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Ahmad Munadi
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Journal of Natural Product for Degenerative Diseases
Published by Universitas Pancasila
ISSN : -     EISSN : 30316847     DOI : https://doi.org/10.58511/jnpdd
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
International Journal of Natural Product for Degenerative Diseases accepts articles in the form of full length original research, short communications, reviews, case reports, letter to editor and new drug information. The journal gives importance to articles from ethnopharmacology, in-vivo and in-vitro studies of and clinical studies comparing different modalities of treatment in the fields of herbal medicine. International Journal of Natural Product for Degenerative Diseases is being published as print and e-version. Main research areas include: Natural Product Pharmacology Herbal Medicine Complementary and Alternative Medicine Ethnopharmacology Traditional systems of Medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 34 Documents
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Formulation of a 2-in-1 Conditioner-Shampoo Containing Morus nigra Ethanolic Extract with Surfactant Combination Octrysa Puspajelita; Tasya Alfina Lestari; Dita Fitriana; Lutfiah Lutfiah; Muhammad Agung Fauzi; Safira Nafisa
Journal of Natural Product for Degenerative Diseases Vol. 3 No. 1 (2025): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v3i1.8390

Abstract

Black mulberry (Morus nigra) is rich in flavonoids and anthocyanins with antioxidant and conditioning properties that can improve hair health. However, its incorporation into a stable 2-in-1 conditioner-shampoo formulation remains limited. This study aimed to formulate and evaluate the physical stability of conditioner-shampoo preparations containing M. nigra ethanolic extract at concentrations of 5%, 10%, and 15% w/w using sodium lauryl ether sulphate (SLES) and cocamidopropyl betaine (CAPB) as surfactant bases. Each formulation was prepared by gradual mixing of aqueous and surfactant phases, followed by the addition of conditioning agents and active extract. Physical characteristics—including organoleptic properties, homogeneity, pH, foam height, and viscosity—were evaluated before and after six cycles of a stability test at 4 °C and 40 °C. All formulas exhibited homogeneous brown appearance with peppermint aroma and acceptable foam stability. The initial pH decreased with increasing extract concentration (F1 = 6.74; F2 = 5.95; F3 = 3.97) and slightly decreased after cycling (F1 = 6.21; F2 = 5.84; F3 = 3.61). Viscosity values ranged from 44,000 to 70,000 mPas and decreased after temperature cycling, whereas foam height remained within acceptable limits (≈ 1.5–2.3 cm). Among the tested formulations, F2 (10% extract) showed the most balanced properties in terms of pH, viscosity, and foam stability. In conclusion, a 10% M. nigra ethanolic extract conditioner-shampoo demonstrated good physical stability and potential as a natural antioxidant and conditioning hair-care product.
In Vitro Penetration of Curcumin Self-Nanoemulsifying Drug Delivery System (SNEDDS) in Transdermal Gel Formulations Sandi Cahya Prawira; Zainur Rahman Hakim
Journal of Natural Product for Degenerative Diseases Vol. 3 No. 2 (2026): JNPDD March In Press
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/v3i2.9213

Abstract

Curcumin is a natural bioactive compound with potent antibacterial properties; however, its clinical utility is restricted by poor aqueous solubility (BCS Class II) and low systemic bioavailability. This study aimed to overcome these barriers by formulating curcumin into a self-nanoemulsifying drug delivery system (SNEDDS) incorporated into a transdermal gel. Optimization involved a synergistic blend of virgin coconut oil (VCO), Tween 80, and Cremophor RH 40, which spontaneously forms a nanoemulsion upon aqueous contact. The optimized formulation yielded nanoparticles with a size of 257.9 nm, a polydispersity index (PDI) of 0.018, and a zeta potential of − 29 mV. In vitro penetration tests using a Franz diffusion cell with guinea pig skin revealed a significant improvement (p < 0.05) in drug delivery. The curcumin SNEDDS gel achieved a cumulative permeation of 187.53 ± 16.27 μg/cm², significantly outperforming the conventional curcumin gel (125.19 ± 8.41 μg/cm²). These findings demonstrate that the SNEDDS based transdermal approach is a highly effective strategy for enhancing skin penetration and the therapeutic potential of curcumin. 
Application of LC–MS in the Development of Natural Product–Based Antidepressant Drugs: A Systematic Literature Review Rumondor, Ridel Yosua; Yantih, Novi; Kholilah; Nur Pujiastuti
Journal of Natural Product for Degenerative Diseases Vol. 3 No. 2 (2026): JNPDD March In Press
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/v3i2.9690

Abstract

 Due to the shortcomings of existing medications, depression remains a worldwide neuropsychiatric disorder requiring innovative therapeutic strategies. Natural compounds represent promising multi-target antidepressant candidates; however, their chemical complexity necessitates advanced analytical tools. This systematic literature review assessed the application of liquid chromatography–mass spectrometry (LC–MS) in the identification, profiling, and standardization of natural antidepressant compounds. A comprehensive search of major databases was conducted following PRISMA guidelines for studies published between 2014 and 2024, with a total of six eligible studies were included in the qualitative synthesis.. The findings indicate that LC–MS, particularly high-resolution platforms such as QTOF and Orbitrap, is the primary method for metabolite profiling and dereplication of bioactive classes including flavonoids, alkaloids, and phenolic acids. Integration of LC–MS data with in vitro and in vivo models has facilitated the correlation of chemical profiles with pharmacological mechanisms, such as neurotransmitter regulation. Despite its pivotal role in evidence-based natural product research, challenges remain in analytical standardization and clinical translation. In conclusion, LC–MS is an indispensable and transformative tool in the development of natural product-based antidepressants, providing robust chemical characterization that supports pharmacological validation and accelerates drug discovery. Future research should emphasize methodological harmonization and systems biology integration to enhance translational impact. 
Liquid Chromatography–Mass Spectrometry in the Development of Natural Product–Based Antihypertensive Drugs: A Systematic Literature Review Nur Pujiastuti; Novi Yantih; Ridel Yosua Rumondor; Kholilah
Journal of Natural Product for Degenerative Diseases Vol. 3 No. 2 (2026): JNPDD March In Press
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/v3i2.9693

Abstract

Hypertension remains a major global health burden, necessitating effective and evidence-based therapeutic strategies. Natural products have emerged as promising sources of antihypertensive agents; however, their chemical complexity requires advanced analytical techniques such as liquid chromatography–mass spectrometry (LC–MS). This study employed a systematic literature review of articles published between 2020 and 2025, retrieved from Scopus, PubMed, and ScienceDirect using predefined inclusion criteria. The review evaluates the application of LC–MS in the identification, metabolite profiling, and standardization of antihypertensive natural products, with emphasis on celery (Apium graveolens). The findings indicate that LC–MS enables accurate identification of key bioactive compounds, including flavonoids, phenolic acids, alkaloids, and phthalides, which are associated with antihypertensive mechanisms such as angiotensin-converting enzyme (ACE) inhibition, vasodilation, and endothelial protection. Integration with pharmacological and in silico approaches further supports the correlation between chemical composition and biological activity. In conclusion, LC–MS is a critical tool in natural product-based antihypertensive drug discovery, particularly for compound characterization and standardization. However, lack of standardized workflows remains a limitation for reproducibility and clinical translation.

Page 4 of 4 | Total Record : 34

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