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Mohammad Rizki Fadhil Pratama
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Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya Building B 1st Floor, RTA Milono St. Km.1,5. Palangka Raya 73111, INDONESIA
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Borneo Journal of Pharmacy
Published by Universitas Muhammadiyah Palangkaraya
ISSN : -     EISSN : 26214814     DOI : https://doi.org/10.33084/bjop
Core Subject : Health,
Medicine & Pharmacology
Borneo Journal of Pharmacy publishes various scientific articles covering Pharmacy and Pharmaceutical Sciences in the field but not limited to: Pharmacology-Toxicology, including pharmacokinetics, pharmacodynamics, pharmacotherapy, and toxicology. Pharmacognosy-Phytochemistry, including pharmacognosy, phytochemistry, ethnobotany, and ethnopharmacology. Pharmaceuticals, including biopharmaceuticals, pharmaceutical technology, formulations, and biotechnology. Analytical Pharmacy-Medicinal Chemistry, including pharmaceutical chemistry, chemical analysis, medicinal chemistry, bioinformatics, pharmacy physics, pharmaceutical analysis, and method validation. Microbiology Pharmacy, including the antibacterial, antifungal, and antiviral activity test. Natural Product Development, including testing the pharmacological activity of extracts, fractions, and plant isolates. Clinical-Community Pharmacy, including monitoring usage, side effects, counseling, and drug use evaluation. Management Pharmacy, including drug management, drug use profiles, pharmaceutical administration, and marketing.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 300 Documents
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Utilization of Emulgel Watermelon (Citrullus lanatus) Flesh Extract as a Topical Antioxidant Yati, Kori; Nugrahaeni, Fitria; Melinda, Rika; Wati, Lilis Rokimah
Borneo Journal of Pharmacy Vol. 7 No. 2 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i2.6599

Abstract

The flesh of watermelon (Citrullus lanatus) contains carotenoid compounds that act as antioxidants. The purpose of this study was to determine the variation in the concentration of carbopol 940 on physical properties, irritation tests, and the stability of emulgel antioxidants against temperature and storage time. Evaluation of the physical properties of C. lanatus pulp extract emulgel includes organoleptic, homogeneity, dosage pH, dispersion, adhesion, emulsion type, viscosity as well as hedonic test and irritation test. Antioxidant stability testing of emulgel was carried out for 28 days at three temperature conditions: 4, 25, and 40°C and tested on days 0, 7, 14, 21, and 28 with the DPPH method. The results of the physical properties evaluation meet the requirements with pH values of 5.50–5.57, dispersion 5–6 cm, adhesion <4 seconds, viscosity 5624–15443 cPs, F2 and F3 hedonic tests are preferred by researchers, and irritation tests of all formulas show no irritation symptoms to all refiners. The results of antioxidant stability of emulgel after storage on the 28th day showed an average result of IC50 temperature of 4°C (112.4547 ± 0.1432 mg/L), 25°C (119.3170 ± 0.1966 mg/L), and 40°C (124.1554 ± 0.1317 mg/L). The results of stability analysis show that temperature and storage duration affect antioxidant stability. The higher the temperature and duration of storage, the antioxidant stability of emulgel decreases. Storage of C. lanatus flesh extract emulgel at 4°C was able to maintain antioxidant activity for 28 days of storage.
Effects of Switching Dose, Dose Variation, and Warfarin Interaction on the Incidence of Stroke Recurrence in Stroke Patients with Atrial Fibrillation Fauzi, Lailla Affianti; Kristin, Erna; Pinzon, Rizaldy Taslim; Kushartanti, Bernadeta Margareta Wara; Arovah, Novita Intan
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.6603

Abstract

Atrial fibrillation (AF) significantly increases the risk of stroke, necessitating anticoagulation therapy. Warfarin, a commonly prescribed anticoagulant regimen, requires careful monitoring to ensure patient safety. This study aimed to assess the impact of dose switching, dose variation, and potential interactions with warfarin on the incidence of stroke recurrence in stroke patients with AF. The study retrospectively analyzed the treatment records of stroke patients with AF in outpatient settings over one year. The subjects comprised 314 patients who received warfarin prescriptions at two Indonesian Hospitals from January 1, 2015, to December 31, 2019. Out of these patients, 50 had recorded data regarding dose adjustments, variations, and interactions. They were divided into two groups: a case group (n=11) with stroke recurrence and a control group (n=39) without recurrence. Statistical analysis, including chi-square tests and odds ratio calculations, revealed that both warfarin dose switching (OR=7.6) and dose variation (OR=6.6) significantly influenced the incidence of stroke recurrence. It implies that inconsistencies or alterations in warfarin dosing substantially elevate the likelihood of experiencing another stroke, potentially due to inadequate anticoagulation leading to clot formation. Interestingly, the analysis of drug interactions did not significantly impact stroke recurrence. In summary, the recurrence of stroke in patients with AF is notably influenced by warfarin dose adjustments and variations rather than drug interactions. This study highlights the critical importance of precise dosing strategies and vigilant monitoring to enhance the efficacy of anticoagulant therapy in this high-risk population.
Antioxidant Activity, Total Phenolics, and Total Flavonoids Content of Bajakah Tampala (Spatholobus littoralis): The Indigenous Herbal Medicine from Kalimantan Mahfudh, Nurkhasanah; Murdi, Habib Basyanur; Utami, Dwi; Ahda, Mustofa; Nashihah, Siti; Andika, Andika
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.6609

Abstract

Bajakah tampala (Spatholobus littoralis), a medicinal plant traditionally used in Indonesia, particularly on Kalimantan Island, has garnered interest for its potential health benefits. However, scientific evidence remains scarce. This study investigated the antioxidant activity of S. littoralis extract and its total phenolic and flavonoid content. Ethanol extraction and evaporation were used to prepare the extract. The DPPH method assessed antioxidant activity, while Folin–Ciocalteu and AlCl3 complexation methods quantified total phenolics and flavonoids, respectively. The S. littoralis extract exhibited strong antioxidant activity with an IC50 value of 54.19 ± 8.15 µg/mL. Additionally, the extract contained substantial levels of phenolics (0.649 ± 0.026% GAE) and flavonoids (1.084 ± 0.043% QE). These findings suggest a link between the high phenolic and flavonoid content of S. littoralis extract and its observed strong antioxidant activity.
Ethnobotanical Study of Medicinal Plants of Banjar and Java Tribes in Pandansari Village, South Kalimantan Sutomo, Sutomo; Aprilianes, Alif Vera; Kartinah, Nani; Arnida, Arnida; Muslimawati, Khoirunnisa; Akbar, Nabila Hadiah
Borneo Journal of Pharmacy Vol. 7 No. 2 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i2.6636

Abstract

In Pandansari village, South Kalimantan, Indonesia, residents from Banjar and Javanese communities traditionally utilize medicinal plants as alternatives to conventional medicine. This study aimed to explore the demographics, plant use practices, and preliminary phytochemical analysis of these plants. Using a qualitative, phenomenological approach, semi-structured interviews and questionnaires were conducted with four purposively selected informants. The findings revealed 52 medicinal plant species. Leaves were the most commonly used plant part (40%), followed by boiling as the preferred processing method (54%) and drinking as the primary route of administration (58%). Two unidentified plants, asam sembelekan and daun malaysia, were frequently mentioned. Phytochemical screening detected flavonoids, saponins, phenols, and terpenoids in asam sembelekan, while daun malaysia contained alkaloids, flavonoids, saponins, and terpenoids. These findings provide a foundation for further research on the efficacy and safety of these traditional medicinal plants in this community.
A Pre-Post Survey Analysis on Pharmacy Students' Perceptions of Pharmacist Roles in the Pharmaceutical Industry Adina, Anugerah Budipratama; Yuwanda, Alhara; Budiastuti, Rizky Farmasita; Nopratilova, Nopratilova; Yusuf, Eddy; Tan, Suk Fei; Mawazi, Saeid Mezail; Herli, Amelia
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.6791

Abstract

The pharmaceutical industry is undergoing rapid evolution, characterized by a complex regulatory landscape and the need for diverse skill sets. This study aimed to assess pharmacy students’ perceptions of the pharmaceutical industry and the impact of a dedicated seminar on their career aspirations and knowledge. A pre-post online survey was administered to 55 undergraduate pharmacy students at the National Pharmacy Seminar 2024, hosted by Jakarta Global University. Data were analyzed using descriptive statistics and the Wilcoxon signed-rank test (p ≤0.05). Results indicate a strong preference for careers in state-owned pharmaceutical companies (63.6%) and research and development departments (34%). The seminar significantly enhanced participants’ understanding of pharmacists’ roles, industry complexities, drug development challenges, and regulatory requirements. Notably, 93% of participants reported that the seminar met their expectations and provided valuable insights for future career exploration. These findings underscore the importance of educational interventions in shaping pharmacy students’ career trajectories and aligning their knowledge with the dynamic pharmaceutical industry.
Molecular Docking and Dynamics of Xylocarpus granatum as A Potential Parkinson’s Drug Targeting Multiple Enzymes Irsal, Riyan Alifbi Putera; Gholam, Gusnia Meilin; Firdaus, Dzikri Anfasa; Liwanda, Novian; Chairunisa, Fernanda
Borneo Journal of Pharmacy Vol. 7 No. 2 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i2.6810

Abstract

Parkinson's disease is a global health challenge affecting over 10 million individuals worldwide, leading to increased disability-adjusted life years (DALYs) and a rise in mortality rates. This study explores the potential anti-Parkinson's properties of Xylocarpus granatum, focusing on its interaction with key enzymes associated with the disease: catechol-O-methyltransferase (COMT), adenosine A2A receptor (A2AR), and monoamine oxidase-B (MAO-B). Using molecular docking and molecular dynamics approaches with YASARA Structure, the ethanol extract of X. granatum was investigated for its mechanism of action. Among 30 compounds, five demonstrated promising binding affinities. Structural flexibility analysis revealed minimal fluctuations in active-site residues, highlighting the stability of key complexes involving kaempferol, epicatechin, epigallocatechin, and native ligands. Molecular Mechanics Poisson–Boltzmann Surface Area (MM-PBSA) simulations provided insights into the binding energy of these complexes. Notably, kaempferol exhibited higher binding energy than the natural ligand, suggesting superior binding affinity. Analysis of the average radius of gyration (Rg) showcased control drug-MAO-B exhibited higher Rg values, indicating a more flexible protein conformation. Confirming mode stability with root mean square deviation (RMSD) analysis shows overall stability, except in the A2AR-bound complex. The study's collective findings underscore the structural stabilization of ligand-protein complexes, contributing valuable insights into the potential anti-Parkinson's properties of X. granatum. These discoveries hold promise for developing more effective therapies for Parkinson's disease and significantly contribute to the neurology field.
Chemoinformatic-aided Antidiabetic Analysis of the Therapeutic Potential of Phytoconstituents in Eremomastax speciosa Extracts Ibrahim, Sulyman Olalekan; Lukman, Halimat Yusuf; Ebhohimen, Israel Ehizuelen; Babamale, Halimah Funmilayo; Abdulkadir, Fatimah Ronke; Hamid, Abdulmumeen Amao; Zubair, Marili Funmilayo; Atolani, Olubunmi
Borneo Journal of Pharmacy Vol. 7 No. 2 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i2.6820

Abstract

This research attempts to establish the antihyperglycemic potential of Eremomastax speciosa, a medicinal plant utilized in traditional West African diabetes therapy, through virtual simulation. While numerous reports have validated its biological potency, studies on the drug-likeness and antidiabetic properties of its compounds are limited.  The in silico pharmacological, and toxicological profile of aqueous, methanolic/methylene phytochemicals from previously reported work was analyzed using Swiss ADME and Protox II online server. The docking process was performed using PyRx-0.8, coupled with AutoDock Vina. Phytochemicals that aligned with Lipinski’s rules for drugs were then subjected to a virtual docking simulation. This simulation replicated the inhibitory effects of E. speciosa phytochemicals on sodium-glucose co-transporters (SGLT2) and α-amylase, similar to metformin, an FDA-approved antidiabetic medicine utilized as a control. Phytochemicals such as 8, 9,10-dimethyltricyclo[4.2.1.1(2,5)]decane-9,10-diol (-6.6 kcal/mol), 11-isopropylidenetricyclo[4.3.1.1(2,5)]undec-3-en-10-one (-7.9 kcal/mol), 4-(1,5-dihydroxy-2,6,6-trimethylcyclohex-2-enyl)but-3-en-2-one (-7.3 kcal/mol), and N-methyl-N-4-[2-acetoxymethyl-1-pyrrolidyl]-2-butynyl]-acetamide (-7.5 kcal/mol) exhibits superior binding affinities to the specific proteins targeted, compared to metformin, implying that E. speciosa is a source of druggable antidiabetic molecules that can be enhanced to achieve better efficacy.
Bromelain-Extracted of Virgin Coconut Oil: Physical and Chemical Stability in Different Temperature During the Storage Harimurti, Sabtanti; Sukamdi, Dyani Primasari; Widada, Hari; Sari, Hasna Fadia; Amid, Azura
Borneo Journal of Pharmacy Vol. 7 No. 2 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i2.6857

Abstract

The bromelain-enzymatic reaction is applied in virgin coconut oil (VCO) production. Hydrolysis of the emulator by bromelain enzyme in coconut milk during fermentation maximized further the separation of oil and water. In the higher demand for VCO in many industries, the VCO stability during transportation and storage must be evaluated.  The research aims to evaluate the physical and chemical stability of the effect of temperature in the storage. VCO's physical and chemical stability was evaluated under two different temperature and storage periods: an elevated temperature of 50°C for 10 days and room temperature (27-30°C) for 50 days. The storage was conducted in a clear glass bottle. The evaluation was based on physical and chemical stability tests before and after storage, including organoleptic, pH changes, density, viscosity, acid number, peroxide number, and saponification number. Based on the data, the quality of the VCO after storing at 50°C for 10 days and 27-30°C for 50 days was found to be changed for pH, specific gravity, viscosity, acid number, peroxide number, saponification number, while for the appearance was found to be no changes. The VCO was very sensitive to environmental effects. Therefore, it is necessary to find the best storage chamber and temperature for stabilizing the VCO.
Ethnobotanical Study and Hedonic Evaluation with Cost Analysis of Banana (Musa paradisiaca L.) Stem Serum Preparation as an Anti-Aging Solution Megawati, Fitria; Dewi, Ni Luh Kade Arman Anita; Agustini, Ni Putu Dewi; Antara, I Putu Satria; Ekayanti, Ni Luh Firda; Darmayanti, Ni Wayan
Borneo Journal of Pharmacy Vol. 7 No. 2 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i2.6872

Abstract

In skincare, particularly facial serums, the utilization of natural ingredients is crucial in addressing various skin issues, notably combating the effects of free radicals that contribute to wrinkles. This study explores the potential of banana (Musa paradisiaca L.) stem extract as an active ingredient in serum formulation due to its rich anthocyanin content known for antioxidant properties. Hedonic testing and cost analysis serve as initial steps in the marketing mix of a product. This research aims to assess the hedonic preferences of various M. paradisiaca stem serum formulations and analyze the production costs. A descriptive research method employing survey and observational techniques was utilized for data collection and descriptive analysis. Hedonic testing was conducted to gauge the personal preferences of panelists toward M. paradisiaca stem serum formulations. Three formulations (F1 with 4%, F2 with 8%, and F3 with 12% M. paradisiaca extract) were evaluated by 40 panelists. Cost analysis of serum production employed quantitative descriptive analysis, computing the cost per unit using a variable costing method. The hedonic evaluation results showed that F1 formulation was highly preferred (79.3%), followed by F2 (73.2%), and F3 (66.8%). Cost analysis using the variable costing method revealed a total production cost of IDR 614,000.00 for 10 packages of M. paradisiaca stem serum formulation, translating to an approximate unit price of IDR 61,400.00.
Integrative Network Pharmacology Unveils Limonia acidissima as a Potential Natural Product for Targeting Cancer Wahyuni, Reni Sri; Muchlisin, M. Artabah; Jamil, Ahmad Shobrun; Astuti, Engrid Juni; Rafikayanti, Agustin
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.6988

Abstract

Cancer remains a formidable health challenge worldwide, with complex molecular mechanisms driving its initiation, progression, and therapeutic resistance. In this study, we employed bioinformatics analyses to elucidate the molecular underpinnings of cancer biology, focusing on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Our GO analysis revealed the enrichment of key biological processes such as protein phosphorylation, regulation of programmed cell death, and transmembrane receptor signaling pathways, underscoring the critical roles of signaling cascades and regulatory mechanisms in tumorigenesis. Similarly, molecular functions such as protein kinase activity and ATP binding were identified as significantly enriched, highlighting the importance of protein kinases and molecular interactions in cancer development and progression. The KEGG pathway analysis further delineated dysregulated signaling pathways associated with cancer, including the MAPK and PI3K-Akt signaling pathways, implicating these pathways as central regulators of cancer progression. These findings deepen our understanding of cancer biology and offer potential targets for therapeutic intervention. Integrating multi-omics data and systems biology approaches may provide deeper insights into the intricate networks underlying cancer pathogenesis, paving the way for developing more effective treatments for cancer patients.

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