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Nanang Yunarto
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Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan Kementerian Kesehatan RI Jl. Percetakan Negara No. 23 - Jakarta 10560
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INDONESIA
Jurnal Kefarmasian Indonesia
Published by Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan
ISSN : 2085675X     EISSN : 23548770     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 8 Documents
 1 
Search results for , issue "VOLUME 9, NOMOR 2, AGUSTUS 2019" : 8 Documents clear
Faktor-Faktor yang Memengaruhi Clinical Outcome Nyeri pada Pasien Diabetes Neuropati di Poliklinik Penyakit Dalam RSUD Kota Yogyakarta Dirga, Dirga; Nugroho, Agung Endro; Pramantara, Dewa Putu
Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 2, AGUSTUS 2019
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v9i2.388

Abstract

The treatment of diabetic neuropathy pain has not possessed an explicit guideline therapy yet, due to the difference perception towards the respond of pain from certain individu. In indonesia, the data regarding factors that could affect clinical outcome of pain are still limited to the meassurement of tolerance, perception, and sensitivity of certain pain. This study aims to describe the clinical outcome of pain along with the affected factors for diabetic neuropathy patients in Internal Medicine Clinics of Yogyakarta City General Hospital. The design of this This study is an analytical descriptive with cross sectional approach to 81 patients of diabetic neuropathy pain. The pain level measurement of patient is conducted with Visual Analog Scale (VAS) Instrument. The obtained data are analyzed statistically by applying Chi Square and logistical regression analysis. The results of this study showed that 60 patients (74,07%) had reached clinical outcome of pain, and 21 patients (25,93%) had not reached clinical outcome of pain. Factors that affecting clinical outcome of pain to diabetic neuropathy patients were BMI non-obesity (p = 0.043), period of diabetic less than 5 year (p = 0.022), anticonvulsant consuming (p = 0.039), and neurotropic vitamin (p = 0.002). According to the result of multivariate analysis by applying logistical regression test, neurotropic vitamin was claimed as the most influential factor towards clinical outcome of neuropathy pain to diabetic neuropathy patients with p = 0.013, OR = 11.109, and Cl = (1,668-73,970).
Analisis Profil dan Faktor-Faktor yang Memengaruhi Perilaku Kepatuhan Pengobatan untuk Pasien Diabetes Mellitus Lanjut Usia Makkulawu, Andi; Setiadi, Adji Prayitno; Rahardjo, Tri Budi Wahyuni; Setiawan, Eko
Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 2, AGUSTUS 2019
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v9i2.405

Abstract

Adherence with medication is one of the important factors in controlling blood glucose levels in patients with diabetes mellitus (DM), which in turn also determines the risk of diabetic complications. The profile and factors that influence adherence behaviour in the use of medication in elderly diabetic patients in Indonesia, especially in East Surabaya, are not yet known. The purpose of this study was to identify profiles and factors that influence the behavior of drug use adherence in elderly DM patients. A cross-sectional study was conducted in 32 Karang Werda or support groups for elderly in East Surabaya. Identification of the respondent’s level of adherence was carried out using the Adherence to Refill and Medication Scale (ARMS) questionnaire while the contributing factors towards adherence behaviour were identified using a published questionnaire. Both questionnaires have been validated in elderly people living in Surabaya. Result of adherence profile analysis was expressed in terms of percentage while determinant factors analysis was identified by using the highest mean among 14 sub-domains included in the questionnaire. In total, 281 elderly diabetic patients were recruited in this study. It was identified that 67.26% of the respondents were classified as non-adherence patients. The dominant factors that contribute to the behavior of medication adherence in elderly diabetic patients were social support, product-related factors, health workers, and emotional factors. Appropriate interventions to optimize the use of medications in elderly diabetic patients need to be identified and implemented according to the identified contributing factors.
Efek Sitotoksik Formula Jamu Daun Sirsak, Buah Takokak, dan Umbi Bidara Upas terhadap Sel Kanker Payudara MCF-7 Widiyastuti, Yuli; Marfuatush Sholikhah, Ika Yanti; Haryanti, Sari
Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 2, AGUSTUS 2019
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v9i2.1049

Abstract

Cancer is one of the leading cause of death in the world. Complicated and high cost treatments of cancer encourages people to look for alternative treatments among others using medicinal plants. Some medicinal plants that are empirically claimed to have anticancer effect are soursop (Annona muricata), takokak (Solanum torvum), and bidara upas (Merremia mammosa). However, these medicinal herbs have not been tested for cytotoxic activity against MCF-7 cancer cells. The purpose of this study was to determine the cytotoxic activity of the anticancer herbal formula consisting those three plants. The effect of each single extract and the combination formula were tested for their activity on cell viability of MCF-7 with MTT assay method. The herbal formula with the most active combination of medicinal plant extracts was further tested for its activity on the expression of Bcl-2 protein by immunocytochemistry methods. The results showed that each single extract and the combination formula gave cytotoxic effect on MCF-7 breast cancer cells. Formula A, consisted of a mixture of soursop leaves, takokak fruit, and bidas upas bulb with a ratio of 1:1:1, results in highest inhibition of the viability of MCF-7 cells with IC50 values of 48 µg/ml. The formula also enhances the apoptosis process in MCF-7 cells which is shown by decreasing the expression of antiapoptotic Bcl-2 proteins.
Identifikasi Senyawa Aktif Ekstrak Buah Mengkudu (Morinda citrifolia L.) dan Potensinya sebagai Inhibitor Karies Gigi Sogandi, Sogandi; Nilasari, Putu
Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 2, AGUSTUS 2019
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v9i2.1289

Abstract

Dental caries is a disease that many people experience, which is formed by the buildup of plaque on the teeth and the presence of bacteria. The bacteria known to be involved in the formation of dental caries is Streptococcus mutans. Dental caries used to be treated using antibiotics. However, it is known that many antibiotics are no longer effective against this bacteria hence it is necessary to look for another alternative. One alternative choice as an antibacterial is Noni fruit. This study aims to identify the bioactive compounds of noni fruit (Morinda citrifolia L) and to know the mechanism of action in inhibiting the growth of Streptococcus mutans. Noni fruit was macerated using 96% ethanol, then fractionated using n-hexane and ethyl acetate. Antibacterial activity test was done using agar difusion method, and identification of bioactive compounds was conducted using GCMS. The results showed that ethyl acetate fraction has the highest inhibitory activity on the growth of Streptococcus mutans with inhibition zone of ±17 mm and MIC (minimum inhibitor concentration) value of 10%. The inhibition mechanism is asumed to be done by making holes in cell membranes, which can be seen from the high concentration of proteins and nucleic acids coming out of cells after treatment that in turn means that cell leakage has occurred. The results of this study indicate that noni fruit (Morinda citrifolia L) contain bioactive quinolone compounds that can be a new source for treating dental caries
Analisis Biaya Obat Unit Rawat Jalan pada Rumah Sakit Badan Layanan Umum (BLU)/ Badan Layanan Umum Daerah (BLUD) di Indonesia Suharmiati, Suharmiati; Handayani, Lestari; Roosihermiatie, Betty
Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 2, AGUSTUS 2019
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v9i2.1369

Abstract

Drugs expenditure is the highest proportion in health services budget. financing for health services in National Universal Health Coverage era is carried out by BPJS payed to referral health facilities namely hospitals. The medicine cost at public service agency/District or Province public service agency is unknown certaintly. This descriptive study was advanced analyzes of the secondary data of 84 hospitals from health financing research in the year of 2016. The result showed that there were problems of drug availability in class B 94,6%, C 78,9% and A 77,8%. The highest proportion of generic drugs cost to total drug cost is class C hospital, followed by B class and A class hospitals i.e 40,57%, 37,83% dan 23,74% respectively. The cost of non generic drug compared to generic drugs at A, B and C class is 2,22 times, 1,15 times and 0,86 times respectively. The highest cost of generic drug is in outpatient specialist services in all class of hospitals. The cost of the drugs was increasing higher as well as the hospital class. Conclusion: The non generic drugs cost dominated in A and B class hospital while C class was generic drug cost. Generic drug use policy should be socialyzed by government and to be considered by management in order to be able to carried out cost efficiency.
Aktivitas Antiinflamasi Crude Extract Fukoidan dari Sargassum crassifolium pada Sel RAW 264.7 yang Diinduksi LPS Hikariastri, Pangartika; Winarno, Hendig; Kusmardi, Kusmardi; Laksmitawati, Dian Ratih; Abdillah, Syamsudin
Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 2, AGUSTUS 2019
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v9i2.1547

Abstract

Inflammation is known as the basic mechanism underlying various chronic diseases. Macrophage activation by inflammatory stimulus induces the release of inflammatory mediators, thus the mediators becoming a promising target of anti-inflammatory drug development. Previous studies indicated that fucoidan has anti-inflammatory activity by inhibiting the release of proinflammatory mediators. The aim of this study is determining anti-inflammatory activity of fucoidan crude extract form Sargassum crassifolium Garut waters by observing its effect on proinflammatory cytokines TNF-α, IL-1β, dan IL-6. Fucoidan is a polysaccharide substance which has various characteristics, depending on the source and the extraction method which is influencing its bioactivity. Sargassum crassifolium collected from Garut-West Java is extracted using diluted HCl 0,1 M and precipitated with ethanol to obtain fucoidan crude extract. The crude extract is tested on LPS-induced RAW 264.7 cells to evaluate its effect on TNF-α, IL-1β, and IL-6 level using ELISA method. The result showed that fucoidan crude extract decreased the level of TNF-α by the dose of 25 and 50 μg/ml, and decreased the level of IL-1β and IL-6 by the dose of 25 μg/ml. The dose of 50 μg/ml failed to inhibit IL-1β and IL-6 production. This study showed that fucoidan crude extract derived from S. crassifolium has anti-inflammatory activity to RAW 264.7 cells by the dose of 25 μg/ml.
Efek Dua Sediaan Ramuan Jamu pada Pasien Obesitas: Studi Klinis dengan Desain Paralel, Random dan Tidak Tersamar Zulkarnain, Zuraida; Nisa, Ulfatun; Wijayanti, Enggar; Fitriani, Ulfa
Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 2, AGUSTUS 2019
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v9i2.1596

Abstract

Obesity is a co-morbidity of cardiovascular disease, diabetes, and other metabolic diseases, which the prevalence increases every year. The use of herbal medicine is an alternative choice to overcome obesity. Clinical observation of decoction of herbal medicine (Dutch teak, kemuning, rhei radix and tempuyung) has been conducted for obesity therapy which has been proven to be effective in reducing body weight and body mass index (BMI). Innovation in steeping form is considered more practical than stew. Randomized open label pararel design research was carried out to assess the equal efficacy of the herbs in stew and steeping form. The number of subjects in each group were 30 subjects, they were patients of of Rumah Riset Jamu (RRJ) Hortus Medicus during June-October 2016 who met the inclusion criteria. BW and BMI are measured on Day-0, 28 and 56, while body height is measured once at Day-0. Both stew and steeping groups drank herbs twice a day for 56 days. At the end of the study, it was found that the mean of declining BW of the decoction group was 67.35 kg to 66.37 kg, while the steeping group 67.41 kg to 66.45 kg. BMI of stew group was decreased 26.85 kg / m2 to 26.46 kg / m2, while in steeping group 26.67 kg / m2 to 26.29 kg / m2. Statistic test result to compare BW and BMI of both two groups before and after treatment showed no significant differences in the two groups (p> 0.05). The ability of herbal medicines in steeping or stew forms can reduce the BW and BMI equally.
Aktivitas Antioksidan serta Penghambatan HMG CoA dan Lipase dari Kombinasi Ekstrak Daun Binahong-Rimpang Temu Lawak Yunarto, Nanang; Aini, Nurul; Oktoberia, Intan Sari; Sulistyowati, Indah; Kurniatri, Arifayu Addiena
Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 2, AGUSTUS 2019
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v9i2.1930

Abstract

TThe prevalence of dyslipidemia in Indonesia continues to increase. Anredera cordifolia and Curcuma xanthorrhiza are empirically used in the community to overcome dyslipidemia disorders. Flavonoids as the main compounds in A. cordifolia and curcumin in C. xanthorrhiza have potential as antioxidant activity. This study aims to determine the in vitro mechanism of A. cordifolia and C. xanthorrhiza to reduce cholesterol associated with antioxidant activity. The testing was carried out on a combination of ethanol extracts of A. cordifolia leaves with C. xanthorrhiza rhizomes (1:1) and their single extract. The antioxidant activity test was conducted using DPPH method by making serial dilution of samples and ascorbic acid with adding DPPH. The inhibitory activity of HMG CoA and lipase enzymes was carried out enzymatically using ELISA as well as simvastatin as the comparison. The results showed that the highest antioxidant activity is in C. xanthorrhiza extract samples IC50 16.21 ± 1.74 µg/mL, but was less potential compared to ascorbic acid IC50 7,63±0,85 µg/mL. The most potential inhibition of HMG CoA and lipase is in C. xanthorrhiza samples IC50 8.35 ± 0.02 and 22.35 ± 1.26 µg/mL. The combination of A. cordifolia and C. xanthorrhiza (1: 1) is better than A. cordifolia extract but lower than C. xanthorrhiza extract in antioxidant activity as well as the inhibition of HMG CoA reductase and lipase. The result showed a correlation that the higher antioxidant activity, the higher inhibitory of HMG CoA reductase and lipase respectively.

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