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Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Published by SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA
ISSN : 2443115X     EISSN : 24771821     DOI : https://doi.org/10.51352/jim
Core Subject : Health, Science,
Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal Ilmiah Manuntung is a journal on pharmaceutical and health sciences published by Sekolah Tinggi Ilmu Kesehatan Samarinda which includes the study of pharmaceutical sciences, medicine, synthetic organic chemistry, organic chemistry of natural materials, biochemistry, analytical chemistry, physical chemistry, biology, microbiology, tissue culture, botany and animals related to pharmaceutical products, nursing, midwifery, health analysts, nutrition and public health.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 326 Documents
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UJI TOKSISITAS AKUT KAPSUL BAWANG PUTIH LANANG (Allium sativum Linn) Lusia Murtisiwi; Novena Yety Lindawati
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i2.65

Abstract

Garlic (Allium sativum Linn) is evidently active against Mycobacterium tuberculosis. Garlic contains allicin that is able to inhibit the bacteria causing tuberculosis. This dried extract garlic is also qualified as content of capsules of traditional medicine, score of Total Plate Count is1.5 (required not over 10); figures of mold and yeast extract of garlic is 4.102 (required not over 104); does not contain microbial pathogens (uncontaminated with coliform bacteria, Escherichia coli, Salmonella sp, and Staphylococcus aureus); and aflatoxin is not detected (required not more than 30 CPM); the average of moisture content is 2% (required notmore than 10%). Capsule of dried extract garlic (Allium sativum Linn) meets pharmaceutical requirements for traditional medicine capsule dosage form, with9 minutes as disintegrating time (required not more than 15 minutes) and meets the uniformity of weight as required for capsule. Results of the research indicates that dried extract of garlic indose above 48.750 mg/ kg body weightto get LD50in garlic, belongs to ‘relatively harmless’. Dried extract garlic in 4 doses variations do not affect the liver functions of mice, so significant clinical toxicity symptoms that happen on entire animals test have not gained yet
UJI EFEKTIFITAS FORMULA SPRAY DARI MINYAK ATSIRI HERBA KEMANGI (Ocimum Sanctum L ) SEBAGAI REPELLENT NYAMUK Aedes aegypti Resmi Aini; Rina Widiastuti; Nuha Afra Nadhifa
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i2.66

Abstract

Dengue fever is transmitted by the bite of Aedes aegypti mosquitoes infected with denguevirus. Preparations antinyamuk much use of harmful chemicals such as DEET (diethylmetatoluamide) and permethrin that can lead to pollution of the environment, leavingno residue and cause resistance to the drug. To determine the activity of essential oils from herbs basil (Ocimum Sanctum L) in the preparation of spray as a mosquito repellent and determine the effective concentrationof the spray.This type of research is True experiment with design Post Test Only Control Group Design. Repellent activity was observed by means of spray is sprayed on the back of the hand probandus, then tested on female mosquitoes with the introduction into the cage containing20 mosquitoes each treatment. Spray essential oils showed repellent activity of Aedes aegypti with a value of correlation r = 0.964 higher concentration of essential oils the fewer mosquitoes that land. Spray herbal essential oil of basil (Ocimum basilicum L) has a repellent activitycompared to the negative control. The effectiveness of the herb basil essential oil sprayobtainedat 74.131 ppm lC50 and lC90 of  775.711 ppm
POTENSI TONGKOL JAGUNG (Zea Mays L.) SEBAGAI SUNSCREEN DALAM SEDIAAN HAND BODY LOTION Dewi Ekowati; Inaratul Rhizky Hanifah
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i2.67

Abstract

The over exposure sunlightis on the skin provides of damage. Skin damage caused the over exposure sunlightis can occur in the short term such as erythema or long term such as premature skin aging and even skin cancer. One way that can be done to minimize the amount of UV that penetrated into the skin is to use sunscreen. Corn cob contain the chemical compounds of phenolic, which suspected to have the protection activity toward the UV B rays. The study aims to make preparations hand body lotion that meet good physical quality of the corn cob extract  as a sunscreen. Hand made three body lotion formula with extract concentrations of corn cob 10% FI, FII FIII 15% and 20%. Testing the physical properties of the test hand body lotion include viscosity, dispersive power and pH. The effectiveness of a sunscreen is based on a determination of the value of the Sun Protection Factor (SPF) in vitro. The third formula has a good physical quality lotion that viscosity 50-1000 dPas, the scatter 5-7 cm, pH 4.5 -7. The effectiveness of sunscreen based on the value of the Sun Protection Factor (SPF), the effectiveness FIII in the category of extra protection is 7.23. SPF value FI  FII 5.13 and 5.67 so that FI and FII into the category of moderate protection
PENGARUH PERBEDAAN CHEMICAL PENETRATION ENHANCER PADA PENETRASI TRANSDERMAL PATCH PROMETAZIN HCL Dwi Nurahmanto
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i2.68

Abstract

This research aims is to create a promethazine HCl patch transdermal drug delivery systems with the most excellent penetration. Transdermal drug delivery can be efficiently used for the active agents which undergo rapid first pass metabolism and oral absorption is often disrupted by nausea and vomiting, hence the transdermal patches of promethazine HCl were prepared by using different penetration enhancers,  propylene glycol, oleic acid and isopropyl alcohol. The prepared formulations were evaluated for thickness, weight variation, moisture content, drug content, morphology, and in vitro permeation studies. The patch morphology studies were performed by Scanning Electron Microscopy (SEM). The amount of promethazine HCl transfered by propylene glycol  25.77 ± 3.0396 ug, isopropil alcohol 25.758 ± 2.9022 ug and oleic acid 25.017 ± 8.1300 ug. The penetration of promethazine HCl patch with oleic acid enhancer, produce the highest penetration than isopropil alcohol and propylene glycol. there was no difference in penetration using propylene glycol and isopropyl alcohol. Oleic acid is the best enhancer for preparations patch containing promethazine HCl although the amount of promethazine HCl contained is the least. The whole formulations comply with the  patch dosage requirements
VALIDASI METODE ANALISIS DAN PENURUNAN KADAR INFUS CIPROFLOKSASIN YANG DIPENGARUHI REAKSI OKSIDASI MENGGUNAKAN HPLC Bekti Nugraheni; Nafi'ah Nafi'ah; B Anggoro
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i2.69

Abstract

Validation of analysis methods is conducted on the assay of the antibiotic ciprofloxacin because it is often used in the treatment of urinary tract infections, respiratory tract infections and gastrointestinal infections. This study aimed to determine the validity of an analytical method. Development of methods used in this study were the mobile phase of methanol: aquabidest : 0.1 M phosphate buffer: acetonitrile (80: 10: 5: 5). Then the ciprofloxacin validation was performed. After the methods validation were valid, the assay of ciprofloxacin in infusion was performed to determine the decreased levels which affected by the oxidation reaction of 0, 60, 90, 150 and 180 minutes. The validation parameters in the research were selectivity, accuracy, precision, linearity, LOD and LOQ. Samples were standart ciprofloxacin used for the validation and infusion of ciprofloxacin for the assay on the sample application that was affected by the oxidation reaction. The used of HPLC met the requirements such as HPLC devices Waters e2695 Separations, SunFireTM column C18, and PDA detector and a flow rate of 1.0 mL / min. This study showed that the result was selective, stated with no emergence of peaks in the matrix. HPLC analysis methods on ciprofloxacin meet the acceptance criteria of accuracy % recovery value solution concentration of ≥10 mg / mL are 90-107%. Precision test qualifies % RSD for solution concentrations ≥10 mg / mL is <7.3%. Linearity r ≥0,997 then it can be concluded that the result was qualified. LOD value is 0.2707 µg / mL and the LOQ value is 0.9026 µg / mL. The results of the assay infusion of ciprofloxacin were found that there was a significant decrease in the levels of ciprofloxacin due to the influence of the oxidation reaction
FORMULASI SEDIAAN SALEP EKSTRAK ETANOL DAUN ALPUKAT (Persea americana Mill.) SEBAGAI ANTIACNE Yulistia Budianti Soemarie; Tri Astuti; Nur Rochmah
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i2.70

Abstract

Currently, the development of acne drugs (antiacne) use  many natural materials because the natural materials can minimize the side effect if compared with synthetic chemicals drugs. Acne can caused by propionibacterium acnes, staphylococcus epidermis and staphylococcus aureu. One of plants that can be used for acne treatment is leaves of Avocado (Persea americana Mill). The aim of this study was to know whether the ethanol extract of leaves of avocado (Persea americana Mill.) can be made into an ointment preparations that fulfill the requirements. Sample in this research was extract of avocado leaves which used maceration method. The ointment formulations were made into some variation concentrations of PEG 400 and PEG 4000: Formula I (30%:70%); Formula II (50%:50%) and Formula III (70%:30%). The results show that the ointment of avocado leaves which fulfilled the requirements of physical properties is formula III with concentration of PEG 400 70 % and PEG 4000 30 %
FORMULASI PATCH KOSMETIK LENDIR BEKICOT (Achatina fulica) DENGAN POLIMER KITOSAN DAN BERBAGAI VARIASI AMILUM Michrun Nisa; Andi Nuraisyah; Nurul Arfiyanti Yusuf; Nurul Alifah K
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i2.71

Abstract

The research on cosmetic patch formulation containing snail slime with a variety starch was aimed to determine the type of starch that could produce a patch preparation with a good physical characteristic had been conducted. Cosmetic patch formulation of snail slime was using combination of chitosan and starch polymers such as corn, potato and tapioca starch. The method was used the solvent evaporation technique. The evaluation of patches include weight uniformity, folding endurance, thickness, moisture content, moisture uptake and stability of the patch. The combination of chitosan and starch polymers produced patches that had pH 5 with color uniformity, smoothness of surface and easily removed from the mold. The results showed that patches containing tapioca starch gave weight uniformity that did not much different on each replication that was 0,568 ± 0,03. Patches containing corn starch provided thickness values on each replication did not much different from 0,16± 0,01. Patches containing potato and tapioca starch produced patches that was accordance with the standard parameter of folding endurance was more than 200 times. Patches containing corn and tapioca starch producing patches accordance with the standard parameter of moisture content were less than 10 %. Patches containing potato starch gave patch a high moisture uptake that was 8,2%. The combination of chitosan and tapioca strach as polymers produced patch preparation with a good characteristic on the formulation of snail slime cosmetic patch.
UJI AKTIVITAS ANTIBAKTERI FORMULASI GEL UNTUK SARIAWAN DARI EKSTRAK DAUN SAGA ( Abrus precatorius Linn. ) TERHADAP BAKTERI Staphylococcus aureus Ratih Dyah Pertiwi; Joni Kristanto; Graha Ayu Praptiwi
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i2.72

Abstract

One of plants used by Indonesian people as a traditional medicine is saga plant (Abrus precatorius L.). This plant has medicinal properties as medication for thrush, cough and laryngitis. Chemical constituents contained in sage leaves which work as antibacterial are flavonoid and saponin. This study aims to determine the optimal concentration of saga leaves extract which can be formulated in a gel dosage form with qualified physical evaluation and has antibacterial activity against Staphylococcus aureus. Saga leaves extract is prepared by maceration method using ethanol 70% as solvent, and then the extract obtained is preliminarily tested to see its antibacterial activity against Staphylococcus aureus with agar diffusion method. Gel formulation for thrush is made with dispersion method in three formulas with variants of active substance concentration that is FI (1%), FII (3%) and FIII (5%). Gel preparation antibacterial activity test is conducted with agar diffusion method as a plate cylinder. Based on this research, it was found that the extract of saga leaves which is positively made is efficacious as antibacterial and can be formulated into a gel preparation for thrush with optimal concentration in F III (5%), this is indicated by widest diameter of the inhibition area against Staphylococus aureus bacteria
UJI CEMARAN BAKTERI COLIFORM PADA MINUMAN AIR TEBU Yullia Sukawaty; Muhammad Kamil; Eko Kusumawati
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v2i2.73

Abstract

Sugarcane juice beverage is a beverage that is found along the village Sempaja and Pelita roads. Contamination in processed beverages derived from sugarcane juice and equipment used allow for contamination by coliform bacteria. The purpose of this study to investigate the contamination of coliform bacteria in water beverage sugar circulating in the village Sempaja and Pelita. Tests using the Most Probable Number (MPN) includes test estimators using lactose broth as the presumptive medium and Brillian Green Lactose Bile Broth as the confirmad medium. The results showed that eight samples tested positive for coliform contaminated with a high of 2800×101 MPN / mL (sample H) and the lowest value 170×101 MPN/mL (sample D). The results obtained show that the sugarcane juice drinks that supply does not meet the standards of Rule Head POM HK.00.06.1.52.4011 No. 2009 with standard quality requirements of 2×101colonies/mL.
IDENTIFIKASI SENYAWA METABOLIT SEKUNDER DAN UJI AKTIVITAS EKSTRAK ETANOL HERBA MENIRAN (Phyllanthus niruri L.) TERHADAP CANDIDA ALBICANS MENGGUNAKAN METODE DIFUSI CAKRAM Anita Apriliana; Eko Kusumawati; Selvitawati Selvitawati
Jurnal Ilmiah Manuntung Vol 3 No 1 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v3i1.84

Abstract

The aim of this research is to know the ability of meniran ethanol extract (Phyllanthus niruri L.) in inhibiting the growth of Candida albicans. The research design is an experimental study. The extract used was herbal meniran extract made by maceration using 70% ethanol solvent, the content of ethanol extract of meniran tested against Candida albicans using disc diffusion method were 5%, 10%, 20%, 30% and 40%. Activity test conducted on Sabaraound Dextrose agar media that has been smeared with Candida albicans culture which has been standardized with Mc Farland standard. The pre-tested disc paper is first dipped into the extract with various concentrations. Incubated at 30 ° C for 24 hours and the inhibit zone formed was measured. The result showed that herbal ethanol extract of meniran resulted in drag zone diameter at Candida albicans ie 8,5 mm; 10.3 mm; 12.6 mm; 14.1 mm and 14.3 mm, for negative control 0 mm and positive control 20.1 mm. Data obtained from the results of the study were analyzed using one way anova method showed p - value <0,05, it was concluded that there was significant difference between negative control, 5%, 10%, 20%, 30%, 40% and positive control.

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