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INDONESIA
Jurnal Kedokteran Syiah Kuala
Published by Universitas Syiah Kuala
ISSN : 14421026     EISSN : 25500112     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Arjuna Subject : -
Articles 545 Documents
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Profil pasien kanker payudara terhadap ekspresi protein reseptor estrogen di RSUD. Dr. Pirngadi Medan tahun 2018-2019 Naomi Laksita Laras; Pimpin Utama Pohan
Jurnal Kedokteran Syiah Kuala Vol 23, No 1: April 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v23i1.24056

Abstract

Kanker payudara merupakan jenis kanker dengan angka kejadian tertinggi dan menjadi penyebab utama kematian di dunia. Angka kejadian tersebut terus meningkat disebabkan oleh berbagai faktor risiko seperti faktor endogen maupun eksogen. Pemeriksaan imunohistokimia seperti reseptor estrogen berguna untuk menentukan terapi dan prognosis pasien. Penelitian ini bertujuan untuk mengetahui bagaimana profil pasien kanker payudara terhadap ekspresi protein reseptor estrogen di RSUD. Dr. Pirngadi Medan Tahun 2018-2019. Penelitian ini merupakan penelitian deskriptif observasional menggunakan desain cross sectional dengan teknik pengambilan sampel random sampling. Data diperoleh secara sekunder dari rekam medis pasien kanker payudara di RSUD. Dr. Pirngadi Medan Tahun 2018-2019. Dari 250 kasus kanker payudara periode 2018-2019, diambil sampel sebanyak 71 buah rekam medis. Dari 71 sampel, sebagian besar pasien terjadi pada kelompok usia 46-55 tahun dengan ER negatif sebanyak 18 orang (58.1%), sebanyak  13 orang (56.5%) pasien  memiliki ukuran tumor T4 dengan ER positif, sebagian besar pasien tidak mengalami metastasis pembuluh limfe, metastasis jauh, tidak memiliki riwayat keluarga dan penggunaan hormon dengan ER negatif dengan masing-masing sebanyak 26 orang (63.4%), 39 orang (66.1%), 36 orang (60%) dan 42 orang (62.7%), sebanyak 20 orang (66.7%)  memiliki IMT obesitas dengan ER negatif, tipe histopatologi duktal invasif dengan ER negatif paling banyak ditemukan sebanyak 41 orang (63.1%) dan grading histopatologi terbanyak pada grade 2 dengan ER negatif sebanyak 26 orang (57.8%). Disimpulkan bahwa hampir keseluruhan pasien berdasarkan karakteristik kanker payudara mayoritas memiliki ER negatif, kecuali pasien ukuran tumor T4 memiliki ER positif.
Effects of acetylcholinesterase inhibitor Donepezil on cognitive function and vital sign in patients with dementia Maria Yosita Ayu Hapsari; Fathu Thaariq Baihaqy; Muhana Fawwazy Ilyas; Pepi Budianto; Revi Gama Hatta Novika
Jurnal Kedokteran Syiah Kuala Vol 23, No 1: April 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v23i1.27558

Abstract

The prevalence of people with dementia is increasing both in Indonesia and throughout the world. Donepezil is one of the dementia therapy options that has been shown to have benefits. This study aims to determine the relationship between the administration of donepezil with cognitive function and vital signs: systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) in patients with dementia. The research was conducted at Dr. Moewardi Hospital (RSDM), Surakarta, Indonesia from September 2021 to February 2022 using a quasi-experimental design with different designs: one-group pretest-posttest design and time-series design. This study followed people with dementia who were given donepezil for 20 weeks. The patient was given donepezil 5 mg daily and scheduled for evaluation by the neurologist every 4 weeks to check vital signs. Cognitive function examination was performed with Mini-Mental State Examination (MMSE) at initial (before drug administration) and final (after 20 weeks). The analytical test included: repeated measures Anova, Friedman alternative, and paired T-test. A total of 27 patients were included in this study. There was an association between the administration of donepezil with cognitive function in patients with dementia at the RSDM (p0.004). Meanwhile, there was no significant association between the administration of donepezil and vital sign parameters (SBP, DBP, and HR).
Prevalence of Epilepsy in Dr. Zainoel Abidin Hospital Banda Aceh Nova Dian Lestari
Jurnal Kedokteran Syiah Kuala JKS Edisi Khusus Oktober 2022
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v0i0.29645

Abstract

Background Studies investigating the prevalence and incidence of epilepsy are increasingly common, particularly in low- and middle-income countries. Prevalence is expectedly lowest early in life, increasing to its highest level during adolescence and early adulthood, decreases after age 30, and remains fairly constant for the remainder of life.2 The prevalence of the disease tends to increase with age, with a peak at 20–29 years and a subsequent decrease, with a ratio of 7.17 (95% CI 4.67– 11.01) in individuals aged 60 years or older. Higher rates can be found when the prevalence is calculated in the context of a prospective survey. In the Rotterdam study that included individuals aged 55 years or older, the overall prevalence of active epilepsy was 9 per 1,000, with an increase with age from 7 per 1,000 for people aged 55– 64 years to 12 per 1,000 for those aged 85–94 years. Sex, while not commonly thought to affect the occurrence of epilepsy, may contribute to differences in epilepsy incidence. The incidence of epilepsy tended to be higher in males than females. Some suggest that females may be more likely to conceal their epilepsy diagnosis if they live in a country where they would be considered unmarriageable or socially marginalized.3,4
Quantitative Evaluation of Antibiotic Usage in ICU Ward at West Nusa Tenggara Province Hospital in 2018 Oci Qonita Londo Woro; Dewi Suryani; Ni Made Amelia Ratnata Dewi
Jurnal Kedokteran Syiah Kuala Vol 23, No 1: April 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v23i1.24796

Abstract

The number of antibiotic resistances in hospitals and healthcare is increasing. The resistances prevalence rate in Intensive Care Unit (ICU) room is 11,6-22,5%. This research aim is to evaluate the usage of antibiotics of patients in ICU at West Nusa Tenggara Provincial Hospital in 2018. This research is observational and applies a cross-sectional design that collects data retrospectively, with the total number of samples are 64 patients who met inclusion criteria and employs DDD/100 patient-days system analysis method. The result of this study shows, among 64 patients; there are 37 male and 27 female patients; 48 adult and 16 elderly patients. Among 11 groups of cases, the highest case is neurosurgery with 30 patients. The total length of stay (LOS) of all patients is 621 days, where the range of LOS is 1-69 days, and the median value is 6 days. According to the calculation, there are 17 types of antibiotics used in the ICU room of West Nusa Tenggara Hospital in 2018. Five varieties of most used antibiotics based on their DDD/100 patient-days are ceftriaxone (60,71), levofloxacin (29,15), meropenem (16,10), metronidazole (11,00), dan amikacin (6,24). The percentage value of those antibiotics respectively is 45,44; 21,82; 12,05; 8,24; dan 4,67%. Based on all types of antibiotics, the range value of DDD/100 patient-days is 60,71- 0,05 DDD/100 patient-days
Progressive trends in prenatal genetic screening Kirolos S. Eskandar
Jurnal Kedokteran Syiah Kuala Vol 23, No 1: April 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v23i1.27105

Abstract

According to the global report on birth defects in 2021, it is estimated that 8 million children are born with birth defects of genetic origin annually. These birth defects vary in their degree of severity; where some types are mild and don’t require treatment but others may necessitate lifelong medications or even cause instant death just after birth. That is why prenatal screening is doubtless necessary to detect such genetic defects before birth aiming to drop the tragedy of these children off. Recently, this approach has been developing towards non-invasive techniques that reduce the risk of miscarriage which was common in the old-fashioned invasive ones. Non-invasive Prenatal Tests (NIPTs) like Chromosomal Microarray Analysis (CMA) and cell-free fetal DNA (cffDNA) caused a breakthrough in the screening methods of chromosomal aneuploidies. Thanks to their benefits, NIPTs are considered a fundamental clinical approach for pregnant women’ screening in multiple countries. Thence, this paper gives prominence to the recentness of NIPTs along with each’s assets, liabilities, and prospective recommendations. In addition, it would demonstrate the importance of modern molecular technologies like next-generation sequencing (NGS) which are enforced for the appliance of NIPTs.
Hubungan Tingkat Pengetahuan Terhadap Perilaku Swamedikasi Obat Asam Mefenamat Pada Mahasiswa Universitas Syiah Kuala Hijra Novia Suardi; Amida Jannatus Saleha; Dina Alia; Zahratul Aini; Hanifah Yusuf; Suryawati Suryawati; Vera Dewi Mulia
Jurnal Kedokteran Syiah Kuala Vol 23, No 1: April 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v23i1.28717

Abstract

Swamedikasi adalah suatu perilaku pemilihan dan penggunaan obat-obatan sendiri yang dilakukan seseorang dalam mengobati gejala penyakit yang dialaminya tanpa menggunakan resep dokter. Jenis obat yang banyak digunakan untuk swamedikasi adalah obat anti nyeri asam mefenamat. Saat ini masih banyak masyarakat yang melakukan praktek swamedikasi secara tidak rasional sehingga menimbulkan masalah seperti efek samping yang berbahaya bagi tubuh. Hal ini dipengaruhi oleh kurangnya pengetahuan masyarakat tentang bagaimana cara melakukan swamedikasi yang tepat, aman, dan rasional. Tujuan penelitian ini adalah untuk mengetahui hubungan tingkat pengetahuan terhadap perilaku swamedikasi obat asam mefenamat pada mahasiswa non kesehatan (Fakultas Hukum) Universitas Syiah Kuala. Penelitian ini merupakan penelitian observasional dengan rancangan cross-sectional. Pengambilan data dilakukan secara online dengan metode proportional random sampling pada mahasiswa Fakultas Hukum Universitas Syiah Kuala. Hasil penelitian dari 104 responden didapatkan sebanyak 52,9% responden memiliki pengetahuan swamedikasi yang cukup dan sebanyak 78,8% responden memiliki perilaku yang cukup mengenai swamedikasi obat asam mefenamat. Hasil uji korelasi Spearman antara pengetahuan dan perilaku didapatkan nilai r=0,032 dan p=0,018 yang menunjukkan adanya hubungan yang signifikan antara tingkat pengetahuan dengan prilaku swamedikasi asam mefenamat dengan korelasi yang lemah pada mahasiswa Fakultas Hukum Universitas Syiah kuala.
Transformasi Pembelajaran Pendidikan Kedokteran Akibat COVID-19 Sekarang dan Mendatang Ryan Herardi; Niniek Hardini; Riezky Valentina Asteri; Lingga Etantyo Praditya; Shahnaz Medina
Jurnal Kedokteran Syiah Kuala Vol 23, No 1: April 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v23i1.25806

Abstract

Abstract. The rise of Coronavirus Disease 19 (COVID-19) pandemic in the late 2019 has affected every aspect of our lives, including the education and learning method. The medical education is also required to shift from face-to-face learning methods to distance-learning methods while maintaining its quality of learning. There are few learning methods applied in the medical education, such as lectures, small group discussions, laboratory activities, clinical skills activities and clinical rotations which involved doctor-patient interactions. All of these learning methods may eventually be transformed to adjust to the regulations of COVID-19 prevention which promote social distancing and prohibit gatherings.
Pengaruh Pemberian Probiotik Limosilactobacillus reuteri dalam Tatalaksana Kolik Infantil Ahmad Iqbal Romdloni
Jurnal Kedokteran Syiah Kuala Vol 23, No 1: April 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v23i1.24641

Abstract

Infantile colic is a condition involving full-force prolonged crying in healthy and thriving infants with no apparent cause. In addition to causing long term effects on infants, this condition also affects parents, including: anxiety, stress, maternal depression risk, and shaken baby syndrome. On the other hand, probiotic administration is proven to reduce crying duration and frequency by balancing gastrointestinal microbiote and metabolite secretion that eases the symptoms of colic. This study was conducted to determine the effect of probiotic administration, particularly Limosilactobacillus reuteri, in infantile colic management. The method used in this research is literature study. Population in this study includes study articles about probiotics and infantile colic with samples taken from 12 articles in SCIMAGO indexed international journals published from 2016 to 2021. This research took place from May to November 2021. Results of 12 research articles shown that the administration of probiotic L. reuteri is able to reduce the incidence of infantile colic characterized by crying frequency and duration decrease and other symptoms, such as : bloating, abdominal muscle tension, flushing, and postural changes, significantly on breastfed infants. Probiotic administration on babies colic is safe. L. reuteri probiotic shows good and consistent effectiveness compared to other probiotics.
ISOLASI BAKTERIOFAG DARI LIMBAH CAIR DENGAN AKTIVITAS LITIK TERHADAP Escherichia coli Boby Franswinsly Ritonga; Maya Savira
Jurnal Kedokteran Syiah Kuala Vol 23, No 1: April 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v23i1.23684

Abstract

Bakteriofag adalah virus yang menginfeksi bakteri tertentu secara spesifik. Pemanfaatan bakteriofag sudah mulai diterapkan dalam bidang kedokteran sejak meningkatnya kasus resistensi antibiotik. Salah satu pemanfaatannya adalah terapi bakteriofag yang bertujuan untuk mengatasi atau mencegah infeksi bakteri. MDR Escherichia coli merupakan salah satu bakteri yang memiliki strain MDR yang telah menjadi masalah kesehatan di beberapa negara. E.coli merupakan bakteri basil gram negatif yang merupakan organisme penyebab banyak penyakit seperti diare, disentri, sistitis tanpa komplikasi, pneumonia, bakteremia, dan peritonitis. Dalam penelitian ini, bakteriofag litik yang dapat menginfeksi E.coli diisolasi dari limbah cair instalasi pengolahan limbah rumah sakit. Penelitian ini bertujuan untuk mengidentifikasi bakteriofag litik E.coli, serta melihat potensinya sebagai agen antibakteri terhadap E.coli ATCC 35218 . Penelitian ini merupakan penelitian deskriptif laboratorik yang diuji pada metode spot test dan plaque assay. Sediaan bakteriofag phage#1a yang merupakan produk akhir pada penelitian ini menunjukkan hasil spot test positif dan memiliki konsentrasi ±7.7x106 PFU/mL. Hasil penelitian ini menandakan bahwa bakteriofag dapat diisolasi dari limbah cair rumah sakit dan telah diuji dapat digunakan sabagai bahan antibakteri. Bakteriofag yang berhasil diisolasi ini diharapkan dapat digunakan untuk mengatasi permasalahan resistensi antibiotik yang selalu meningkat setiap tahunnya.
Perbandingan tekanan intra okular sebelum dan setelah operasi fakoemulsifikasi pada pasien katarak senilis di Rumah Sakit Umum Daerah dr. Zainoel Abidin Saiful Basri; Zakiaturrahmi Zakiaturrahmi; Sabila Qurasifa
Jurnal Kedokteran Syiah Kuala Vol 23, No 1: April 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v23i1.31497

Abstract

Abstrak. Katarak senilis merupakan kekeruhan pada lensa mata yang terjadi pada usia di atas 50 tahun. Katarak yang menyebabkan kebutaan dapat dicegah dengan tindakan operasi. Metode operasi yang paling sering digunakan di Indonesia adalah fakoemulsifikasi. Salah satu komplikasi yang dapat terjadi setelah operasi katarak ialah peningkatan tekanan intra okular (TIO). Penelitian ini bertujuan untuk mengetahui perbandingan TIO sebelum dan setelah operasi fakoemulsifikasi pada pasien katarak senilis. Penelitian ini merupakan penelitian observasional analitik menggunakan pendekaran cross-sectional dengan teknik consecutive sampling dan jumlah sampel penelitian 25 responden yang memenuhi kriteria inklusi dan eksklusi. Pengumpulan data meliputi usia, jenis kelamin, TIO sebelum operasi, satu hari setelah operasi, dan satu pekan setelah operasi. Analisis statistik yang digunakan ialah uji t berpasangan. Hasil penelitian ini menunjukkan bahwa distribusi pasien katarak senilis tertinggi pada kelompok usia 60-69 tahun berjumlah 15 orang (60,0%) dan jenis kelamin laki-laki sebanyak 18 orang (72,0%). Berdasarkan hasil analisis menunjukkan adanya perbedaan TIO sebelum dan satu hari setelah operasi fakoemulsifikasi pada pasien katarak senilis dengan p value 0,000 (p ≤ 0,05), namun tidak adanya perbedaan TIO sebelum dan satu pekan setelah operasi fakoemulsifikasi pada pasien katarak senilis dengan p value 0,440 (p 0,05). Kesimpulan pada penelitian ini ialah peningkatan TIO terjadi pada satu hari setelah operasi dengan perbedaan yang signifikan dan penurunan TIO terjadi pada satu pekan setelah operasi yang hampir sama dengan nilai TIO sebelum operasi fakoemulsifikasi. Kata Kunci: Katarak Senilis, Fakoemulsifikasi, Tekanan Intra Okular Abstract. Senile cataract is a clouding of the eye lens that develops after the age of 50. Cataracts that cause blindness can be prevented by surgery. The most frequently used surgical method in Indonesia is phacoemulsification. One of the complications that can occur after cataract surgery is increased intraocular pressure (IOP). This study aims to determine the comparison of IOP before and after phacoemulsification surgery in senile cataract patients. This study was an analytic observational study using a cross-sectional approach with consecutive sampling techniques and a total sample of 25 respondents who met the inclusion and exclusion criteria. Data collection included age, sex, and IOP before surgery, one day after surgery, and one week after surgery. The statistical analysis used was the paired t-test. The results of this study indicated that the highest distribution of senile cataract patients was in the age group of 60–69 years, with 15 people (60.0%) and men with 18 people (72.0%). Based on the results of the analysis, it was determined that there was a difference in IOP before and one day after phacoemulsification surgery in senile cataract patients with a p value of 0.000 (p ≤ 0.05), but there was no difference in IOP before and one week after phacoemulsification surgery in senile cataract patients with a p value of 0.440 (p 0.05). The conclusion in this study was that an increase in IOP occurred one day after surgery with a significant difference and that there was a decrease in IOP one week after surgery that was almost the same as the IOP value before phacoemulsification surgery. Keywords: Senile Cataract, Phacoemulsification, Intra-Ocular Pressure

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