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Mohammad Rizki Fadhil Pratama
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Borneo Journal of Pharmacy
Published by Universitas Muhammadiyah Palangkaraya
ISSN : -     EISSN : 26214814     DOI : https://doi.org/10.33084/bjop
Core Subject : Health,
Medicine & Pharmacology
Borneo Journal of Pharmacy publishes various scientific articles covering Pharmacy and Pharmaceutical Sciences in the field but not limited to: Pharmacology-Toxicology, including pharmacokinetics, pharmacodynamics, pharmacotherapy, and toxicology. Pharmacognosy-Phytochemistry, including pharmacognosy, phytochemistry, ethnobotany, and ethnopharmacology. Pharmaceuticals, including biopharmaceuticals, pharmaceutical technology, formulations, and biotechnology. Analytical Pharmacy-Medicinal Chemistry, including pharmaceutical chemistry, chemical analysis, medicinal chemistry, bioinformatics, pharmacy physics, pharmaceutical analysis, and method validation. Microbiology Pharmacy, including the antibacterial, antifungal, and antiviral activity test. Natural Product Development, including testing the pharmacological activity of extracts, fractions, and plant isolates. Clinical-Community Pharmacy, including monitoring usage, side effects, counseling, and drug use evaluation. Management Pharmacy, including drug management, drug use profiles, pharmaceutical administration, and marketing.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 300 Documents
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Iron-Overload Conditions: Manifestations to the Kidney Organs – A Review Heriatmo, Nadia Larasinta; Estuningtyas, Ari; Soetikno, Vivian
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.4411

Abstract

Excess iron is a risk factor for organ dysfunction and damage resulting in various organ diseases such as liver, heart, and kidney, diabetes mellitus, and neurodegenerative diseases. Iron overload in some individuals is caused by various factors, including genetic predisposition such as genetic hemochromatosis, repeated transfusion of red blood cells, and parenteral iron administration in conditions of transfusion-dependent anemia. A disturbance in the globin gene in diseases such as β-thalassemia major causes an imbalance of the globin chain, resulting in chronic anemia in the sufferer. It has been reported that the human body does not have a mechanism for eliminating excess iron levels. Routine transfusion has become a solution to overcome chronic anemia so that patients can maintain hemoglobin levels, and the result of this transfusion repetition is the accumulation of iron in various organs, such as the heart, liver, endocrine glands, pancreas, lungs, and kidneys. Excess iron can be toxic to the body due to the formation of harmful free radicals that can damage cells and tissues. An increase in excessive ROS can result in the saturation of the antioxidant system. The presence of free radicals can lead to damage and the occurrence of filtration dysfunction in the glomerulus.
Cover, Content, and Editorial Note from Borneo J Pharm Vol. 5 No. 4 November 2022 Chief Editor of Borneo J Pharm
Borneo Journal of Pharmacy Vol. 5 No. 4 (2022): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v5i4.4444

Abstract

Assalamu’alaikum Wr. Wb. Alhamdulillahirabbil ‘alamin. The next edition of the Borneo Journal of Pharmacy (Borneo J Pharm) has been published in November 2022. This edition contains ten articles: Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceutical, Analytical Pharmacy-Medicinal Chemistry, Microbiology Pharmacy, Natural Product Development, and Clinical-Community Pharmacy. This edition includes writings from three countries: China, Indonesia, and Nigeria. The authors come from several institutions, including IPB University, Universitas Pembangunan Nasional Veteran Jakarta, Universitas Pelita Harapan, Adamawa State Polytechnic, Modibbo Adama University of Technology, Yola, Universitas Abdurrab, Universitas Gadjah Mada, Universitas Borneo Lestari, Universitas Airlangga, Universitas Islam Negeri Maulana Malik Ibrahim Malang, National Research and Innovation Agency Republic of Indonesia, Kebbi State University of Science and Technology, Aliero, Institut Sains dan Teknologi Nasional, Sekolah Tinggi Ilmu Farmasi Makassar, Universitas Ahmad Dahlan, and The First Affiliated Hospital of Nanjing Medical University. Editorial boards are fully aware that there is still room for improvement in this edition; hence with all humility, willing to accept constructive suggestions and feedback for improvements to the publication for the next editions. The editorial board would like to thank all editors and reviewers, and contributors of the scientific articles who have provided the repertoire in this issue. We hope that all parties, especially the contributors, can re-participate for publication in the next edition on February 2023. Wassalamu’alaikum Wr. Wb.
An Initial Investigation of the Potential of Robusta Coffee, Arabica Coffee, and Caffeine in Asthma Treatment through the Evaluation of 5-Lipoxygenase Inhibition Activity Yuniarta, Tegar Achsendo; Handayani, Rosita
Borneo Journal of Pharmacy Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i1.4448

Abstract

Numerous studies have documented the potential of coffee to aid in asthma prevention. Nevertheless, research into how coffee influences asthma management has not been available. One known mechanism by which asthma medications work involves inhibiting 5-lipoxygenase (5-LOX) activity. This study aims to determine the potency of Coffea canephora var. Robusta extract (CRE), Coffea arabica extract (CAE), and caffeine are the primary isolates against 5-LOX activity. Extraction was performed by a reflux procedure using 96% ethanol with a sample-total solvent ratio of 1 : 10, an extraction time of 1 hour, and the extraction was conducted in triplicate. Fractionation was carried out by liquid-liquid partition using a chloroform-water system. Caffeine further purification was performed by the sublimation method, and the inhibition of 5-LOX activity was evaluated using the spectrophotometric method at λ = 234 nm. Apigenin was used as a positive control. From the experiment conducted, the IC50 of the CRE, CAE, caffeine, and apigenin against 5-LOX was 32.2 ± 1.4, 42.1 ± 2.3, 14.3 ± 1.6, and 7.4 ± 1.7 µg/mL, respectively. Continued efforts to isolate bioactive compounds from coffee extract led to the discovery of caffeine, which exhibited a more potent inhibitory effect on 5-LOX. The inhibition of 5-LOX activity by caffeine occurs in a non-competitive manner.
Antioxidant Activity and Phytochemicals of Locally Consumed Plant Foods from Baguio City, Philippines Paolo Robert P. Bueno; Rachel Camille R. Cabrera; Gracia Fe B. Yu
Borneo Journal of Pharmacy Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i2.4546

Abstract

In the Philippines, Baguio City – known as the “City of Pines” – holds the country’s major source of temperate climate vegetables. With increased dietary awareness, the consumption of plant foods rich in antioxidants has become relevant. Twenty-nine methanolic extracts from Baguio-produced plant foods were evaluated for antioxidant potential using DPPH, ferric reduction antioxidant power (FRAP), metal chelation, superoxide anion, nitric oxide, hydroxyl radical scavenging activities, MTT reduction, and phytochemical tests. Fagopyrum tataricum leaves, Vaccinium myrtoides fruit, and Morus alba fruit showed the most effective DPP radical, concentration-dependent reducing power, but low metal chelating activity. Solanum tuberosum tuber (22.86±63.26%) showed effective concentration-dependent chelating activity at 125 μg/mL. Citrus aurantium fruit (26.77±9.24%) and Raphanus raphanistrum root (41.13±0.11%) demonstrated an effective scavenging activity against superoxide anions at 45.5 μg/mL. Significant nitric oxide scavenging activity was observed in some fruits. Brassica oleracea Cab leaves (54.36 ± 2.38%) showed the highest inhibitory activity against hydroxyl radicals at 166.7 μg/mL. Phytochemical analyses showed that most plant samples revealed the presence of glycosides, terpenes/terpenoids, and steroids/phytosterols, while few contained phenolic and tannin components. These phytochemicals may explain the dual behavior as an antioxidant or a prooxidant observed. Thus, determining food antioxidant component types and their concentration is necessary to maximize the potential to scavenge oxidants.
Morphology Analysis of Hair Photoinduced and Chemical Damaged After Treatment with Sappan Wood (Caesalpinia sappan L.) Hair Tonic using SEM Sari, Dina Yuspita; Widyasari, Ratna; Astuti, Indri
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.4652

Abstract

Exposure to sunlight for a long time and repeatedly can also cause chemical and physical damage to human hair. Clinically, microscopic analysis using a scanning electron microscope (SEM) can assess hair damage by identifying the characteristic morphology of hair damage. This study aims to analyze the morphology of damaged hair chemically induced using 3% H2O2 and photoinduced UVB radiation before and after applying sappan wood (Caesalpinia sappan) hair tonic. The active ingredients used were ethanol extract, ethanol fraction, and chloroform-methanol fraction of C. sappan, which contains an antioxidant compound. Caesalpinia sappan simplicia was macerated using 96% ethanol and then partitioned using n-hexane. The ethanol fraction was then applied using vacuum column chromatography using chloroform : methanol (5 : 1) as eluent. The extracts and fractions were then formulated into hair tonic preparations. For SEM analysis, hair samples were coated with a sputter gold coater machine and divided into five treatments: undamaged hair, damaged hair with 3% H2O2 and UVB rays as a positive control, and treatment I, II, and III, in which the hair was damaged with 3% H2O2 and UVB rays respectively, then FI, FII, and FIII were applied, respectively (2000x magnification). Damaged hair with UVB induction shows moderate damage, and 3% H2O2 shows moderate to severe damage. The results in the treatment group show that the three hair tonics coated the hair cuticle, indicating an interaction with the hair fiber, and modified the cuticle by coating the cuticle.
Characterization of Secondary Metabolites Profile from Methanol Fraction of Temurui (Murraya koenigii (Linn.) Spreng) Leaves Using UPLC-MS Intania Permata; Adlis Santoni; Afrizal Afrizal; Trisno Afandi
Borneo Journal of Pharmacy Vol. 6 No. 3 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i3.4662

Abstract

The leaves of the temurui (Murraya koenigii (Linn.) Spreng) plant have long been known and used by Indonesian and even Asian people as a traditional medicine to treat stomach aches and diabetes. This study aimed to determine the secondary metabolite profile of the methanol extract of M. koenigii leaves. Murraya koenigii leaves fine powder was extracted in stages using n-hexane, ethyl acetate, and methanol. Each extract was prepared using a mixture of water, formic acid, acetonitrile, and formic acid, then injected into the UPLC-MS, then analyzed with MassLynx and ChemSpider. The results showed that the metabolite profile of the methanol extract of M. koenigii leaves contained 13 compounds, including phenolic, steroid, and alkaloid groups. Those compounds could be tested to identify their bioactivity.
Fibrinolytic Protease Activity of Crude Enzyme from Fermented Sunflower (Helianthus annuus) and Common Bean (Phaseolus vulgaris) seeds by Rhizopus microsporus var. oligosporus FNCC 6010 in Solid State Fermentation Rebhika Lusiana; Achmad Toto Poernomo; Achmad Syahrani
Borneo Journal of Pharmacy Vol. 6 No. 3 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i3.4665

Abstract

In the entire world, cardiovascular diseases (CVDs) are the main cause of death. For the treatment of CVDs, microbial fibrinolytic enzymes are highly regarded as novel therapeutic candidates. This study was purposed to determine the fibrinolytic protease activity produced by fungus source, which is Rhizopus microsporus var. oligosporus FNCC 6010 in fermented sunflower (Helianthus annuus) seed and common bean (Phaseolus vulgaris) seed. Fermentation was carried out by solid-state fermentation method at an initial pH of 5, incubation temperature of 33±1°C, and incubation time of 24 hours. The fermented seed was extracted to obtain supernatant as the crude enzyme. The proteolytic activity assay was done by the skimmed milk agar (SMA) plate method to obtain the proteolytic index, and the fibrinolytic activity assay was conducted by the fibrin-agarose plate method to get the fibrinolytic index. The results show that crude enzymes from fermented H. annuus and P. vulgaris seeds by R. microsporus have fibrinolytic protease activity with proteolytic index 2.64 ± 0.01 and 2.23 ± 0.04, respectively. The fibrinolytic index is 2.40 ± 0.06 and 1.64 ± 0.06, respectively. Therefore, the crude enzyme has the potential to be further researched as a candidate for thrombolytic agents. The purification, characterization, and in-depth research are needed to develop enzymes into preparations for preventing and treating CVDs.
In-Silico Design and Evaluation of the Anti-Wolbachia Potential of Boron-Pleuromutilins Fabian Audu Ugbe; Gideon Adamu Shallangwa; Adamu Uzairu; Ibrahim Abdulkadir
Borneo Journal of Pharmacy Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i2.4677

Abstract

Filariasis (Lymphatic filariasis and Onchocerciasis) is a common neglected tropical disease caused by parasitic nematodes called filarial worms, which often host the Wolbachia bacteria. A good treatment approach seeks Wolbachia as a drug target. Here, a computer-aided design of some boron-pleuromutilin analogs was conducted using the ligand-based drug design approach while performing molecular docking investigation and pharmacokinetics analyses to evaluate their drug-likeness properties. The newly designed compounds (49a, 49b, and 49c) showed improved inhibitory activities (pEC50) over those of the template and the clinically relevant pleuromutilins (retapamulin and lefamulin) in the order; 49b (pEC50 = 9.0409) > 49c (8.8175) > 49a (8.5930) > template (49) (8.4222) > retapamulin (6.7403) > lefamulin (6.1369). Standard docking performed with OTU deubiquitinase (6W9O) revealed the order of binding energies; 49c (-88.07 kcal/mol) > 49b (-84.26 kcal/mol) > doxycycline (-83.70 kcal/mol) > template (-82.57 kcal/mol) > 49a (-78.43 kcal/mol) > lefamulin (-76.83 kcal/mol) > retapamulin (-76.78 kcal/mol), with the new compounds all showing good pharmacological interactions with the receptor’s amino acids. The new analogs were also predicted to be orally bioavailable with better pharmacokinetic profiles than the template, retapamulin, lefamulin, and doxycycline having no more than one violation of Lipinski’s ROF. Therefore, the newly designed compounds could be considered potential anti-filarial drug candidates.
Phytochemical Analysis and Anti-Inflammatory Activity of The Combination of Trigona apicalis propolis Extract and Honey Paula Mariana Kustiawan; Chaerul Fadly Mochtar Luthfi M; Sinta Ratna Dewi; Jati Pratiwi; Novia Misnawati Aisyiyah; Alfin Syahrian Dwi Nugraha; Irfan Muris Setiawan
Borneo Journal of Pharmacy Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i2.4696

Abstract

Chronic inflammation is common in infectious diseases, rheumatoid arthritis, gout, and autoimmune diseases. However, using non-steroidal anti-inflammatory drugs (NSAIDs) is accompanied by dangerous side effects. Therefore, searching for safer alternative therapies without side effects is very important. A natural blend of ingredients produced by stingless bees from plants was potential as a remedy. Meanwhile, the potential of kelulut bee products from East Kalimantan as an anti-inflammatory is still unknown. This study aimed to compare the chemical composition of kelulut bee (Trigona apicalis) products and evaluate the anti-inflammatory effect of honey, propolis, and their combination. Propolis extract and honey were determined as secondary metabolites. An anti-inflammatory in vivo assay triggered the edema using carrageenan on male mice and measured its anti-inflammatory power value. Propolis extract and honey from T. apicalis have a promising anti-inflammatory effect and are significantly higher than the positive control. Meanwhile, combining propolis extract and honey did not enhance the anti-inflammatory effect. In addition, combining honey and propolis preparations with a ratio of 75 : 25 has a better effect on reducing edema volume than the other two combinations. Still, it is not better than the treatment with propolis extract or honey alone. The content of polyphenol compounds found in honey and propolis preparations is thought to have an important role in reducing edema volume.
Anti-Rheumatoid Arthritis Activity of 96% Ethanol Extract of Eleutherine bulbosa Bulbs with Arthritis Induction Adjuvant Method Muthia, Rahmi; Wati, Helmina; Jamaludin, Wahyudin Bin; Kartini, Kartini; Setiawan, Finna; Zanirah, Gina Rizki
Borneo Journal of Pharmacy Vol. 6 No. 4 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i4.4704

Abstract

An autoimmune condition known as rheumatoid arthritis (RA) results in chronic joint inflammation. Side effects that occur during long-term RA treatment are dangerous. Therefore, many people prefer herbal medicines, estimated to have lower side effects; one such herb is bawang dayak (Eleutherine bulbosa Urb.) bulbs. This study aimed to determine the class of compounds and the effective dose of the 96% ethanol extract of E. bulbosa bulbs, which had an anti-RA effect in the Wistar strain with the Adjuvant Induced Arthritis (AIA) model. Eleutherine bulbosa bulb extract was macerated with 96% ethanol. In the tests with extract doses of 100, 200, and 400 mg/KgBW and methylprednisolone 15 mg/KgBW, the induction used Complete Freund's Adjuvant (CFA). Treatment was provided from day eight through 21 of the test's 21-day duration. Phytochemical screening results contain alkaloids, flavonoids, phenols, quinones, saponins, steroids, and tannins. The percentage inhibition of edema volume and joint thickness, respectively, extract doses of 100, 200, 400 mg/KgBW, and methylprednisolone 15 mg/KgBW were 27.9585%, 49.3446%, 53.3239%, and 58.4629%; as well as 64.9809%, 73.8022%, 74.1444%, and 74.1825%. After analyzing the results, it was determined that E. bulbosa bulb extracts in 96% ethanol can treat RA at effective 200 and 400 mg/KgBW (p-value <0.05).

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