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The Journal General Health and Pharmaceutical Sciences Research
Published by Sekolah Tinggi Ilmu Kesehatan Kesetiakawanan Sosial Indonesia
ISSN : 30266114     EISSN : 30266106     DOI : 10.57213
Core Subject : Health, Education,
Health Professions Nursing Other
This journal is The Journal General Health and Pharmaceutical Sciences Research which is peer-reviewed and open. The field of study in this journal includes the General Health and Pharmaceutical Sciences Research
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 89 Documents
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Cost-Effectiveness Analysis of Mental Health Programs in Middle Eastern Conflict Zones Helsa Nasution; M. Agung Rahmadi; Luthfiah Mawar; Nurzahara Sihombing
The Journal General Health and Pharmaceutical Sciences Research Vol. 3 No. 2 (2025): The Journal General Health and Pharmaceutical Sciences Research
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/tjghpsr.v3i2.669

Abstract

This meta-analysis evaluates the cost-effectiveness of mental health interventions implemented in conflict-affected regions of the Middle East between 2010 and 2023, compiling data from 47 programs across eight countries. Statistical analysis reveals substantial variation in program effectiveness levels (Cohen's d = 0.78, 95% CI [0.65, 0.91], p < 0.001), with cognitive behavioral therapy (CBT) demonstrating the highest cost-effectiveness ratio, registering an ICER of $2,340 per QALY gained. Multilevel regression findings indicate that community-based intervention approaches consistently prove more cost-efficient than those conducted in clinical settings (β = 0.67, p < 0.001), yielding an average savings of 43% per participant. Remote teletherapy programs exhibit significant potential, particularly in regions with limited access to services, with an ROI reaching 1.89 (95% CI [1.65, 2.13]). The economic burden analysis estimates that untreated mental health conditions incur an average annual cost of $4,623 per individual, whereas intervention expenses amount to approximately $1,876 per patient per year, resulting in a benefit-cost ratio of 2.47. This study expands upon prior research by Tol et al. (2011) and McBain et al. (2016), which were limited to clinical outcomes without addressing the economic dimension. In contrast to the study by Reed et al. (1994), which explored general health economics within conflict zones, this research specifically quantifies the cost-effectiveness of mental health interventions in Middle Eastern conflict areas. It reveals that cultural adaptation within intervention programs can enhance return on investment by up to 31%. Finally, this review uniquely demonstrates that community-based mental health programs integrated within conflict zones can meet the cost-effectiveness thresholds recommended by WHO-CHOICE while maintaining a high level of clinical efficacy.
Gambaran Karakteristik Nyeri Kronik Paska Operasi pada Pasien Rawat Jalan di Poli Bedah dan Poli Obstetri dan Ginekologidi RSU di Medan Nahly Bayo Anggito Ritonga; Muhammad Jalaluddin Assuyuthi Chalil
The Journal General Health and Pharmaceutical Sciences Research Vol. 3 No. 2 (2025): The Journal General Health and Pharmaceutical Sciences Research
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/tjghpsr.v3i2.679

Abstract

Chronic pain is pain that persistent and will continue beyond the proper healing time, there are two time points used in daily practice, namely 3 months and 6 months after the first injury. Sensitivity of peripheral nociceptive neurons and central underlying the process of transition from acute pain to chronic pain. There are several factors that influence the increasing incidence of postoperative chronic pain including preoperative, intraoperative and postoperative factors. Untreated acute postoperative pain also increases the risk of increasing chronic postoperative pain. In Asia, the prevalence of chronic pain varies widely, between 7% in Malaysia to 60% in Cambodia. The prevalence of postoperative chronic pain in adults is reported to be around 20% in developed countries. The incidence includes all ages with a higher incidence in women and the elderly. The purpose of this study was to describe the characteristics of postoperative chronic pain in outpatients in the surgical polyclinic and obstetrics and gynecology polyclinic at RSU Medan. The type of research used in this study was Observational with a Cross Sectional method approach. Based on the research that has been done, it was found that ages 26-35 years experienced the most chronic pain, namely as much as 29.8% and women experienced more chronic pain compared to men. Based on this study it was found that the majority of respondents experienced moderate pain intensity as many as 36 respondents (63.2%). There were descriptions of characteristics that were mostly 26-35 years old.
Faktor – Faktor yang Mempengaruhi Penurunan Kualitas Tidur pada Mahasiswa Fakultas Kedokteran UMSU Angkatan 2018 Arjuna Trimulya; Heppy Jelita Sari Batubara
The Journal General Health and Pharmaceutical Sciences Research Vol. 3 No. 2 (2025): The Journal General Health and Pharmaceutical Sciences Research
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/tjghpsr.v3i2.680

Abstract

Sleep is a basic need for every human being. Every human being needs adequate sleep in order to obtain a healthy and good body. Poor sleep quality is one of the causes of many medical ailments and has a strong relationship between physical, psychological and sleep health. According to several studies on sleep quality, a person's sleep quality is influenced by several factors such as physical activity, stress and emotion, surfing the internet, watching television and having other habits such as drinking alcohol, smoking and fast food. The student group is a group that has a fairly solid activity. Students can experience disturbances in the circadian cycle due to increased pressure from the academic environment so that groups of students do not have enough sleep. Some of the stressors from Medical Faculty students include busy class schedules, piled up assignments, anxiety before exams that affect the sleep quality of the Medical Faculty students. To determine the relationship between physical activity and emotional stress on decreased sleep quality in students of the Faculty of Medicine, UMSU class 2018. This study used an analytical descriptive method with a cross sectional design. The data was processed using the SPSS Chi-Square test in June 2022 at the Faculty of Medicine, University of Muhammadiyah North Sumatra. Based on the results of the analysis, the demographic characteristics of the average age of respondents were 22 (range 22-24) years and 97 (74%) of respondents were women, the frequency of poor sleep quality was the highest (79.4%), the frequency of light physical activity as much as (55%) and the frequency of moderate emotional stress (84%). Multivariate analysis showed that the factors that influence the decrease in sleep quality were emotional stress with p value = 0.001. Physical activity statistically did not affect the decrease in sleep quality with p value = 0.993. There is a significant relationship between emotional stress and decreased sleep quality in students of the Faculty of Medicine, University of Muhammadiyah North Sumatra, Class of 2018.
Identifikasi Bahaya dan Penilaian Risiko Ergonomi Petani Padi Dusun Gugur, Kecamatan Matesih, Kabupaten Karanganyar Nabylla Sharfina Sekar Nurriwanti
The Journal General Health and Pharmaceutical Sciences Research Vol. 3 No. 2 (2025): The Journal General Health and Pharmaceutical Sciences Research
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/tjghpsr.v3i2.681

Abstract

The agricultural sector is an informal sector that often does not receive full attention regarding occupational safety and health. One of the common hazards found in the informal sector is ergonomic hazards. This study aims to identify hazards and assess ergonomic risk among rice farmers in Dusun Gugur, Matesih Subdistrict, Karanganyar Regency. The study was conducted from August to December 2024 using a descriptive observational method with a cross-sectional time approach. The sample consisted of 20 rice farmers selected using accidental sampling. Primary data were collected through focus group discussions and direct field observations. The hazard identification results showed that the most dominant ergonomic risks included prolonged bending postures, repetitive body movements, and the frequent carrying of heavy loads during work. Based on the risk assessment, most farming activities were categorized as high ergonomic risk. These findings highlight the need for ergonomic interventions to reduce the risk of musculoskeletal disorders, which can impact the health and productivity of farmers.
A Literature Study on Complementary Therapies for the Management of Anemia in Adolescent Girls Tri Sartika; Ayu Devita Citra Dewi
The Journal General Health and Pharmaceutical Sciences Research Vol. 3 No. 2 (2025): The Journal General Health and Pharmaceutical Sciences Research
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/tjghpsr.v3i2.692

Abstract

Anemia is a common health issue among adolescent girls, primarily due to increased iron demands during growth and menstruation. This literature study aims to synthesize existing research on complementary therapies for managing anemia in this population. The study employed a literature review design with a systematic search of scientific articles published between 2018 and 2025. Data were collected from multiple electronic databases, including PubMed and Google Scholar, using keywords such as "anemia," "adolescent girls," "complementary therapy," "iron deficiency," "herbal medicine," and "nutritional intervention." Only peer-reviewed articles, clinical trials, systematic reviews, and meta-analyses published in English were included. The review found that natural interventions like Moringa oleifera leaf extract, beetroot juice, dates with lime juice, and educational programs are effective, affordable, and culturally acceptable for improving hemoglobin levels and anemia prevention. However, many studies have limitations such as small sample sizes and short intervention durations. Future research should focus on more rigorous designs with larger samples and longer follow-ups. Combining nutritional supplementation with health education offers a promising holistic approach to managing anemia in adolescent girls.
The Effectiveness of Pure Honey Administration on Hemoglobin Levels in Pregnant Women at TPMB Choirul Mala, Palembang City Deby Meitia Sandy; Suci Sulistyorini
The Journal General Health and Pharmaceutical Sciences Research Vol. 3 No. 2 (2025): The Journal General Health and Pharmaceutical Sciences Research
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/tjghpsr.v3i2.693

Abstract

Anemia during pregnancy remains a significant global health issue, particularly in low- and middle-income countries. Iron (Fe) tablets are the standard treatment, but alternative natural supplements such as pure honey may enhance hemoglobin levels through their nutritional and antioxidant properties. This study aims to  analyze the effectiveness of pure honey combined with Fe tablets on hemoglobin levels among pregnant women with anemia at TPMB Choirul Mala, Palembang. This quasi-experimental study employed a pretest-posttest control group design. A total of 30 pregnant women with anemia were selected through purposive sampling from a population of 66 who attended ANC visits between September and December 2024. Participants were divided equally into intervention and control groups. The intervention group received 2 tablespoons of certified pure honey and one 60 mg Fe tablet daily for 4 weeks, while the control group received only the Fe tablet. Hemoglobin levels were measured before and after the intervention. Data were analyzed using the Wilcoxon and Mann–Whitney tests. The intervention group showed a significant increase in mean hemoglobin level from 9.2 g/dL to 10.8 g/dL (p = 0.002), while the control group increased from 9.0 g/dL to 10.4 g/dL (p = 0.004). The difference in hemoglobin increase between groups was statistically significant (p = 0.041). The combination of pure honey and Fe tablets is more effective in increasing hemoglobin levels than Fe tablets alone. Pure honey may serve as a beneficial complementary therapy in managing anemia during pregnancy.
Literature Study: Complementary Therapy in Stimulating the Development of Infants Aged 0–12 Months Susmita Susmita; Juni Harista
The Journal General Health and Pharmaceutical Sciences Research Vol. 3 No. 2 (2025): The Journal General Health and Pharmaceutical Sciences Research
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/tjghpsr.v3i2.706

Abstract

The 0–12 month period is a critical phase in infant development, covering motor, cognitive, and emotional domains. Early stimulation has been proven to prevent developmental delays that may affect later life stages. Complementary therapies such as infant massage and baby gym are widely applied as non-pharmacological, safe, low-cost interventions that can be practiced at home by parents. To systematically review the scientific evidence regarding the effectiveness of complementary therapies in stimulating the development of infants aged 0–12 months. This literature study involved a review of articles published between 2018–2024 from PubMed and Google Scholar. Inclusion criteria included experimental and quasi-experimental studies evaluating the effect of complementary therapies (infant massage, baby gym, or others) on infant development. Six relevant studies were identified, including four on baby gym and two on infant massage. All studies reported significant improvements in gross motor development following intervention. Infant massage also showed additional benefits such as increased weight gain and enhanced mother-infant bonding. Complementary therapies such as infant massage and baby gym are effective and practical strategies for stimulating infant development. However, further research with more robust experimental designs is needed to strengthen the evidence base.
Menjelajahi Sifat Antiinflamasi dan Antioksidan Jahe Merah pada Pencegahan Terjadinya Polikistik Ovarium Syndrome (PCOS): Studi In Silico dan In Vivo Siti Mudrikatin; Herin Herin
The Journal General Health and Pharmaceutical Sciences Research Vol. 3 No. 2 (2025): The Journal General Health and Pharmaceutical Sciences Research
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/tjghpsr.v3i2.770

Abstract

Background of the incident of increasing cases of polycystic ovary syndrome (PCOS) with a prevalence of insulin resistance of 50-75%, insulin resistance will cause oxidative stress due to hyperglycemia which will then increase proinflammatory cytokines in TNF-α and other cytokines, thus triggering an increase in inflammation resulting in an increase in infertility cases of 89.6%. The aim is to investigate the prevention of PCOS through red ginger injected with testosterone propionate in vivo, insilico using open babel software on PyRx V.1.0. The in vivo method is an experimental laboratory study, using two five rats of the rattus norvegicus type divided into five groups using PCOS prevention through red ginger, examinations carried out on blood and ovarian organs, preparations were made which were observed with a binocular microscope on TNF-a examination with immunohistochemistry, ELISA examination on insulin levels, blood examination on blood glucose, data analysis was carried out using one way ANOVA. The study began with the preparation of control activator ligands, 6-Shogaol (Pubchem ID 5281794) and 6-Gingerol (Pubchem ID 442793) and target receptors TNF-α (PDB ID: 2AZ5) and KEAP1-NRF2 (PDB ID: 5CGJ), Insilico results that occur in red ginger are able to interact at a similar position in the interaction of TNF-α with control compared to KEAP1. In vivo research results showed that testosterone propionate 100 mg / kg BW significantly increased the inflammatory cytokine TNF-α, along with polycystic markers in folliculogenesis (p <0.05) compared to negative controls and administration of red ginger at 800 mg / kg significantly decreased TNF-α levels. red ginger also prevents the occurrence of pcos. The conclusion shows that the bioactive 6-shogaol 6-gingerol in red ginger can provide preventive benefits in polycystic ovary syndrome (pcos) by modulating the inflammatory pathway.
Hubungan Jumlah Perdarahan Intra Operasi dengan Kejadian Hipotermi pada Pasien Anestesi Umum di RS PKU Muhammadiyah Yogyakarta Dwinna Sastra Mutia; Astika Nur Rohmah; Nia Handayani
The Journal General Health and Pharmaceutical Sciences Research Vol. 3 No. 2 (2025): The Journal General Health and Pharmaceutical Sciences Research
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/tjghpsr.v3i2.779

Abstract

This study investigates the relationship between intraoperative blood loss and the incidence of hypothermia in patients undergoing general anesthesia at PKU Muhammadiyah Yogyakarta Hospital. General anesthesia, while commonly used for its effectiveness and patient comfort, is associated with various physiological changes, including postoperative hypothermia. Hypothermia can lead to serious complications such as delayed recovery, increased bleeding, infection risk, and impaired wound healing. One contributing factor is blood loss during surgery, which reduces the body’s ability to regulate temperature. This research employed an observational analytic method with a cross-sectional approach involving surgical patients who received general anesthesia. Data were collected on the volume of intraoperative bleeding and the presence of hypothermia in the recovery phase. The findings indicate a significant correlation between the amount of blood lost during surgery and the occurrence of hypothermia. These results suggest that early identification and management of blood loss are essential to prevent hypothermia and its associated risks. The study emphasizes the importance of temperature monitoring and bleeding control in improving patient safety and outcomes during surgical procedures involving general anesthesia
Efektivitas Edukasi Kesehatan Reproduksi pada Siswa Siswi di MTSN 01 Kendari Hartati Bahar; Nabila Rezky Amalia; Nur Indriyani; Putri Gizka Gauzalia; Sri Rahayu; Sri Tandi Gala; Widya Sartika
The Journal General Health and Pharmaceutical Sciences Research Vol. 3 No. 2 (2025): The Journal General Health and Pharmaceutical Sciences Research
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/tjghpsr.v3i2.766

Abstract

The issue of adolescent reproductive health remains a major challenge in Indonesia, significantly impacting the future of the younger generation. Research by the Indonesian Child Protection Commission (KPAI) and the Ministry of Health in October 2020 indicated that approximately 62.7% of Indonesian adolescents had engaged in premarital sexual relations, with 20% of 94,270 out-of-wedlock pregnancies occurring in adolescent girls, and 21% of these resulting in abortion. This study aimed to enhance MTsN 01 Kendari students with knowledge about the importance of reproductive health, and to measure their knowledge levels through pre-post questionnaire distribution using educational media. The research employed a Pre-Experimental design with a One Group Pre-test - Post-test Design. The study population consisted of 7th-grade students from MTsN 01 Kendari, with a sample size of 35 individuals selected using purposive sampling. Data collection involved questionnaires administered to respondents before and after the educational intervention. The study results showed that the education significantly improved students' knowledge of reproductive health. Based on the pre-test results, 31 (88.57%) students were in the "good" category and 4 (11.43%) were in the "sufficient" category. Subsequently, a significant change was observed in the knowledge distribution based on the post-test, where 35 (100%) students were in the good category. Analysis using a paired-samples t-test revealed that p(0.000)<α(0.05), indicating that H0 was rejected and H1 was accepted. This demonstrates a significant difference between the mean results of the pre-test and post-test after the educational intervention.

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