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INDONESIA
Jurnal Tumbuhan Obat Indonesia
Published by Universitas Tidar
ISSN : 1979897X     EISSN : 23548797     DOI : https://doi.org/10.31002/jtoi
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Medicine & Pharmacology Public Health
Jurnal Tumbuhan Obat Indonesia is published periodically twice a year. Result or review written by researcher from university or research Institute. Journal TOI has had an ISSN print version since 2008 and has an online Volume 6 number 1 year 2013.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 70 Documents
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Total Phenolics and Flavonoids Content of Pemphis acidula Leaves Extract, In Vitro Antioxidant and Antidiabetic Activity, and Characterization of The Extract Towards Standardized Antidiabetic Herbal Medicine Mardianawati, Nurlita; Sulastri, Lilik; sinaga, ernawati
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.1852

Abstract

Diabetes mellitus is a prevalent metabolic disorder that still remains a threat to public health all over the world. Oxidative stress is a critical factor in the pathogenesis and progression of diabetes mellitus and its associated complications. Plants contain many antioxidant compounds that can provide protection against free radical-related diseases. The present study aims to evaluate the potential of ethanol extract of Pemphis acidula leaves as antidiabetic agent by measuring its total phenolics and flavonoids content, and its antioxidant and α-amylase inhibitor activity as well. The total phenols content was determined using Follin-Ciocalteu method and total flavonoids content was determined using the AlCl3 colorimetric method, while in vitro antioxidant activity was evaluated using DPPH method. Results of the study showed that ethanol extract of Pemphis acidula leaves contains total phenolics and total flavonoids equivalent to 5390mg GAE/100 grams of extract and 581.66mg QE/100 grams of extract respectively, and it had also been proven that the extract has strong antioxidant and α-amylase inhibitor activity with IC50 of 57.71 ppm and IC50 of 70.05 ppm respectively. From these results, it can be concluded that ethanol extract of Pemphis acidula leaves has the potential as an anti-diabetic agent.
Crude Drugs Standardization, Total Flavonoid and Phenolic Content Profile, and Antimicrobial Activity of Red Ginger and Lemongrass Combination Puspitasari, Adinda; Hamad, Alwani; Hartanti, Dwi
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2008

Abstract

Baturraden people use a combination of red ginger rhizomes and lemongrass leaves for the treatment of masuk angin. This study aims to evaluate the quality profile of red ginger and lemongrass crude drug, total flavonoid content (TPC), total phenolic content (TFC), and the antimicrobial activities of their combination water extracts. The quality of both crude drugs was standardized to Indonesian Herbal Pharmacopeia (IHP). The TPC and TFC of red ginger and lemongrass combination in five different ratios were determined by standard UV-Vis spectrophotometry methods. The antimicrobial activity was evaluated using the microdilution method against patient-isolated multidrug-resistant (MDR) Staphylococcus aureus and Candida albicans. Lemongrass crude drugs were of good quality, while red ginger did not meet the acid-insoluble ash and volatile matter content requirements. The combination showed the highest TFC in a 75:25% ratio, while that of TPC was 50:50%. All combinations of lemongrass and red ginger extracts inhibited MDR Staphylococcus aureus and Candida albicans with a minimum inhibitory concentration (MIC) of 0.16 mg/ml. Candida albicans were more susceptible to the combination extracts. Red ginger rhizomes and lemongrass leaves 75:25% and 50:50% ratios showing comparable effects to the respective components. Hence, the combination of red ginger and lemongrass in 75:25 and 50:50% ratios potentially developed further for their masuk angin efficacy.
Antikeloid Activity and Irritation Test of Combination Extract of Tithonia diversifolia A. Gray and Nerium indicum Mill in vivo Yuliani, Fara Silvia; Wahyuningsih , Mae Sri Hartati
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2046

Abstract

Keloids, marked by overgrowth of fibrous tissue beyond wound boundaries, present therapeutic challenges due to recurrence and the side effects of current treatments. Conventional methods, including surgery and radiotherapy are often costly and carry risks such as recurrence, pain, and infection. This has led to increasing interest in natural alternatives. This study investigates the antikeloid potential of a combination extract from Nerium indicum Mill (N. indicum) and Tithonia diversifolia A. Gray (T. diversifolia) in an in vivo rabbit ear hypertrophic scar model. The efficacy of the extract was evaluated using the Scar Elevation Index (SEI), while irritation tests assessed its potential for localized skin reactions. Five groups were tested: three groups receiving different doses of the combination extract, a negative control (aquadest), and a positive control (triamcinolone acetonide). The results showed that SEI values in all treatment groups were significantly reduced compared to the negative control (p<0.05), indicating reduced scar prominence. The Draize test further classified the extract as a minimal irritant, supporting its safety for topical application. These findings suggest that the combination extract of N. indicum and T. diversifolia is a promising, safer, and natural alternative for keloid treatment, particularly in managing hypertrophic scars.  
Ekstrak Akar Purwoceng sebagai neuroprotektan Terhadap Model Stroke pada Tikus: Memori Spasial, Jumlah Sel Piramidal, Ekspresi SOD1 dan SOD2 Munawaroh, Fauziyatul; Efiyanti, Christy; Utami, Putri; Dewi, Trisni; Batubara, Irmanida
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2236

Abstract

Stroke due to cerebral ischemia is one of the leading causes of disability worldwide. Animal models of cerebral ischemia that is often used is Global Cerebral Ischemia (GCI). In GCI, the hippocampus is the most susceptible to neuronal cell death. Complications that occur after ischemia are due to increased oxidative stress. Some compounds in purwoceng are reported to have antioxidant activity which oxidative stress have not been studied in the GCI model stroke. This study aims to examine the effect of purwoceng extract on a stroke model (GCI) as a neuroprotective agent in the prevention of stroke complications that have not been previously studied. 25 rats with a stroke model were given purwoceng root extract with 3 doses (20, 30, and 40mg/kg BW) orally for three days. The mice were then tested for memory with the Morriz Water Maze (MWM) test; then histopathological analysis of pyramidal cells in the hippocampus and the expression of SOD1 and SOD2 genes was analyzed using RT-PCR. The MWM test showed that the memory results at the dose of 20mg/kg BW were better than that of the GCI group (p=0.0384), and the PCR of SOD2 showed improvement at the dose of 20mg/kg BW (p=0.0171). No significant difference in histopathological analysis and SOD1 mRNA expression across group. The administration of purwoceng root extract at a dose of 20 mg/kg BW had the effect of improving memory and SOD2 expression in GCI model rats
Potential of Secondary Metabolites from Acriopsis liliifolia Leaves as a Tyrosinase Inhibitor: Docking Study Khoeriyah, Ni'matul; Wannawijaya, Nashwa Maheswari; Apsari, Cintya Nurul; Nuraini, Latifa
Jurnal Tumbuhan Obat Indonesia Vol. 17 No. 2 (2024): December 2024
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v17i2.2246

Abstract

The demand of natural chemicals with high effectiveness and low side effects increases plant exploration, including in the cosmetic and pharmaceutical fields. Trend of skin-lightening products is in great demand, causing its development to overgrow. Acriopsis liliifolia is an orchid species commonly found in Java and its leaves contain many secondary metabolites, thus attracting attention to be studied its potential as a tyrosinase inhibitor to overcome hyperpigmentation. This study explores potential of secondary metabolites in A. liliifolia leaves as tyrosinase inhibitors through microchemical tests, secondary metabolite profiling with LC-HRMS, and docking study using MOE. The results of the microchemical test showed that this orchid contains flavonoid, phenolic, terpenoid, and alkaloid compounds. Secondary metabolite profiling with LC-HRMS produced 130 compounds, then 15 of the most potential compounds were selected. The docking study showed that prolylleucine had lowest S score of -8,738 kJ/mol, lower than native ligand, kojic acid. This indicates that prolylleucine has a significant binding affinity to tyrosinase enzyme receptor through twelve bonds on the active site of enzyme. Prolylleucine can be used as a lead compound for further testing. Keywords: Acriopsis liliifolia, secondary metabolites, leaves, tyrosinase inhibitor, molecular docking.
Modifikasi Struktur Eugenol Menjadi Etil 2-(4-Alil-2-Metoksifenoksi) Asetat Melalui Reaksi Alkilasi dengan Etil Kloroasetat Agistya, Hamida Azza; Fadlan, Arif; Masitoh, Heni
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 1 (2025): July 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.1045

Abstract

Eugenol, a natural product with broad and promising biological activity, possesses three reactive functional groups of hydroxyl, allyl, and methoxy, which can be transformed through chemical reactions into various derivatives. The reaction of eugenol and ethyl chloroacetate with a mole ratio of 1:1 has been reported to produce an alkylation product. However, the use of dry acetone as a solvent and the reflux condition for 12 hours were the drawbacks of this reaction. The structural modification of eugenol into ethyl 2-(4-allyl-2methoxyphenoxy) acetate as an alkylation product was further studied in this paper. The alkylation reaction of eugenol and ethyl chloroacetate was performed in dimethylformamide with a mole ratio of 6:10 (method A), 1:1 (method B), 1:4 (method C), and 1:4 (method D) at room temperature (methods A and D) and under reflux conditions (methods B and C). The results showed that the alkylation reaction with a mole ratio of 1:4 at room temperature (method D) produced ethyl 2-(4-allyl-2-methoxyphenoxy)acetate as a pure compound with a yield of 94%. The structure of the alkylation product was determined by FTIR, NMR spectroscopy, and mass analysis. Ethyl 2-(4-allyl-2-methoxyphenoxy)acetate is a key compound in the development of various eugenol-derived active compounds.
Pemanfaatan Gel Ekstrak Belimbing Wuluh sebagai Antibakteri Penyembuh Luka Diabetes Melitus Tipe II pada Tikus yang Terinduksi Stz-Na Muna, Laili; Unsa Izzati; Rafiastiana Capritasari; Febriana Astusi
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 1 (2025): July 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.1805

Abstract

Diabetes is a degenerative disease with a reasonably high prevalence rate. This is due to the community's low lifestyle, so there is an uncontrolled increase in glucose levels in the blood. If this condition is not handled properly, increased blood glucose levels will cause complications in the form of wounds that are difficult to heal. Improper treatment can result in infection and damage, so the affected body part can be amputated. The treatment on the market is clindamycin, an antibiotic that can cause resistance if it is used in the long term. The use of the star fruit extract of Belimbing wuluh, which has a mechanism as antibacterial properties, is a treatment option to reduce the risk of using antibiotics. The purpose of this study was to determine the effectiveness of using star fruit water extract as a wound closure developed into a gel preparation. The group in this study was divided into 6 test groups, namely the non-diabetic group (1 group) and the STZ-Na-induced diabetes group (5 groups). The test treatment of Belimbing wuluh water extract was divided into three concentration range groups, which are 2.5%, 5%, and 10%, with a positive control ratio of clindamycin, and the observation of diabetes parameters was weight loss and percentage of wound closure. The results showed that the decrease in blood glucose levels (IBD) affected the wound closure rate, a macroscopically important parameter for accelerating the wound healing process (PL). Weight loss in test animals is also a parameter of type 1 DM due to STZ-Na induction. In the P3 group, the %PL result was 40%, which was better than the P1 of 9.33%. However, it was no better than the clindamycin-positive control group of 52.67%. In the wound healing process, the higher the concentration of Belimbing wuluh extract used, the faster the wound healing process. This is due to the content of secondary metabolites in Belimbing wuluh, which act as antibacterial agents.
Karakterisasi Senyawa Aktif Ekstrak Daun Buas-buas (Premna serratifolia) sebagai Anti Kanker Kolon pada Sel WiDr Hadiarti, Dini; Mukhlishin, Hamdil
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 1 (2025): July 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.1416

Abstract

The leaves of Buas-buas or Premna serratifolia (P. serratifolia) have been used in Asian countries to treat inflammation, respiratory disorders, and postnatal recovery. Previous studies have demonstrated its anticancer activity against HT-29 and DLD-1 colon cancer cell lines; however, the isolation approach was selective and did not detect the range of active compounds or their functional groups. This study aims to identify functional groups and active compounds using Ultra High Performance Liquid Chromatography–High Resolution Mass Spectrometry (UHPLC-HRMS) and Fourier Transform Infrared Spectroscopy (FTIR) without isolation, and to evaluate cytotoxicity against WiDr cells. The research included ethanol extraction of P. serratifolia leaves, fractionation with n-hexane, ethyl acetate, and water, phytochemical, in vitro cytotoxicity assays, and FTIR and UHPLC-HRMS analyses. Phytochemical screening indicated the presence of flavonoids, tannins, saponins, and steroids. Aside from the ethanol extract, all three fractions showed moderate cytotoxic activity, with the ethyl acetate fraction (IC₅₀ = 49.12 μg/mL) selected for further analysis. FTIR spectra revealed functional groups including –OH, C–H, C=O, C=C, –CH₃, C–O, and =C–H. UHPLC-HRMS identified compounds such as luteolin, quercetin, apigenin, kaempferide, aurantioobtusin, isorhamnetin, scrofulein, and 5,7-dihydroxy-6-methoxy-3-phenyl-4H-chromen-4-one in the ethyl acetate fraction, with mass accuracy ranging from –0.53558 to 3.07641 ppm.
Pengaruh Emulgator Terhadap Stabilitas dan Aktivitas Tabir Surya Krim Ekstrak Mahkota Dewa dan Kencur Jalil, Nur Khairi; Maulita Indrisari; Ikbal; Nurul Hikma
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 1 (2025): July 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.2633

Abstract

Paparan sinar ultraviolet (UV) yang berlebihan berpotensi menimbulkan kerusakan jaringan kulit, mempercepat penuaan, hingga meningkatkan risiko kanker kulit. Upaya pencegahan dilakukan melalui penggunaan tabir surya untuk membatasi penetrasi UV ke kulit. Dua sumber bahan aktif alami yang prospektif digunakan yaitu buah mahkota dewa dan rimpang kencur, buah mahkota dewa mengandung senyawa glukosida benzofenon yaitu phalerin dan rimpang kencur mengandung etil-parametoksisinamat yang merupakan senyawa turunan sinamat. Tujuan penelitian untuk menemukan konsentrasi emulgator yang optimal yang dapat meningkatkan stabilitas produk serta memperbaiki kinerja perlindungan terhadap sinar UV. Ekstrak diperoleh melalui proses maserasi menggunakan etanol96%, selanjutnya diformulasi dalam bentuk sediaan krim sebanyak 9 formula dengan variasi konsentrasi berbagai emulgator yaitu novemer, viscolam dan  tween 80-span 80 lalu dilakukan pengujian efektivitas tabir surya dari krim ekstrak dengan menghitung nilai %Te, %Tp, dan SPF. Hasil penelitian menunjukkan emulgator viscolam dengan konsentrasi 4% (formula VI) merupakan formula krim yang paling stabil berdasarkan parameter organoleptis, homogenitas, pH, tipe emulsi, viskositas, daya sebar serta daya lekat dan hasil pengujian tabir surya  dikategorikan sebagai proteksi ekstra dengan nilai %Te 3,83854 dan sunblock dengan nilai %Tp 2,703703 sedangkan nilai SPF 74,4323 yang memberikan efek proteksi ultra. Kata kunci: Ekstrak, Mahkota Dewa, Kencur, Emulgator, Tabir surya.
Characterization of Yellow Tabebuia Flower Extract (Tabebuia aurea) Nanoparticles and Bioactivity as Antioxidant: Karakterisasi Nanopartikel Ekstrak Bunga Tabebuya Kuning (Tabebuia aurea) dan Bioaktivitas sebagai Antioksidan Yunita, Yunita; Syarifah, Anisa Lailatusy; Rahayu, Lina Oktavia; Wijayanti, Ernanin Dyah
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 1 (2025): July 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i1.2174

Abstract

Degenerative diseases can be prevented by natural antioxidants in plant. Yellow tabebuia flower is natural antioxidants. Plant extracts can develope into green synthesis nanoparticle to increase the effectiveness as medicinal materials. This research aims to determine the characteristics of yellow tabebuia flower extract nanoparticles and bioactivity as antioxidants. The methods included preparation and extraction of simplisia using ethanol solvent by maceration and sonication. The extract was determined flavonoid and phenol content by colorimetric method and antioxidant activity by DPPH method. The extract was also made into nano particles by ionic gelation method, with variations addition of tween 80 as much as 0.5, 0.75 and 1 ml. The results of this research are extract has a yield 13.09%, contains flavonoids, tannins, phenolics, alkaloids, saponins and terpenoids. The value of total flavonoid content is 0.59%, total phenolic content is 3.11% and antioxidant activity test has IC50 value of 165.26. The use ionic gelation method can reduce particle size. Three formulas that made the variation surfactant addition has a particle size of 47-283 nm, in addition tween80 1 ml has the smallest particle size of 47 nm with a zeta potential value of 39.3 mV. Keywords: yellow tabebuia flower extract, nanoparticles, antioxidant activity

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