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Journal of Natural Product for Degenerative Diseases
Published by Universitas Pancasila
ISSN : -     EISSN : 30316847     DOI : https://doi.org/10.58511/jnpdd
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
International Journal of Natural Product for Degenerative Diseases accepts articles in the form of full length original research, short communications, reviews, case reports, letter to editor and new drug information. The journal gives importance to articles from ethnopharmacology, in-vivo and in-vitro studies of and clinical studies comparing different modalities of treatment in the fields of herbal medicine. International Journal of Natural Product for Degenerative Diseases is being published as print and e-version. Main research areas include: Natural Product Pharmacology Herbal Medicine Complementary and Alternative Medicine Ethnopharmacology Traditional systems of Medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 31 Documents
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Gel Formulation from a Combination of Sidaguri Leaf Extract (Sida rhombofolia L.) and Chinese Petai Leaves (Leucaena leucocephala L) as Inhibitors of Acne-causing Bacteria (Propionibacterium acne and Staphylococcus aureus) Andriana, Andriana; Chaidir, Chaidir; Rahmat, Deni
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 1 (2023): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i1.4619

Abstract

Acne vulgaris, a chronic inflammatory disease of the pilosebaceous unit, is the most common skin condition. Propionibacterium acnes and Staphylococcus aureus are two bacteria that can cause infections. Chinese Petai leaves are known to inhibit acne growth. Sidaguri leaves are also thought to have antibacterial activity. The aims of this study were to determine the effect of the combination of the two extracts on inhibiting the growth of acne-causing bacteria, also to test the gel formula to meet physical and chemical parameters as well as stability to temperature and storage, as well as to test acute dermal. irritation to rabbits. Each extract with a concentration of 0.19%; 0.39%; 0.78%; 1.56%; 3.125%; 6.25%; 12.5%; 25%; 50% were incubated and then the inhibition zone was measured, then the minimum inhibition zone concentration of the two extracts was determined to determine the lowest concentration of the extract that still provided antibacterial activity against the tested bacteria using the well-diffusion method. The extract combination is formulated in a gel preparation with Carbopol 940, Propylene glycol, Phenoxyethanol, TEA, and Aquadest as excipients. Test the antibacterial activity of gel preparations using the well method with positive control clindamycin gel. Then evaluation of the formula includes evaluation of physics, chemistry, and microbiology. The results showed that the combination gel had activity against P. acne and Staphylococcus aureus at a concentration of 3.12% : 1.56%. The combined gel preparation of the two extracts also has a synergistic effect in inhibiting acne bacteria. The formula is resistant to temperature and storage, and it can satisfy chemical and physical parameters.
Development of Gel Preparations from a Combination of Iler Leaf Extract and Patchouli Oil as a Repellent Against Aedes aegypti Mosquitoes Wahyuni, Ayu Nuki; Anny Victor Purba; Ratna Djamil
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 1 (2023): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i1.4676

Abstract

Dengue Hemorrhagic Fever (DHF) is an abnormal health condition caused by the dengue virus through the bite of the Aedes aegypti mosquito. The use of repellent to prevent mosquito bites can provide protection against DHF. DEET, a synthetic repellent with usage that has spread throughout the world, is reported to have toxic effects and cause irritation. Leaves of iler and patchouli oil are plants of the Lamiaceae family with repellent activity. This study aimed to obtain a repellant gel combination of iler leaf extract and patchouli oil. Gel preparations are made with a combination of Iler Leaf Extract and Patchouli Oil at concentrations of 12.5%, and 2%. Physical and chemical quality parameter test, stability test, acute dermal irritation test, and repel effectiveness test were tested on Aedes aegypti mosquitoes. Gel preparations showed a homogeneous physical appearance, greenish-brown color with an aromatic distinctive odor, a viscosity value of 16000 cPs, pH 6.32, and thixotropic flow properties. Gel preparations are effective as a mosquito repellent for 3 hours with a protection power of 56.82%. The gel preparation storage temperature, besides the resulting gel, does not irritate, and it is physically stable at 4 ± 2oC and 25 ± 2oC and is slightly less stable at 40 ± 2oC.
Antioxidant Activity Cultivated of Soursop (Annona muricata L.) Leaves Extract in Jayasari Village, Pangandaran District, West Java Zahara, Indah; Anwar, Effionora; Laksmitawati, Dian Ratih; Rahmat, Deni
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 1 (2023): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i1.5317

Abstract

Indonesia is a source of raw materials for tropical medicines that treat various diseases. One of the places to plant soursop leaves in West Java is Jayasari Village, Pangandaran District. Annona muricata Linn (Soursop) leaves is a medicinal plant widely used as an anti-diabetic, anti-inflammatory, insecticide, antimalarial, anticancer, antibacterial, and antioxidant. Soursop leaves have many benefits because they contain phytochemical compounds. This study aims to determine the phytochemical content, total flavonoid content, and antioxidant activity of A. muricata leaves. This research was carried out in several steps, including extraction, evaporation, phytochemical testing, total flavonoid content, and antioxidant activity. Phytochemicals were extracted with 96% ethanol by maceration. Measurement of flavonoids in extracts was determined using standard quercetin and UV-Vis spectrophotometry method. Antioxidant activity was carried out through a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical removal test. The results showed that the ethanol extract of soursop leaves contained alkaloids, flavonoids, phenolics, saponins, and tannins. The results of measurements of flavonoids from the ethanol extract of soursop leaves showed that 1 g of the extract contained 8.32 mg of quercetin equivalent. The ethanol extract of soursop leaves has antioxidant activity, as indicated by the scavenging of DPPH radicals with an IC50 of 56.73 ppm.
Antioxidant and Antidiabetic Compounds from Ebony Leaf Extract (Diospyros celebica Bakh.) and Their Correlation with Total Phenolic and Flavonoid Compounds in Various Solvent Extraction Apriandini, Lisya; Hanafi, Muhammad; Djamil, Ratna; Desmiaty, Yesi; Narrij Lotulung, Puspa Dewi; Artanti, Nina
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 1 (2023): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i1.5454

Abstract

Ebony (Diospyros celebica. Bakh) is a native plant of Indonesia that is used as a traditional medicine for diabetes mellitus. Previous studies state that ethanol extract from ebony leaves significantly reduced blood glucose levels of diabetic rats induced by alloxan. This ability is thought to be caused by secondary metabolites which is phenolic and flavonoid compound. However, research related to structure compounds in extract and composition of solvent variations in the extraction process to get the most optimal activity and also their correlation with total phenolic and flavonoid compounds has not been carried out. This study aimed to evaluate the composition of the optimum solvent in the extraction process and also to know the structure compounds contained in the extract. In the present study, we extracted the ebony leaves with three solvents of different polarity (ethanol-water), i.e. ethanol 50% (EtOH), EtOH 70%, and EtOH 96%. Quantitative estimation of total phenolic and flavonoid contents. These extracts were future evaluated for their activity and the content of compounds in the extract was identified using LCMS/MS. The results showed that phenolic compounds that have been identified in ebony leaf extract are methyl gallate and (-)-Epiafzelechin 3-gallate and we found there were significant differences in all test parameters between the three extracts which is EtOH 96% extract gave the best.
Preparation, Evaluation, and In Vitro Antiacne Activity of Cymbopogon citratus DC and Cymbopogon nardus (L.) Rendle Essential Oil Microemulsion Datubara, Martaulina Elisabet; Kumala, Shirly; Rahmat, Deni
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 1 (2023): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i1.5463

Abstract

This study was conducted to formulate and evaluate a topical anti-acne microemulsion containing essential oils of Cymbopogon citratus DC and Cymbopogon nardus (L). Using the disc diffusion method, the antibacterial activity of the essential oils of C. citratus and C. nardus against Propionibacterium acne and Staphylococcus epidermidis was investigated. After identifying the active concentration, the formula for a topical microemulsion was devised and tested for physical and chemical parameters. The results revealed that the essential oils of C. citratus and C. nardus had antimicrobial activity against P. acnes and S. epidermidis. The results demonstrated that the obtained microemulsion meets the physical and chemical requirements and possesses antimicrobial activity. It can be concluded that the essential oils extracted from C. citratus and C. nardus have the potential for further development and commercial application in the treatment of acne.
Enhanced Efficacy of Kaffir Lime (Citrus hystrix) Essential Oil Spray Gel Against Aedes aegypti Mosquitoes Nugroho, Gumilar Adhi; Desmiaty, Yesi; Fahleni, Fahleni; Lhu Muslimah, Lhu; Andam Dewi, Mira
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 1 (2023): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i1.5469

Abstract

The primary mode of dengue disease transmission is by the Aedes aegypti mosquito. The essential oil derived from Kaffir lime (Citrus hystrix) leaves comprises 66.85% beta-citronellal, 6.59% beta-citronellol, 3.90% linalol, and 1.76% citronellol. These constituents exhibit repelling properties. The objective of this study was to develop a spray gel formulation using kaffir lime leaf essential oil to create an efficient repellent. The process involves tearing fresh kaffir lime leaves and subsequently distilling them with distilled water. The distillation procedure yields an essential oil that is subsequently incorporated into a spray gel formulation, with varying concentrations of 1%, 5%, and 10%. Based on the findings of the efficacy test from 3 spray gel formulas through mosquito repelling activity conducted over 6 hours, it can be concluded that all tested formulas exhibited variation in effectiveness in repelling mosquito bites. The efficacy of the protection index against Aedes aegypti mosquito bites is contingent upon the concentration of kaffir lime essential oil in the formulation. There is a positive correlation between concentration and the duration of protection.
Formulation and evaluation of Anti-aging Serum Containing a Combination of Mugwort (Artemisia capillaris) Extract and Vitamin C as an Antioxidant Utami, Fit Indri Intan; Qodriah, Rahmatul; Budiati, Anarisa; Mumpuni, Esti
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 1 (2023): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i1.5524

Abstract

Mugwort (genus Artemisia) is a skincare ingredient originating from a South Korean beauty trend having antioxidant properties and is currently popular globally. The aim of this research is to formulate and determine the antioxidant activity of anti-aging serum containing Mugwort (Artemisia capillaris) and Vitamin C extract as antioxidants. All formulas were adjusted to a pH range of 5.0 – 5.2. Each formula was characterized based on antioxidant activity using the DPPH method. Serum with mugwort extract (F1) and serum with a combination of mugwort extract and vitamin C (F3) show strong antioxidant activity with an IC50 of 99.70 and 82.92 ppm, respectively. Anti-aging serum containing mugwort (Artemisia capillaris) extract and vitamin C provides strong antioxidant activity with an IC50 of 82.92 ppm (F3).
Study of Potential Antiobesity Compounds from Amylchlorogenate Derivates on Leptin Hormone and their Toxicity using Molecular Docking Approach Faridah; Shirly Kumala; Gumilar Adhi Nugroho; Partomuan Simanjuntak
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 2 (2024): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i2.6070

Abstract

Chlorogenic acid, a type of phenolic acid, is a polar compound that has anti-obesity effects with unclear mechanisms. This study aims to obtain compounds that are active as antiobesity, their interaction with receptors and its toxicity. This research was carried out in several steps, internal validation of targets and methods using Yasara, docking of test compounds and positive control using PLANTs, interaction visualization using Pymol and toxicity testing using Protox-II. Validation results show four receptors and test method meet the requirements. Docking results of setmelanotide on receptor code 1PXH -113.81; 2QBP -109.163; 2QBR -110.113, 2; QBS -110.817 kcal/mol respectively. The docking results of the test compounds in 1PXH namely 7,4,5-Triamylchlorogenate (compound a) -114,333 kcal/mol. In 2QBP namely 7,3'-Diamylchlorogenate (110,152) (compound b), (compound a) (-109,818), 7,4,3',4'-Tetraamylchlorogenate (compound c) (-115,309), 7,5,3',4'-Tetraamylchlorogenate (compound d) (-112,85), 7,4,5,3',4'-Pentaamylchlorogenate (compound e) (-110,414) and 2',5'-Diamylchlorogenic acid (compound f) (-113, 565) kcal/mol. In 2QBR namely, (compound a) (-114,276), (compound e) (-111,059), and (compound f) (-110,398) kcal/mol. In 2QBS namely, (compound a) (-113.53), and (compound d) (-111,676) kcal / mol. The active site of amino acids that have affinity are, ARG45 and LYS120 in 1PXH; ASP48, SER118 and ARG47 in 2QBP; ASP48 and ARG24 in 2QBR; ASP48 and GLN262 in 2QBS code. Toxicity tests obtained oral LD50 of 5000 mg/kg BW (compounds a and f); 3800 mg/kg BW (compounds b, c, d and e). The potential compound that was active in all the test receptor codes was 7,4,5-Tripentylchlorogenate (compound a). All active test compounds were relatively safe.
Formulation of Instant Granule of Japanese Taro Tuber Extract (Colocasia esculenta L. Schoot) Based on Milk With Various Binders for Stunting Prevention Budiati, Anarisa; Kartiningsih; Satrio Damar Wicaksono
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 2 (2024): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i2.6106

Abstract

Japanese taro root extract (Colocasia esculenta L. Schoot) includes Fe and Zn, which the body need to prevent stunting. The goal of this investigation was to see how different binder types affected the physical and chemical properties of instant granule preparations. The formula for an instant granule dry extract of Japanese taro root was developed using the wet granulation method with various binders, including PVP (F1), Mucillago amili (FII), and Na-CMC (FIII), and then tested for physical, chemical, and Fe and Zn content using Atomic Absorption Spectrophotometry. The test findings showed that the flow rate of instant granules of Japanese taro root extract formulations I, II, and III was (4.6840-4.7956) g/s, with an angle of repose of 26.86-31.08°. The granules had particle sizes ranging from 670,2295-703,2438 μm, a compressibility index of 15.91-19.00%, and moisture content of 2.80-3.58%. The immediate granule test was performed after being dispersed in water; formulations I, II, and III had dispersion periods of 40.33-50.33 seconds, specific gravity of 1.0099-1.0101 g/mL, viscosity of 1.3589-1.6352 cps, sedimentation volume of 0.940-0.955, and pH of 6.60-6.65. Formulas II using 10% muchilago amyl binder had the greatest Fe and Zn levels, at 34.40 mg/kg and 16.19 mg/kg, respectively. The statistical test revealed a significant effect of different binders on angle of repose, moisture content, dispersion time, pH, and viscosity of Japanese taro root extract granules (p-value < 0.05).
Effects of 70% Ethanol Extract of Foeniculum vulgare and Coleus amboinicus as a Potential Diarrhea Treatment Using Intestine Transit Method Heriatmo, Nadia Larasinta; Sumarny, Ros; Pratama, Yori Chikita; Putri, Arini Amalia
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 2 (2024): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i2.6137

Abstract

Diarrhea is a condition where the frequency of defecation increases more than three times a day. In underdeveloped nations like Indonesia, diarrhea is a sickness that frequently affects people. Diarrhea can be fatal, causing dehydration and even death if not treated properly. Using alternative treatments like fennel seeds and cumin leaves is one way to treat diarrhea. Fennel seeds and cumin leaves includes secondary tannin metabolites that are effective antidiarrheal agents. Test the antidiarrheal effect of Foeniculum vulgare ethanol extract (FVEE) and Coleus amboinicus ethanol extract (CAEE) using the intestinal transit method on mice was carried out on 9 groups, each group consisting of 5 mice: negative control, Loperamide control, Diapet® control, FVEE and CAEE at doses of 100, 200 and 400 mg/kg. To induce diarrhea through oral administration, castor oil was used in experiments. Four hours following the start of the induction, the treatment group received. They received norit an hour later, and the mice were sacrificed 20 minutes after receiving norit. The intestines were taken out of the mice after they had been dissected, starting from the rectum to the pylorus. Measured the length of the intestine overall and the portion that passed through the norit marker. Calculations were made to determine how much of the gut went by a marker compared to the entire intestine. The results of the study showed that FVEE has an antidiarrheal effect at a level of 100 mg/kg and CAEE has an antidiarrheal effect at a dose of 200 mg/kg.

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