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Muhammad Iqhrammullah
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Narra X
Published by PT Narra Sains Indonesia
ISSN : -     EISSN : 29882990     DOI : DOI: https://doi.org/10.52225/narrax
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health
Narra X is a multidisciplinary journal, published three times in a year (April, August, and December). The journal aims to act as a platform for rapid scientific communication while upholding the highest integrity. Articles are published in a form of Original articles, Short Report, Case Reports, Methods articles, Review articles, and Letters to the Editor. All submitted articles are subjected to peer-review prior to their publication. As a multidisciplinary journal, Narra X welcomes articles from any subject field, depending on the editorial capacity. At the moment, Narra X is handled by section editors in the following fields: Health and medicine Chemistry Biology Mathematics Physics Narra X is online only journal and all articles do not have page numbers; instead, they are given a unique article number.
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Articles 6 Documents
 1 
Search results for , issue "Vol. 3 No. 1 (2025): April 2025" : 6 Documents clear
Associations between seizure management and sleep disorders in children with epilepsy: A cross-sectional study in Medan, Indonesia Suistaya, Novi A.; Dimyati, Yazid; Siregar, Olga R.; Harahap, Juliandi; Dewi, Ika C.; Lubis, Mahrani; Mukhtar, Fatima AS.; Alharbi, Olayan
Narra X Vol. 3 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v3i1.168

Abstract

Sleep disorders are prevalent in children, particularly those with chronic illnesses such as epilepsy, where they disrupt sleep quantity, quality, or timing. The aim of this study was to analyze factors associated with sleep disorder among epileptic children admitted to Haji Adam Malik General Hospital, Medan, Indonesia. The study employed cross sectional design, recruiting 49 children (4–10 years old) with epilepsy at Haji Adam Malik General Hospital from February to June 2024. Data collection was carried out using the Children's Sleep Habit Questionnaire (CSHQ) questionnaire. Further, data on Anti-Epileptic Drugs (AED) intake and history and type of seizures were collected. Pearson’s Chi-square test was employed to analyze the association of the demographic, seizure characteristics, and AED with sleeping disorder. The findings suggest that sleep disorder in children with epilepsy was prevalent (n=26, 53.1%), mostly occurring in boys (32.7%) and those receiving valproic acid (n=9, 34.6%) and its combination with levetiracetam (n=8, 30.8%). Chi-square test results showed that seizure history intake (p<0.001), AEDs intake (p<0.001), and type of AED (p=0.010) were significantly associated with sleep disorder. In conclusion, seizure management strategies and AED regimens can influence sleep disorders in children with epilepsy. Therefore, revisiting and modifying AED treatments may be required to improve both seizure control and sleep quality in affected patients.
Burnout and study engagement among medical students during COVID-19 pandemic: A cross-sectional study in Aceh, Indonesia Al-Gunaid, Seba; Syukri, Maimun; Kurniawan , Ferry D.; Rizal, Syamsul; Novirianthy, Rima
Narra X Vol. 3 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v3i1.165

Abstract

Medical students are particularly vulnerable to burnout due to the demanding and resource-constrained nature of their training. Burnout negatively impacts academic and personal well-being, potentially impacting future professional practice and patient care. To date, no studies have examined burnout prevalence among medical students in Aceh. The aim of this study was to determine the association between burnout and academic engagement among medical students at Syiah Kuala University, as well as the relationship with age, sex, and year of study. This cross-sectional study was conducted among medical students in Aceh, Indonesia, between October 1, 2021, and March 13, 2022. Total sampling was employed to select study participants. Data were collected using an e-questionnaire using the Oldenburg Burnout Inventory questionnaire adapted for students (OLBI-S) and Utrecht Work Engagement Scale for Students (UWES-S-9) for academic engagement. The total number of participants was 286 students. Most participants were female (n=202, 70.6%), while male students were 84 (29.3%). The prevalence of burnout was 36% (n=102). Gender (p=0.65) and study year (p=0.62) were not associated with disengagement, a subscale of the OLBI-S. Similarly, exhaustion scores did not differ significantly by gender (p=0.48) or study year (p=0.28). In conclusion, fewer than half of the medical students experienced burnout during the COVID-19 pandemic, with no association found between burnout and gender or study year.
Role of vitamin C in reducing cardiovascular oxidative stress: An in vivo study using sepsis rat models Raihani, Rifa; Sovira, Nora; Andid, Rusdi; Yusuf, Sulaiman; Safri, Mulya; Dimiati, Herlina; Fajri, Fauzan; Sentosa, Sukmawan F.; Hasan, Denny I.
Narra X Vol. 3 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v3i1.179

Abstract

The aim of this study was to evaluate the effect of vitamin C on reducing cardiovascular oxidative stress in sepsis rat models. An experimental animal study with a post-test control group design was conducted at the Laboratory of Animal Research, Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia, from September to December 2023, using 18 male Wistar strain rats (Rattus norvegicus). Rats were divided into three groups: control (Group K), lipopolysaccharide 5 mg/kg body weight (BW) (Group L), and lipopolysaccharide 5 mg/kg BW with oral vitamin C (18 mg/day) (Group LC). Rats were euthanized after two weeks with ketamine (15–20 mg/kg intraperitoneally) and cervical dislocation. Blood samples (3 mL) and heart organs were collected. Nitric oxide (NO) levels were measured through enzyme-linked immunosorbent assay (ELISA), and cardiac muscle cells were observed using an Olympus CX21 microscope.  The LC group exhibited a significantly lower mean endothelial dysfunction score than the L group (p<0.001), although no significant difference in NO levels was observed between L and LC groups (p=0.262), indicating that vitamin C did not significantly affect NO levels. This suggests that the improvement in endothelial function observed in the LC group may be mediated through mechanisms other than NO modulation. The MANOVA test revealed that vitamin C administration accounted for 84.8% of changes in endothelial function in the sepsis rat model (p<0.001). In conclusion, vitamin C confers a protective effect against severe cardiac and endothelial damage, as evidenced by the amelioration of necrosis, inflammatory cell infiltration, congestion, and vacuolization caused by lipopolysaccharide.
Oral microbiome: A paradigm shift in dental diagnosis Megantoro, Aryo; Alphianti, Likky T.; Gunawan, Paulina N.; Bachtiar, Endang W.; Bachtiar, Boy M.
Narra X Vol. 3 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v3i1.197

Abstract

For decades, the diagnosis of oral diseases primarily relied on clinical symptoms presented by patients. This traditional approach, which included visual inspection, palpation, and assessment of discomfort, provided limited insights into the underlying microbiological factors contributing to oral diseases. Recent studies have identified specific microorganisms believed to play pivotal roles in oral disease development, particularly in conditions such as dental caries, periodontal disease, and pulpitis. The challenge lies in the dynamic nature of the oral microenvironment, where the microbial community can shift rapidly due to changes in diet, hygiene practices, and overall health, complicating attempts to establish direct causative links between specific pathogens and oral diseases. The aim of this study was to explore the role of the oral microbiome in advancing dental diagnostics and to assess how integrating microbial analysis can improve early detection and personalized treatment of oral diseases. Research into the oral microbiome has brought about a paradigm shift in understanding dental diagnostics. Advances in molecular biology techniques, such as next-generation sequencing (NGS) and polymerase chain reaction (PCR), have enabled more detailed examination of microbial communities within the oral cavity. This shift from a purely symptom-based diagnostic approach to one that incorporates microbial analysis represents a significant advancement in dental care. For instance, identifying specific bacterial profiles associated with caries could facilitate the implementation of personalized preventive measures, such as tailored oral hygiene regimens or dietary recommendations. Moreover, integrating microbiological data into clinical practices could lead to improved diagnostics for conditions that are traditionally difficult to assess. By adopting a more comprehensive view that includes microbial assessments, clinicians can better understand the interplay between oral microbiota and systemic health, as oral diseases are often linked to broader health issues. Another challenge is that this approach requires interdisciplinary collaboration among dental practitioners, microbiologists, and public health experts. This collaboration is essential to translate abstract microbiological findings into practical diagnostic indicators that can be utilized in clinical settings. Furthermore, with the advent of new technologies, maintaining accurate interpretations of microbiome data presents another layer of complexity, as variations in sample collection, processing, and analysis can lead to differing results. In summary, the elevated role of the oral microbiome in dental diagnostics marks a significant transition from traditional, symptom-focused approaches to more holistic methodologies that consider the underlying microbial communities. By leveraging advanced technologies, dental practitioners can enhance their diagnostic capabilities, leading to improved outcomes for patients suffering from various oral diseases.
Life expectancy in Iraq from 1950 to 2024: A retrospective time-series analysis Ahmed, Darya R.
Narra X Vol. 3 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v3i1.205

Abstract

Life expectancy is a vital demographic indicator reflecting the health and well-being of a population. The aim of this study was to analyze life expectancy trends in Iraq from 1950 to 2024 using Worldometer data aggregated from United Nations statistics. The Iraqi population increased from 6.37 million in 1955 to 46.04 million in 2024, representing a 623% increase, with urbanization rising from 38.4% to 71.8%. Fertility rates declined from 6.0 live births per woman in 1955 to 3.2 in 2024, peaking at 7.1 in 1970 before steadily decreasing.  Life expectancy improved significantly from 37.4 years in 1950 to 72.4 years in 2024, with a narrowing gender gap: life expectancy for men increased from 34.3 years in 1950 to 70.5 years in 2024, while for women, it rose from 41 years to 74.2 years over the same period. The median age also increased slightly, from 19.5 years in 1955 to 20.6 years in 2024. Infant mortality rates dropped dramatically, from 206.6 deaths per 1,000 live births in 1950 to 18.7 in 2024, and under-five mortality fell from 357.9 to 22.4. Despite historical conflicts, improvements in healthcare and living conditions highlight Iraq’s dynamic demographic changes, presenting the ongoing challenges and opportunities posed by its rapid growth and urbanization.
Phagocytic receptors regulate Drosophila larval growth Nagaosa, Kaz
Narra X Vol. 3 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v3i1.210

Abstract

Drosophila melanogaster is a key model organism for biological research due to its genetic manipulability and high degree of evolutionary conservation with humans. Phagocytic receptors play a central role in apoptotic cell clearance, a fundamental process that is highly conserved across species. Previous studies have identified two major phagocytic receptors in Drosophila: integrin αPS3βν and Draper, both of which contribute to apoptotic cell removal. However, the physiological significance of these receptors under normal developmental conditions remains unclear. Therefore, the aim of this study was to investigate the role of these receptors in developmental timing. The results demonstrated that double mutants lacking both receptors exhibited significant developmental delays, especially during the larval stage (p<0.001). Moreover, tissue-specific knockdown experiments revealed that phagocytic receptors within the fat body are mainly involved in regulating developmental timing (p=0.028). Further results established that nutrient availability influenced the extent of growth delay, suggesting that these receptors may play a role in nutrient-dependent growth regulation. Taken together, these findings suggest that phagocytic receptors contribute to maintaining proper growth timing in Drosophila larvae, potentially through energy metabolism pathways.

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