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Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Published by Asosiasi Riset Ilmu Kesehatan Indonesia
ISSN : 3031013X     EISSN : 30310148     DOI : 10.61132
Core Subject : Health,
Health Professions Nursing Public Health
Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Alam, Biokimia, Analisis Kimia, Kimia Fisika, Biologi, Mikrobiologi, Jaringan Budaya, Botani dan Hewan terkait Produk Farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Gizi dan Kesehatan Masyarakat.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 378 Documents
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Phytochemical Investigation and GC-MS analysis of Tribulus terrestris L. cultivated in Iraq Amani Amer Tawfeeq; Tahany Amir Tawfeeq; Zahraa A.E Al Naqqash; ZIinah Alaa Kamal
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.594

Abstract

Tribulus terrestris L.,Gokshur in Sanskt, is an annual herbaceous, little prostrate, silky from the Zygophyllaceae family. It is found in extensive, arid, and scorching regions of India. is used in traditional folk medicines as an aphrodisiac, astringent, lithotriptic, diuretic, and urinary disinfectant. however, uneven, pinnae, elliptical leaves. Sprinkled, round, compressed, five-cornered, transverse partitioned carpel fruits with many seeds ripen in July. Pieces of the cylindrical-fibrous root are 7-18 cm and 0.3-0.7 cm wide. According to reported studies, the investigations indicated the presence of the saponins ;gitogenin, tigogenin, neogitogenin, hecogenin, and flavonoid tribuloside was kaempferol-3-glucoside. Furthermore, Tribulus terrestris plays a vital role in hepatotoxicity and is greatly reduced by Tribulus extracts. Similarly, T.terrestris plays a remarkable role in reducing the elevated level of serum glucose, triglycerides, VLDL, and cholesterol. This study aims to conduct a preliminary analysis of the phytochemicals of Tribulus leaves cultivated in Iraq and to determine the active constituent of the ethanolic extract of the leaves using Gc-Mass. Qualitative detection of herbal leaves in Iraqi soil, investigated by GC-MASS revealed important constituents. The funding shows a new compound; dihydrocoumarin and other major constituents neophytadiene and alpha-tocopherol.
The Intraoperative use of Prophylactic Steroids Therapy on Postoperative Cough for Heavy Smoker Patient Under Elective Extra Thoracic Surgery Ahmed Yasser Raddad; Ahmed Adil Ahmed; Nazzal Jebur Mzaiel
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.598

Abstract

Introduction: Anesthesia is a complex pharmacological Response induced by a chemically heterogeneous class of Drugs, the so-called general anesthetics Every year, tens of Millions of patients are exposed to general anesthetics Drugs that remove the most precious human attribute Consciousness. By allowing for prolonged invasive Procedures, general anesthesia is one of the foremost Achievements of modern medical science However, there Is no objective or widely accepted definition of general Anesthesia. Aim of the study: The aim of study uses of prophylactic nebulized steroids therapy on postoperative cough in a heavy smoker patient under elective extra thoracic surgery. Results: The data was analyzed using the statistical program IBM SPSS Statistic 28 the results attached below were obtained based on the following hypotheses and aim of this study (The aim of study use of prophylactic steroids therapy on postoperative cough for heavy smoker patient under elective extra thoracic surgery). Discussion: In this study, it was attempted to determine the effect of steroids therapy on post-operative cough in patients ­smoking. And there was high-significant data for each drug group. From this data we note that from study questionnaire the use of nebulizer pulmicort which is making less side effect on patients from than using systemic dexamethasone to patients. and be better drug used for patient who have chronic disease such as (hypertension, diabetic mellitus, problem in respiratory system and complication. Conclusion: from all results in this study, we can conclude that there is a significant effect on shortness of breath and high significant data variable effect on cough according to data research.
Penilaian Risiko menggunakan Metode Failure Mode and Effects Analysis (FMEA) terkait Kontaminasi Silang pada Area Pengemasan di Industri Farmasi “XYZ” Azzahra, Annisa Maulida
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.600

Abstract

Cross-contamination occurs due to other previously produced products, other rooms or areas producing different products, and particles from machinery or equipment. Quality risk management can be a preventive measure in reducing the potential for cross-contamination that occurs in the pharmaceutical industry. One part of quality risk management is risk assessment. One of the most common and effective methods is the Failure Mode and Effect Analysis (FMEA) method. This risk assessment is carried out using the stages of risk identification, risk analysis, and risk evaluation using categorization based on the Risk Priority Number (RPN). Based on the risk assessment using the FMEA method regarding cross-contamination in the Packaging area in the "XYZ" pharmaceutical industry, it can be concluded that the results of observations and interviews with operators and Packaging Supervisors identified 19 risks which were categorized as low, medium, high, and very high. Based on the results of the risk assessment obtained, the risk of cross-contamination that needs to be controlled is those with an RPN value of 30 ≤ RPN ≤ 60 (medium); 75 ≤ RPN ≤ 100 (high); RPN ≥ 150 (very high). Therefore, the "XYZ" pharmaceutical industry needs to determine and implement risk control measures. By adequately controlling the potential risk of cross-contamination, it will ensure the safety and quality of the products produced.
Produksi Protein Sel Tunggal dari Aspergillus niger Kultur dengan Kulit Nanas (Ananas comosus L. MERR) Media Limbah Yuli Apriani Br.Lubis; Yayuk Putri Rahayu; Gabena Indrayani Dalimunthe; Haris Munandar Nasution
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.602

Abstract

Introduction: Single Cell Protein (SCP) is a term used for proteins produced from microbes such as bacteria, algae, yeasts, and fungi. One of the fungi known to produce PST is Aspergillus niger. Objective: The purpose of this study was to determine whether pineapple peel waste could produce single cell protein from A. niger culture and to determine differences in protein production with the addition of nutrients in the fermentation medium. Methods: This research method is an experimental method with the independent variables being MFKN1 medium (Pineapple Skin Fermentation Medium with the addition of KH2PO4 and sugar), and MFKN2 medium (Pineapple Skin Fermentation Medium with the addition of KH2PO4, (NH4)2SO4 and sugar); and the length of fermentation time used are days-0, 2, 4, and 6. The dependent variables of this study were analysis of protein content, dry weight of cells, glucose levels, pH and temperature. The data from this study were statistically analyzed using the two way Anova method. Results: The results of this study obtained the highest protein content in MFKN2 media, namely 0.80% (day-2); cell dry weight 0.473 g; glucose level 1.3406%; pH 4.6 and temperature 31 oC. Meanwhile, the highest protein content in MFKN1 media was 0.59% (day- 4); cell dry weight 0.346 g; glucose level 1.3406%; pH 3.7 and temperature 26.6 oC. Conclusion: The conclusion of this study is that pineapple peel waste can produce single cell protein from A. niger culture and there are differences in protein production results with the addition of nutrients, where protein content in MFKN2 medium is higher than protein content in MFKN1 medium.
Effect Toxoplasmosis on Thyroid Hormone Ohood Mozahim Shakir; Redhaa Haider Kamil; Ola Husein Kadum
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.605

Abstract

The study was conducted from January 2021 to March 2022. The study included samples of female patients arriving at some private laboratories in Samarra. The study included (50) serum samples from women arriving at health centers. The study groups were divided into two groups of women, the first group included (35) serum samples from pregnant women who suffered from previous miscarriages, and the second group was the control group, which included 15 samples from healthy women. Blood samples were collected in a volume of (5) ml in clean dry tubes and placed in an incubator at 37°C for (5) minutes, then the coagulated fraction was separated from the clear solution using a centrifuge at a speed of (2000 cycle/min) for (15) minutes. The clear solution represents the blood serum that was drawn using a micropipette, which was divided into (7) parts using plastic tubes, then the samples were kept at a temperature of 20 °C until the required tests were performed on them. Concentrations of thyroid hormon, (T3), (T4) and (TSH), were measured by used the equipment of all test.
Pengaruh Variasi Trietanolamin terhadap Evaluasi secara Fisik Sediaan Krim Body Scrub dari Serbuk Belimbing Wuluh (Averrhoa bilimbi Linn) Senya Puteri Amalia; Rianita Meilinda; Erma Septiani; Priscilla Harviana Damayanti; Muhammad Hafizh Abiyyu Fathin Fawwazi; Desy Ayu Lestari
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.607

Abstract

Body scrub is a type of cosmetic preparation that has seen increased use, particularly with the incorporation of natural ingredients as its base. Belimbing wuluh (Averrhoa bilimbi Linn.) is a traditional medicinal plant known for its high content of saponins, flavonoids, tannins, glycosides, and formic acid, all of which contribute to its significant antioxidant activity. This makes it a promising candidate for development into a cosmetic product for skin care. This study involved the formulation of body scrub preparations using A. bilimbi powder, with variations in triethanolamine (TEA) as an emulsifying and alkalizing agent to optimize the resulting product formula, which was then tested physically. The A. bilimbi fruit was processed into simplicia, which was subsequently ground and formulated into three different body scrub formulas. These three formulas were subjected to organoleptic tests, homogeneity tests, and pH tests to assess the impact of varying TEA concentrations. The results indicate that TEA influences the texture and pH values of the body scrub preparations. However, the distribution of the preparations based on the homogeneity test results showed no significant differences among the three formulas. The study identified Formula II, with a 3% TEA concentration, as the most optimal formula, meeting SNI standards for pH and demonstrating the best organoleptic properties among the three formulas.
Pola Peresepan Obat Antihipertensi pada Pasien BPJS Kesehatan dibeberapa Apotek Daerah Bandung Periode November 2023 Dinda Juliana; Dika Pramita Destiani
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.612

Abstract

Hypertension is a non-communicable disease that always increases every year. Hypertension is known as a silent killer because patients who suffer from hypertension rarely feel the symptoms. Common symptoms of hypertension can be headaches in the back of the neck, blurred vision, and others. The blood pressure of hypertension sufferers is above 140/90 mmHg. This study aims to see the pattern of prescribing antihypertensive drugs in BPJS Kesehatan patients including gender, age, patient diagnosis, and combination of antihypertensive drug classes. The method used is descriptive observational research. This study was conducted using 195 prescriptions in the period November 2023. The results obtained were that hypertension sufferers were more dominated by women with a total of 131 sufferers with a percentage of 67% compared to men with a total of 64 sufferers with a percentage of 33%. The age most affected by hypertension is people aged 51 years - 75 years with a total of 143 people and a percentage of 73.33%. 92 of 195 (47.18%) patients did not have other diseases such as diabetes mellitus, hyperlipidemia, heart, GI, and asthma. Single therapy of antihypertensive drugs was most commonly prescribed by doctors with a total of 127 patients with a presentation of 65.13% compared to patients who used combination therapy of two or more antihypertensive drugs. Calcium antagonist or CCB drugs were most commonly used by BPJS patients at several pharmacies in the Bandung area used in the prescription analysis with a total of 107 patients with a percentage of 54.87%.
Uji Antioksidan Batang Waltheria Indica pada Kondisi Minimal di Daerah Gambut Yuliana Yuliana; Samsul Hadi; Indryani Syarifuddin; Kartini Kartini; Pertiwi Awilda; Sheila Nurrahmah; Siti Rahimah
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 2 (2024): March : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i2.620

Abstract

Free radicals are unpaired electron molecules that are unstable and can attack important macromolecules causing cell damage in the body. Antioxidants themselves are compounds that can prevent oxidative reactions by free radicals. One of the plants that has the potential as an antioxidant is Walther indica. This study aims to determine the antioxidant activity and determine the total flavonoid content of Waltheria indica stem extract. The method used in this study is the DPPH method which is used to determine antioxidant activity. The antioxidant activity of the Waltheria indica ethanol extract was obtained with an IC50 value of 148.7116 ± 2.061 with a moderate antioxidant category.
Variasi Konsentrasi Fase Gerak pada Analisis Hidrokuinon dalam Sabun Pemutih dengan Metode Kromatografi Kertas Anik Eko Novitasari; Lailatul Fitriyah; Rosidah Rosidah
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.637

Abstract

Hydroquinone is a compound that is often used in skin whitening beauty products. According to BPOM 2007, the use of hydroquinone at levels above 2% can cause skin disorders, namely hyperpigmentation which can lead to skin cancer. This research was conducted to qualitatively analyze the hydroquinone compound found in skin whitening soap which does not have a BPOM number. The aim of this research is to determine the presence of hydroquinone compounds contained in skin whitening soap samples and to determine the differences in Rf values ​​resulting from the comparison of the concentrations of the mobile phase used. Qualitative analysis was carried out by calculating the Rf value of paper chromatography using a comparison of variations in mobile phase concentration, namely 50% ethanol: chloroform (1: 1) and 90% ethanol: chloroform (1: 1). The analysis results show that the standard Rf value of hydroquinone from the eluent of 50% ethanol and chloroform is 0.46, where this Rf value is the same as the Rf value from sample number 5, namely 0.46. Meanwhile, the Rf value using 90% ethanol and chloroform eluents in sample No. 5 is 0.67, which is not the same as the standard Rf value, namely 0.56. Of the whitening soap samples, 1 sample showed a positive result containing hydroquinone.
Pengembangan Media Audio Visual Melalui Youtube Tentang Cara Menjaga Personal Hygiene Saat Menstruasi di Smpn 18 Surakarta Putri Zakia Ulfa
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.642

Abstract

Personal hygiene is the improvement of health through the implementation of hygiene measures carried out during menstruation with the aim of maintaining individual cleanliness and health so as to obtain physical, psychological well-being and increase the degree of welfare. The purpose of this study is to find out how the procedure for developing audio-visual media with youtube and to find out the feasibility of audio-visual media through assessments from experts and respondents. This research is included in Research and Development (R&D) with reference to the research model from Borg & Gall. The results of this study show that the average value of the validation test for material experts is 95% with the category of very feasible and 95% of media experts with the category of very feasible. The feasibility test of the product with student validation was 86.2% with the category of very feasible. The conclusion that this audio-visual media received a good response to be used as an educational medium on how to maintain personal hygiene during menstruation.

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