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Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Published by Asosiasi Riset Ilmu Kesehatan Indonesia
ISSN : 3031013X     EISSN : 30310148     DOI : 10.61132
Core Subject : Health,
Health Professions Nursing Public Health
Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Alam, Biokimia, Analisis Kimia, Kimia Fisika, Biologi, Mikrobiologi, Jaringan Budaya, Botani dan Hewan terkait Produk Farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Gizi dan Kesehatan Masyarakat.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 352 Documents
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Hubungan Dukungan Keluarga dengan Kecemasan Pasien Preoperasi di Rumah Sakit Umum Daerah Meuraxa Kota Banda Aceh Elvi Savira; Urip Pratama; Riyan Mulfianda
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1835

Abstract

The surgery often causes anxiety, which has an impact on physical and psychological conditions of preoperative patients. The data from WHO shows that 50% patients all over the world experienced anxiety, where 5-25% patients are between 5 and 20 years old, and 50% patients are 55 years old. Pre-operational anxiety reaches 534 million patients. Many factors affect anxiety in patients, including family support. This study aims to acknowledge the correlation between family support and anxiety of post-surgery patients in Meuraxa Regional General Hospital, Banda Aceh. This study employs an analytical correlational method with a cross-sectional approach by involving 51 patients selected using an accidental sampling technique. A family support questionnaire is adopted from Nurwulan, with a Cronbach's alpha 0.856. The questionnaire of anxiety using the APAIS scale of Cronbach's alpha 0.825. Univariate and bivariate analysis using the chi-square test. The results indicate that among 51 respondents, the level of anxiety is in a medium state, as 26 respondents (51.0%), family support is in the high category, 47 respondents (92.2%), with a P-value 0.026 (P-value < 0.05). In conclusion, there is a significant relationship between family support and preoperative anxiety at Meuraxa General Hospital Banda Aceh. Families are expected to continuously provide emotional, informational, instrumental, and appraisal support so that patients feel calmer, are able to reduce excessive anxiety, and are better prepared to undergo surgery.
Peran Elektrokardiografi dan Kriteria Peguero–Lo Presti dalam Diagnosis Hipertrofi Ventrikel Kiri Muhammad Daniyal
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1844

Abstract

Left ventricular hypertrophy (LVH) can be identified through both electrocardiography (ECG) and echocardiography, with echocardiography recognized as the gold standard for the assessment of LVH. This imaging modality determines the presence of LVH by evaluating the left ventricular mass index (LVMI). For diagnostic purposes, LVH is defined in males as a left ventricular mass index greater than 115 g/m² and in females as greater than 95 g/m². Despite the high accuracy of echocardiography in diagnosing LVH, access to this examination is not universal across all healthcare facilities. Consequently, electrocardiography, a widely available, non-invasive, and cost-effective diagnostic tool, serves as an alternative for the diagnosis of LVH. Several criteria exist for the electrocardiographic assessment of LVH, including the Sokolow-Lyon and Cornell voltage criteria. However, the sensitivity of these electrocardiographic methods remains relatively low, with reported sensitivities of 17% for the Sokolow-Lyon criteria and 35% for the Cornell criteria. In left ventricular hypertrophy, the interstitium experiences changes characterized by fibrosis and other deposits. These alterations can reduce the expression of hypertrophic myocardial tension and limit the diagnostic capabilities of surface electrocardiograms. Additionally, several factors influence electrical tension, including variations in chest wall thickness, heart muscle activity, the distance of the electrode from the left ventricle, and lung activity. The presence of these limiting factors can increase the rate of false negatives in diagnosis. In 2017, Peguero and Lo Presti introduced novel criteria for the diagnosis of LVH, defined by evaluating the deepest S wave and summing it with the S wave in lead V4. According to these new criteria, LVH is identified as ≥ 2.8 mV in men and ≥ 2.3 mV in women. The Peguero-Lo Presti criteria demonstrate improved sensitivity when compared to traditional criteria such as Sokolow-Lyon and Cornell, offering enhanced diagnostic accuracy.
Pengaruh Konsumsi Jus Buah Bit Lemon dengan Tablet Fe terhadap Peningkatan Kadar Hemoglobin Ibu Hamil Trimester III di Kota Semarang Fitriyani Indah Lestari; Qomariyah Qomariyah; Nella Vallen I.P
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1848

Abstract

Background: Anemia in pregnancy increases the risk of maternal and fetal morbidity and mortality, with a higher incidence in the third trimester. Although Fe tablets serve as the main therapy, non-pharmacological alternatives such as beetroot and lemon juice also have the potential to raise hemoglobin levels. Objective: To determine the effect of consuming beetroot-lemon juice combined with Fe tablets on hemoglobin levels in third-trimester pregnant women in Semarang. Method: This study applied a quasi-experimental design with a two-group pre-test post-test approach, allowing the measurement of hemoglobin level changes before and after the intervention. The study population consisted of all pregnant women in their third trimester, with gestational ages between 32 and 38 weeks, registered at two community health centers: PMB Puji Widiastuti, Amd.Keb, with 16 anemic respondents, and PMB Ika Febri Setyaning Astuti, Str.Keb, with 15 anemic respondents. A total of 31 respondents were obtained using total sampling. Data collection was conducted through observation sheets, and analysis was performed using the Mann Whitney statistical test. Results: The intervention group, which consumed beetroot and lemon juice along with Fe tablets, achieved a Mean Rank of 13.41, whereas the control group recorded a Mean Rank of 18.77, with an effectiveness difference of 5.36. Statistical analysis yielded a p-value of 0.048, indicating a significant difference between the groups. In conclusion, the combination of beetroot and lemon juice with Fe tablets effectively increased hemoglobin levels among third-trimester pregnant women with anemia. This finding suggests that such combination therapy can serve as a valuable alternative in the management of anemia during pregnancy.
Microbiome Relationship in Autism Spectrum Disorder (ASD): Subject Review Hiba Hazim Hamid; Kais Kassim Ghaima
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1849

Abstract

Importance of gut microbiota during neurodevelopment has increased, as has the potential relationship between the gut microbiota and (ASD). Complex associations between gut microbiota and ASD are explored here, including significant pathways such as immune modulation, neurotransmitter control, and gut-brain axis signaling. Based on available data, individuals with ASD possess distinctive microbial signatures that are characterized by reduced diversity and altered abundance of specific bacterial species. Such modifications could be related to symptoms of the behavioral nature, neuroinflammatory, as well as gastrointestinal. ASD growth as well as severity could be influenced by the composition of microbiome, depending on genetic, nutrition, microbial exposure during the earliest phases, as well as antibiotic use. Additional therapies based on the microbiome that presented the potential to alleviate the symptoms related to ASD include the use of probiotics, prebiotics, diet modification, as well as fecal microbiota transplantation (FMT). Still, establishing the causal associations, standardizing the procedure of handling the patients, as well as solving the problem related to the manipulation of microbiome, are still challenging activities, though. Large-scale, long-term studies need to be the core agenda of subsequent research, so that specific microbial signatures associated with ASD will be clearly defined, as well as tailored therapies that address the microbiome will be developed. Understanding more about the role that the microbiota plays during ASD may open up the diagnosis as well as the therapy based on the entirely new concepts, something that will ultimately benefit the patients who possess the disorder.
Hubungan Kualitas Tidur Terhadap Kadar Hemoglobin pada Calon Pendonor di Unit Donor Darah PMI Provinsi Sulawesi Selatan Adinda Ashari; Hairuddin K; Dahniar Dahniar
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1851

Abstract

Blood transfusion requires the availability of high-quality blood, which is determined, among others, by the donor's hemoglobin (Hb) level. One factor that may affect Hb is sleep quality. Objective: This study aims to determine the relationship between sleep quality and hemoglobin levels among prospective blood donors at UDD PMI South Sulawesi Province in 2025. Methods: An observational analytic study with a cross-sectional design was conducted involving 100 respondents selected using purposive sampling. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), while Hb levels were measured using a hemoglobinometer. Data analysis was performed using the Chi-Square test with a significance level of p ≤ 0.05. Results: The majority of respondents (75%) had good sleep quality, while 25% had poor sleep quality. Normal Hb levels (12.5–17 g/dL) were found in 96% of respondents, while 3% were low and 1% were high. The Chi-Square test showed a significant relationship between sleep quality and Hb levels (p = 0.050). Conclusion: Good sleep quality is significantly associated with normal hemoglobin levels in prospective donors. Educational programs about healthy sleep patterns before donation are necessary to improve donor eligibility and ensure a safe blood supply.
Pengaruh Hidroterapi dan Quadriceps Exercise Terhadap Penurunan Nyeri pada Osteoarthritis Knee E Y Syafitri; L S Wibisono; Najizah F; Syurrahmi Syurrahmi
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1857

Abstract

Knee osteoarthritis is one of the most prevalent musculoskeletal disorders in the elderly, characterized by progressive degeneration of articular cartilage, chronic pain, joint stiffness, and reduced functional capacity. In Indonesia, the prevalence of knee osteoarthritis is notably high, affecting over 30% of individuals aged above 60 years. This condition leads to significant health burdens, impaired quality of life, and increased economic costs. Non-pharmacological management strategies such as hydrotherapy and quadriceps exercise are widely recommended to relieve pain and improve joint function. Hydrotherapy utilizes the physical properties of water including buoyancy, hydrostatic pressure, viscosity, and warmth to reduce joint loading, enhance circulation, and promote relaxation. Quadriceps exercise, on the other hand, focuses on strengthening the quadriceps muscle to stabilize the knee joint, thereby reducing pain and improving functionality. The combination of these two interventions is expected to provide greater benefits than a single modality. Research Design: This study employed a quasi-experimental design with a one-group pre-post test approach on 12 elderly respondents with knee osteoarthritis at OSF Magdalena Daemen BSB Convent. Pain was measured using the Visual Analogue Scale (VAS) before and after the intervention, which consisted of hydrotherapy and quadriceps exercise administered twice a week for four weeks. Results: The findings showed a decrease in the mean pain score from 4.42 to 3.08, with the Wilcoxon test yielding p = 0.001 (p < 0.05), indicating a significant difference in pain levels before and after the intervention. Conclusion: The combination of hydrotherapy and quadriceps exercise is effective in reducing pain in patients with knee osteoarthritis.
Perbandingan Akurasi Foto Toraks dan Ultrasonografi Dada dalam Diagnosis Efusi Pleura: Suatu Kajian Literatur Salsa Nabila Inong Ramadhana
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1864

Abstract

Pleural effusion is the accumulation of fluid in the pleural cavity, which is a common clinical condition requiring rapid and accurate diagnosis. Imaging modalities such as chest X-ray and ultrasound (USG) of the chest play a crucial role in identifying and evaluating this condition. Chest X-ray remains the most widely used initial screening tool due to its availability and ease of use. However, chest USG offers higher sensitivity, especially in detecting small effusions, assessing fluid characteristics, and guiding diagnostic and therapeutic procedures. Additionally, USG provides real-time imaging, enhancing the safety and effectiveness of interventions such as aspiration or drainage. Although both modalities are important, USG provides more detailed information, particularly in evaluating more complex pleural fluid conditions. This review discusses the latest evidence regarding the sensitivity, specificity, advantages, and limitations of both imaging techniques. Understanding the complementary roles of chest X-ray and USG is essential for optimizing diagnostic strategies, ultimately improving clinical outcomes and enabling more effective management of pleural effusion.
Senyawa Alami sebagai Kandidat Obat Antikanker: Suatu Tinjauan Kimia Medisinal Cheriel Dhiya Nazwa Alivia; Saeful Amin
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1865

Abstract

Cancer remains a major challenge in modern medicine due to drug resistance and the adverse effects of conventional therapies, making it one of the leading causes of death worldwide. Continuous scientific efforts aim to discover safer and more effective treatments. Owing to their structural diversity, strong bioactivity, and relatively low toxicity, natural compounds show great promise as sources of anticancer drug candidates. This article aims to explore the role of medicinal chemistry in investigating, modifying, and optimizing natural bioactive compounds to develop more effective, selective, and stable anticancer agents with improved bioavailability. A narrative review was conducted using scientific literature published between 2020 and 2025 from PubMed, ScienceDirect, Google Scholar, and ResearchGate. The findings indicate that eugenol, berberine, hesperidin, piperine, and quercetin exhibit anticancer activities through apoptosis induction, inhibition of proliferation, and antioxidant and anti-inflammatory mechanisms. Modern medicinal chemistry relies on understanding structure–activity relationships (SAR), chemical modification, and nanoparticle formulation to enhance biological performance. In addition, in silico techniques such as molecular docking and QSAR analysis are applied to study ligands and receptors and predict bioavailability improvements. The development of natural products as rational, effective, and safe anticancer drug candidates is strengthened by integrating experimental, computational, and pharmaceutical approaches.
Hubungan Pemberian ASI Eksklusif dengan Status Gizi pada Bayi di Wilayah Kerja Puskesmas Kuta Cot Glie Kabupaten Aceh Besar Kurniatun Kurniatun; Khaira Rizki; Muhammad Daud
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1882

Abstract

Exclusive breastfeeding ensures the optimal development of children's potential intelligence. Babies without complete exclusive breastfeeding are more vulnerable to malnutrition. They face risks of both under-nutrition and over-nutrition. This study aims to determine the correlation between exclusive breastfeeding and nutritional status among infants in Kuta Cot Glie Public Health Center, Aceh Besar. This research was an analytical study with a cross-sectional approach. The sample consisted of 74 infants aged 0-6 months, selected using a Total Sampling technique. The study was conducted from May 1st to 23rd, 2025. The data were analyzed using univariate and bivariate methods with the Chi-Square test. Of the total 74 respondents, 44 respondents (59.5%) had a normal nutritional status. Additionally, 43 respondents (58.1%) were exclusively breastfed. The Chi-Square test showed a p-value = 0.001 < 0.05. The findings indicate a correlation between exclusive breastfeeding and nutritional status in infants. This study suggests that mothers exclusively breastfeed their babies. Therefore, mothers should also increase their knowledge by seeking information from various sources, such as clinics and professionals. This can help them understand the benefits of exclusive breastfeeding and how to prevent malnutrition in infants.
Pendekatan In Silico dalam Penemuan Senyawa Bioaktif Tanaman sebagai Kandidat Obat Antidiabetes Fatihatul Makia, Fina; Amin, Saeful
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1887

Abstract

This paper presents a narrative review focusing on the significance of in silico methodologies in identifying and evaluating natural bioactive compounds as promising antidiabetic agents. By examining scientific publications from 2020 to 2025, the review highlights substantial evidence that various plant-derived metabolites such as flavonoids, phenolic acids, terpenoids, and glycosides from Orthosiphon stamineus, Moringa oleifera, Syzygium polyanthum, Tinospora crispa, and Albizia saman demonstrate notable affinity toward several crucial enzymes implicated in type 2 diabetes, including DPP-4, SGLT-2, α-glucosidase, and PTP1B. Findings from molecular docking analyses and ADMET simulations indicate that many of these compounds exhibit favorable pharmacokinetic behavior, strong receptor interactions, and minimal toxicity, suggesting their potential as multitarget natural therapeutics with synergistic modes of action. Utilizing in silico screening as an initial step effectively predicts biological activity and pharmacological profiles prior to experimental validation through in vitro and in vivo testing, thus reducing both time and research expenditure. The synergy between computational modeling, medicinal chemistry, and phytochemical exploration establishes a scientific framework that supports the advancement of rational, safe, and sustainable herbal-based antidiabetic drug development derived from Indonesia’s vast biodiversity and encourages self-reliance within the national pharmaceutical sector.

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