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Journal of Natural Product for Degenerative Diseases
Published by Universitas Pancasila
ISSN : -     EISSN : 30316847     DOI : https://doi.org/10.58511/jnpdd
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
International Journal of Natural Product for Degenerative Diseases accepts articles in the form of full length original research, short communications, reviews, case reports, letter to editor and new drug information. The journal gives importance to articles from ethnopharmacology, in-vivo and in-vitro studies of and clinical studies comparing different modalities of treatment in the fields of herbal medicine. International Journal of Natural Product for Degenerative Diseases is being published as print and e-version. Main research areas include: Natural Product Pharmacology Herbal Medicine Complementary and Alternative Medicine Ethnopharmacology Traditional systems of Medicine
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 31 Documents
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Identification of Ethanol Extract Butterfly Pea Flower (Clitoria ternatea) with LC-HRMS and Antioxidant Activity Testing Setya, Ninik; Syamsudin; Deni Rahmat; Nenden Lilis
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 2 (2025): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i2.8283

Abstract

Butterfly Pea Flower (Clitoria ternatea) is a plant rich in bioactive compounds, such as flavonoids, anthocyanins, and phenolic compounds, which have the potential to provide health benefits. This study aims to identify active compounds in butterfly pea flower extract and evaluate their antioxidant activity. Compound identification was performed using LC-HRMS is an analytical technique that combines liquid chromatography (LC) with high-resolution mass spectrometry (HRMS), while antioxidant activity was tested using radical scavenging DPPH (2,2-diphenyl-1-picrylhydrazyl). Analytical results showed that butterfly pea flower contain major flavonoid compounds, Butterfly Pea Flower contain compounds glycitein, quercetin, apigenin, kaemferol, laserpitin. The antioxidant activity test showed that Butterfly Pea Flower extract has a weak antioxidant capacity, which has the potential to counteract free radicals and reduce oxidative stress. These findings confirm that butterfly pea flower s have potential as a natural source of antioxidants that can be developed for pharmaceutical and functional food applications.
Review article : The Possible Application of Natural Ingredients in Cosmetics for Hair Growth and Strengthening Budiati, Anarisa; Fit Indri Intan Utami
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 2 (2025): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i2.8379

Abstract

Hair is the most significant aspect in supporting look, it requires regular care for problematic scalp and hair, which can be achieved by using products containing hair and scalp care chemicals. The use of natural ingredients as main raw materials and additional raw materials has long been carried out in the cosmetics industry, because they are known to be rich in nutritional content and benefits so they can be used to make beauty and hair care products. The main objective of this literature study activity is to identify the potential contained in the natural to use strengthening and regrowing on the scalp and hair. The literature study was carried out by searching national and international journal literature from 1981 to 2023 regarding natural ingredients in products, namely: lavender, peppermint, rosemary, grapeseed oil, olive oil and bidara oil. Based on literature studies, the results showed that the natural ingredients contained in the product have been proven to have the potential to regrowing, moisturize, strengthen and nourish the scalp and hair, as well as being more environmentally friendly than chemicals and safe to use.
Development and Optimization of Facial Wash Gel with Okra Fruit (Abelmoschus esculentus) Extract: a Study on HPMC Concentration Variations Ana Yulyana; Annisya Maulidia Putri; Eko Mugiyanto
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 2 (2025): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i2.8392

Abstract

The stability of facial wash gel formulations is influenced by the concentration of Hydroxypropyl Methylcellulose (HPMC), which plays a crucial role in determining viscosity, homogeneity, spreadability, and foam stability. This study aimed to evaluate and optimize the physical stability of facial wash gel containing okra extract 3% (Abelmoschus esculentus (L.) Moench) by varying HPMC concentrations (1, 1.5, and 2%). The formulations were assessed for homogeneity, syneresis, pH stability, viscosity, spreadability, and foam stability over a 28-day storage period at room temperature (25°C). Statistical analysis was performed using SPSS version 27, including Shapiro-Wilk normality test, Levene’s test for homogeneity, One-Way ANOVA, and Tukey’s post-hoc test to determine significant differences among formulations. The results showed that HPMC concentration significantly influenced gel stability. F1 (1% HPMC) exhibited syneresis, excessive spreadability, and lower viscosity, indicating poor structural integrity. F2 (1.5% HPMC) maintained moderate stability but showed significant changes in spreadability over time. F3 (2% HPMC) demonstrated the best stability with optimal viscosity, minimal syneresis, controlled spreadability, and consistent foam formation. pH values for all formulations remained within the acceptable range (4.5–7.8, SNI 16-4380-1996). Foam stability (60–70%) met regulatory standards (SNI 16-4085-1996), with higher HPMC concentrations contributing to increased foam retention. The study confirms that HPMC concentration is a key determinant of gel stability. F3 (2% HPMC) exhibited the most stable formulation, balancing viscosity, spreadability, and foam stability, making it the optimal formulation for facial wash gel development. These findings highlight the importance of gelling agent optimization in cosmetic formulations, ensuring both product stability and consumer acceptability.
Anti-Inflammatory and Analgesic Effect: an Experimental Study of Purple Leaves (Graptophyllum pictum (L.) Griff) Decoction Sondang Khairani; Rika Sari Dewi; Yeshika Krispansis Maelissa
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 2 (2025): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i2.8421

Abstract

Purple leaves (Graptophyllum pictum (L.) Griff) are known to contain flavonoid compounds as anti-inflammatory and analgesic properties. This study aims to obtain the efficacy of purple leaf decoction as anti-inflammatory and analgesic. The anti-inflammatory study used the Winter method with Sprague Dawley rat test, were divided into 5 groups, negative control was only given aquadest, positive control with a dose of diclofenac sodium 8.0208 mg/200g BW, and 3 groups of decoction with doses of 5.4 mg/200g BW, 10.8 mg/200g BW and 21.6 mg/200g BW. Anti-inflammatory testing was carried out by measuring the decrease in the volume of edema on the soles of the rat's feet. Analgesic testing using the Siegmund method with Deutche Denken Yoken mice. The mice were divided into 5 groups, negative control was only given aquadest, positive control with a dose of diclofenac sodium 1.1586 mg/20g BW, and 3 groups of decoction with doses of 1 mg/20g BW, 2 mg/20g BW and 4 mg/20g BW. The analgesic study was carried out by calculating the decrease in the number of writhing mice. The results of the percentage of anti-inflammatory effectiveness of purple leaf decoction doses (5.4 mg/200g BW, 10.8 mg/200g BW and 21.6 mg/200g BW) were 51.77%, 68.77% and 79.46%, respectively. The results of the percentage of analgesic effectiveness of purple leaf decoction doses (1 mg/20g BW, 2 mg/20g BW and 4 mg/20g BW) were 54.03%, 71.62% and 79.73%, respectively. Based on the test results, it can be concluded that purple leaf decoction has an anti-inflammatory and analgesic effect.
Formulation, characterization, antioxidant and sun protection factor activity of red pomegranate (Punica granatum l.) peel extract in sunscreen lotion Faizatun, Faizatun; Tanoto, Vingko; Maharani, Syifa Caroline
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 2 (2025): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i2.8444

Abstract

Red pomegranate (Punica granatum L.) contains phenolic compounds of elagic acid as antioxidants and flavonoids and tannins as sunscreens in protecting the skin against ultra violet radiation. The aim of this study was to determine the sunscreen and antioxidant activity of red pomegranate peel extract, also the formation of its stable sunscreen lotion and to determine its SPF and antioxidant activity. Red pomegranate peel was macerated with 70% ethanol and concentrated. Antioxidant activity testing using FRAP method and determination of SPF value, spectrophotometric method was used along with Mansur equation. Lotion formulation was done by adding red pomegranate peel extract as much as 0.06% (F1); 0.12% and 0.24% (F2). The lotion preparation was evaluated for physical and chemical parameters including organoleptic, homogeneity, viscosity and flow properties, lotion type, pH, spreadability, determination of SPF value and stability test using freeze and thaw method. The results showed the IC50 value of red pomegranate peel extract was 12.42 ± 0.01 bpj and the value of sunscreen activity at a concentration of 400 bpj gave an SPF value of 25.91 ± 0.01. The result of testing the physical properties showed that the lotion type was o/w, viscosity ranges from 10400 to 12000 cPs, pH test from 7.25 to 7.60, spreading power from 6.31 to 6.42 cm. The lotion was stable as there was no phase separation observed after centrifugation, freeze-thaw and thermal stress tests. For the lotion of red pomegranate peel extract showed antioxidant activity with IC50 values of 98.73 bpj (F1); 68.89 bpj (F2); 48.30 bpj (F3) and sunscreen values of 13.11 ± 0.02 (F1); 20.78 ± 0.02; 24.78 ± 0.04. It can be concluded that red pomegranate peel extract has very strong antioxidant activity and sunscreen activity with moderate protection, and can be formulated into lotion preparations with good quality parameters.
Sun Protection Factor Activity of Crude Extract, Nanoparticle Extract, and Lyophilised Powder of Arabian Bidara Leaves (Ziziphus spina-christi (L.) Desf.) Budiati, Anarisa; Kartiningsih; Lady Auria Ananova; Theresia Andrian
Journal of Natural Product for Degenerative Diseases Vol. 3 No. 1 (2025): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v3i1.9023

Abstract

Arabic Bidara Leaves (Ziziphus spina-christi (L.) Desf.) contain flavonoids, including quercetin, which has SPF properties. The goal of this research was to examine the properties and SPF activity of crude extract, nanoparticle extract, and lyophilized powder of Arabian Bidara Leaves. Arabian Bidara Leaves were extracted using the UAE technique with 70% ethanol solvent. The crude extract was converted into nanoparticle extract using the ionic glass process and then freeze dried to produce lyophilized powder.  Then the properties and SPF value were investigated.  The study found that the crude extract of Arabian Bidara Leaves has a brownish green color, 10.42%±0.36 water content, 4.68±0.01 pH, and 19.98±0.15 SPF. The nanoparticle extract has a clear yellow color, distinct odor, liquid form, and can be stored for 5 days without sediment formation. It has a particle size of 268.6 nm±3.75, polydispersity index of 0.547±0.06, zeta potential of -6.07 mV, adsorption efficiency of 89.60%, spherical morphology, and an SPF value of 29.96±0.69. The lyophilized powder is brown, flake-shaped, and has an SPF of 29.27±0.76. The results of this investigation show that the leaves of the Arabian bidara have SPF activity in the ultra protection category.
Phytotherapy's Impact on Immune Regulation in Degenerative Diseases Nadya Aulena, Desi; Julian, Iqbal
Journal of Natural Product for Degenerative Diseases Vol. 3 No. 1 (2025): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v3i1.9261

Abstract

This literature review looks at how phytotherapy affects immune regulation in degenerative diseases like neurodegenerative, autoimmune, and metabolic disorders. We begin by outlining a theoretical framework that explains how chronic inflammation, caused by pathways such as NF-κB and the NLRP3 inflammasome, plays a central role in these conditions. Next, we explore how different phytochemicals, including flavonoids, stilbenes, and phenolic acids, achieve their therapeutic effects by influencing these important inflammatory pathways, lowering cytokine production, and offering antioxidant support. The review applies this knowledge to specific diseases, emphasizing how compounds like curcumin and resveratrol may help reduce neuroinflammation and improve immune balance. Finally, we discuss the main challenges related to bioavailability and standardization, suggesting future research paths to realize the full potential of these natural compounds as effective strategies for managing chronic degenerative conditions.
Formulation and Evaluation of Gel of Binahong Leaves Nanoparticle Extract (Anredera cordifolia (Ten.) Steenis) as an Antioxidant and Sunscreen Fathiyah Ghina; Ro’ufi Absor; Deni Rahmat
Journal of Natural Product for Degenerative Diseases Vol. 3 No. 1 (2025): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/v3i1.9216

Abstract

Binahong leaves are a herbal plant that is used to cure several diseases in Indonesia. Binahong leaves have flavonoids that can be potentially beneficial for antioxidants and sunscreen. The study aims to formulate an extract and a nanoparticle extract from binahong leaves into a gel and determine antioxidant and sunscreen activity. Binahong leaves were macerated using 70% ethanol and concentrated with a rotary evaporator. Then the extract was made into nanoparticles using the ionic gelation method. The nanoparticles were characterized for particle size, zeta potential, and morphological shape. The results showed that the nanoparticles were 192.7 nm in size, zeta potential of +25.3 mV, and spherical in shape. Antioxidant and sunscreen activity tests were analyzed using a UV-Vis spectrophotometer. Determination of antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenger activity method. The binahong leaves extract and nanoparticles had IC50 values of 68.78 ppm (moderate) and 152.18 ppm (weak). The antioxidant gel binahong leaves had IC50 of Formula II (174.85 ppm) and Formula III (221.14 ppm). The sunscreen activity was analyzed by determining the SPF value. Binahong leaves extract and nanoparticles had SPF values of 16.92 and 21.55 (ultra category). The sunscreen gel binahong leaves extract (formula II) and nanoparticles (formula III) had SPF values of 2.61 and 3.3 (minimal category). Gel preparations were evaluated, including organoleptic, homogeneity, spreadability, viscosity, and pH test. Binahong leaves extract and nanoparticles extract had antioxidant activity and SPF value that could be formulated into a gel preparation. 
Pharmacognostic and Phytochemical Characterization of Colocasia esculenta var. antiquorum Corm (Araceae) and Preliminary Evaluation of Its Antimicrobial Activity Sumiyati, Yati; Yesi Desmiaty; Gumilar Adhi Nugroho; Fauzia Noprima Okta
Journal of Natural Product for Degenerative Diseases Vol. 3 No. 1 (2025): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/v3i1.9218

Abstract

Colocasia esculenta has been reported in reputable journals to exhibit various bioactivities, including antioxidant, anti-inflammatory, and antidiabetic properties. This study aimed to investigate the pharmacognostic characteristics and phytochemical profile of Colocasia esculenta var. antiquorum corm (Araceae). The corms were collected, authenticated, oven-dried, and subjected to preliminary pharmacognostic and phytochemical analyses. Pharmacognostic evaluations included organoleptic, microscopic, and physicochemical examinations. The dried corm powder was extracted with distilled water, followed by qualitative phytochemical screening. The extract was found to contain saponins, flavonoids, tannins, and triterpenoids. Antimicrobial activity was further evaluated against Staphylococcus aureus, Escherichia coli, and Candida albicans, which were selected as representative pathogenic microorganisms for Gram-positive bacteria, Gram-negative bacteria, and fungi, respectively. These microorganisms were chosen based on previous reports demonstrating that the ethanolic leaf extract of taro exhibited antifungal activity against Candida albicans and antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella, and Escherichia coli. However, no inhibitory effect was observed in this study. All analyses were performed in accordance with the guidelines of the Indonesian Herbal Pharmacopeia. The findings provide reference data for the pharmacognostic identification of Colocasia esculenta corm and highlight its phytochemical constituents. Further investigations on other biological activities are required to validate its therapeutic potential. 
Development, Optimization, and Characterization of Wet-Granulated Curcumin Nanostructured Lipid Carrier Tablets Mantika Atiqah Baihaty; Gumilar Adhi Nugroho; Deni Rahmat; Faridah Faridah
Journal of Natural Product for Degenerative Diseases Vol. 3 No. 1 (2025): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/v3i1.9214

Abstract

Curcumin has been widely recognized for its broad therapeutic potential, including its emerging role as an antiviral agent. However, its clinical translation is limited by poor aqueous solubility, rapid metabolism, and low oral bioavailability. To address these challenges, nanostructured lipid carriers (NLCs) have been proposed as a promising delivery system to enhance curcumin stability and systemic availability. This study aimed to formulate curcumin-loaded NLCs, optimize their physicochemical characteristics, and develop an oral tablet dosage form using the wet granulation method with super-disintegrant variation. The optimized NLC formulation was prepared and subsequently freeze-dried prior to compression into tablets. Particle size, polydispersity index (PDI), zeta potential, morphology, entrapment efficiency (EE), and loading capacity (LC) were evaluated. Tablets were formulated using starch, croscarmellose sodium (2% and 3%), PVP, aerosil, and Avicel PH 102, followed by assessment of physical quality parameters including weight uniformity, hardness, friability, disintegration, and dissolution profile. The optimized NLCs exhibited desirable nanoscale characteristics, with particle size of 70.95 nm, PDI 0.379, zeta potential −23.9 mV, spherical morphology, EE 99.75%, and LC 9.93%. The resulting tablets were yellow, bitter, and odorless, with acceptable pharmacopeial quality. Weight and size uniformity were within limits, hardness was 3.81 kg/cm² and 4.38 kg/cm², friability 1.45% and 0.50%, and disintegration times 1.86 min and 1.28 min for 2% and 3% super-disintegrant, respectively. Dissolution profiles indicated 26.12% and 25.79% release within the test period. Curcumin can be successfully formulated into stable NLCs with excellent encapsulation efficiency and incorporated into wet-granulated tablets meeting pharmacopeial standards. The use of 3% croscarmellose sodium provided the most favorable disintegration profile, suggesting its potential as an optimized oral dosage form to improve curcumin delivery and bioavailability.

Page 3 of 4 | Total Record : 31

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