cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Rinto Susilo
Contact Email
medicalsains@gmail.com
Phone
+6285691055898
Journal Mail Official
medicalsains@gmail.com
Editorial Address
https://ojs.ummada.ac.id/index.php/iojs/about/editorialTeam
Location
Kab. cirebon,
Jawa barat
INDONESIA
Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 32 Documents
 1   2   3   4 
Search results for , issue "Vol 8 No 4 (2023)" : 32 Documents clear
OPTIMIZATION OF AFRICAN LEAF EXTRACT CREAM FORMULA (Vernonia amygdalina Del.) AS AN ANTIBACTERIAL Staphylococcus aureus Iklila Zahra; Ana Indrayati; Ilham Kuncahyo
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.884

Abstract

The use of natural ingredients as active medicinal substances has been developed again, one of which is African leaf extract (Vernonia amygdalina Del.), which is used as an antimicrobial bacterium against Staphylococcus aureus, which causes skin disease. The aim of this study was to compare the antibacterial activity of African leaf extracts and fractions, as well as to optimize the cream preparation formula using a factorial design with a combination of stearic acid, triethanolamine (TEA), and Adeps lanae with the critical parameters of pH, viscosity, spreadability, Franz diffusion, and KBM value. This study used experimental methods to determine the highest antibacterial activity by disc diffusion from extracts and active fractions of African leaves using solvents of different polarities. The extract or fraction with the highest antibacterial activity was formulated using a combination cream of stearic acid, triethanolamine, and adeps lanae. After obtaining the cream formula, physical testing of the cream, penetration test, and antibacterial test using macrodilution were performed, and the most optimal formula was determined using a factorial design. The extract standardization test results met both specific and non-specific parameters. In the disc diffusion antibacterial test, the highest activity was found in the African leaf extract (13.23 ± 0.757 mm) against Staphylococcus aureus bacteria. Variations in cream composition affect pH, viscosity, spreadability, and Franz diffusion...
COST-EFFECTIVENESS ANALYSIS OF ANTICOAGULANT USAGE IN COVID-19 PATIENTS AT 45 KUNINGAN HOSPITAL Juju Jumiati; Yusi Anggriani; Yati Sumiyati; Umar Santosa
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.892

Abstract

Cost-effectiveness analysis (CEA) is a pharmacoeconomic method that compares prices from all sources consumed (cost) with the outcome value of a program or intervention to obtain objective answers to the selection of drugs that are effective in terms of benefits and costs. COVID-19, or Coronavirus Disease 2019, is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2) and causes acute respiratory distress, including fever, coughing, and shortness of breath. Fondaparinux, aside from heparin and enoxaparin, can be given as an anticoagulant therapeutic option in hospitalized COVID-19 patients, according to the third edition of the COVID-19 care recommendations. This study aimed to find the most cost-effective therapy among heparin, enoxaparin, and fondaparinux in COVID-19 patients at the RSUD’45 Kuningan. It also applied descriptive non-experimental research methods with retrospectively collected data. The intervention that had been studied was the administration of anticoagulant medication, where the effectiveness of the drug was observed in the reduction of D-dimer levels to normal levels. Meanwhile, the costs were observed from the perspective of a healthcare provider, specifically the RSUD’45 Kuningan. The study sample included 107 patients, with 13 receiving heparin, 41 receiving enoxaparin, and 53 receiving fondaparinux. Bivariate analysis using the chi-square test revealed no significant difference between the drug groups in the proportion of patients who improved and did not improve (sig. value = 0.610)...
QUALITY ANALYSIS AND IDENTIFICATION OF FUNCTIONAL GROUPS OF SWEET ORANGE (Citrus sinensis) PEEL ESSENTIAL OIL USING FTIR Citra Dhea Cantika; Laela Hayu Nurani; Nina Salamah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.898

Abstract

Organic waste in the form of citrus fruit peels has not been handled seriously, causing environmental pollution, such as the emergence of unpleasant odors.  Therefore, waste management becomes a more valuable product or item.  Citrus peel oil counterfeiting often occurs because there is no Indonesian National Standard (SNI) for citrus peel oil as a quality standard, making it difficult to identify the falsity of finished citrus peel oil products in the market. Research was conducted to test the quality of sweet orange peel oil so that it could be used as a standard to identify the content of sweet orange peel oil using the FTIR method. Oil quality testing included an organoleptic test, specific gravity, refractive index, and acid number. The oil quality test results showed clear yellow oil with a distinctive sweet orange peel aroma, specific gravity of 0.845, refractive index of 9.263, and acid number of 1.1. FTIR analysis revealed spectra that appeared in the region of 1490 with strong intensity (C-H aromatic), 1645 with medium intensity (C=C), and 2860 with medium intensity (C-H aliphatic). FTIR spectra of sweet orange peel oil showed similarity with limonene with a hit quality value of 958, the content of sweet orange peel oil is dominated by limonene compounds. Keywords: sweet orange peel, Essential oil, FTIR, Limonene, Oil quality
ANTIDIABETIC ACTIVITIES OF KEMUNING LEAF EXTRACTS (Murraya paniculata) AND MORINGA LEAF (Moringa oleifera) IN DIABETIC RATS Susilo Margining Raharjo; Titik Sunarni; Nuraini Harmastuti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.903

Abstract

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. The development of diabetic complications plays a pathological role in increasing Reactive Oxygen Species (ROS) levels, which induce oxidative stress. The aim of this study was to examine the antidiabetic activities of kemuning and moringa leaves based on glucose, SOD, and GPx levels, and the protective activity of pancreatic cells in STZ-NA-induced rats. The kemuning and moringa leaves were dried, finely powdered, and extracted by the remaceration method using 96% ethanol. The test was carried out on 30 rats that were divided into 6 treatment groups, namely the normal control group, negative control, positive control (glibenclamide), extract dose of 76.5 mg. /200 g BW : 6.5 mg/200 g BW, 114.75 mg/200 g BW : 3.25 mg/200 g BW and 38.25 mg/200 g BW : 9.75 mg/ 200 g BW. The antidiabetic test was carried out using STZ-NA, glucose levels were measured, and SOD and GPx levels in the liver supernatants were measured. Cell protection was tested using the cell damage score method. The data obtained were analyzed using one-way ANOVA variance. The results showed that kemuning and moringa leaves at a dose of 38.25 mg/200 g BW: 9.75 mg/200 g BW were able to lower blood glucose levels, increase the activity of SOD and GPx, and protect pancreatic cell damage in STZ-NA rats. Keywords: Antidiabetic, antioxidant, moringa, kemuning, SOD, GPx
EVALUATION OF THE ANTIHYPERTENSIVE DRUGS IN PREECLAMPSIA PATIENTS TO CLINICAL OUTCOMES AT RSUD SEKARWANGI ON 2021 PERIOD Nisa Rokhmah; Oktaviana Zunita; Alya Septiani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.917

Abstract

Preeclampsia is a pregnancy complication with several symptoms, such as hypertension, proteinuria, and edema. Such symptoms occur in pregnant women after the gestational age reaches 20 weeks. Preeclampsia is divided into mild preeclampsia (PER) and severe preeclampsia (PEB). Antihypertensive drugs are used to lower blood pressure and proteinuria levels in patients with preeclampsia. The purpose of this study was to obtain a profile of antihypertensive drugs and monitor changes in clinical outcomes in patients with preeclampsia. This was a retrospective cross-sectional study using secondary data from the medical records of preeclampsia patients. Of the 54 patients who met the inclusion criteria with the age at which most preeclampsia was 21–35 years old, 33 (61.11%) patients and 32 (59.62%) patients had PEB. The most widely used antihypertensive drug was a combination of methyldopa and nifedipine, with 27 (50%) patients receiving combination therapy. After treatment with antihypersensitive drugs, 50 (92.60%) patients experienced a decrease in blood pressure, 45 (83.33%) patients experienced a decrease in proteinuria levels, and 45 (83.33%) patients had normal birth conditions. Antihypertensive treatment for preeclampsia patients has a relationship with a decrease in the patient’s blood pressure (p-value = 0,007), but there was no relationship with a decrease in proteinuria levels (p-value = 0,660) and condition of baby birth (p-value = 0,446).  Keyword: Preeclampsia; Antihypertensive Drugs; Clinical Outcomes
EVALUATION OF APHRODISIAC ACTIVITY OF ETHYL ACETATE FRACTION OF CLOVE LEAVES (Syzygium aromaticum L.) IN MALE WHITE RATS (Rattus norvegicus) Muthmainah Tuldjanah; Rezky Yanuarty; Agung; Ayu Wulandari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.918

Abstract

Clove leaves contain antioxidant compounds such as saponins, flavonoids, tannins, sterols, and essential oils. Among those chemical constituents, eugenol, eugenol acetate, caryophyllene, and sesquiterpenes were believed to have aphrodisiac activity. This study aims to investigate the potential aphrodisiac effects of the ethyl acetate fraction of clove leaves (Syzygium aromaticum L) administered at a dose of 250 mg/kg BW. The research employed an experimental method with a modified post-test randomized controlled group design and utilized a total of 45 white rats, consisting of 15 males and 30 females, divided into three treatment groups in a 1:2 ratio. Each group consisted of 5 male rats and 10 female rats. The three groups included the healthy control group (Na-CMC 0.5%), the positive control group (treated with X-Gra 52.5 mg/kg body weight) and the treatment group receiving clove leaf extract samples at a dosage of 250 mg/kg BW. The results indicate that the ethyl acetate fraction of clove leaves contains steroids and alkaloids with mount latency (ML), intromission latency (IL) ejaculation latency (EL), mount frequency (MF), intromission frequency (IF) and ejaculation frequency (EF) of 11.40 s, 15.80 s, 6.228 s, 23.60, 14.60, and 1.60 s, respectively. Based on these findings, it can be concluded that it has the potential to be used as an aphrodisiac agent. Keywords: Aphrodisiac, Syzygium Aromaticum L., ethyl acetate fraction, clove leaves, ejaculation frequency
FORMULATION AND PHYSICAL EVALUATION OF EFFERVESCENT GRANULES OF MINT LEAF EXTRACT (Mentha x piperita L) AS STIMULANSIA Herliningsih; Angga Anugra Diputra; Haty Latifah; Melinda Fuji Rahayu
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.922

Abstract

Indonesia is a country with a diverse biodiversity spread across various regions. Several types of plants in Indonesia can be utilised as herbal medicines. One such plant suitable for medicinal purposes is mint leaves (Mentha x piperita L.). The chemical content found in mint leaves includes essential oils that serve as stimulants. This research aims to determine whether mint leaf extract can be used to create an effervescent granule formulation. Effervescent granules are produced using the wet granulation method, incorporating the active ingredient of mint leaf extract with different concentrations: F0: without the addition of mint leaf extract; F1: mint leaf extract added with a concentration of 15%; and F2: mint leaf extract added with a concentration of 17%. The effervescent granule formula is then evaluated based on its physical characteristics. Phytochemical screening of mint leaves yielded positive results, indicating the presence of essential oils. All mint leaf extract formulations tested for physical evaluation met the specified criteria. Flow properties and angle of repose testing resulted in values between 2-3 seconds for flow properties and 35°-36° for the angle of repose. Compressibility testing produced results ranging from 5% to 15%, pH testing yielded results between 5 and 6, and dissolution time results ranged from 40 to 41 seconds.  Keywords: Mint leaves, extraction, wet granulation, effervescent granules
EFFECTIVENESS TEST OF WOUND PATCH PREPARATIONS OF GOTU KOLA LEAF EXTRACT (Centella asiatica (L.) Urb.) ON INCISION WOUND IN RABBITS Marini Marini; Nur Azizah; Devin Nur Rohman; Angga Anugra Diputra
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.923

Abstract

A wound patch is a dosage form that delivers drugs through the skin to produce systemic effects, with the advantage of controlled drug release. Centella asiatica (L.) Urb.) is widely used to heal incision wounds on the skin. The most important component was asiaticoside, which plays a major role in accelerating wound healing. This  study  was  conducted  to  test  the  effectiveness  of  transdermal  patches  from Centella asiatica (L.) Urb.) against incision  wounds was performed on 5 rabbits divided into different treatment groups, namely group I without treatment, group II wound patch base (negative control), group III plaster (positive control), and groups IV and V, comprising a wound patch of gotu kola leaf extract at concentrations of 16% and 32%, respectively. The data obtained were statistically tested for normality using the Shapiro-Wilk test.  The results showed that the wound patch preparation of 16% gotu kola leaf extract showed  a significant difference (p < 0.05) in wound length reduction compared to the negative and normal controls.  The wound healing time observed at concentrations of 16% and 32% provided wound healing effects. The best effect was observed at a concentration of 16%, with an average wound closure time of 12 days. It can be concluded that gotu kola leaf extract in the form of a wound patch preparation was effective in wound healing. Keywords: Gotu kola leaf extract; incision wound; Wound patch; Effectiveness test
FORMULATION AND STABILITY OF STERILE GEL OF AGARWOOD LEAVES EXTRACT (Gyrinops Versteeg (Gilg.) Domke) FOR DIABETIC WOUNDS Silvi Nurafni; Antonius Padua Ratu; Anisya Dwi Shakil; Siska Fitri Herdiyanti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.924

Abstract

Agarwood leaves contain high levels of secondary metabolites due to increased metabolic processes in agarwood trees infected with fungi. Through this metabolic process, leaves contain secondary metabolites, flavonoids, and tannins. This causes agarwood leaves to have potential as an anti-inflammatory agent for treating diabetic wounds, aimed to formulate a sterile gel preparation of agarwood leaf extract and evaluate its quality, including sterility tests and stability tests (cycling tests) including organoleptic tests, homogeneity, spreadability, adhesive power, viscosity, and pH. A sterile gel formula was prepared with an extract concentration of 4% and variations of Carbopol 940 (gelling agent), namely 0.75%, 1.0%, and 1.25%. The results showed that F1, F2, and F3 were sterile and free of bacterial and fungal growth. The stability test before and after the cycling test in organoleptic tests F1, F2, and F3 were brown, had a distinctive odor of gaharu leaves, and had a soft texture. The homogeneity tests F1, F2, and F3 Homogeneous. The pH values before the cycling test were F1 5.63, F2 4.55, and F3 4.57, whereas after the cycling test, they were F1 5.05, F2 4.87, and F3 4.63. Adhesion time before cycling test F1 02.97 seconds, F2 03.15 seconds, F3 04.86 seconds while after cycling test F1 02.64 seconds, F2 03.04 seconds, F3 03.08 seconds. Spreadability test before cycling test F1 5.4 cm, F2 4.6 cm, F3 3.7 cm, while after cycling test F1 5.0 cm, F2 4.7 cm, F3 3.5 cm ...
REVIEW : THE EFFECT OF MEDICATION REMINDER APPLICATIONS ON MEDICATION COMPLIANCE IN TYPE 2 DIABETES MELLITUS PATIENTS Deni Hendra Alamsyah; Yani Mulyani; Marita Kaniawati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.926

Abstract

Diabetes Mellitus (DM) is a medical disorder that is characterized by elevated blood glucose levels. Its prevalence is increasing globally, with Indonesia projected to have 21.3 million type 2 DM patients by 2030. Medication compliance is crucial in managing diabetes, and medication reminder applications can effectively enhance patient adherence. We conducted a systematic review of 10 national and international journals from to 2013-2023 using PubMed, Google Scholar, and Science Direct, focusing on the following keywords: Diabetes, Medication Compliance, Medication Reminder Application. Our findings suggest that patient knowledge and compliance play a pivotal role in the success of therapy management and that medication reminder applications have a positive impact on enhancing medication adherence. Ensuring that patients with diabetes have access to these tools may improve treatment outcomes. Keywords: Diabetes Mellitus Type 2; Medication Compliance; Medication Reminder Application, Medication Adherence; Medication Reminder App

Page 2 of 4 | Total Record : 32

 1   2   3   4 

Filter by Year

2023 2023


Reset
Filter By Issues
All Issue Vol 10 No 4 (2025): Forthcoming Issue Vol 10 No 3 (2025) Vol 10 No 2 (2025) Vol 10 No 1 (2025) Vol 9 No 4 (2024) Vol 9 No 3 (2024) Vol 9 No 2 (2024) Vol 9 No 1 (2024) Vol 8 No 4 (2023) Vol 8 No 3 (2023) Vol 8 No 2 (2023) Vol 8 No 1 (2023) Vol 7 No 4 (2022) Vol 7 No 3 (2022) Vol 7 No 2 (2022) Vol 7 No 1 (2022) Vol 6 No 2 (2021) Vol 6 No 1 (2021) Vol 5 No 2 (2021) Vol 5 No 1 (2020) Vol 4 No 2 (2020) Vol 4 No 1 (2019) Vol 3 No 2 (2019) Vol 3 No 1 (2018) Vol 2 No 2 (2018) Vol 2 No 1 (2017) Vol 1 No 2 (2017) Vol 1 No 1 (2016) More Issue