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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 32 Documents
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Search results for , issue "Vol 8 No 4 (2023)" : 32 Documents clear
ANTIOXIDANT ACTIVITY OF ROASTED KEDAWUNG SEED (Parkia timoriana) USING SCAVENGER FREE RADICAL DPPH METHOD Ismanurrahman Hadi; Teguh Adiyas Putra; Reza Alrayan; Arif Setiawansyah; Dewi Luthfiana; Perdana Priya Haresmita
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.932

Abstract

Kedawung seeds (Parkia timoriana) contain polyphenolics and flavonoids that can provide pharmacological activities, such as antioxidants. In several regions of Indonesia, kedawung seeds are preserved using the roasting method. This study aimed to analyze the effect of roasting on the content of phytochemical compounds and determine their antioxidant activity using the DPPH method. Roasted kedawung seeds were extracted using a maceration method in ethanol. Phytochemical screening was performed to qualitatively analyze the contents of several phytochemical compounds in the extract. The results showed that roasted kedawung seed extract contained alkaloids, flavonoids, saponins, and terpenoids. Antioxidant testing was performed using the DPPH method with ascorbic acid as a positive control. The IC50 value of ascorbic acid, P. timoriana seed and roasted seed of P. timoriana measured each 12.3 ppm; 20.6 ppm and 9.8 ppm; which categorized as strong antioxidant compounds. These results indicated an increase in the antioxidant effect after roasted seed processing. It concluded that the roasting process could enhance antioxidant effect of P. timoriana seed  Keywords: Kedawung seeds, roasted method, antioxidant, DPPH
EFFECTIVENESS PROFILE OF AMLODIPINE AND LISINOPRIL IN HYPERTENSION OUTPATIENTS AT PRATAMA CLINIC SIDOARJO Andri Priyoherianto; Elly Purwati; Erna Fitriany; Husna
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.941

Abstract

Hypertension is the leading cause of premature death worldwide. An estimated 1.28 billion  adults aged 30-79 years worldwide have hypertension. Treatment of hypertension is usually aimed at preventing morbidity and mortality from hypertension. The choice of drugs for each patient's hypertension depends on the metabolic and subjective side effects caused. This study aims to determine the effectiveness profile of antihypertensive drugs amlodipine 10 mg or lisinopril 10 mg in outpatients at the Sidoarjo Pratama Clinic for January- March 2023. This research method is observational, with a cross-sectional approach and data collection. Quantitative analysis was then done using the statistical program SPSS 24 with univariate analysis. The results of the independent t-test showed a significance value for the systolic category of 0.780 > 0.05 and a significance value for the diastolic category of 0.931 > 0.05. Patients receiving therapy with amlodipine 10 mg or lisinopril 10 mg reached the target in 30 patients. After doing the independent t-test before and after therapy in both the systolic category and the diastolic category, it can be concluded that there is no significant difference in the effectiveness of the two groups. Keywords: Amlodipine, Blood Pressure, Hypertension, Lisinopril
ARTICLE REVIEW: THE TREATMENT PROBLEM AND ADVERSE DRUG REACTIONS IN THE TREATMENT OF MULTIDRUG-RESISTANT TUBERCULOSIS Sartika Aprianti; Prayudi Santoso; Melisa Intan Barliana; Ivan Surya Pradipta
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.988

Abstract

Multidrug-resistant tuberculosis (MDR-TB) is the resistance of Mycobacterium tuberculosis to at least two tuberculosis (TB) drugs, rifampicin and isoniazid. The disease requires a long treatment duration with several second-line drugs. This leads to a globally low success rate of approximately 56% for MDR-TB treatment.  Studies have reported that adverse drug reactions (ADRs) contribute to high rates of non-compliance, treatment discontinuation, and failure. This narrative review aimed to provide information about MDR-TB treatment modalities, various ADRs, challenges encountered in MDR-TB treatment, and instances of ADRs that can impact treatment success. This narrative review study was conducted by searching for scientific information from the primary electronic databases PubMed and Google Scholar, covering 2012-2022. Based on the literature search results, 14 studies were identified, demonstrating challenges in TB and MDR-TB treatment, along with 6 ADRs that can influence treatment success in MDR-TB patients. ADRs during MDR-TB treatment can affect patients’ physical, mental, and social well-being as well as their beliefs and behaviors related to treatment. Comprehensive support from families, communities, and healthcare providers is essential to assist patients in addressing treatment challenges and adverse ADRs. Rapid identification and strategies for monitoring and managing treatment challenges and ADRs can improve compliance and success of MDR-TB treatment. Keywords: Adverse Drug Reactions, Drug Side Effects, Multi Drug-Resistant Tuberculosis (MDR-TB), Treatment Success
STUDY OF POTENTIAL DRUG INTERACTIONS IN HYPERTENSION PATIENS AT THE INPATIENT INSTALLATION OF PERMATA CIREBON HOSPITAL Risa Deviani Azzahra; Nur Rahmi Hidayati; Indah Setyaningsih; Sulistiorini Indriaty; Lela Sulastri; Nina Karlina
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.997

Abstract

Identification of drug interactions in hypertensive patients needs to be performed because they affect the achievement of therapeutic effects and can increase the risk of side effects. This study aimed to determine patient characteristics (age, gender, drug items used, and comorbidities), the potential for drug interactions in hypertensive patients, the severity of potential drug interactions, and the type and number of drugs that interact in hypertensive patients at the time of installation. Inpatient at Permata Cirebon Hospital. The sample in this study included patients diagnosed with hypertension at the Inpatient Installation of Permata Cirebon Hospital in 2022 who met the inclusion criteria. This was a descriptive analytical study with retrospective data on patient characteristics (age, sex, drug items used, and comorbidities). The results were analyzed in the form of an overview of potential drug interactions using the Medscape application in the form of percentages and tables. The results of the study of 264 samples of hypertension patients taken by random sampling obtained for drug interaction based on severity events were as many as 149 patients (56,44%) with the highest number of gender, namely women as many as 154 patients (58,33%), the level of severity at most, namely monitors as many as 261 events (82,33%). The most interacting drug was Amlodipine with Metformin, with 27 monitored interactions (8,52%). Drug interactions can occur due to the number of drug therapies used and the presence of comorbidities. Keywords: Hypertension, Drug Interactions, Permata Cirebon Hospital.
DEVELOPMENT OF KNOWLEDGE, PERCEPTIONS, AND PUBLIC ATTITUDES QUESTIONNAIRE FACING THE ERA OF COMPULSORY HALAL MEDICINE CERTIFICATION Ahmad Azrul Zuniarto; Nurkhasanah Mahfudh; Dyah Aryani Perwitasari; Siti Pandanwangi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1002

Abstract

A questionnaire is an instrument used to collect data from several people or respondents through a set of questions to be answered. The validity and reliability of the questionnaire describe how well the preparation of the questionnaire was related to the measurement scale. Reliability indicates that the questionnaire is consistent when repeatedly used. This study aimed to obtain a valid and reliable questionnaire on community knowledge, perceptions, and attitudes toward halal drugs.  The reliability of the knowledge questionnaire, perceptions, and attitudes was defined using  Cronbach's alpha. This cross-sectional study was conducted online from January to February 2023, with 600 respondents in six provinces on Java Island. The knowledge questionnaire validation test used Point Biserial, perception, and attitude of using the Pearson Product Moment. The majority of respondents were aged <25 years (73%), the dominant last level of education was the secondary level (66.5%), and most of the jobs were students (38.7%). The r value of the knowledge domain obtained is (0.209-0.662) which was greater than the r table (0.080) and met the validity criteria, the perception domain (0.471-0.764), and the attitude domain (0.250-0.757) which is greater than the r table and satisfies the validity criteria. The Cronbach’s alpha value of the knowledge domain obtained was 0.730, that of the perception domain was 0.756, and that of the attitude domain was 0.723, which was > 0.6 and meets the reliability criteria...
CORRELATION OF MEDICATION ADHERENCE WITH THE CHARACTERISTICS AND QUALITY OF LIFE OF TUBERCULOSIS PATIENTS IN DR. DRADJAT PRAWIRANEGARA HOSPITAL Yusransyah Yusransyah; Rozwaliza Annintan; Farahdina Chairani; Baha Udin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1005

Abstract

Tuberculosis remains a health threat in Indonesia because its prevalence is relatively high; therefore, special tuberculosis control is needed. One way to control tuberculosis is to increase compliance with treatment, which can affect quality of life. The main objective of this study was to determine the relationship between the level of treatment compliance and the characteristics and quality of life of patients at dr. Dradjat Prawiranegara Serang Hospital. This study used a cross-sectional, observational research method. Data were collected by distributing questionnaires filled out through direct interviews with the patients. The questionnaires used were the MARS and EQ-5D-5L questionnaires were used. The subjects in this study were outpatients with tuberculosis who were undergoing treatment at our hospital. The Drajat Prawiranegara Serang Hospital met the inclusion and exclusion criteria. Sequential sampling was used as a sampling technique in this study. Statistical data analysis was performed using the chi-square test and correlation. The number of respondents in this study who met the inclusion criteria was 30. As many as 80.0% of tuberculosis patients adhere to taking medication, and 83.3% of tuberculosis patients have a good quality of life. The results of statistical tests show that there is a relationship between the level of compliance of tuberculosis patients and the level of knowledge, income, attitude of health workers, and family support. In contrast, the variables of the level of education, employment, motivation, distance to health facilities, and quality of life did not have a significant relationship with the level of tuberculosis patient compliance...
ACTIVITY OF ZEBRINA PENDULA SCHNIZL. EXTRACT AGAINST STAPHYLOCOCCUS AUREUS, CANDIDA ALBICANS, AND BACILLUS SUBTILIS Ririn Puspadewi; Mira Andam Dewi; Anggi Gumilar; Luki Yogaswara Yusuf; Estefania Amaris Ivana; Tiara Parmayani; Alpina Rismayati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1008

Abstract

Zebrina pendula Schnizl., known for its medicinal properties against dysentery, contains chemical compounds like polyphenols, flavonoids, quinones, and terpenoids. Despite its potential, research on Zebrina pendula Schnizl. remains limited. This study aimed to assess the antimicrobial activity of Zebrina pendula Schnizl. extract against Staphylococcus aureus, Candida albicans, and Bacillus subtilis, using the microdilution method. The stages of the study include determination, phytochemical screening of Zebrina pendula Schnizl., standardization, multilevel extraction using n-hexane, ethyl acetate, and 96% ethanol, and antimicrobial activity testing via microdilution method to determine Minimum Inhibitory Concentrations (MIC) and Minimum Bactericidal Concentrations (MBC).
FORMULATION, AND CHARACTERIZATION OF NANOSTRUCTURED LIPID CARRIER (NLC) CONTAINING QUERCETIN Asti Rahayu; Astrid Kusuma Putri; Nadya Ambarwati; Fithri Farchah Frischah Sari; Rizky Anugrah Dirgantara Putra
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1009

Abstract

Quercetin, like triterpenoids, decreases blood glucose levels. Quercetin has several limitations including low solubility, low percutaneous permeability, and low bioavailability. The formulation of quercetin preparations in a Nanostructured Lipid Carrier (NLC) system is one solution to increase its solubility. The quercetin NLC system was successfully formulated by the high shear homogenization method at a speed of 6000 rpm. The solid lipid glyceryl monostearate and  sunflower oil play important roles in the formation of NLC. The physicochemical characteristics examined in this study included the particle size, dispersion, viscosity, pH, and entrapment efficiency. The particle size of NLC quercetin ranges from 22.98 ± 0.008 nm to 41.04 ± 0.082 nm, with p-values < 0.05. The dispersion power of quercetin NLC ranges from 5.12 ± 0.11 cm to 7.01 ± 0.28 cm, p values < 0.05. The resulting pH range is 7.3 ± 0.01 to 7.4 ± 0.01, and the resulting viscosity is 223.7 ± 9.8 cps to 492.0 ± 0.0 cps. Entrapment efficiency range of (62.20 ± 0.245)% to (86.17 ± 0.287)% ( p < 0.05). The ratio of solid lipid concentration to liquid lipid concentration in NLC quercetin has a significant effect on particle size, dispersion, and entrapment efficiency.  Keywords: Nanostructured Lipid Carrier, Quercetin, Lipid, Glyceryl Monosterate, Sunflower Oil
FORMULATION AND EVALUATION OF EFFERVESCENT GRANULE OF WHITE TEMU RHIZOME EXTRACT (Curcuma zedoaria (Christm.) Roscoe.) AS ANTIOXIDANT Reza Pratama; Deny Puriyani Azhary; Soni Muhsinin; Adinda Khumairani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1050

Abstract

More than 9,606 plant species have medicinal properties, but only around 3-4% of these have been cultivated commercially and used in traditional medicine in Indonesia. One of the natural ingredients believed to have properties is the white temu rhizome. White Curcuma rhizomes are usually processed into food and drinks. White ginger rhizome has antioxidant activity. Antioxidants are secondary metabolites found in herbal plants and have pharmacological activities that can minimize free radicals. Several studies have shown that white ginger rhizomes have antioxidant activities that can remove free radicals. This research aims to formulate an effervescent granule preparation. for white temu rhizome extract (Curcuma zedoaria (Christm.) Roscoe) using the wet granulation method, which meets the requirements for the physical properties of granules and has antioxidant activity. Several formulae were selected from various combinations. Next, an evaluation was performed to determine the physical properties and activities of the formulated granules. The evaluation results showed that all formulations met the requirements of the physical properties of the granules. Qualitative antioxidant activity testing using TLC plates showed positive antioxidant results in the extract and effervescent granule preparation of white curcuma rhizome extract and in quantitative testing it was found that the IC50 value of white curcuma rhizome extract was in the strong category and in the effervescent granule preparation of white curcuma rhizome extract, the granules were found to be in the strong category. Keywords: Effervescent Granule, Extracts, White Temu Rhizome (Curcuma zedoaria (Christm.) Roscoe), Antioxidants
ANALGETIC ACTIVITY DETERMINATION OF PAPAYA LEAVES (Carica papaya L.) AND BASIL LEAVES (Ocimum sanctum L.) EXTRACTED USING NATURAL DEEP EUTECTIC SOLVENT Renny Amelia; Yuniarti Falya; Tomi; Daryuti; Eka Umi Barkah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.1079

Abstract

Natural deep eutectic solvents (NaDES) are obtained from an adequate mixture of hydrogen bond acceptors (HBA) and donors (HBD), which can bond through the interaction of hydrogen bonds to form a eutectic with a low melting point. NADES has been implemented in several studies as an effective extraction method, but it is still not widely used. C. papaya leaves and O. sanctum leaves have been widely known to have various pharmacological activities. The aim of this study was to determine the best analgesic ability of the NADES extract of C. papaya and O. sanctum leaves. The extraction process used was Microwave-Assisted Extraction (MAE). The liquid extract was tested for antioxidant activity and analgesic activity using doses of 600 mg/kgBW, 800 mg/kgBW, and 1000 mg/kgBW. The results show that The IC50 values of the NADES extract of C. papaya and O. sanctum leaves were 920 ppm and 882 ppm, respectively. Both analgetic percentages are equivalent to the positive control starting from a concentration of 800 mg/kgBW, where the analgetic percentage of the NADES extract of papaya leaves and basil leaves is 59.80% and 54.57% respectively that included in weak category. It can be concluded that both NADES extracts of papaya and basil leaves have analgetic capabilities.  Keywords: Natural Deep Eutectic Solvent (NADES), Carica papaya, Ocimum sanctum, analgetic activity.

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