1% effectiveness.
Efektivitas Ekstrak Kulit Rambutan (Nephelium lappaceum L.) pada Kadar Kreatinin dan Struktur Histologi Ginjal Tikus Obesitas Shalsabila, Fitria; Lisdiana, Lisdiana
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1197

Abstract

Obesity is a condition characterized by the accumulation of excess fat in the body that can cause systemic metabolic changes. Rambutan peel is known to be rich in bioactive compounds such as geraniin, corilagin, ellagic acid, and other active compounds. This study aims to analyze the effect of rambutan peel extract on creatinine levels and kidney histology in obese rat models. The experimental research method used a post-test only control group design. A total of 25 male rats were divided into 5 groups: Normal group (K-); Obese group induced by coconut oil and 15% sugar water (K+); Obese group given ellagic acid (T1); Groups T2 and T3 induced by coconut oil and 15% sugar water and rambutan peel extract at doses of 15 mg/kgBW and 30 mg/kgBW. The parameters of this study were creatinine levels and kidney glomerular diameter. Data analysis used one-way ANOVA and Tukey HSD tests. The results of the study showed that rambutan peel extract could significantly reduce creatinine levels and glomerular diameter (p<0.05). The most optimal reduction was shown at a dose of 30 mg/kgBW for both creatinine levels and glomerular diameter. It can be concluded that rambutan peel extract has the potential to reduce creatinine levels and improve glomerular diameter in obese rat models.
Integrasi Profil Fitokimia Berbasis GC–MS dan Evaluasi Farmakologis In Vivo dalam Menilai Potensi Antidiabetes Ekstrak Etanol Scleria sumatrensis Retz. pada Model Tikus Diabetes Induksi Aloksan. Pareta, Douglas Natan; Montolalu , Friska Mery; Keno , Aprillia Vincensia; Kanter , Jabes Wolter; Tombuku , Joke Luis; Sambou , Christel Nataniel; Natanel , Andri; Santoso , Rahmat; Hariyadi, Hariyadi; Runtu , Alter Yantje
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1198

Abstract

This study evaluated the antidiabetic activity and phytochemical profile of the ethanolic extract of Scleria sumatrensis Retz. Using an alloxan-induced diabetic rat model. Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg BW) after a 12-hour fasting period, and fasting blood glucose was measured at three standardized time points: GD1 (baseline), GD2 (72 hours post-induction), and GD3 (day 14 post-treatment). GC–MS analysis revealed several major constituents, including ethyl α-D-glucopyranoside, ethyl linoleate, ethyl linolenate, phytol, tocopherol, and β-sitosterol, which are associated with improved insulin sensitivity, modulation of PPAR-γ–related pathways, antioxidant protection of pancreatic β-cells, and reduced intestinal carbohydrate digestion. Rats were assigned to negative control (vehicle), positive control (metformin 45 mg/kg BW), and extract-treated groups (75, 150, and 300 mg/kg BW). Percentage reduction from GD2 to GD3 was analyzed using one-way ANOVA followed by Tukey’s post-hoc test. The extract produced a significant and dose-dependent decrease in fasting glucose (p < 0.001). All extract doses differed significantly from the negative control, and the 300 mg/kg dose demonstrated glucose-lowering efficacy comparable to metformin. These findings indicate that Scleria sumatrensis possesses vigorous antihyperglycemic activity consistent with its lipophilic phytochemical composition. Further studies are required to verify the underlying mechanisms and identify the most active constituents.
Pengaruh Pelatihan Keterampilan Dasar Posyandu Terhadap Pengetahuan : Studi Quasi Eksperimen pada Tenaga Kesehatan di Dinas Kesehatan Kota Medan Tahun 2024 Kartini, Endang; Wandra, Toni; Hutajulu, Johansen; Nababan, Donal; Tarigan, Frida Lina
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1201

Abstract

The role of health workers as supporters and trainers in improving performance, providing motivation for Posyandu cadres to always be involved in all Posyandu activities. The level of knowledge of health workers in assessing basic Posyandu skills will greatly determine the quality of services provided. The formulation of the problem in this study through preliminary research conducted on health workers in 10 health centers in Medan City showed that the average value of their knowledge about Posyandu was 63.5 (target ≥ 70). This study aims to determine the effect of health worker training conducted by the Medan City Health Office. The study was conducted using a quasi-experimental method. The number of research samples was 30 people. The material provided was the latest concept and regulation on the integration of primary services at Posyandu. With interactive lecture training methods, group discussions, role play and field practice. The results showed that the mean pre-test value was 72.52 while the mean post-test value was 92.56, there was an increase in value of 29.81 and after being tested with Wilcoxon the p-value was <0.001. The results show that there is a significant difference in the knowledge of training participants about integrated health posts. Knowledge variables according to age, gender, education, work unit, length of service are not factors that influence the pre-test and post-test scores of health workers. It can be concluded that the training that has been given has increased the knowledge of health workers from the post-test assessment conducted. The results of this study are expected to be a medium for evaluating the implementation of basic competency training for integrated health posts for health workers so that the next training period can provide better results.
Identifikasi Kontaminasi Bakteri Staphylococcus aureus pada Daging Sapi di Pasar Kota Binjai Asmaq , Nur; Nasution , Rahmad Hidayat
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1240

Abstract

Livestock products are generally very easily contaminated by bacteria because they contain high nutritional value, especially protein. This study aimed to identify Staphylococcus aureus contamination in beef samples taken from traders at Tavip Market and Kebun Lada Market in Binjai City. The study used 13 beef samples collected through a random sampling method. Each sample weighed 100 grams and was taken with sterile equipment, then transported in a cool box at a low temperature of approximately ±4°C. Other materials used included Buffer Peptone Water (BPW), Baird Parker Agar (BPA), and Coagulase Rabbit Plasma (CRP), which are specific media for S. aureus. Total Counting of S. aureus Bacterial Colonies Using the Total Plate Count (TPC) Method. The results showed that all 13 samples tested positive for S. aureus contamination, exceeding the Indonesian National Standard limit of 10² CFU/g, with the highest colony count reaching 2.9 × 10⁴ CFU/g. This indicates that the level of S. aureus bacterial contamination exceeds the Indonesian National Standard (SNI) limit, necessitating improved sanitation and hygiene in the market. Consumers are advised to thoroughly cook meat before consumption.
The Literature review: Investigasi Perbandingan Antioksidan pada Tanaman Obat Herbal di Pulau Jawa dengan Spektrofotometri UV-Vis dan Metode DPPH (2,2-difenil-1-pikrilhidrazil) Sebayang , Madame Marselly; Mierza , Vriezka
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.554

Abstract

Due to environmental changes and pollution due to free radicals, interest in alternative medicine is increasing, especially on the island of Java. Natural health solutions are increasingly needed, which is what prompted this research. We measured the concentration of antioxidant compounds using the UV-Vis spectrophotometric method and the free radical scavenging capacity of plant extracts using the DPPH method. Using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and UV-Vis spectrophotometric methods with IC50 value determination, this article aims to investigate and compare potential herbal plants found on the island of Java. This research was carried out using a literature review method by considering inclusion and exclusion criteria with keywords such as antioxidants, herbal medicinal plants, UV-Vis spectrophotometry, and DPPH method. The results showed that the plant species studied had different antioxidant activities. Some herbs have high levels of antioxidants, so they may be used as natural health supplements. Additionally, this study emphasizes how important it is to use accurate analytical methods to evaluate antioxidant content. To provide a comprehensive picture of the antioxidant potential of each plant, UV-Vis spectrophotometry and DPPH methods work together. The results show that this study identified several herbal plants on the island of Java that have high levels of antioxidants. These plants can be used to develop herbal-based health products. To carry out a comparative evaluation of antioxidant content, the UV-Vis and DPPH spectrophotometric methods were proven to be effective. This discovery can be the basis for further research and development of more effective and useful herbal health products.
Analisis dan Faktor Interaksi Obat Pada Pasien Hipertensi di Daerah Pesisir Surabaya Faizah, Ana Khusnul; Nurrahman, Nani Wijayanti Dyah; Damayanti , Amitasari
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.602

Abstract

Hypertension is a severe health problem that generally requires combination therapy. Using a combination of antihypertensive therapy and long-term therapy requires monitoring the effects of potential drug-drug interactions (PDDIs) experienced by patients. This study aims to determine the drug interaction profile related to severity and mechanism. The method was descriptive and observational by recapitulating the prescription in several pharmacies in the coastal area of Surabaya. The samples are prescriptions consist of antihypertensives with other drugs. This research was conducted for three months. This study showed that 43% potential drug-drug interactions. The pharmacodynamic interactions are slightly more dominant (49%) than pharmacokinetics (45%). Meanwhile, the highest severity of drug interactions, namely minor (49%), followed by moderate (39%) and severe (12%), was in the last position. The modest drug interaction at a moderate level is amlodipine, which can decrease the pharmacological effect of metformin. Therefore, pharmacists need to monitor blood sugar levels regularly. Serious interactions are indeed the lowest incidence; otherwise, the effects can be dangerous, so pharmacists need to monitor patients who receive drugs with severe drug interactions. One of them is amlodipine and simvastatin, which can increase the risk of rhabdomyolysis from statins. Pharmacists have an important role in monitoring the effects of drug interactions in hypertensive patients. Patients get the maximum therapeutic effect with minimal drug interactions or prevent drug interactions.
Studi Pemberian Diuretik Pada Pasien Sirosis Hepatik Dengan Komplikasi Asites di RSUD dr. Iskak Tulungagung. Annastasya P.D. , Agies; Puspitasari, Alvina Arum; Hasmono , Didik; Muzayyanah , Binti
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.741

Abstract

According to the World Health Organization (WHO), cirrhosis is a structural change of the liver from normal to abnormal, characterized by fibrosis. Ascites is the most common complication in liver cirrhosis patients with the primary trigger (75%) is portal hypertension. The treatment focuses on removing the fluid from the peritoneal cavity. This study aim to understanding the pattern of diuretic use as ascites therapy in patients with cirrhosis hepatic. An observational study with a retrospective and descriptive approach using total sampling method in patients diagnosed with cirrhosis and ascites who received diuretics at Dr Iskak Tulungagung general hospital during January-December 2022 were conducted. The tools used in this study include medical records, data collection sheets, clinical data sheets, and laboratory data. Among 62 patients, 16 (26%) received spironolactone monotherapy, 9 (14%) furosemide monotherapy, 21 (34%) combination therapy, and 16 (26%) underwent switching between regimens. Spironolactone, particularly at 100 mg orally once daily, either alone or in combination with furosemide (40 mg intravenously once daily), was the most frequently prescribed diuretic regimen. These findings indicate that the therapeutic approach applied in clinical practice has generally followed the AASLD guideline recommendations.
Pengaruh Edukasi dan Konseling Apoteker terhadap Kepatuhan dan Kualitas Hidup Pasien Kanker Payudara: Literatur Review Budi, Hermawan Setya; Sutrisno, Entris
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.982

Abstract

Pharmacist-led interventions, particularly through education and counselling, play an essential role in supporting treatment adherence and improving the quality of life of breast cancer patients. This article aims to review the influence of pharmacist interventions—such as medication counseling, side effect management, and adherence monitoring—on patient understanding, psychological aspects, and quality-of-life indicators. Results from various experimental studies and randomized controlled trials suggest that structured pharmacist interventions can improve patient understanding, reduce anxiety, and support adherence to long-term therapies such as tamoxifen and chemotherapy. Improvements were also observed in various domains of quality of life, including physical, emotional, and social functioning. However, some studies show inconsistent results, especially in terms of statistical differences in changes in quality of life, which may be due to factors such as sample size, duration of intervention, or other variables, including family support and disease prognosis. Overall, the involvement of pharmacists is an integral part of oncology care, serving as both an educator and a long-term therapy companion.

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