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Mohammad Rizki Fadhil Pratama
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Borneo Journal of Pharmacy
Published by Universitas Muhammadiyah Palangkaraya
ISSN : -     EISSN : 26214814     DOI : https://doi.org/10.33084/bjop
Core Subject : Health,
Medicine & Pharmacology
Borneo Journal of Pharmacy publishes various scientific articles covering Pharmacy and Pharmaceutical Sciences in the field but not limited to: Pharmacology-Toxicology, including pharmacokinetics, pharmacodynamics, pharmacotherapy, and toxicology. Pharmacognosy-Phytochemistry, including pharmacognosy, phytochemistry, ethnobotany, and ethnopharmacology. Pharmaceuticals, including biopharmaceuticals, pharmaceutical technology, formulations, and biotechnology. Analytical Pharmacy-Medicinal Chemistry, including pharmaceutical chemistry, chemical analysis, medicinal chemistry, bioinformatics, pharmacy physics, pharmaceutical analysis, and method validation. Microbiology Pharmacy, including the antibacterial, antifungal, and antiviral activity test. Natural Product Development, including testing the pharmacological activity of extracts, fractions, and plant isolates. Clinical-Community Pharmacy, including monitoring usage, side effects, counseling, and drug use evaluation. Management Pharmacy, including drug management, drug use profiles, pharmaceutical administration, and marketing.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 300 Documents
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Diuretic Activity of Various Herbs in India: A Mini Review Shaikh, Sufiyan Yusuf; Shaikh, Aftab Tanveer; Shaikh, Moinuddin Arif
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.5217

Abstract

One of the primary uses of medicinal plants is as a diuretic. Both mono- and polyherbal-based diuretic formulations have been used in various parts of the world, including in India. One estimate states that more than 650 mono- and polyherbal formulations are in clinical use, including decoctions, tinctures, pills, and capsules made from over 75 plants. Many studies have been conducted supporting the diuretic properties of conventional herbal remedies. This article discusses many herbal plants from India that have historically been used as diuretics and identifies the chemical components with diuretic activity. In addition, this brief review also discusses several plant drugs and their pharmacological profile, concentrating on the administered dose and the bioactive extracts involved in the diuresis process. For researchers, searching for the best therapeutic plants for diuretic research may be a significant turning point in using various herbs from India.
Multiple Sclerosis: Current Knowledge of the Pathology and Use of Monoclonal Antibodies as a Promising Therapy Castellón-Arias, Josué; Gazel-Meléndez, Luana; Guido-Villalobos, Rebeca; Jiménez-Díaz, Ariela; Valera-Rangel, Johana; Mora-Román, Juan José
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.5317

Abstract

Multiple sclerosis is an autoimmune condition characterized by an inflammatory condition and neuron demyelination, leading to a significant deterioration in the patient's quality of life as the disease progresses. The immune system reactivity in this pathology is mainly mediated by reactive T lymphocytes against myelin. The harmful substances production and proinflammatory cell infiltration occur. Currently, there is no cure, so treatment focuses on reducing the development of the individual's long-term disability by addressing symptoms, acute exacerbations, and slowing progress. The traditional treatment includes immunosuppressive substances such as corticosteroids and interferons. However, an approach to more specific, highly effective therapies such as monoclonal antibodies is currently being sought. Ofatumumab, ocrelizumab, alemtuzumab, and rituximab are commercialized monoclonal antibodies. Likewise, therapies in the research phase, such as ublituximab, inebilizumab, GNbAC1, and elezanumab, can be found. Therefore, research must continue to have more information to increase the availability of therapeutic options for patients.
Aloe vera Gel Ameliorates Fat-Rich and High Fructose (FRHF) Diet-Induced Pancreatic and Splenic Damage in Mice Nathan Isaac Dibal; Zainab Muhammad Goni; Martha Orendu Oche Attah; Umar Imam; Muhammad Abdullahi; Muzammil Bashir; Usman Adam; Fatima Aisami; Mohammed Shuwa; Sunday Joseph Manye; Madu Nom Gadzama; Musa Samaila Chiroma; Helga Bedan Ishaya
Borneo Journal of Pharmacy Vol. 6 No. 3 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i3.5351

Abstract

High-fat diet alone or in combination with high fructose has been known to induce diabetes, obesity, hypertension, and immune dysfunction. The study evaluates the role of Aloe vera in fat-rich and high fructose diet-induced (FRHFD) hyperglycemias in addition to testicular and splenic morphology in mice. Twenty BALB/c Mice were randomly distributed into four groups (n=5). The groups were fed on a normal diet, FRHFD, FRHFD + 10 g A. vera, and FRHFD + 20 g A. vera for 10 weeks. All the mice were sacrificed a day after the 10 weeks of treatment. The result showed that mice fed on FRHFD plus A. vera had a significantly lower (p<0.05) blood glucose level relative to the FRHFD-fed mice. The mice fed on FRHFD plus A. vera had a significantly lower (p<0.05) blood glucose level relative to the FRHFD-fed mice. Aloe vera was found to ameliorate FRHFD-induced pancreatic islet and acini damage. It also prevented distorted lymphoid cells and testicular damage induced by FRHFD. Aloe vera prevents hyperglycemia and protects pancreatic islets in FRHFD-fed mice. It further prevents immune dysfunction and protects against testicular damage. Hence, A. vera supplementation could be an alternative and/or complementary therapy for hyperglycemia-related disorders.
Genetic CYP2A6 Polymorphism May Worsen Glycohemoglobin Levels: Study among Javanese Indonesian Smokers Patramurti, Christine; Virginia, Dita Maria
Borneo Journal of Pharmacy Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i1.5467

Abstract

We have examined the inactive CYP2A6 alleles gene, including CYP2A6*4, CYP2A6*7, and CYP2A6*9, associated with glycohemoglobin levels among Javanese Indonesian smokers. There are 106 smokers participating in this study. Due to the number of cigarettes smoked per day, there are three groups of smokers: light, intermediate, and heavy smokers, with 98.7% being light and intermediated smokers while the rest are heavy smokers. All participants had smoked for more than 10 years, indicating they had been exposed to nicotine for a long time. Based on their genotype, there were four groups of smokers, including fast, intermediate, slow, and poor metabolizers. Most fast and intermediate metabolizers have HbA1c levels in the normal range (<5.7). On the other hand, most slow metabolizers have Hb1c levels >5.7, and all fast metabolizers have HbA1c levels >5.7, indicating that they the prediabetes and diabetes. The chi-square test showed a relationship between CYP2A6 polymorphism and HbA1c levels among the participants (P-value 0.000 <0.005 and χ2=54.6, df=1). The presence of an inactive allele will worsen the HbA1c levels in smokers.
Marine Sponge Xestospongia sp.: A Promising Source for Tuberculosis Drug Development - Computational Insights into Mycobactin Biosynthesis Inhibition Arfan, Arfan; Asnawi, Aiyi; Aman, La Ode
Borneo Journal of Pharmacy Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i1.5513

Abstract

Mycobacterium tuberculosis (MTB) remains the leading cause of infection, with a significant fatality rate, owing primarily to drug resistance. MTB contains the enzyme salicylate synthase, which regulates mycobactin production to bind iron ions from the host cell, facilitating the bacteria to grow and reproduce. This study investigates the potential of marine sponges to inhibit the MTB salicylate synthase by exploiting a computational approach combining molecular docking and dynamics simulations. Forty-six compounds from Xestospongia sp. were chosen from the Marine Natural Products database. The docking results selected four compounds (CMNPD15071, CMNPD7640, CMNPD26706, and CMNPD7639) from this sponge, which provide more negative binding energy than their inhibitors (RVE). After reclassifying their interactions, such as hydrophobic and hydrogen bonds, CMNPD15071 (Sulfuric acid mono-(8-methoxy-12b-methyl-6-oxo-2,3,6,12b-tetrahydro-1H-5-oxa-benzo[k]acephenanthrylen-11-yl) ester) and CMNPD7640 (secoadociaquinone B) performed molecular dynamics simulations to assess their stability. These two compounds show a promising stability profile compared to RVE based on RMSD, RMSF, SASA, and gyration analysis. Furthermore, the binding affinity prediction of these two compounds using the MM/GBSA calculation method reveals that CMNPD15071 (-38.48 kJ/mol) had the highest affinity for binding to MTB salicylate synthase compared to RVE (-35.36 kJ/mol) and CMNPD7640 (-26.03 kJ/mol). These findings demonstrate that compounds from Xestospongia sp. can block MTB mycobactin biosynthesis by inhibiting salicylate synthase.
Nanoemulsion Mouthwash Formulation of Bajakah Tampala (Spatholobus littoralis Hassk.) Skin Extract Against Candida albicans Hamzah, Hasyrul; Gunawan, Dede Reza; Pratiwi, Sylvia Utami Tunjung; Bakhtiar, Muh. Irham; Pratama, Virgiawan Yoga; Subhan, Muhammad; Maulana, Riza
Borneo Journal of Pharmacy Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i1.5548

Abstract

Candida albicans can cause two infections in humans: superficial and systemic. The ability of C. albicans to infect the host is influenced by virulence factors and character changes so that it can fool the immune system. From the character change factor, C. albicans can form a biofilm. This study aims to determine the good concentration in inhibiting and determine the antifungal and antibiofilm activity of nanoemulsion mouthwash formulation of bajakah tampala (Spatholobus littoralis Hassk) skin extract against C. albicans. This research was conducted with an experimental method. The formulation used a spontaneous magnetic stirrer technique to make nanoemulsion preparations. Antifungal and antibiofilm tests were carried out by dilution method using a 96-well plate and a microplate reader with a wavelength of 620 nm to determine the percentage inhibition against C. albicans and determine MIC50 and MBIC50. The results showed that the nanoemulsion mouthwash formulation of S. littoralis inhibited the planktonic and biofilm of C. albicans. The concentration of 1% is expressed as MIC50 and MBIC50. Therefore, the nanoemulsion formulation of S. littoralis extract could inhibit the growth of C. albicans in the oral cavity.
Cover, Content, and Editorial Note from Borneo J Pharm Vol. 6 No. 2 May 2023 Chief Editor of Borneo J Pharm
Borneo Journal of Pharmacy Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i2.5599

Abstract

Assalamu’alaikum Wr. Wb. Alhamdulillahirabbil ‘alamin. The next edition of the Borneo Journal of Pharmacy (Borneo J Pharm) was published in May 2023. This edition contains ten articles: Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceutical, Analytical Pharmacy-Medicinal Chemistry, Natural Product Development, and Management Pharmacy. This edition includes writings from five countries: Indonesia, Nigeria, the Philippines, Taiwan, and the United States. The authors come from several institutions, including Universitas Ahmad Dahlan, Universitas Muhammadiyah Mataram, University of California, Los Angeles, National Research and Innovation Agency Republic of Indonesia, Universitas Muhammadiyah Prof. Dr. HAMKA, Universitas Muhammadiyah Kalimantan Timur, Universitas Gadjah Mada, Universitas Sembilanbelas November Kolaka, Universitas Halu Oleo, Universitas Lambung Mangkurat, Universitas Jenderal Achmad Yani, Ahmadu Bello University, Institut Kesehatan Helvetia, Taipei Medical University, Sekolah Tinggi Ilmu Farmasi Riau, University of the Philippines Manila, and Universitas Diponegoro. Editorial boards are fully aware that there is still room for improvement in this edition; hence with all humility, willing to accept constructive suggestions and feedback for improvements to the publication for the next editions. The editorial board would like to thank all editors and reviewers, and contributors of the scientific articles who have provided the repertoire in this issue. We hope all parties, especially the contributors, can re-participate for publication in the next edition on August 2023. Wassalamu’alaikum Wr. Wb.
Bibliometric Study of Microwave-Assisted Synthesis of Flavanone Derivatives Poerwono, Hadi; Rudyanto, Marcellino
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.5602

Abstract

This study aims to describe various studies related to synthesizing flavanone derivatives using the microwave-assisted method with a bibliometric approach. Metadata information was collected from Scopus on June 30th, 2023, with three keywords (microwave-assisted OR microwave, synthesis, and flavanone) searched for article titles, abstracts, and keywords. Analysis and research mapping were carried out with VOSviewer. Of the 33 articles relevant for analysis, 15 keyword clusters were obtained, most of which contained a list of flavanone derivatives. Interestingly, none of these clusters contain keywords for well-known compounds from the flavanone group, such as pinostrobin, pinocembrin, or hesperetin. In other words, there is an excellent opportunity to obtain novelty for microwave-assisted derivatization studies of flavanones. The chances of publication of these studies are greater in Chemistry of Heterocyclic Compounds (Springer Nature), Oriental Journal of Chemistry (Scientific Publishers), and Tetrahedron Letters (Elsevier), each with three documents. Meanwhile, most researchers on this topic come from India with 13 documents. This information allows researchers on this topic to determine potential flavanones that have the opportunity to be derivatized by the microwave-assisted method.
Rilmenidine Protects Against Joint Damage in MIA-induced Model of Osteoarthritis in Rats Osman Kukula; Mustafa Nusret Çiçekli; Caner Günaydın; Seda Kırmızıkan; Selenay Sevinç Şarklıoğlu
Borneo Journal of Pharmacy Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i1.5864

Abstract

Osteoarthritis is a common problem, and its incidence significantly increases with age. Patients suffer from excruciating pain while moving, and currently, major treatment options consist of surgery. Rilmenidine is a potent antihypertensive agent with a high affinity for imidazoline and alpha2 adrenergic receptors. Based on the knowledge that these receptors are also related to bone turnover and pain, we aimed to reveal the effect of rilmenidine on the osteoarthritis model in rats. Monosodium iodoacetate was used to induce osteoarthritis. Animals were treated with rilmenidine (0.5, 2 mg/kg) for 14 days. A hot plate test was performed to assess pain response before and end of the drug treatments, in addition to the walking track analysis. Twenty-four hours after the last drug treatment, serum levels of receptor activator of nuclear factor kappa-Β ligand and osteoprotegerin were measured. Hematoxylin eosin and safranin-O staining were used to evaluate monosodium iodoacetate and rilmenidine-induced changes in the hindlimb joints. Our results demonstrate that rilmenidine(2 mg/kg) prevented monosodium iodoacetate-induced thermal hyperalgesia with improved walking behavior in the walking track test. Additionally, rilmenidine(2 mg/kg) prevents monosodium iodoacetate-induced increase in the nuclear factor kappa-Β ligand and osteoprotegerin levels in the serum. Histopathological analysis shows that rilmenidine is protective on the joint capsules and matrix. Our results suggest that rilmenidine shows an antinociceptive effect on monosodium iodoacetate-induced osteoarthritis via improving bone turnover.
Comparative Phytochemical Profiling and Biological Activities in the Flowers and Stalks of Tulbaghia violacea Maleka, Gontse; Oyerinde, Rebecca Opeyemi; Risenga, Ida Masana
Borneo Journal of Pharmacy Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i1.6035

Abstract

Tulbaghia violacea is indigenous to Southern Africa and has been used extensively in traditional medicine in this region. Extensive research has been documented on the bioactive compounds found in the leaves and roots but not in the flowers and stalks. Thus, this study assessed the phytochemical profile and biological activities in the flowers and stalks of T. violacea. Methanolic and aqueous extracts of the air and freeze-dried T. violacea were screened for phytochemicals, and then antioxidant and antibacterial assays were performed. Phytochemicals such as phenols, tannins, flavonoids, coumarins, and terpenoids are present in either of the tested plant parts. The flowers contain most of the phytochemicals being tested and a higher total phenolic, tannin, and proanthocyanidin content than the stalks. The flowers exhibit the strongest scavenging activity against 2,2-diphenylpicryhydrazyl radicals and metal oxidants. The hydrogen peroxide scavenging activities show that the aqueous flower extracts have a higher radical scavenging activity than stalks. In contrast, the methanolic stalk extracts have a higher antioxidant activity than the flowers. Antibacterial activity is only exhibited in the flowers, showing resistant and intermediate inhibition zones of Escherichia coli and Staphylococcus aureus growth, respectively. This study validates the use of T. violacea in traditional medicine, and these results are significant for conserving the species as specific plant parts can be harvested to treat specific ailments. This study suggests the potential application of T. violacea, particularly the flowers and stalks, in the pharmaceutical and cosmetic sectors.

Page 22 of 30 | Total Record : 300

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