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Journal of Food and Pharmaceutical Sciences
Published by Universitas Gadjah Mada
ISSN : 20897200     EISSN : 23390948     DOI : https://doi.org/10.22146/jfps.8237
Core Subject : Health, Science, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience
Journal of Food and Pharmaceutical Sciences offers scientists, researchers, and other professionals to share knowledge of scientific advancements. The journal will publish original research articles, review articles, short communication, and letter to editor. The area of focus should cover all aspects of food and pharmaceutical sciences. The range of topics covered in the journal include: New Horizons in Food Research; Food Chemistry; Integrated Food Science; Health, Nutrition, and Food; Food Engineering, Materials Science, and Nanotechnology; Toxicology and Chemical Food Safety; Food Microbiology and Safety; Drug Discovery; Computational Chemistry and Molecular Modeling; Pharmaceutical Biotechnology and Protein-Peptide Chemistry; Pharmaceutics, Biopharmaceutics, Drug Delivery, and Pharmaceutical Technology; Pharmaceutical Nanotechnology; Pharmacokinetics, Pharmacodynamics, and Drug Transport Metabolism; Analytical and Bioanalytical Chemistry; Pharmaceutical Chemistry; Natural Medicine and Nutraceutical; Chemical Processing of Pharmaceuticals including Crystallization, Lyophilization, and Chemical Stability of Drugs; Immunology, Biochemistry, and Cell and Molecular Biology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 154 Documents
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Uji Aktivitas Antioksidan dan Penetapan Kadar Flavonoid Total dan Fenolik Total Ekstrak Sidaguri (Sida rhombifolia L.) Asma Asma; Abdul Rohman; Djoko Santosa; Mohamad Rafi; Nanik Siti Aminah; Muhamad Insanu; Irnawati Irnawati
Journal of Food and Pharmaceutical Sciences Vol 10, No 2 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.4955

Abstract

Sidaguri atau Sida rhombifolia L. telah digunakan oleh masyarakat sebagai obat tradisional, yaitu: penghilang rasa nyeri, radang, asam urat, penyakit kuning, muntah darah, dan sakit gigi. Faktor yang mempengaruhi produksi kandungan metabolit sekunder adalah kondisi lingkungan seperti tempat tumbuh, iklim, interaksi intra dan inter-spesifik serta waktu panen. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan serta kadar flavonoid dan fenolik total ekstrak sidaguri berdasarkan tempat tumbuh. Sampel diekstraksi dengan ultrasonic-assisted extraction (UAE) dan diuji penangkapan radikal bebas menggunakan metode 2,2’-difenil-1-pikrilhidrazil (DPPH) dan 2,2’-azino-bis(3-diethyl4benzothiazoline-6-sulfonic acid) (ABTS), serta penetapan kadar flavonoid total dan kandungan fenolik total. Hasil uji aktivitas antioksidan sidaguri dari Cangkringan dan Ngemplak memiliki aktivitas antioksidan tertinggi baik pada metode penangkapan radikal DPPH dengan nilai IC50 masing-masing sebesar 0,400±0,004 dan 0,403±0,004 mg/mL, maupun metode ABTS dengan nilai TEAC masing-masing sebesar 40,733±0,240 dan 35,598±0,153 mg/g serbuk sidaguri, dengan kadar flavonoid total masing-masing sebesar 10,095±0,068 dan 12,066±0,025 mg/g serbuk sidaguri dan kadar fenolik total masing-masing sebesar 56,45±0,068 dan 31,502±0,025 mg/g serbuk sidaguri.
Optimization of Bentonite Bar Soap Formula with Combination of Coconut Oil and Soybean Oil Using Simplex Lattice Design Method Farah Ataya; Abdul Rohman
Journal of Food and Pharmaceutical Sciences Vol 10, No 2 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.5302

Abstract

Muslim population in Indonesia reaches 87% and is one of the countries with the largest muslim population according to the 2010 population census. Thaharah is one of the things that Muslims pay much attention to, especially in worship. One of thaharah is washing up from najis mughallazah. Soap is skin cleansing preparations that has become a public basic needs so that the innovation of soap formulation containing bentonite as a component that can washed the najis mughallazah to make it easier for Muslims to thaharah. This study optimizes the formula for bentonite bar soap with combination of coconut oil and soybean oil using the Simplex Lattice Design method. The optimum formula obtained was then verified using the one sample T-test method. To determine the optimum formula, it is necessary to test the physical and chemical properties such as foaming power and foam stability and follows the parameters of the Standar Nasional Indonesia such as foaming water content, pH, total fat, insoluble substance in ethanol, free alkali/ free fatty acid and unsaponifiable fat. Bentonite soap with the optimum formula was then tested for consumer acceptance. The optimum formula from the prediction consisted of 76.58% coconut oil and 23.42% soybean oil. The test results of the formula produced soap with hard properties and good foaming and met several requirements of SNI 3532:2021.
Effectiveness of Helichrysum italicum Essential Oil on Wound Healing Linda Julianti Wijayadi; Kelvin Kelvin
Journal of Food and Pharmaceutical Sciences Vol 10, No 2 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.5324

Abstract

Helichrysum italicum essential oils (EOs) has long been known as a medicinal agent, especially in wound healing. This is inseparable from the chemical compounds contained in it, such as abundant monoterpenes and sesquiterpenes. The purpose of this systematic review is to examine various studies on the effectiveness of H. italicum EOs on wound healing. Research data searches were conducted through Google Scholar, Proquest, Science Direct, SpringerLink, Wiley Online Library, Taylor & Francis Online and PubMed over the last 10 years by following inclusion and exclusion criteria. Obtained as many as 11 studies that match the criteria. Based on the review of these studies, it was found that H. italicum EOs has good wound healing abilities when viewed from various aspects such as its chemical components, biological activity and its effect on injured body tissues. These chemical components vary in type and amount because they are influenced by various aspects. Biological activities such as antioxidant, antimicrobial, and anti-inflammatory effects have also been shown to be contained in this oil because it affects various phases of wound healing, namely hemostasis, inflammation, proliferation and remodeling phases. This is also inseparable from the accuracy of the type of vehicle used.
Optimization of Polyvinyl Alcohol (PVA) and Xanthan Gum Edible Film (Crocus sativus L.) as Antibacterial against Staphylococcus aureus Prihandi Surya Samudra; Lilies Wahyu Ariani; Intan Martha Cahyani
Journal of Food and Pharmaceutical Sciences Vol 10, No 3 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.5352

Abstract

Staphylococcus aureus is a normal bacteria flora in the oral cavity and often causes infections. Saffron (Crocus sativus L.) contains flavonoids that can inhibit the growth of Staphylococcus aureus. Saffron extract is formulated into edible film preparations because it can control drug release and maintain active substances, especially antibacterial ones. This study aims to determine the effect of comparing PVA and xanthan gum concentrations on edible film preparation physical characteristics and antibacterial activity. Also, to find out the optimal formula. This study uses the Simplex Lattice Design method and Design Expert to determine the concentration ratio. The optimization parameters of the preparation included pH, soluble time, water absorption, and antibacterial activity test using the well diffusion method. The ANOVA results showed that adding PVA concentration accelerated the dissolution time and increased the antibacterial inhibition. The addition of xanthan gum concentration increased the pH value and water absorption. The test results obtained pH 5.52, dissolution time 22.25 seconds, water absorption capacity is 43.95%, and antibacterial inhibition is 0.53 cm. The optimal formula was received at the concentration of PVA at 5.59% and xanthan gum at 0.41%. T-test shows that the equation of each optimal parameter is valid.
Analisis Antioksidan Ekstrak Etanol Daun Ceguk (Combretum indicum L.) varr.M dengan Berbagai Lokasi Kalimantan Selatan, Indonesia Samsul Hadi; Umi Nur Hapifah; Amalia Khairunnisa
Journal of Food and Pharmaceutical Sciences Vol 10, No 3 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.5427

Abstract

Indicum has 2 variations, especially in terms of flowers, namely elongated and rounded types with antioxidant effects. So the aim of this research is to know the antioxidant of C. Indicum leaves, one of the varieties in Banjar, Banjarbaru and Tanah Laut areas, that variety is C. indicum varr.M. Antioxidant testing using TLC and quantitative using UV-Vis spectrophotometer. The antioxidant results qualitatively have antioxidant activity marked by a yellowish white stain. The quantitative test results of Banjar, Banjarbaru and Tanah Laut have 97.2219±0.263 ppm, 50.0832±0.078 ppm and 56.2046±0.185 ppm IC50 values. The results of One Way Anova analysis on the ethanol extract of elongated C. indicum leaves from Banjar, Banjarbaru and Tanah Laut had significant differences between each location and other locations. Based on these results Banjarbaru has the best antioxidants.
Potential Activity of Caryophyllene Derivatives as Xanthine Oxidase Inhibitor: An in silico Quantitative Structure-Activity Relationship Analysis Arif Setiawansyah; Baiq Maylinda Gemantari
Journal of Food and Pharmaceutical Sciences Vol 10, No 3 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.5485

Abstract

As the enzyme responsible for the uric acid formation, Xanthine oxidase was considered to be a therapeutic target for hyperuricemic treatment. This study was carried out to assess the potential of caryophyllene, and its derivates usually present in the natural product to inhibit Xanthine oxidase. The molecular docking using Autodock Tool and Biovia Discovery Studio was conducted to visualize the molecular interaction and to reveal the structure-activity relationship of those compounds. The results showed that the derivates of caryophyllene showed a higher affinity to Xanthine Oxide than Allopurinol. Among those all, caryophyllene oxide has the most stable bonding to xanthine oxide. Structure-activity relationship analysis showed that the chemical properties of the compound affected the affinity and molecular interaction to the enzyme as the target site in this study. The number of double bonds, substituents position, conformational structure related to steric hindrance, and the presence of lactone ring were assumed to influence the xanthine oxide inhibitory activity of caryophyllene derivates.
The Effect Of Milk Kefir With Sorgum Flour On Body Weight, Appearance, And Abdominal Fat In Mice Obesity Induced Indri Dewi Listiani; Rizki Nurmalya Kardina
Journal of Food and Pharmaceutical Sciences Vol 10, No 3 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.5511

Abstract

In obese patients, one way to prevent obesity with the right method is to modulate the intestinal microflora. The purpose of this study was to identify and analyze the differences in administration of milk kefir with additional sorghum flour on body weight, appetite, and abdominal fat in mice (Mus musculus) induced obesity.This type of research is a true experimental in vivo using a randomized controlled design pretest – posttest control group design. The experimental animals used were 34 healthy mice (Mus musculus). Data analysis with normal distribution was tested by One Way Anova, otherwise Kruskal Wallis was tested. Meanwhile, categorical data were tested Univariate. The results showed that in the third treatment (P3) mice experienced differences in the treatment given milk kefir with the addition of sorghum flour and high fat diet feed for 8 weeks or 56 days there was a difference in weight loss as measured by weight gain (p<0.05), then there wasn’t difference in appetite (p>0.05), while there was a difference in abdominal fat compared to the control group. So, for those who are obese, it’s expected that milk kefir products with sorghum can be used as a daily drink to help reduce body weight and abdominal fat.
Optimasi Fosfatidilkolin dan Span 80 sebagai Penyusun Vesikel Transfersom Natrium Diklofenak menggunakan Design-Expert Wa Ode Sitti Zubaydah; Suryani Suryani; Nur Janna Kurniawati
Journal of Food and Pharmaceutical Sciences Vol 10, No 3 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.5581

Abstract

Natrium diklofenak merupakan golongan NSAID (Non Steroid Anti-Inflammatory Drugs) yang banyak diresepkan untuk inflamasi dan nyeri. Namun dalam penggunaannya secara oral, natrium diklofenak mengalami first pass metabolism di hati sehingga hanya sekitar 50% saja obat yang sampai pada sirkulasi sistemik dan jika seringkali diberikan dengan dosis yang lebih tinggi dapat memperparah efek samping di saluran pencernaan. Karena beberapa kerugian diklofenak pada penggunaan oral, maka diklofenak dikembangkan ke sistem penghantaran transdermal dalam hal ini nanovesikel transfersom yang dipilih sebagai alternatif untuk mengatasi permasalahan tersebut. Penelitian ini bertujuan untuk memformulasi vesikel transfersom natrium diklofenak dengan perbandingan (4,5%:0,5%), (4,5%:1%), (4%:0,5%) dan (4%:1%) agar diperoleh perbandingan formula optimum vesikel transfersom natrium diklofenak dengan basis fosfatidilkolin kedelai dan span 80 menggunakan design expert dan untuk mengetahui karakteristik transfersom natrium diklofenak berupa efisiensi penjerapan, distribusi ukuran partikel dan zeta potensial. Optimasi formula transfersom menggunakan metode desain faktorial 22 dengan faktor fosfatidilkolin kedelai dan span 80 menggunakan respon efisiensi penjerapan dan ukuran vesikel. Hasil dari penelitian ini yaitu formula optimum dengan konsentrasi fosfatidilkolin kedelai 4,5% dan span 80 0,5% serta pengujian karakteristik vesikel transfersom allopurinol dengan efisiensi penjerapan 99,56%, distribusi ukuran partikel 160,1 nm dan zeta potensial -57,1 mV.
Optimization of Polyvinyl Alcohol (PVA) and Glycerin in Kolang Kaling Peel-Off Gel Mask Formula (Arenga pinnata.) Ni Putu Diah Swari Maharani; Intan Martha Cahyani; Eka Susanti Hanhadyanaputri
Journal of Food and Pharmaceutical Sciences Vol 10, No 3 (2022): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.5718

Abstract

Aging is caused by free radicals, one of which is ultraviolet light which can form ROS. Galactomannan compounds have the potential as antioxidants that can counteract free radicals. Kolang kaling contains many galactomannan compounds. Kolang kaling is processed into a peel-off gel mask, where PVA and glycerin are essential ingredients. PVA can form a polymer film layer, but if the layer is not balanced, glycerin is used as a humectant. The results of the FTIR analysis showed that the functional groups were D-galactopyranose and D-mannopyranose, which were characteristic of the functional groups of galactomannan. The IC50 of kolang kaling powder is 23.8720 ppm, a powerful antioxidant. The interaction of PVA and glycerin increased drying time, viscosity, antioxidant activity, and decreased dispersion, adhesion, and pH. The optimal formula obtained was 14.47% PVA and 15.73% glycerin. The results of the One Sample T-Test validity test found that the results of the equations of each test were valid.
The Characteristic and Antibacterial Activity of Nanosilver Biosynthetic using Sweet Orange Ermawati, Dian Eka; Putro, David Sarono; Amaris Susanto, Nindita Clourisa
Journal of Food and Pharmaceutical Sciences Vol 11, No 1 (2023): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.5760

Abstract

Sweet orange contains citric acid and ascorbic acid that act as a silver ion bioreducer to form nanosilver (AgNPs). Silver ion green synthesis using sweet orange peel resulted in smaller particle sizes than C. lemon and C. limeta. Therofore, this study aims to determine the characteristic of nanosilver biosynthetic using sweet orange bioreductor and antibacterial activity. Silver nitrate solution of 1.0 mM was mixed with sweet orange juice - peel infusion in ratio of 3.0: 0.0; 1.5: 1.5; and 0.0: 3.0 mL. The process was conducted using a water bath at 60 ˚C for 45 minutes. The formation of AgNPs is indicated by a color change from colorless to yellowish-brown using UV/Vis spectrophotometer and PSA. The stability test of AgNPs is determined for 30 days storage at room temprature and their antibacterial activity against S. aureus and S. epidermidis. The results showed that sweet orange juice accelerated the color change at the SPR range of AgNPs at 438-459 nm, but it is less stable. The mix solution of sweet orange juice and sweet orange peel infusion of 1.5: 1.5 mL are stable and promising as an antibacterial agent. Futhermore, the AgNPs produced had a particle size of 41±10 nm and a spherical shape.

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