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Journal of Nutraceuticals and Herbal Medicine
Published by Universitas Muhammadiyah Surakarta
ISSN : -     EISSN : 26154609     DOI : https://doi.org/10.23917/jnhm
Core Subject : Health,
Medicine & Pharmacology
Journal of Nutraceuticals and Herbal Medicine contains peer-reviewed article and research dedicated to advancing the scientific knowledge base of health, especially health nutrition, nutraceuticals and nutrition formula for human essential. This journal includes original research concerning the herbal medicine phytochemical, phytopharmacy, phytopharmacology, phytotheraphy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Farmakologi
Articles 5 Documents
 1 
Determination Of Total Phenolic, Flavonoid Contents, And Antioxidant Activity Evaluation of Ethanolic Extract From Plumeria Alba Attasih, Monicia; Muhtadi; Pambudi, Dwi Bagus; Saad, Muhammad
Journal of Nutraceuticals and Herbal Medicine Vol 5, No 1 (2024): JNHM 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v5i1.3700

Abstract

A polluted environment and an unhealthy lifestyle can result in an increase in the number of free radicals in the body. This condition can be reduced by consuming antioxidant-rich plants. This study aims to determine the antioxidant activity of the ethanol extract of the Cambodian plant (Plumeria alba L.) and its correlation with phenolic and flavonoid levels. Sample extraction was carried out using the maceration method, antioxidant activity was measured using the DPPH and CUPRAC methods, and total flavonoid and phenolic levels were measured using the spectrophotometer method. The results showed that the ethanol extract of P. alba L stems had inactive antioxidant activity, while the ethanol extract of P. alba L flowers and leaves had weak antioxidant activity with IC50 values of 266.72 ppm and 312.96 ppm. The ethanol extract of P. alba L flowers and leaves has an antioxidant capacity of 208.82 and 207.81 mg trolox equivalent/g extract. The total phenolic content measured from the ethanol extract of P alba L flowers and leaves was 2.28 and 48.43 mg gallic acid equivalent/g extract, while the flavonoid content was 29.73 and 31.26 mg quercetin equivalent/g extract. The antioxidant activity of the extract was positively correlated with phenolic and flavonoid levels.
Antiobesity Activity Of A Combination Of Extracts From Porang Tubers ( Amorphopallus Muelleri ) and Jati Belanda Leaves ( Guazuma Ulmifolia ) In Obesity Rat Models Fahmi, Muhammad Zaini; Muhtadi; Hidayatullah, Muhammad Haqqi
Journal of Nutraceuticals and Herbal Medicine Vol 5, No 1 (2024): JNHM 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v5i1.3703

Abstract

Obesity is an excessive accumulation of fat due to an imbalance in energy intake with energi expenditure for a long time. Obesity can be reduced by taking drugs. One of the commonly used herbal medicines for obesity is porang tubers and Dutch teak plants. The purpose of this study was to prove the anti-obesity activity of the combination of porang tuber extract with Dutch teak leaf extract in obese rat models. Anti-obesity effect test was carried out for 14 days on obese rats. The antiobesity effect was assessed by the index Lee ≥ 0,3 and weight loss. This study was conducted using 5 groups of test animals, namely the negative group (PGS 1%), positive (orlistat 7.57 mg/kgBW), and 3 groups of a combination of porang tuber extract and Dutch teak leaves, 50 + 62.5; 50 + 125; 50 + 250 mg/kgBW. Weight loss occurred in groups II, IV,and V, in groups I there was an increase in body weight. The mean results of the Lee index of groups I, II, III, IV, and V were 0,31 ± 0,02, 0,29 ± 0,01, 0,29 ± 0,01, 0,29 ± 0,01, and 0,30 ± 0,01. Data analysis using the Kruskall-Wallis test resulted in no significant difference of 0.715 (p>0.05) on day 14 which showed that the combination of porang tubers and Dutch teak leaves had no anti-obesity effect.
Antidiabetic Activities and Phytochemical Screening of Broccoli Plants (Brassica oleracea L. var. italica) Chairunnisa, Alya; Haryoto, Haryoto; Abdul, Ahwan
Journal of Nutraceuticals and Herbal Medicine Vol 5, No 1 (2024): JNHM 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v5i1.3705

Abstract

Diabetes mellitus is a metabolic disease that is characterized by hyperglycemia which is closely related to pancreatic β cell dysfunction and insulin resistance. Brassica oleracea L. var. italica is a member of the Brassicaceae family which has antidiabetic properties. These effects are caused by the presence of various phytochemical compounds in broccoli plants, flavonoids, tannins, saponins, alkaloids, steroids, glucosinolates, isothiocyanates, and phenolics. The aim of this review is to find out the antidiabetic activity of broccoli plants and the mechanism of action of phytochemical compounds in broccoli plants that support these benefits. The preparation of this review was sourced from articles obtained from the PubMed and Google Scholar databases with the interval 2012-2021 publication year. Based on the selected articles, it shows that the content of phytochemical compounds in broccoli plants has an effect on reducing blood sugar levels through various mechanisms. Therefore, the results of this study are expected to be used as support for the use of broccoli plants as antidiabetic agents.
White Mangrove Pidada (Sonneratia Alba) Leaves Extract in Handbody Lotions: A Qualitative Evaluation and Alignment With Indonesian National Standards Nisa, Husna Idza Auziadzatun; Pambudi, Dwi Bagus; Mugiyanto, Eko
Journal of Nutraceuticals and Herbal Medicine Vol 5, No 1 (2024): JNHM 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v5i1.4409

Abstract

The White Mangrove Pidada Leaves (Sonneratia alba) serve as a source of secondary metabolites, including phenols, tannins, steroids, and flavonoids, known for their high antioxidant content, making them effective in countering free radicals. The choice of a handbody lotion formulation is based on its easy skin absorption, non-sticky nature, and absence of residue upon application. The focus of this study is to evaluate the handbody lotion formulation enriched with White Mangrove Pidada Leaves extract. Utilizing a qualitative approach, this study employed a cycling test conducted over three cycles for the evaluation of handbody lotion formulations. After three cycles, Formula A demonstrated a semi-solid consistency, light green color with a grape scent, pH 6, and homogeneity. Notably, it showcased a spreadability of 4.925 cm, adhesiveness of 1.76 seconds, and viscosity of 6.791 mPa.S. In the case of Formula B, a semi-solid with a light green color and grape scent, despite having pH 6, exhibited a lack of homogeneity, with a spreadability of 5.175 cm, adhesiveness of 1.37 seconds, and viscosity of 6.592 mPa.S. Formula C, characterized as a semi-solid with a dark green color and grape scent, displayed homogeneity, pH 6, a spreadability of 5.25 cm, adhesiveness of 2 seconds, and viscosity of 7.568 mPa.S. The findings lead to the conclusion that, following three cycles, the handbody lotion formulations align with the criteria established by the Indonesian National Standard (SNI).
Cytotoxicity of Moringa Plants ( Moringa Oleifera L.) on Cancer Cells Haryoto, Haryoto; Suranto, Choirun Nisa
Journal of Nutraceuticals and Herbal Medicine Vol 5, No 1 (2024): JNHM 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jnhm.v5i1.4446

Abstract

Moringa ( Moringa oleifera L.) is one of the herbal plants that grows in Indonesia. Moringa oleifera has many properties, namely that it can act as an antidiabetic, antibacterial, antitumor, antipyretic, antiepileptic, antiinflammatory, antiulcer, antispasmodic, diuretic, antihypertensive, cholesterol lowering, antioxidant, hepatoprotective, antifungal. The aim of preparing this review is to determine the cytotoxic activity of Moringa oleifera L.) and the mechanism of action of secondary metabolites that can be isolated from Moringa. The preparation of this review comes from articles obtained through the Google Scholar database , PubMed and Sciencedirect with the keywords namely " Cytotoxic AND " Moringa oleifera lam" AND Anticancer AND IC50 values ". The inclusion criteria set were original articles or articles full text in PDF format regarding the potential cytotoxic activity of the Moringa oleifera L. plant in vitro with a publication year range of 2012-2021, using the MTT assay method , has an IC value of 50 < 50 µg/mL in the leaves and seeds and has an IC value 50 < 100 µg/mL in other plant parts . From these criteria, 10 suitable articles were obtained . The results of the analysis show that the cytotoxic activity of M. oleifera against several cancer cells can be categorized as active to very active . Next, it can be seen if it has anticancer activity M. oleifera is obtained from secondary metabolites resulting from extraction M. oleifera . Secondary metabolites that have been isolated from M. oleifera is known to contain lectins, routine, quercetin, astragalin, isoquercetin, glucomoringin, 7-Octenoid Acid, Oleamide, and 1-Phenyl-2-Pentanol. This metabolite has an anticancer mechanism in the form of inducing apoptosis through : (1 ) ROS -mediated signaling pathways , (2) targeting the anti-apoptotic protein BCL-2 family, (3) regulation of the tumor suppressor protein p53, (4) inhibition of NF- κB, and ( 5) decrease in MAPK signal.

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