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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 26 Documents
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Search results for , issue "Vol 10 No 1 (2025)" : 26 Documents clear
FORMULATION AND ANTIOXIDANT ACTIVITY FACE TONER BUTTERFLY PEA FLOWER KOMBUCHA (Clitoria ternatea L.) WITH DPPH METHOD Rizikiyan, Yayan; Hidayat, Salsabila Aulia; Suharyani, Ine; Sulastri, Lela; Indriaty, Sulistiorini; Karlina, Nina
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1686

Abstract

Antioxidants can be given to the skin through cosmetics such as face toners. One source of antioxidants is obtained through the fermentation of butterfly pea flower kombucha (Clitoria ternatea L.), which has been proven to have better antioxidant activity than butterfly pea flower extract alone. This study aimed to determine the metabolite compounds in butterfly pea flower kombucha and create a facial toner formulation with good antioxidant activity. The butterfly pea flower kombucha was fermented for 6 days at room temperature. Facial toners were made with concentrations of 5%, 7,5% and 10%. Evaluation of the face toner includes organoleptic, homogeneity, pH, specific gravity, and viscosity tests. The antioxidant activity test used the DPPH (1,1-diphenyl-2-pycrilhydrazil) method, with vitamin C as a positive control. The results showed that there were alkaloids, flavonoids, saponins, and terpenoid compounds in butterfly pea flower kombucha. Face toners with concentrations of 5%, 7.5%, and 10% could be prepared and met all evaluations (organoleptic tests, homogeneity, pH, specific gravity, and viscosity). Antioxidant test results on formula 1 IC50 50,21±SD 0,01 (strong), formula 2 IC50 44,32±SD 0,02 (very strong) and formula 3 IC50 38,62±SD 0,03 (very strong). The higher the concentration of butterfly pea flower kombucha, the higher the antioxidant activity. Butterfly pea flower kombucha (Clitoria ternatea L.) which is formulated as a face toner preparation has strong to very strong antioxidants, and the increasing concentration of active ingredients had an effect on antioxidant activity.  Keywords: face toner, butterfly pea flower kombucha, DPPH method, antioxidant activity
IMPROVED SOLUBILITY NOVEL MULTICOMPONENT CRYSTALS OF FENOFIBRIC ACID-ACETYLSALISYLIC ACID Anggraini, Deni; Novita, Gressy; Wulandari, Intan
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1690

Abstract

Solubility is an important physicochemical property of active pharmaceutical ingredients. Poor water solubility of active pharmaceutical ingredients leads to low bioavailability; therefore, efforts are needed to improve the solubility of active pharmaceutical ingredients. The goal of this study was to prepare and characterize novel multicomponent crystals of fenofibric acid (FA) using acid acetylsalicylic (ACE) as a coformer and to evaluate the solubility enhancement when prepared for multicomponent crystal formation.  Solid characterization of the novel multicomponent crystals was performed using powder X-ray diffraction (XRD), differential scanning diffraction (DSC), Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), polarized microscopy, and solubility tests. Multicomponent crystals were prepared by the solvent drop grinding method using a few drops of an ethanol pro analyzer. The results showed that the solubility of multicomponent crystalline fenofibric acid was 4.7 times greater than that of pure fenofibric acid. Differential Scanning Calorimetry characterization results show the novel multicomponent crystals  with a sharp endothermic peak at 136,65 oC. The PXRD diffractograms show no new diffraction peaks and a decrease  in intensity. FT-IR spectroscopic analysis showed no new functional groups, and most of the transmittance peaks of the multicomponent crystals were superimposed between the peaks of fenofibric acid and acetylsalicylic acid. The novel multicomponent crystals fenofibric acid with acetylsalicylic acid as a coformer can improve the solubility of fenofibric acid  Keywords: Acetylsalicylic acid ; Fenofibric acid ; Multicomponent crystals ; Solubility  
THE POTENTIAL OF BLACK CUMIN SEED OIL (Nigella sativa L.) AS A HALAL ANTIBACTERIAL AGENT AGAINST EXTENDED SPECTRUM ?-LACTAMASE (ESBL)-PRODUCING ESCHERICHIA COLI Tomi; Nurrosyidah, Iif Hanifa; Muzzayinah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1706

Abstract

Infectious diseases remain a major issue in tropical countries such as Indonesia. Infectious diseases can be caused by pathogenic microorganisms such as bacteria, viruses, parasites, or fungi. Development of antibacterial agents from natural sources is essential to combat the growing issue of antibiotic resistance. One potential plant is black cumin seed (Nigella sativa L.) contains thymoquinone, a compound known for its antibacterial properties. In addition to thymoquinone, the essential oil of black cumin contains thymol, carvacrol, and p-cymene, along with metabolites such as alkaloids, saponins, and tannins. This study aimed to investigate the antibacterial activity of black cumin seed oil (Nigella sativa L.) against Extended Spectrum ?-lactamase-producing Escherichia coli (E. coli ESBL). The antibacterial test in this study used the disc diffusion method at various concentrations, including 100%, 75%, 50%, and 25%. The extract was obtained by distillation, using pure water as the solvent. The test groups included a negative control, positive control using chloramphenicol, and negative control using pure water. The results of the antibacterial activity test showed that the positive control produced an average inhibition zone of 25 mm, classified as susceptible, whereas the negative control showed no inhibition zone (0 mm). At 100% concentration, the inhibition zone averaged 18,67 mm, at 75% it averaged 16 mm, at 50% it averaged 11,67 mm, and at 25%, the inhibition zone averaged 6,67 mm. The three lower concentrations were categorized as resistant.  
A STUDY ON THE KNOWLEDGE AND ATTITUDES OF INDONESIAN WOMEN REGARDING MENSTRUAL CUPS AS ENVIRONMENTALLY FRIENDLY MENSTRUAL PRODUCTS Alfiani, Fitri; Yuniko Febby H Fauzia; Azkya, Fharelina N
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1338

Abstract

Inadequate menstrual hygiene can increase the risk of reproductive tract infections, including pelvic inflammatory disease, dysmenorrhea, and infertility. Therefore, the use of safe and effective menstrual products is essential. Currently, disposable pads are widely recognized products. Disposable pad waste is deemed environmentally detrimental, leading to an estimated annual production of 113,000 tons. Menstrual cups are a viable long-term alternative, since they can be reused for up to ten years, effectively prevent leaks, accommodate various activities, and diminish the risk of toxic shock syndrome. Examining Indonesian women's knowledge and attitudes about menstrual cups is crucial, as it substantially aids in advancing the attainment of Sustainable Development Goals (SDGs). Procedure. This was a quantitative study utilizing anonymous web-based questionnaires. Outcomes.  Of the Indonesian women, 75.97% possessed limited knowledge, while only 24.03%weree well-informed about menstruation cups as eco-friendly menstrual devices. 85.06% of Indonesian women were disinclined to utilize menstruation cups, while only 14.94% expressed a willingness to adopt these environmentally friendly menstrual devices. The ?-value was 0.514>0.05, which represents statistical insignificance; hence, knowledge was not associated with attitude.  Keywords: attitude; knowledge; menstrual_cup; menstruation; women_health  
COMPARISON OF TOTAL FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY OF PURPLE LEAF EXTRACT (Graptophyllum pictum (L.) Griff.) USING MACERATION AND SOXHLETATION EXTRACTION METHODS Darotulmutmainnah, Azmi; Marini, Marini; Herliningsih, Herlingsih; Handayani, Hana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1608

Abstract

Purple leaves in Indonesia can be used as an anti-inflammatory medication and laxative to treat hemorrhoids, rheumatism, boils, and skin diseases. Purple leaves are also used as free-radical antidotes. This was due to the presence of secondary metabolite compounds in purple leaves. The right extraction method determines the amount of flavonoids that can be extracted and achieves a high flavonoid content. This study aimed to determine the total flavonoid content and antioxidant activity of purple leaves using different extraction methods, namely maceration and Soxhletation. This study employed an experimental method of testing total flavonoid levels using UV-Vis spectrophotometry and antioxidant activity using the DPPH method. The results showed that the maceration method yielded a total flavonoid level of 4,422 ± 0,047 ppm, which was higher than that obtained using the Soxhletation method (1,547 ± 0,027 ppm). In the antioxidant activity test, vitamin C was used as a comparator, with an IC50 of 2.263 ppm (very strong). The IC50 of purple leaf extract using the maceration method was 123,32 ppm (medium), while the soxhletation method yielded an IC50 of 104,42 ppm (medium). This shows that vitamin C has more potent antioxidant activity in counteracting free radicals than purple leaf extract, using maceration and Soxhletation methods. The  results showed a significant difference in total flavonoid levels using different extraction methods, while there was no significant difference in the antioxidant activity of purple leaf extract using maceration and  Soxhletation methods.   Keywords: antioxidant, extraction, flavonoid, maceration, purple leaf, soxhletation  
FORMULATION AND EFFECTIVENESS TEST OF THE WOUND HEALING GEL RED PIDADA FRUIT (Sonneratia Caseolaris) SKIN EXTRACT Rusdeni, Sofia; Rini Dwiastuti; Phebe Hendra; Hasyrul Hamzah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1633

Abstract

Red pidada fruit peel extract gel preparation can increase the efficiency and comfort of topical use because of its activity in the healing of open wounds. The aim of this research was to determine how variations in HPMC levels affect the physical quality and stability of red pidada fruit peel extract gel preparations, using the maceration method to obtain thick extracts and formulations with different HPMC concentrations (1% HPMC, 3% and HPMC 5% formula were tested for physical quality and stability, including the Storage Stability Test for 4 weeks. Effectiveness testing was also carried out in white mice using an incision wound method with a depth of 1.5 mm and macroscopic observation. The effectiveness test concentration was set to 5%. The results of data analysis using the Spss One Way ANOVA test showed that higher HPMC levels resulted in a thicker gel, viscosity, stickiness, spreadability, and higher pH. It can be concluded that the gel formulation that meets the requirements is that formula 2 provides organoleptic test results with a thick green color typical of red pidada, good homogeneity test, spreadability test 5.52 cm, adhesion test 2.61 minutes, viscosity test 2700cCps, pH test 4.92. During storage, the gel exhibited good consistency. The longer the storage time, the closer the pH changes to alkaline values. With the Anova value, there is a significant difference in the three formulas with a value of p=0.005 Keywords: red pidada (Sonneratia caseolaris) fruit peel, wound healing, HPMC, gel
FORMULATION AND EFFICACY TEST OF STICK-HEEL MOISTURIZER MADE FROM 96% ETHANOL EXTRACT OF PAPAYA (Carica papaya L.) LEAVES Marangyana, I Gede Bagus Indra; Listiani, Putu Ayu Ratih
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1649

Abstract

Papaya leaves contain phytochemicals including alkaloids, phenols, flavonoids, tannins, saponins, and steroids, which can function as natural moisturizers to maintain healthy heels. Papaya leaves were extracted using the maceration method with 96% ethanol solvent and evaporated on a rotary evaporator to obtain a thick extract. The yield was 10.2%. It was subsequently combined at concentrations of 5 %, 10 %, and 15% to create a moisturizing heel stick preparation. The physical quality of the stick heel moisturizer preparations was assessed using tests for homogeneity, spreadability, adhesion, pH, organoleptic properties, and moisturizing properties. The mixture produces a brownish-green stick, a semi-solid texture, a distinctive odor of papaya leaves, a pH of 6, good homogeneity, good adherence, and qualified spreadability. The moisturizing test results for FI 5%, FII 10%, and FIII 15% had average values of 2.23%, 1.56%, and 1.15%, respectively. The results of SPSS testing also showed various average values that were significant (p<0.05). From the obtained data, FIII was determined to be the most effective moisturizing formula. Keywords: Papaya leaf, stick heel, moisturizer.
COST MINIMIZATION ANALYSIS OF ANTIHYPERTENSIVE DRUG USE IN CHRONIC KIDNEY DISEASE PATIENTS UNDERGOING HEMODIALYSIS Utami, Indah Kurnia; Rakanita, Yasinta; Dewi, Niluh Puspita
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1655

Abstract

Hypertension is the primary cause of Chronic Kidney Disease (CKD), as it damages blood vessels in the kidneys. The most commonly used management for hypertension as monotherapy includes Calcium Channel Blockers (CCB) such as Amlodipine and Angiotensin Receptor Blockers (ARB) such as candesartan. Patients with CKD undergoing hemodialysis depend on dialysis machines, which impacts their economic burden. Therefore, a cost analysis review of drugs with the same therapeutic goals is necessary. This was a non-experimental study with a descriptive design. Data were collected through retrospective purposive sampling from January to December 2023 using medical records and payment data for inpatient treatments with hemodialysis that met the inclusion criteria. Direct medical costs included antihypertensive, other medication, service and facility fees, and medical support costs. Of the 100 samples that met the inclusion criteria from January to December 2023, amlodipine was the most commonly used antihypertensive (56%), followed by candesartan (38%). The average direct medical costs were IDR 184.350 for Amlodipine and IDR 561,339 for candesartan. The patient characteristics by gender showed a higher percentage of males (52%) than of females (48%). By age, the majority were in the late adult group (67%), whereas the elderly accounted for (33%). The Amlodipine group achieved more significant cost minimization than the candesartan group. Future studies should examine the potential of amlodipine in reducing the economic burden of limited resources.  Keywords: antihypertensive, CMA, CKD
ARTICLE REVIEW: POTENTIAL PHARMACOLOGICAL ACTIVITY OF LOBI-LOBI FRUIT (Flacourtia inermis, Roxb) Adiwinata, Much Cheril Wicaksono; Vitamia, Cszahreyloren
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1665

Abstract

The Lobi-lobi fruit is a tropical plant that is rich in secondary metabolites. Many studies have discussed the usefulness of secondary metabolites in this fruit. This study aimed to explore the secondary metabolites and pharmacological activities of lobi-lobi fruit (Flacourtia inermis, Roxb). The methods used included a literature review of various scientific journals discussing the health potential of fruits. The results showed that the lobi-lobi fruit extract had significant antioxidant activity with an IC50 value of 104.223 ?g/mL, and showed potential as an antidiabetic and antibacterial agent. This discussion highlights the importance of bioactive components, such as phenolics, for providing therapeutic effects. The conclusion shows that this fruit has potential as a source of natural medicine and requires further research. Keywords: secondary metabolites, flacourtia inermis, pharmacological activity
DRUG DOSE ADJUSTMENT IN CHRONIC KIDNEY FAILURE PATIENTS AT HOSPITAL X Nurdiansyah, Iid; Susilo, Rinto; Setyaningsih, Indah; Putri, Anisa
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1669

Abstract

Chronic Kidney Disease (CKD) is a significant global health issue, with increasing incidence rates, high treatment costs, and poor prognosis. Adjusting drug dosages in patients with CKD is essential to prevent worsening conditions and ensure proper therapy. This study examines the drug adjustment practices at Hospital X. This research method uses a descriptive research uses secondary data from medical records (Jan-Dec 2021) of CKD patients at Hospital X. Data include patient demographics, comorbidities, medications, and dosage adjustments according to the Renal Pharmacotherapy Handbook. Results: Among the 52 patients, the majority were female (60%) and aged 46-65 years (57%). Ranitidine was the most prescribed drug (47.37%) for CKD patients, with 56.76% dosages aligning with renal dosing guidelines. This study concluded that ranitidine was the most common medication, and over half of the prescriptions were aligned with the renal dosing guidelines. Keywords: drug dose adjustment, chronic kidney failure,  renal pharmacotherapy

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