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Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan
Published by Asosiasi Riset Ilmu Kesehatan Indonesia
ISSN : 3031013X     EISSN : 30310148     DOI : 10.61132
Core Subject : Health,
Health Professions Nursing Public Health
Organisasi Farmasi, Kedokteran, Kimia Organik Sintetis, Kimia Alam, Biokimia, Analisis Kimia, Kimia Fisika, Biologi, Mikrobiologi, Jaringan Budaya, Botani dan Hewan terkait Produk Farmasi, Keperawatan, Kebidanan, Analis Kesehatan, Gizi dan Kesehatan Masyarakat.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 378 Documents
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Gambaran Pengetahuan Sikap dan Tindakan Terhadap STBM Pilar Pertama Stop BABS di Desa Haya Kecamatan Tehoru Kabupaten Maluku Tengah Baharudin Layn
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1949

Abstract

The background of this study is the practice of open defecation (OD), which is a public health problem. OD refers to the act of disposing of feces in open areas such as rice fields, fields, bushes, rivers, and beaches, which can pollute the environment, soil, air, and water. This study aims to determine the knowledge, attitudes, and practices of the community in RT 05 Haya Village, Tehoru District, Central Maluku Regency regarding stopping ODD. This study used a descriptive method, with a sample of 40 families selected through a random sampling technique. Data were collected using a questionnaire. The results showed that most people had quite good knowledge about ODD, with 50% of respondents in the quite good category. Community attitudes were also quite good, with 70% of respondents showing a positive attitude towards stopping ODD. However, community actions were still less good, with 42.5% of respondents showing less good actions regarding ODD. The conclusion of this study is that although the knowledge and attitudes of the community in Haya Village were quite good, their actions were still lacking. Therefore, cooperation is needed between the village government, Tehoru Health Center, and community leaders to regularly hold outreach regarding BABS.
Identifikasi Bakteriuria Asimtomaik pada Siswa SMA Kristen Passo Kota Ambon Tahun 2025 Yulianti Ely
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1950

Abstract

The background of this study is bacteriuria, which is a cause of Urinary Tract Infections (UTIs). Bacteriuria indicates the growth of microorganisms in the urine, which is influenced by increased secretion of the hormone progesterone. This study aims to determine the characteristics of asymptomatic bacteriuria in Passo Christian High School students. The method used in this study is a descriptive method with a total sample of 25 students selected using a total sampling technique. The results showed that respondents were aged between 15 and 20 years, with 18 male respondents (72%) and 7 female respondents (28%). The results of urine culture and colony count examinations showed that 25 respondents (100%) had negative results, meaning that no bacteriuria was detected in these students. The conclusion of this study is that no indication of asymptomatic bacteriuria was found in Passo Christian High School students, indicating that in this sample, none of the students experienced urinary tract infections caused by bacteriuria.
Can Aquatic Bacteria Save The Planet? A Review of Gene Expression Technologies Associated with the Degradation of Plastic Polymers / Review Article Muna Mohammed Khayri; Hiba Naser Ali Alsahoo; Abdalkader Saeed Latif; Reyam Naji Ajmi
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1834

Abstract

The global environmental crisis caused by plastic pollution has intensified in recent years, particularly in aquatic ecosystems such as rivers, lakes, and oceans, creating an urgent need for effective and sustainable solutions. This article explores the potential role of aquatic bacteria in degrading plastic polymers by reviewing the biological and molecular mechanisms these microorganisms use to break down complex synthetic materials. Special attention is given to key genes and enzymes involved in plastic degradation, including PETase and MHETase, which play a critical role in the decomposition of polyethylene terephthalate (PET). In addition, the article highlights advanced gene expression and analysis techniques, such as metagenomics, transcriptomics, and proteomics, to better understand bacterial activity and degradation dynamics in natural environments. The main problem addressed is the continuous and unsustainable production and consumption of plastics, which has resulted in extensive pollution of freshwater and marine systems, while conventional waste treatment methods remain largely ineffective. The objective of this article is to provide a comprehensive scientific review of biotechnological approaches used to analyze and utilize aquatic bacteria for plastic degradation, focusing on molecular aspects and environmental applications. Using a literature review method, studies published between 2018 and 2024 were analyzed to evaluate effective bacterial models, technological challenges, and future prospects. The findings indicate that aquatic bacteria offer promising potential as biological tools for mitigating plastic pollution through sustainable environmental strategies.
Synthesis of Vanadium Pentoxide (V₂O₅) by Green Method Using Olive Oil as A Reducing Agent and Study of its Physical Properties Saleh Yaseen, Ahmed; Yosef Othman Homeda; Mohammad M. Al-Tufah; Mutlak Saud Khalaf; Mohannd Faisal Shareef
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1943

Abstract

This study reports the green synthesis of vanadium pentoxide (V₂O₅) using virgin olive oil as a natural and environmentally benign reducing agent. The approach aims to minimize the environmental impacts associated with conventional synthesis routes. Structural and physicochemical characterizations confirmed the successful formation of nanoscale V₂O₅. X‑ray diffraction (XRD) analysis indicated an average crystallite size of approximately 16.57 nm, evidencing high crystallinity. Fourier‑transform infrared spectroscopy (FTIR) revealed characteristic V=O and V–O–V vibrations with bands associated with physisorbed water, confirming the correct oxide framework. Field‑emission scanning electron microscopy (FE‑SEM) showed irregularly shaped nanoparticles with a representative particle diameter of ~32.62 nm. Brunauer–Emmett–Teller (BET) and Barrett–Joyner–Halenda (BJH) analyses yielded a specific surface area of 10.817 m²/g, a total pore volume of 0.024277 cm³/g, and a broad mesoporous distribution (20–90 nm). Energy‑dispersive X‑ray spectroscopy (EDX) confirmed the purity of V₂O₅ with weight fractions of V (69.40%) and O (30.60%), consistent with the stoichiometric composition. Overall, the results demonstrate the effectiveness of olive oil as a green reducing agent for preparing nanoscale V₂O₅, which is promising for catalysis, energy storage, sensors, and clean‑energy applications.
Pengukuran Emisi Gas Buang pada Bus Antar Kota di Terminal Transit Passo Kecamatan Baguala Kota Ambon Kornelis U. Rumselly; Arfan Ohorella
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1959

Abstract

Background. Public transportation of vehicles coming in and going out from the Passo Transit Terminal, along with its location close to the market, can influence the levels of CO and HC in the exhaust gases from the vehicles. This can affect the air quality around the area. This is because the intercity buses use diesel fuel, some of them are old, and others have been operating for about 10 years with only 4 to 5 months before their last maintenance. Because of this, the researcher wants to study the levels of CO and HC in the exhaust gas emissions from the vehicles. Research Objective. To check the air quality of the exhaust gas emissions from intercity buses at the Passo Transit Terminal. Method. This study is a descriptive research that includes laboratory tests conducted at the HipperKes Laboratory Center. The population of this study includes 20 intercity buses, with a sample of 2 buses selected based on inclusion and exclusion criteria. Results and Discussion. The results of the CO levels show that bus 1 has 1.77% and bus 2 has 0.22%, which exceed the standard quality level of 0.5% as stated in the Regulation of the Minister of Environment and Forestry Number 8 of 2023. Conclusion and Suggestions. The parameters measured do not meet the required exhaust emission quality standards. The community and passengers are encouraged to increase awareness and use personal protective equipment such as masks
Serum Irisin and Asprosin Levels as Potential Biomarkers an Type 2 Diabetes Mellitus and its Renal Complications: A Biochemical Investigation of Hormonal and Metabolic Profiles Rasool, Aqeel M.; Alaa Hussein J. Al-Qaisi
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 1 (2026): Januari: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i1.1960

Abstract

This study investigates the levels of asprosin and irisin in patients with type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN), and evaluates their relationships with insulin resistance, glycemic control, and renal function. Additionally, it explores their diagnostic performance as potential non-invasive biomarkers for the early detection of DN using ROC curve analysis. A controlled prospective study was conducted involving 130 participants, categorized into healthy controls, T2DM patients, and T2DM with DN. Serum asprosin, irisin, and insulin levels were measured using ELISA, while biochemical and renal parameters such as fasting blood glucose, HbA1c, creatinine, urea, and eGFR were assessed using standard spectrophotometric techniques. ROC analysis was employed to assess the diagnostic accuracy of asprosin and irisin. Asprosin levels were significantly elevated, while irisin levels were markedly reduced in DN patients compared to T2DM and control groups (p < 0.001). Moreover, DN patients exhibited higher levels of fasting glucose, HbA1c, HOMA-IR, creatinine, and urea, with lower eGFR, indicating substantial renal dysfunction. ROC analysis revealed that asprosin had an AUC of 0.910 (95% CI: 0.839–0.981), with 90.0% sensitivity and 88.9% specificity at a cutoff value of 11.27 ng/mL. Irisin showed an AUC of 0.886 (95% CI: 0.812–0.960), with 95.0% sensitivity and 71.1% specificity at a 158.25 ng/mL cutoff. Asprosin and irisin are strongly associated with insulin resistance and renal impairment in patients with T2DM and DN. Their high diagnostic performance supports their utility as promising non-invasive biomarkers for the early detection and monitoring of diabetic nephropathy progression.
The Impact of Polycyclic Aromatic Hydrocarbons on Environment and Humans Zeinab Ali Mohammad
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1964

Abstract

This research seeks to define polycyclic aromatic compounds, which are chemical compounds consisting of fused aromatic rings that do not contain heteroatoms or substituents. Many of these compounds are known to be carcinogenic and are primarily produced through the incomplete combustion of carbon-containing fuels such as wood, coal, diesel, grease, and tobacco. Pure polycyclic aromatic compounds generally appear as colorless, white, or pale green solids that often develop a yellowish tint over time. These substances are commonly found in coal tar, crude oil, creosote, and tar deposits in industrial and urban environments. Despite their widespread occurrence and potential health risks, only a limited number of polycyclic aromatic compounds are utilized in industrial applications, including the manufacture of medicines, dyes, plastics, and pesticides. Furthermore, this research examines the distribution, persistence, and accumulation of these compounds in the environment, as well as their toxicological effects on human health, ecosystems, and long-term environmental sustainability.
Pengaruh Tehnik Relaksasi Benson terhadap Fungsi Kognitif Lansia Penderita Hipertensi Asrina Pitayanti; Priyoto Priyoto; Iva Milia Hani
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 3 No. 6 (2025): November: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v3i6.1987

Abstract

Benson Relaxation Technique on improving cognitive function in elderly with Hypertension. Using a Quasi-Experimental design with a One-Group Pretest-Posttest Design approach. The research sample of 10 elderly with Hypertension who showed indications of mild cognitive impairment, was taken through a Purposive Sampling technique. The Benson Relaxation Technique intervention was given 3 times a week for 2 consecutive weeks (a total of 6 sessions), with a duration of 15-20 minutes per session. Cognitive function was measured using the Mini-Mental State Examination instrument. Analysis used the Wilcoxon Signed Rank Test. The Pretest results showed all respondents were in the Mild Cognitive Impairment category. After the intervention, there was a significant increase in cognitive function: 40% of respondents experienced an increase in status to the Normal category while the other 60% remained in the Mild Cognitive Impairment category. The bivariate test Mann-Whitney U test showed a significance value of p = 0.001 (<0.05). These results prove a significant difference between cognitive scores after the Benson Relaxation intervention. Research results show that the Benson Relaxation Technique effectively improves cognitive function. Benson Relaxation activates the parasympathetic nervous system, improving memory and attention in elderly people with hypertension.
Pengaruh Pemberian Pill Card terhadap Kepatuhan Minum Obat Antihipertensi pada Pasien Hipertensi Rawat Jalan Puskesmas Rawat Inap Satelit Bandar Lampung Audry Lintang Hasanuddin; Rasmi Zakiah Oktarlina; Dwi Aulia Ramdini; Oktafany Oktafany
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 1 (2026): Januari: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i1.2004

Abstract

Hypertension is one of the most common non-communicable diseases in Indonesia. Hypertensive patients must have high self-efficacy to comply with antihypertensive medication so that blood pressure can be controlled and complications prevented. Therefore, intervention is needed to improve therapy compliance. One intervention that can be given is the provision of pill cards. This study was a quasi-experimental design with a pre-intervention post-intervention control group design. Sampling was conducted using non-probability purposive sampling from July to September 2025. A total of 106 respondents were divided into two groups, with 53 respondents in the control group and 53 respondents in the intervention group. The control group was only given the MMAS-8 questionnaire, while the intervention group was given pill cards and the MMAS-8 questionnaire. In the intervention group, prior to intervention, 25 patients (47.2%) had low compliance, 21 patients (39.6%) had moderate compliance, and 7 patients (13.2%) had high compliance. After the intervention, there was a significant increase, with 21 patients (39.6%) showing high compliance, 26 patients (49.1%) showing moderate compliance, and 6 patients (11.3%) showing low compliance. Providing pill cards to outpatients with hypertension can improve patient medication adherence. Based on the results of the Wilcoxon Signed Ranks Test, a value of (p<0.001) was obtained, indicating that H0 was rejected and there was a significant effect.
Profil Aktivitas Farmakologis Daun Pepaya Segar pada Sistem Saraf: Suatu Kajian Berdasarkan Perbedaan Konsentrasi Nurul Izzatul Jannah; Husnul Hatima; Dhiva Rabiatul Maulia; Nurazizah Khairani; Fauziah Zakilah; Rahasia Rahasia; Sisma Efendi; Nur Aulia; Muh.Yusuf Al Habib Rachman; Andi Utari Prasetya Ningrum
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 1 (2026): Januari: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i1.2010

Abstract

The extract of Carica papaya L. leaves contains phytochemical compounds such as flavonoids, alkaloids, phenolics, and saponins that play a role in biological activities, including antioxidants, anti-inflammatory, analgesic, and modulation of the nervous system. This study aims to evaluate the effects of fresh papaya leaf extract on the central nervous system (CNS) and autonomic nervous system based on varying extract concentrations. The study used test animals with treatment groups consisting of negative control, positive control, and extracts at concentrations of 4%, 8%, and 16%. Parameters observed included parasympathomimetic (PSM), parasympatholytic (PSL), sympathomimetic (SM), sympatholytic (SL), analeptic effects (ANA), CNS stimulation (SSSP), CNS depression (DSSP), and muscle relaxation (RO). The results showed that the 16% concentration produced the highest PSM activity (46.82%) and dominant CNS stimulation (38.59%), while DSSP and RO decreased at higher concentrations. This phenomenon indicates that increasing the extract concentration does not always enhance CNS depression, but rather leads to stimulation. These findings support the potential of papaya leaf extract as a neuroprotective and multifunctional agent. Further research is needed to confirm its molecular mechanisms and clinical effectiveness as a phytotherapy candidate.

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