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Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Published by Asosiasi Riset Ilmu Kesehatan Indonesia
ISSN : 3031013X     EISSN : 30310148     DOI : 10.61132
Core Subject : Health,
Health Professions Nursing Public Health
Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Alam, Biokimia, Analisis Kimia, Kimia Fisika, Biologi, Mikrobiologi, Jaringan Budaya, Botani dan Hewan terkait Produk Farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Gizi dan Kesehatan Masyarakat.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 378 Documents
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Modification of Gemifloxacin Drug Antibacterial to Promising Anti-Prostate Cancer PC3 Azomethine Compounds: Synthesis and in Vitro Studies Rand Thair Abdulkader; Reyam H. Marah; Aqeel Mohamed; Abbas K. Abbas
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.665

Abstract

In this study, we report a novel azomethine derivatives synthesis (H and G) by reacting pure Gemifloxacin drugs with 2-aminobenzaldehyde and 2-methylbenzaldehyde. Spectroscopic techniques, such as FT‐IR spectroscopy, characterized the derivatives (G and H). All the synthesized derivatives (G and H) were evaluated in vitro against microorganisms such as Bacillus subtilis and E. coli by zone inhibition method and screened for antimicrobial activities and anti-Prostate cancer PC3 cell viability cell lines.
Evaluasi Pengelolaan Produk Rantai Dingin pada Pedagang Besar Farmasi X Berdasarkan Pedoman CDOB 2020 Wuri Ariestika Sari; Eri Amalia
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.670

Abstract

Cold Chain Products are pharmaceutical preparations sensitive to temperature, requiring consistently maintained temperature conditions from production, storage, and transportation to the final consumer. Environmental changes, such as temperature fluctuations and direct sunlight exposure, can reduce product quality, leading to the loss of the product's therapeutic potential. Therefore, Pedagang Besar Farmasi (PBF) play a crucial role throughout the distribution chain of cold chain products to ensure that the quality and effectiveness of the products are maintained. This study aims to evaluate the implementation of cold chain product management at a PBF in Tasikmalaya City according to the applicable guidelines, namely the Good Distribution Practices (CDOB). The study employs observation and interview methods, with evaluation using a research tool in the form of a checklist developed based on aspects of cold chain product management according to the 2020 CDOB guidelines. Based on the evaluation of cold chain product management implementation according to CDOB, a PBF in Tasikmalaya City has successfully implemented CDOB aspects well.
Formulasi Sediaan Lip Balm dari Ekstrak Buah Murbei (Morus Alba L.) Sebagai Pewarna Alami Fitri Hafidhah Uluhidayah; Liandhajani Liandhajani
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.673

Abstract

Using lip balm is very easy to apply to the lips and lip balm can also moisturize and brighten the lips. Lip balm is resistant to body temperature, and is harmless and smooth when applied so that the lips are cared for and healthy. The anthocyanin contained in mulberry fruit has the potential to act as a purplish red natural dye depending on the presentation of the mulberry fruit extract used, which has the positive side of being an antioxidant and scavenger of free radicals. The aim of this research was to determine the formulation and stability of the lip balm preparation formula using mulberry fruit extract (Morus alba L.) as a natural coloring with an accelerated stability test using 4 cycles. Using this research method, material testing includes organoleptic tests, homogeneity tests, melting point tests, pH tests, spreadability tests, adhesion tests, spreadability tests, stability tests, and hedonic tests, as well as preparation irritation tests. Based on the results of research on making lip balm from mulberry fruit extract as a natural coloring, it can be formulated in lip balm preparations, however if 20% extract is used it can affect the physical properties of the lip balm preparation, neither the 5%, 10%, 15% and 20% formulas. irritation was found.
Potensi Interaksi Obat pada Pasien Geriatri Diabetes Melitus Tipe 2 di RSUD Dr. Moewardi Surakarta Tahun 2023 Dilla Ayu Septiyani; Adhi Wardhana Amrullah; Rolando Rahardjoputro
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.674

Abstract

Type 2 diabetes mellitus represents a persistent metabolic dysfunction marked by elevated blood glucose levels attributable to insulin resistance. Geriatrics pertains specifically to individuals aged 60 years and older. Managing diabetes mellitus necessitates intricate therapeutic interventions, often comprising single or combined pharmacological agents aimed at achieving euglycemia. The concurrent administration of multiple medications, termed polypharmacy, amplifies the likelihood of pharmacological interactions. This investigation endeavors to delineate potential drug interactions observed in geriatric inpatients afflicted with type 2 diabetes mellitus at Dr. Moewardi Regional General Hospital in Surakarta throughout the calendar year 2023. The study adopted a descriptive observational design employing a cross-sectional approach. Data collection was conducted retrospectively through purposive sampling based on the medical records of geriatric patients at Dr. Moewardi Regional General Hospital in Surakarta. Inclusion criteria encompassed patients aged 60 years and older diagnosed with type 2 diabetes mellitus who had been hospitalized. Exclusion criteria included incomplete or illegible medical records, patients diagnosed with anemia and hemoglobinopathies, and those who expired during treatment. The findings revealed that out of 100 patients, 96 experienced drug interactions. Most patients (47.00%) were aged between 66 and 74 years. Females constituted a larger proportion (51.00%) of the patient cohort. Among hospitalized patients, 83 (83.00%) were admitted for 2-6 days. A total of 70 patients (70.00%) were prescribed between 4 and 13 medications. The predominant severity level of drug interactions was moderate, comprising 1,017 cases (74.60%). Pharmacodynamic mechanisms accounted for most drug interactions observed, totaling 1,054 cases (77.30%).
Faktor-Faktor yang Mempengaruhi Kehamilan Risiko Tinggi di Klinik Evie Kecamatan Babalan Kabupaten Langkat Provinsi Sumatera Utara Tahun 2024 Damayanty S; Ade Rachmat Yudiyanto; Indra Agussamad; Rahmi Larasati
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 3 (2024): May : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i3.675

Abstract

Background​ Pregnancy risk tall is dangerous pregnancy​ life Mother or the baby she was carrying . Furthermore number pain or death mother and fetus during pregnancy , childbirth and the postpartum period will happens to everyone pregnancy with factor high risk .​ Pregnancy risky tall can influenced by factors medical and non- medical . Pregnancy risk tall is something pregnancy Where soul and health mother and or baby can threatened . Purpose For know the influencing factors pregnancy risk high at the Evie sub-district clinic babalan regency step 2024. Method Research design used​​ in study This is Descriptive analytic with Retrospective approach . Deep sample study This is all over Mother pregnant women with risk data tall as many as 55 mothers pregnant. Analysis data using analysis univariate and bivariate . From the statistical test results obtained The p value is 0.22 (p<0.005) which is significant There is meaningful relationship​ between Education and pregnancy risk tall . From the statistical test results obtained The p value is 0.000 (p<0.005) which is significant There is meaningful relationship​ between Knowledge with pregnancy risk tall . From the statistical test results obtained The p value is 0.980 (p<0.005) which means None meaningful relationship​ between Attitude with pregnancy risk tall.
Knowledge, Attitude and Practice Regarding Breast Cancer and Breast Self-Examination Among A Sample Of Women In Al-Diwaniyah City Sarah Abdul Kareem Abdul Jabar; Hassan Raji Jallab
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.677

Abstract

Background: breast cancer is the most common cancer among women, also it is the leading cause of cancer-related deaths in low-resource countries. So, every woman should know what it looks like, be aware of any changes, and know what to do if they are discovered. Meanwhile, early diagnosis and management are fundamental steps toward increasing survival and improving the quality of life Aims: The purpose of this study is to determine the knowledge, attitudes and practices of women in Al_Diwaniaya city regarding breast self-examination, and to explore their level of knowledge about breast cancer focusing on some risk factors.Method:  Cross- sectional _ study was conducted among 350 women aged more than 18 years who attended breast screening department in Al- Diwaniyah teaching hospital during the period of study using face-to-face interviews questionnaire. Results: The total sample included in this study was 350 females, regarding the score of knowledge, the results showed near half of participants having moderate knowledge (49.1%), On the other hand, the attitude of study people was more interesting by enrolling questions. Concerning the attitude score, the findings indicated that 64% of the subjects had a moderate attitude. In terms of practice score, the findings revealed that 57% of participants had poor practice and only 6% had good practice. The study discovered that the age groups under 40 had better knowledge, attitudes, and practices than the age groups over 40, with a positive correlation also (p<0.001) in high education group.Conclusions: The results showed most of participants having moderate to good knowledge (78%) moderate attitude but poor practice of breast self-examination. the gap in knowledge in fields of breast self-examination emphasizes on the need to raise awareness among women about the correct method and timing of it.
Knowledge, Attitude and Practice Of Self Medication (Self Drugs Prescription) Among Students In Al-Qadisiyah University/ College Of Medicine Israa Mahmood Abd Al-Zihra; Fatima Abd Alkathem Redha Alkhalidi
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.678

Abstract

Background: Self-medication is defined as using medicinal products to treat the disorders or symptoms diagnosed by oneself, Self-Medication is common practice worldwide in both developed and developing countries, Regulations usually distinguish between prescription-only medicines (POM) and over the counter (OTC) drugs. inappropriate self-treatment can pose various risks including drug side effects, recurrence of symptoms, drug resistance, etc. the purpose of this study was to investigate the knowledge, attitude, and practice of medical students towards self-medication.  Subjects and Methods: A cross-sectional study was carried out among five stages that were selected by the simple random sampling for choosing the students. Data collections were performed from the beginning of March to October 2023. Data were collected with A four-part researcher questionnaire. It was designed to address the students’ knowledge, attitude, and practice. Statistical analysis was performed using Statistical Package for the Social Sciences 23 software. Results: Out of 462 questionnaires distributed, 445 questionnaires were completed; giving a response rate of 96.3%. According to the results, 310 (69.7%) students had carried out self-medication within the past one year. Common cold was the most common ailment treated with self-medication (73.9%) and antipyretics analgesics (64.5%) were the most used drugs. The primary information sources used by the students were their academic knowledge and books (47.4%). Health problems are not serious the most reason for self-medication in the study and lack of knowledge about medicine the highest causes for not taking medication. Conclusion: students’ knowledge of self-medication appears to be good and significantly high. As well self-medication was highly practiced among the students. Therefore, medical students should be viewed as important contributors to the public health care system, and future health professionals should be properly educated on good pharmacy practice and responsible self-medication.
Risk Factors That Lead To Poor Glycemic Control In Type 2 Diabetic Patients Attending Al Diwaniya Diabetes Mellitus Center In 2023 Lara Noori Hamza; Hassan Raji Jallab
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.679

Abstract

Background: Diabetes mellitus (DM) is the most common metabolic disorder worldwide. DM is the most common chronic illness in adults. It is estimated that 300 million people will have DM by 2025, and it will reach approximately 439 million and the prevalence is estimated to be 7.7% by 2030. The decrease of blood glucose levels in patients with DM decreases the mortality and morbidity rates significantly.Objective: To identify the potential risk factors of poor glycemic control among patients having type2 Diabetes mellitus in Al-diwaniya city. Methods: A total of 340 patients were included in the study. This was cross sectional study conducted in the Diabetes  Center at Al-diwaniya city, Iraq, from period of 1st of February to the 1st September2023. Based on the cutoff point of Glycosylated hemoglobin of 7, the poor control were the patients with (Glycosylated hemoglobin is ≥ 7) and the good control were the diabetic patient with Glycosylated hemoglobin is <7. A questionnaire developed to gather the demographic, lipid profile, disease characteristics and lifestyles behaviors and filled by the researcher through direct interview. Results: The total number of poor controls was 221 and the good control was 119 patients. There was no significant difference between the two groups regarding sex, age, marital status and occupation. A significant association was observed between the control status and high education level (p=0.001) dyslipidemia (p=0.001), cholesterol level (P=0.002), high TG level (p<0.001), and LDL level (p=0.025). Smoking, Body Mass Index and HDL level were not significant factors (p>0.005). All disease characteristics including the duration, family history of DM, FBS, type of medication were significant factors (p<0.001). Lifestyles  behaviors including  self-monitoring, healthy diet, physical activity, and adherence were significant factors (p<0.001). Conclusion: The most important potential risk factors for poor control diabetes were dyslipidemia, poor adherence and longer duration of diabetes. Enhancement of education of the patients and their healthcare providers on these factors are great benefit in glycemic control.
Formulasi Sediaan Granul Effervescent dari Ekstrak Buah Kurma Ajwa (Phoenix Dactylifera L.) sebagai Sumber Karbohidrat Liandhajani Liandhajani; Ratih Hardianti
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.688

Abstract

Ajwa date (Phoenix dactylifera L.) from Medina, Saudi Arabia, contains a high carbohydrate content. Dates are commonly recognized to be available in two forms: dried fruit that may be consumed directly and concentrated date juice. Concentrated date juice usually gives an unpleasant taste when consumed and requires a large container for storage. This study aims to formulate the effervescent granules using two combinations of acids, namely citric acid and malic acid as a source of acid and sodium bicarbonate as a source of base. The research process was began with macerating dates with 96% ethanol solvent and making a dry extract. Furthermore, effervescent granule preparations were made in three formulations with the ratio of sodium bicarbonate and acid (citric acid : malic acid) as follows: formulation I = 2.5: (2:1), formulation II = 3: (2:1), formulation III = 3.5: (2:1). The results showed that, each 5g serving size contained 84.41 g of carbohydrate in the form of effervescent granules. In formula I, the test results obtained were pH 4.82, water content 4.14%, flow speed 11.58 g/second, angle of repose 25.36o, and dispersion time 28.91 seconds. Then, in formula II, the test resultedin pH 5.27, water content 3.80%, flow speed 12.39 g/second, angle of repose 26.69o and dispersion time 26.19 seconds. Moreover, the test findings for formula III, were pH 5.76, water content 3.86%, flow speed 11.83 g/second, angle of repose 26.63o and dispersion time 29.55 seconds. The differences between acid and base concentration ratio in the three formulas above affect the physical properties of effervescent granule preparations, with formula II producing the best carbonation of the three.
Faktor – faktor yang Berhubungan dengan Kebersihan Gigi dan Mulut pada Lansia Aisyah AR; Hasrini Hasrini; Amirah Maritsa; Zahrawi Astrie Ahkam; Fidzah Nurfajrina Murad; Arfiah Jauharuddin
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 1 No. 6 (2023): November : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v1i6.692

Abstract

The lack of oral hygiene become a problem for elderly. The main aims of this research is to analyze the related factors due to oral hygiene consists of age, sex, education degree, occupation, marital status, knowledge, motivation, physical dependence, culture, anxiety, economic of family and elderly. The design of this research were descriptive analytic and cross sectional. UPTD Puskesmas I Penebel was the location where this research was conducted. Purposes sampling technique was used with the total samples where 80 respondents. The results showed the significant correlation between oral hygiene and knowledge (p value 0,013, r = 0,277), motivation (p value 0,005, r = 0,311), physical dependence (p value 0,011, r = 0,285), economic of family and elderly (p value 0,0000, r = 0,400), anxiety (p value 0,0185, r = -0,265). There was no correlation between culture and oral hygiene (p value 0,187, r = -0,149). Based on this research, it is recomended that oral hygiene supposed to be clearly informed to elderly by elderly posyandu (integrated treatment) activities, and regularly oral hygiene checkup which is integrated in puskesmas (civic health Centre).

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