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Jurnal Sains dan Kesehatan
Published by Universitas Mulawarman
ISSN : 23030267     EISSN : 24076082     DOI : 10.25026/jsk
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Jurnal Sains dan Kesehatan menerima naskah karya asli (Artikel Penelitian, Artikel Review, dan Studi Kasus), baik eksperimental maupun teoretis, dalam bidang-bidang berikut: Sains dan Kesehatan (Kedokteran, Farmasi, Kesehatan Masyarakat, Keperawatan, Kebidanan, Gizi, dan lain-lain). Tujuan penerbitan Jurnal Sains dan Kesehatan adalah untuk menyediakan informasi ilmiah tentang perkembangan ilmu dan teknologi di bidang Ilmu Pengetahuan dan Kesehatan.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 764 Documents
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Perbandingan Statin Terhadap Kejadian Efek Samping Terkait Myalgia: Comparison of Statins to Side Effect Events Related Myalgia Irene Mahwal; Eka Kartika Untari; Nurmainah Nurmainah
Jurnal Sains dan Kesehatan Vol. 4 No. 2 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i2.906

Abstract

Statin adalah golongan hiperlipidemia yang paling umum dilaporkan terkait kejadian myalgia dengan dosis 10-80 mg/hari. Kejadian myalgia yang diinduksi statin menjadi perhatian bagi peneliti, mengingat jumlah pasien hiperkolesterolemia yang menggunakan terapi statin cukup tinggi. Penelitian bertujuan untuk mengetahui golongan statin yang berpotensi menyebebkan kejadian myalgia serta untuk mengetahui tingkat keparahan myalgia akibat penggunaan statin, sehingga dapat meningkatkan kewaspadaan masyarakat dalam mengatasi kejadian efek samping akibat penggunaan statin. Metode penelitian menggunakan desain observasional analitik cross-sectional, dengan instrumen pengumpulan data menggunakan kuesioner FIQR dalam bentuk google form. Hasil penelitian menunjukkan kasus myalgia paling banyak ditemui pada responden yang berusia 36-45 tahun (26,08 %), dan kejadian paling sedikit terjadi pada pasien > 65 tahun (8,69 %). Hasil data distribusi jenis kelamin, perempuan memiliki prevalensi sebesar 56,52 % dan laki-laki sebesar 43,47 %. Golongan statin yang digunakan oleh responden penelitian adalah simvastatin dengan presentase sebesar 58,69 %, sedangkan responden yang menggunakan atorvastatin dengan presentase 41,30 %. Kejadian myalgia yang dialami oleh responden memiliki tingkat keparahan ringan dengan proporsi sebanyak 43 orang, hingga sedang dengan proporsi 3 orang. Kesimpulan dari penelitian ini adalah golongan statin yang berpotensi menyebabkan kejadian myalgia yaitu, simvastatin dan atorvastatin, dengan tingkat keparahan myalgia yaitu ringan hingga sedang.
Peran Disregulasi Imunitas dalam Terapi Kusta pada Area Endemis: Artikel Review: The Role of Immune Dysregulation in Leprosy Treatment in Endemic Areas: Review Article Flora Ramona Sigit Prakoeswa; Faradiba Maharani
Jurnal Sains dan Kesehatan Vol. 4 No. 1 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i1.912

Abstract

Leprosy, a chronic infectious disease caused by Mycobacterium leprae, causes health problems and endemic in several countries. The number of new cases of leprosy is constantly reported in endemic countries. Therapeutic efforts in leprosy patients are carried out with the aim of reducing the level of transmission and disability of leprosy patients. Leprosy therapy with the use of a multidrug regimen (MDT) has been shown to be able to reduce the number of leprosy cases but has not been able to suppress the rate of growth of new leprosy cases. The constant number of new cases of leprosy in endemic areas indicates community infection and the inability of MDT as a single strategy to complete treatment and stop the transmission of leprosy. The transmission of leprosy is known to be multifactorial involving: microbial factors, host factors, and environmental factors. These factors are thought to cause immune dysregulation and increase the risk of leprosy infection in people living in endemic areas. An understanding of immune dysregulation is needed to achieve succesful treatment and the eradication of leprosy.
Laporan Kasus: Terapi Covid-19 pada Pasien dengan Komorbid Hipertensi: Case Report: Covid-19 Therapy in Patients with Comorbid Hypertension Putri Dina Mahera Laily
Jurnal Sains dan Kesehatan Vol. 4 No. 2 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i2.914

Abstract

Corona Virus Desease 2019 (COVID-19), is a disease caused by corona virus. According to the World Health Organization (WHO), COVID-19 is a tragedy in the world of global health. The main clinical manifestations are cough, fever, shortness of breath and in some cases can cause multiple organ failure, septic shock and metabolic acidosis which is difficult to correct. Where people who are elderly and have chronic disease generally have a poor prognosis. Prompt and appropriate therapy is expected to save patients. Until now, scientific evidence regarding the effectiveness and safety of these therapies is still very little. This study aims to evaluate the effectiveness and safety of COVID-19 therapy in COVID-19 patients with comorbid hypertension. The therapy used in this patient was azithromicin, ceftriaxone, levofloxacin and meropenem; Antiviral therapy was given hydroxychloroquine; symptomatic therapy for fever was given paracetamol; hypertension therapy was given amlodipine; Support therapy was given salbutamol and dexamethasone; Additional therapy was given vitamin C 1000 mg / 24 hours, and zinc. There was no worsening effect on the patient after receiving this therapy. Patients get treatment at RSUP Dr. Sardjito then was discharged after treatment without any complaints and with PCR swabs were negative results. Keywords: Therapy, COVID-19, Comorbid, Hypertensi
Hubungan Kadar Hemoglobin Sebelum Operasi dengan Kebutuhan Transfusi Sel Darah Merah Intra Operasi pada Pasien Bedah Pintas Arteri Koroner di RSUD Abdul Wahab Sjahranie Samarinda: The Correlation between Preoperative Hemoglobin Level and Red Blood Cell Transfusion Intraoperative among Patients with Coronary Artery Bypass Graft at RSUD Abdul Wahab Sjahranie Muhammad Akbar Rizqullah Rusydi; Ivan Joalsen Manggara Tua; Agustina Rahayu Magdaleni
Jurnal Sains dan Kesehatan Vol. 4 No. 2 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i2.928

Abstract

Coronary Artery Bypass Graft (CABG) is a surgical procedure used to create bypass around the blocked coronary artery). Packed Red Cell (PRC) is required during CABG to balance hemoglobin level and the amount of red blood cell tranfused is basically estimated by observing preoperative hemoglobin level. Based on these reasons, the researcher aims to find the correlation between preoperative hemoglobin level and intraoperative red blood cell transfusion. The observational analytical design using cross sectional method was applied. The purposive non-probability sampling was used to select the research samples. Thirty-five samples fulfilling the inclusive and exclusive criteria were obtained. The findings revealed that patients’ preoperative hemoglobin level was normally transfused with 0 – 249 cc red blood cell for 18 intraoperative patients (51.4%). Patients’ preoperative hemoglobin level normally transfused with 250 – 500 cc red blood cell was only five patients (14.3%). The abnormally preoperative hemoglobin level transfused with 250 – 500 cc red blood cell was for 10 intraoperative patients (28.6%), whereas the abnormally preopreative hemoglobin level transfused with 0 – 249 cc red blood cell was only two patients (5.7%). It can be concluded that there is a correlation between preoperative hemoglobin level and intraoperative red blood cell transfusion with p value = 0.000 (p <0,05).
Gambaran Karekteristik Fraktur Radius Dital di RSUD Abdul Wahab Sjahranie Samarinda Tahun 2017-2019: Overview of Distal Radius Fracture Characteristics at Abdul Wahab Sjahranie Hospital, Samarinda in 2017-2019 Muhammad Abduh Bachrl Ihza; Gregorius Tekwan; Abdul Mu’ti
Jurnal Sains dan Kesehatan Vol. 4 No. 2 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i2.929

Abstract

Distal Radius Fractures are the most common fractures in the world. 17.5% of fractures are categorized as distal radius fractures. Distal radius fractures can occur in both young age and old age. Distal radius fractures mostly occur in young adult age group due to high-energy trauma, and in senior age group due to low-energy trauma and osteoporosis. This research aims to capture the overview of distal radius fracture characteristics at RSUD (Rumah Sakit Umum Daerah – Regional Public Hospital) Abdul Wahab Sjahranie Samarinda. The data in this research are secondary data, gathered from medical records of patients. This research was performed in February 2021. This research is a Descriptive Retrospective study. 146 patients diagnosed with distal radius fractures from January 2017 – December 2019 were selected as samples, using Total Sampling method. The result showed that most cases of distal radius fractures occurred in 10-19 years age group (29 patients, 19.9%), male (87 patients, 59.6%), students (47 patients, 34.2%). Furthermore, the most common type of fractures found was closed fracture type (137 patients, 93.8%), the most common clinical fracture found was unidentified fracture (65 patients, 44.5%), and the most common cause of fractures was from trauma (90 patients, 61.6%).
Pelaksanaan Nasional Health Insurance Pada Aspek Kepesertaan Untuk Mencapai Universal Health Coverage: The Implementation of National Health Insurance on The Aspect of Participation to Achieve Universal Health Coverage Syifa Shidqi Putri; Chriswardani Suryati; Nurhasmidar Nandini
Jurnal Sains dan Kesehatan Vol. 4 No. 2 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i2.931

Abstract

National Health Insurance in a country is a program to achieve Universal Health Coverage which ensures that every citizen in the population has access to health services. The existence of mandatory NHI membership rules makes participation a very important aspect. In the development of the implementation of NHI, there was a phenomenon of decreasing participation which became the reason for researchers to research to analyze factors related to NHI participation, obstacles, and efforts made to maintain and increase participation. This research is a type of Literature Review research with a simple data analysis method (simplified approach). There are 12 national articles and 8 international articles that have been selected by researchers as research material. The results showed that the factors related to NHI participation were divided into 3 main factors, namely predisposing factors, enabling factors, and needs factors. The predisposing factors include age, gender, education, occupation, and the number of family members. Enabling factors include knowledge, income/income, and family support. Meanwhile, the need factor contains perception and motivation factors. In addition to finding factors, this study also found obstacles that affect participation in NHI, and efforts that can improve aspects of NHI participation.
Pengaruh Pemberian Minyak Ikan terhadap Hasil Terapi Pasien Skizofrenia Rawat Inap Berdasarkan Skala PANSS: The Effect of Fish Oil Administration on the Therapeutic Outcome of Schizophrenic Inpatients Based on the PANSS Scale Warrantia Citta Citti Putri; Nishia Waya Meray; Indah Woro Utami
Jurnal Sains dan Kesehatan Vol. 3 No. 6 (2021): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pemberian minyak ikan sebagai terapi tambahan skizofrenia dapat menurunkan nilai Positive and Negative Syndrome Scale (PANSS) pada pasien rawat inap di Rumah Sakit Grhasia. Penelitian cross sectional dilakukan dengan pre-test and post-test with control group design, minyak ikan diberikan 2 kali sehari 1 kapsul selama 6 minggu dan skala PANSS digunakan untuk menilai efektifitas terapi. Untuk pengambilan sampel diambil menggunakan metode consecutive sampling dan data yang diperoleh akan dianalisis menggunakan uji-t berpasangan. Hasil penelitian menunjukkan rata-rata 50 poin pada 22 kelompok perlakuan dan rata-rata penurunan sebesar 39,4 poin pada 22 kelompok kontrol. Dapat disimpulkan pemberian minyak ikan sebagai terapi tambahan dalam pengobatan pasien skizofrenia akan memberikan hasil terapi yang lebih baik daripada tidak diberikan tambahan minyak ikan.
In Silico Study of Bajakah Compounds (Spatholobus suberectus) to Protease SARS-CoV-2 Inhibitor Norhayati Norhayati; Andika Andika; Aris Purwanto
Jurnal Sains dan Kesehatan Vol. 5 No. 2 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i2.950

Abstract

Coronavirus Disease 2019 or COVID-19 is caused by a virus called Severe Acute Respiratory Syndrome Coronavirus 2. Until now, there is no specific treatment guide in dealing with COVID-19 in Indonesia. The curative pharmacological therapy for COVID-19 used is antiviral such as lopinavir, ritonavir, and oseltamivir, currently based on trial and error. This study carried out a Molecular Docking Analysis of 16 compounds owned by the Bajakah plant (Spatholobus suberectus). Oseltamivir was used as a control, and validation was carried out on a natural ligand, namely boceprevir against the main protease CoV or Mpro, 7C6S and the result was 1.47 Å using Toshiba hardware and AutoDock Tools, ChemSketch, Discovery Studio, Avogadro, UCSF Chimera software. Lipinski Rules of Five (RO5) analysis and ADMET analysis using SWISSADME and admetSAR. Licochalcone A compound had the best binding energy and inhibition constant values of -7.98 kcal/mol and 1.42 ?M. In contrast, the 6-Methoxyeriodictyol compound had fewer binding energy and inhibition constants, namely -5.24 kcal/mol and 143.04 ?M, respectively. In addition to the licochalcone A compound, the afrormosin compound, 3'4'7'-trihydroxyflavone, formononetin, cajanin, and dihydrokaempferol showed good binding energy values and inhibition constants compared to oseltamivir (control), so that these compounds have the potential to inhibit Mpro SARS-COV-2 or the virus that causes COVID-19. Analysis of Lipinski Rules of Five and ADMET is used to determine the properties of a molecule on the pharmacokinetics of drugs in the human body, and the results obtained to meet the requirements so that it is potentially effective for oral consumption.
Profil Penyakit Periodontal Pada Penderita Diabetes Melitus Berdasarkan Tipe Diabetes Melitus, Jenis Kelamin, dan Usia di RSUD dr. Kanujoso Djatiwibowo Pada Tahun 2016-2020: Profile of Periodontal Disease Accompanied by Diabetes Mellitus Based on Diabetes Mellitus Type, Gender, and Age at RSUD dr. Kanujoso Djatiwibowo 2016-2020 Aanisah Nida Aliyah; Listyawati Listyawati; Nuryanni Dihin Utami
Jurnal Sains dan Kesehatan Vol. 4 No. 2 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i2.954

Abstract

Penyakit periodontal adalah suatu keadaan peradangan dan degenerasi dari jaringan lunak maupun tulang penyangga gigi. Etiologi utama penyakit periodontal adalah faktor lokal yakni kondisi rongga mulut yang meningkatkan kerentanan seseorang terhadap infeksi periodontal atau yang dapat merusak jaringan periodontal dan dapat diperparah dengan adanya faktor sistemik diantaranya penyakit diabetes melitus. Tujuan penelitian ini adalah untuk mengetahui profil penyakit periodontal yang disertai diabetes melitus berdasarkan jenis penyakit periodontal,  tipe diabetes melitus, jenis kelamin, dan usia di IRJA Publik Poliklinik Gigi dan Mulut RSUD dr. Kanujoso Djatiwibowo pada tahun 2016-2020. Penelitian ini merupakan deskriptif dengan sumber data sekunder berupa rekam medis pasien penyakit periodontal yang disertai diabetes melitus di IRJA Publik Poliklinik Gigi dan Mulut RSUD dr. Kanujoso Djatiwibowo pada tahun 2016-2020. Hasil penelitian didapatkan distribusi frekuensi pasien penyakit periodontal yang disertai diabetes melitus sebanyak 1 kasus. Jenis kelamin yang lebih dominan yakni perempuan sebanyak 3 pasien dan laki-laki sebanyak 1 pasien dengan jenis penyakit periodontal chronic periodontitis dengan DM tipe unspecified diabetes mellitus without complication. Pasien berjenis kelamin laki-laki dengan usia 63 tahun.
Gambaran Peresepan Antibiotik, Biaya, Efektifitas Terapi Pasien Demam Tifoid Rawat Inap RS Palang Biru Kutoarjo : The Image of Prescribing Antibiotics, Cost, Effectiveness of Therapy Thypod Fever Inpatient at Palang Biru Hospital Kutoarjo Ima Raharti; Endang Yuniarti; Eka Wuri Handayani
Jurnal Sains dan Kesehatan Vol. 4 No. 2 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i2.979

Abstract

Demam tifoid merupakan penyakit infeksi akut dan bersifat sistemik yang disebabkan oleh bakteri Salmonella typhy. Pada pengobatan demam tifoid diperlukan terapi antibiotik. Pengeluaran biaya antibiotik dapat mencapai 50% dari total anggaran obat namun belum bisa menjamin efektifitas dalam perawatan. Penelitian ini bertujuan untuk mengetahui gambaran pola peresepan antibiotik dan biaya perawatan pada pasien demam tifoid rawat inap di RS Palang Biru Kutoarjo. Penelitian ini dirancang dengan metode desain cross sectional. Pengambilan subyek penelitian menggunakan teknik purpose sampling dari populasi yang memenuhi kriteria inklusi periode Januari – Desember 2019. Data yang diperoleh dianalisis dengan metode statistik kemudia dibuat tabel dan disajikan secara deskriptif. Sampel dalam penelitian ini sebanyak174 pasien. Jenis antibiotik yang digunakan pada pasien demam tifoid rawat inap di RS Palang Biru Kutoarjo yaitu cefotaxim, ceftriaxon, ciprofloxacin, metronidazol, chloramfenicol, cefixim, amoxicillin, ampicillin dan cefadroxil. Pemakaian antibiotik paling banyak yaitu cefotaxim(51,9%) dan ceftriaxon (35,4%) dengan total biaya perawatan 2.737.851 dan 2.478.835   Kata kunci: Antibiotik, Demam Thypoid, Biaya, Efektivitas  

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