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Journal of Natural Product for Degenerative Diseases
Published by Universitas Pancasila
ISSN : -     EISSN : 30316847     DOI : https://doi.org/10.58511/jnpdd
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
International Journal of Natural Product for Degenerative Diseases accepts articles in the form of full length original research, short communications, reviews, case reports, letter to editor and new drug information. The journal gives importance to articles from ethnopharmacology, in-vivo and in-vitro studies of and clinical studies comparing different modalities of treatment in the fields of herbal medicine. International Journal of Natural Product for Degenerative Diseases is being published as print and e-version. Main research areas include: Natural Product Pharmacology Herbal Medicine Complementary and Alternative Medicine Ethnopharmacology Traditional systems of Medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 31 Documents
 1   2   3   4 
Formulation and Characterization of Antioxidant Capsules Containing Cantigi Extract-loaded Nanoparticles Synthesized Via Nanoprecipitation Method Kosasih, Kosasih; Deny Susanti; Immanuel Puji Hosanna Asianski; Dede Irving Maryanto
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 2 (2024): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i2.6352

Abstract

Cantigi extract exhibit numerous activities, including antioxidants. Various dosage forms have been developed, except a capsule formulation. Capsule formulation offers numerous advantages. Objectives: To prepare and characterize the cantigi extract, extract-loaded nanoparticles, capsules containing extract, and capsules containing nanoparticles as antioxidants. Methods: The Cantigi extract was prepared using the maceration method and characterized for both specific and non-specific parameters. The preparation of extract-loaded nanoparticles utilized the nanoprecipitation method with gelatin, poloxamer, and glutaraldehyde as the polymer, stabilizer, and crosslinker, respectively. Characterization of the nanoparticle included particle size, polydispersity index, zeta potential, and entrapment efficiency. Capsule formulation (F): F1 contained the extract, while F2 contained the nanoparticles. Capsule characterization involved assessment of content uniformity, weight variation, disintegration, and release profile. Antioxidant activity was measured using the DPPH method for extract, nanoparticles and capsules. Results: The cantigi extract met specific and non-specific parameters. Nanoparticle size was found to be 235.8+12.62 nm with a polydispersity index of 0.226+0.050, a zeta potential of -8.53+0.27 mV, and an entrapment efficiency of 52.69+1.06%. Characteristics of F1 and F2 included content uniformity of 97.24+4.23 and 89.86+1.48%, weight variation of 185.5+1.31 and 127.22+1.86%, disintegration time of 3.67-4.08 and 5.35-5.97 minutes, extract content of 97.24+4.23 and 89.86±1.48%, and release rate of 86.78+3.98 and 61.79+3.48%, respectively. Antioxidant activities of the extract, extract-loaded nanoparticles, and capsules (F1 dan F2) were determined to be 17.40+0.94, 33.60+1.85, 66.81+1.46, and 106.61+3.32 ppm, respectively. Conclusion: Cantigi extract and nanoparticles exhibited potent antioxidant activities while meeting quality parameters. The capsule formulation displayed varying antioxidant activities and release profiles, with capsules containing nanoparticles demonstrating a sustained release profile.
The Formulation and Test of Antioxidant Activity from Serum Gel of the Extract Chrysanthemum Flower (Chrysanthemum Indicum L.) Shelly Taurhesia; Dellia Nursyifa Rosdiana; Diah Kartika Pratami
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 2 (2024): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i2.6376

Abstract

Skin as the outermost layer of the body will be first exposed to UV light, and pollution which may form free radicals and lead to premature aging, so the application of antioxidants is indispensable. One of the skin cares that are in great demand is serum. A plant that has a high content of antioxidants and is widely cultivated in Indonesia is the chrysanthemum flower (Chrysanthemum indicum L.). Previous research stated that the IC50 value of chrysanthemums was 43.34 ppm. This study aimed to determine the IC50 value contained in chrysanthemum flower extract and formulate it into serum gel that contains antioxidants and meets physical parameters. The method used in determining the IC50 value is the DPPH method. The formulation was carried out by adding different levels of chrysanthemum flower extract to the formula. The evaluation test includes organoleptic, pH, spreadability, viscosity, and antioxidant activity and stability test at room temperature (25oC) and high temperature (40oC). The results obtained were IC50 values of chrysanthemum flower extracts was 32.78 ± 0.01 ppm while the IC50 of serum gel were 109.10 ± 0.1 ppm (F1) and 73.51 ± 0.08 ppm (F2) and after 4 weeks stored at room temperature the IC50 114.02 ± 0.09 ppm (F1) and 76.39 ± 0.06 ppm (F2). The conclusion is that chrysanthemum flower extract has a very strong antioxidant activity, and the serum gel has a strong antioxidant activity and is stable at both room temperature and 40oC for 4 weeks.
Study of The In Vivo Anti-Inflammatory, Antipyretic and Analgesic Effect of The Ethanol Extract Indian Nettle Plant (Acalypha indica Linn) Khairani, Sondang; Ros Sumarny; Yurista Elystra
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 2 (2024): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i2.6506

Abstract

The body can experience fever and pain, when inflammation occurs. Indian nettle plant (Acalypha Indica Linn.) are known to contain flavonoid compounds which are thought to have anti-inflammatory, antipyretic, and analgesic effect. This study aims to test the anti-inflammatory, antipyretic, and analgesic effect of the ethanol extract of 70% Indian Nettle plant. Method each test used 5 groups, negative control all given Na CMC 0,5%. Antiinflammatory use rats with Winter method, aspirin 40,43mg/200gBB, the test group dose 70mg/200gBW (I), 140mg/200gBW (II), 280mg/200gBW (III), antipyretics use rats with Brewer's yeast method, aspirin 21,45mg/200gBW, the test group dose 70mg/200gBW (I), 140mg/200gBW (II), 280mg/200gBW (III). Analgesic use mice with the Siegmund method, aspirin 3,10mg/20gBB, the test group dose of 10mg/20gBB (I); 20mg/20gBB (II); 40mg/20g BW (III). Results Kruskall Wallis test, the anti-inflammatory effect significant difference to negative control, p value <0,05. Percentage of inhibition positive control edema and test dosage I, II, and III obtained 34,44%; 18,88%; 21,37%, and 29,61%. The Mann Whitney test, the antipretic and analgesic effects significant difference to the negative control, p value <0,05. The decreased percentage of fever in positive control and dosage I, II, and III test preparations was 3,74%; 2,60%; 2,55%; 3,01%. Inhibition percentage of stretching positive control and test dosage I, II, and III obtained 41,05%; 24,46%; 27,78%; and 33,31%. Conclussion: Wriggling inhibition (analgesic) had the highest presentation dose III 33,31% compare to anti-inflammatory and antipyretic activities, lower than aspirin as positive control 41,05% (p<0,05).
Literature Study: Potential of Garcinia latissima Miq. for Skin Care - a Mini Review Neneng Siti Silfi Ambarwati; Yesi Desmiaty; Mari Okatini Armandari; Sri Irta Widjajanti; Triastity, Sarinah; Yolanti
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 1 (2024): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i1.6663

Abstract

The species Garcinia Latissima Miq. is native to Southeast Asia's tropical rain forests, primarily in Papua and Maluku. This plant is well-known for its thick-skinned fruit, used as a spice in traditional recipes. Garcinia Latissima Miq is also used in traditional medicine. Its use as a traditional medicine is because Garcinia Latissima Miq. has long been recognized as a source of phenolic compounds, and earlier research has shown that the chemicals extracted have biological activity as antioxidants, antibacterials, and antimicrobials. This study aimed to gather adequate information on the Garcinia Latissima Miq. plant's potential for usage as a cosmetic or skincare ingredient. A literature review was done in this study to obtain data from prior investigations. According to the findings of this investigation, the Garcinia Latissima Miq. plant possesses anti-elastase, which helps maintain skin elasticity, and contains flavonoids that inhibit tyrosinase in melanogenesis. Garcinia Latissima Miq. plant has the potential to maintain skin elasticity and brightness.
In Silico Studies: Stigmastan-3,6-dione in the Ethyl Acetate Fraction of Momordica charantia L Fruit has immunostimulant and anti-inflammatory activity Rachmi Ridho; Bambang Pontjo Priosoeryanto; Esti Mumpuni; Andri Prasetiyo; Syamsudin Abdillah
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 1 (2024): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i1.6865

Abstract

Momordica charantia L fruit provides an immunomodulatory effect by stimulating certain components of the body's immune system. Bioactive phytochemicals from M. charantia L function as anti-inflammatory agents by reducing levels of pro-inflammatory cytokine secretion including IL-1, IL-6, IL-8, TNF-α, NF-kB. This research looks at the insilico mechanism of action of the active ingredient of the EtOAc fraction of M. charantia L fruit as an immunostimulant and anti-inflammatory. The materials and methods used were an Intel Core i7 10 Th Gen laptop, Chem Office Professional 17.1, Chem 2D, Chem 3D software, PDB code (6W9K) and ligand (TUA), Stigmastan-3,6 dione (C29H48O2) from the EtOAc fraction of fruit M. charantia L was docked using MVD software, RMSD and RMSF values ​​were viewed using Yasara Software, pkCSM online tool to predict compound toxicity, toxicity prediction (LD50) was used by Protox online tool. The results of molecular docking of standard compounds, namely Methylprednisolone and Prednisolone and Stigmastan-3,6-dione, have Rerank Score values of -120.62, -121.47, -79.50, respectively. The lower the Rerank score value, the lower the binding energy between the protein and the ligand, causing the protein and ligand bonds to be more stable and it is predicted that the activity of the compound will be greater. The movement of RMSD values ​​between 0.6-1.9 Å for the 3 (three) compounds, is still within stable limits and does not undergo conformation. The RMSF value of the 3 (three) compounds has the same amino acid residue pattern. The insilico toxicity prediction for the 3 (three) compounds is still within safe limits. The EtOAc fraction of M. charantia L fruit with the active compound Stigmastan-3,6-Dione in its mechanism of action in silico shows activity as an anti-inflammatory and immunostimulant that works on the NF-kB pathway.
Anti-Inflammatory and Analgesic Effect from Decoction of Itchy Leaves (Laportea decumana (Roxb.) Wedd.) Khairani, Sondang; Rika Sari Dewi; Yeshika Krispansis Maelissa
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 1 (2024): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i1.7371

Abstract

Itchy leaves have the ability as analgesics, anti-inflammatory, asthma, antimalaria and antihypertension. Empirically in Maluku and Papua, itchy leaves are used topically to treat pain and inflammation. This study aims to examine the antiinflammatory and analgetic effects orally of an Itchy leaves decoction. Anti-inflammatory testing using the Winter method, rats were divided 5 groups negative control given aquadest, positive control given sodium diclofenac 1.8 mg/200 g BW rats, the test group given an infusion of itchy leaves dose 0.3 g/Kg BW (I), 0.6 g/Kg BW (I) and 1.2 g/Kg BW (III). Analgesics testing using Siegmund method, mice were divided 5 groups, negative control given aquadest, positive control given sodium diclofenac 0.26 mg/20 g BW mice, the test group given decoction of itchy leaves dose 0.4 g/Kg BW (I), 0.8 g/Kg BW (II) and 1.6 g/Kg BW (III). Results of Mann-whitney test, infusion of itchy leaves had a significant anti-inflammatory and analgesic effect on the negative control group, p value <0.05. Precentage of positive control edema inhibition and the test group dosage I, II, III was obtained by 27.94%; 15.97%; 25.89%; and 26.86%, percentage inhibition of positive control and the test group dosage I, II, III was obtained by 59.42%; 43.93%; 45.70% and 80.22%. Itchy leaves decoction has a lower anti-inflammatory effect than diclofenac sodium. The analgesics effect of decoction of Itchy leaves at doses of 0.4 g/Kg BW and 0.8 g/Kg BW was lower, dose of 1.6 g/Kg BW was higher than diclofenac sodium.
Molecular structure similarity analysis using Tanimoto coefficient and its correlation analysis with Maltase-glucoamylase inhibitory activity of Nigella sativa’s compounds Andayani, Nurita; Mulatsari, Esti
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 1 (2024): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i1.7385

Abstract

Nigella sativa is one of the medicinal plants that are efficacious for treating diabetes mellitus. Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia due to damage of insulin action, insulin production, and/or both. In this study, the molecular structure similarity analysis of the compounds in Nigella sativa to acarbose and the correlation analysis of the similarity with its activity as antidiabetic with the mechanism of maltase glucoamylase (MGAM) inhibition was carried out. Similarity analysis has been done used Tanimoto coefficient. The prediction of MGAM inhibitory activity has been done using molecular docking with molegro virtual docker. The Kaempferol 3-glucosyl-(1-2)-galactosyl-(1-2)-glucoside; (S)-2,3-Epoxysqualene; Quercetin 3-glucosyl-(1-2)-galactosyl-(1-2)-glucoside; Oleic Acid has activity as an inhibitor of MGAM with rerank score -107.8770, -102.1760, -95.7338, -92.4246 respectively and these has Tanimoto score 0.426, 0.319, 0.413, 0.357 respectively. The correlation analysis obtained that there is a significant relationship between the Tanimoto Coefficient and Rerank Score with the opposite relationship because the correlation value is negative. Greater the degree of molecular structure similarity of Nigella sativa’s compounds to acarbose more likely has the similar biological activity as MGAM inhibitory
Evaluation of Physical Attributes and Efficacy of Lip Balm Formulated with Okra Fruit Extract (Abelmoschus esculentus (L.) Moench Fructus) Ana Yulyana; Alfioni Wulandari J.E; Saiful Bahri; Eko Mugiyanto
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 1 (2024): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i1.7452

Abstract

The okra fruit (A esculentus fructus) is renowned for its significant antioxidant properties, attributed to its rich content of bioactive compounds. Despite its high antioxidant activity, which has been extensively documented, its potential as a component in cosmetic formulations particularly lip balm preparation remains underutilized. This study seeks to address this gap by incorporating okra fruit extract into lip balm formulations and evaluating the resulting physical and functional attributes. Lip balm formulations were developed with three varying concentrations of Ethanol okra fruit extract: F1 (1%), F2 (3%), and F3 (5%). A series of comprehensive evaluations were conducted to assess the physical stability and performance of the lip balms, including organoleptic properties, homogeneity, pH, melting point, spreadability, and overall stability. Stability was monitored over a 28-day period at room temperature to simulate typical storage conditions. The antioxidant efficacy of the okra extract was quantified using the DPPH (1,1-diphenyl-2-picrylhydrazyl) assay, which yielded an IC50 value of 10.06 µg/ml, reflecting its potent free radical scavenging capacity. In comparison, the lip balm formulations demonstrated higher IC50 values, with Formulation I (FI) at 46.35 µg/ml, Formulation II (FII) at 40 µg/ml, and Formulation III (FIII) at 30.23 µg/ml, indicating a reduction in antioxidant activity in the formulated products compared to the pure extract.. The lip balm formulations exhibited a distinct okra aroma, smooth texture, and uniform color variations ranging from light brown (F1), brown (F2), to dark brown (F3). pH values ranged from 5.40 to 5.81, and melting points were between 49.6°C and 52.9°C, all within the acceptable range as per SNI 16-4769-1998 standards. ANOVA statistical analysis revealed no significant changes (p > 0.05) in melting point and spreadability over time. However, significant differences (p < 0.05) were noted in pH values, with further analysis indicating that formulations F2 and F3 differed significantly from F1 (p < 0.05). These results demonstrate that okra fruit extract not only enhances the antioxidant properties of lip balm but also maintains its stability and functionality, supporting its potential as a valuable ingredient in cosmetic formulations.
The Effectiveness of Sunscreen Cream with Ethanol Extract of Sungkai Leaves (Peronema canescens Jack) Budiati, Anarisa; Aulena, Desi Nadya; Khirana, Roro Dyah Ayu Chandra; Fitriyani, Dwi
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 1 (2024): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i1.7456

Abstract

Sungkai (Peronema canescens Jack) (PCL) contains flavonoid compounds that can absorb UV light therefore having the potential to be developed as a raw material for cosmetics that functions as a sunscreen. The research aims to formulate PCL extract into a sunscreen cream. Sungkai leaves are macerated using 96% ethanol solvent. Specific and non-specific parameter tests were carried out on the extract as well as antioxidant tests using the DPPH method and SPF tests using the Mansur method. The results of this research showed that 96% ethanol extract of PCL had a blackish-green color, pH 5.25; the ethanol and water-soluble essence levels were 6.25% and 5.17%. The water content obtained is 27.4%; drying shrinkage is 0.46%; total ash content is 0.12% and acid insoluble ash content is 0.1%. The antioxidant value obtained was 35.06 ppm. Three cream formulations were prepared (FI of 0.1753%, FII of 0.3506%, and FIII of 0.5259%) and evaluated for organoleptic, homogeneity, cream type, viscosity, pH, particle size, and spreadability tests for one month at 25℃ and 40℃. The organoleptic test results of the cream have a soft texture, with varying colors; light green (FI), green (FII), and dark green (FIII) color. Other evaluation test results show that the cream has a pH of 5.16 - 6.73, a spreadability of 6.47 - 8.07 cm, a viscosity of 15466.67 - 38933.33 cPs, a particle size of 9.88 - 16.17 µm and an SPF of 17.68 (FI), 27.46 (FII), and 33.64 (FIII) with ultra protection on all three. PCL extract after being formulated into creams shows high SPF activity with F3 as the best formula. PCL extract can be formulated into a cream form that meets physical and chemical quality parameters.
Anti-inflammatory Activity of Glucomannan Resulting from β-mannanase Enzyme Hydrolysis in RAW 264.7 Cells Nuraini, Nuraini; Effionora Anwar; Dian Ratih Laksmitawati; Hendig Winarno; Siti Irma Rahmawati
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 2 (2025): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i2.7797

Abstract

Glucomannan is a polysaccharide of the hemicellulose type, composed of glucose and mannose chains. It has the ability to form solutions that expand and thicken. The bioactivity of carbohydrates is influenced by the length of their saccharide chains. Hydrolysis can alter the structural dimensions of polysaccharides, including molecular weight, type, number, and position of substituent groups, which in turn impacts their biological activity. Various methods can modify carbohydrate structures to enhance their value, with degradation being one such method. Enzymatic degradation is particularly advantageous due to its high specificity, efficiency, and minimal side effects. Numerous studies have identified glucomannan as having immunomodulatory effects on macrophage cells. When stimulated with lipopolysaccharides, macrophages release various cytokines and inflammatory mediators, such as TNF-α, iNOS, and NO. This study explored the potential anti-inflammatory effects of glucomannan (GM) and its enzymatically hydrolyzed form (Enz-GM) on RAW 264.7 cells. The research involved degrading glucomannan using the β-mannanase enzyme, followed by in vitro testing of the degradation product (Enz-GM) for anti-inflammatory activity. This was achieved using an ELISA kit to measure the expression of IL-6, TNF-α, and iNOS. The results showed that Enz-GM at pH 9 (Mw 1.24 kDa) significantly reduced the pro-inflammatory cytokines IL-6 and iNOS (p ≤ 0.05) compared to GM, while TNF-α expression did not show a significant difference between Enz-GM and GM.

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