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Makassar Natural Product Journal
Published by Universitas Muslim Indonesia
ISSN : -     EISSN : 29870895     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Makassar Natural Product Journal merupakan salah satu jurnal yang dikelola oleh Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Maret 2023. Makassar Natural Product Journal merupakan jurnal ilmiah yang terbit secara on-line dan menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang obat bahan alam.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 53 Documents
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REVIEW ARTIKEL: AKTIVITAS ANTIOKSIDAN EKSTRAK BUAH TOMAT (Solanum lycopersicum L.) Faradiba, Faradiba; Hasfikasari, Prity; Amin, Asni
Makassar Natural Product Journal (MNPJ) April 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i1.148

Abstract

Tomat merupakan salah satu buah yang mengandung aktivitas antioksidan yang tinggi karena memiliki kandungan likopen di dalamnya. Antioksidan merupakan senyawa yang dapat menangkal radikal bebas. Radikal bebas dapat diperoleh dari dalam tubuh (endogen) dan dari luar tubuh (eksogen). Metode yang digunakan yaitu metode deskriptif melalui studi literatur ilmiah. Studi literatur ini bertujuan untuk membandingkan kandungan antioksidan yang ada pada buah tomat. Hasil yang di peroleh yaitu perbedaan nilai IC50 pada setiap jurnal yang digunakan. Adanya perbedaan tingkat antioksidan yang diperoleh dikarenakan perbedaan asal dan perbedaan umur buah tomat yang digunakan.
the Uji Toksisitas Ekstrak Etanol Kulit Batang Pala (Myristica fragrans Houtt) Terhadap Artemia salina Leach Handayani, Virsa; Gazali, Anggun; -, Auliawati
Makassar Natural Product Journal (MNPJ) April 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i1.151

Abstract

ABSTRACT Nutmeg (Myristica fragrans Houtt) is a multipurpose plant that comes from the Myristicaceae family and has properties to treat indigestion, diarrhea, plague parasites and rheumatism. Nutmeg bark contains secondary metabolite compounds of alkaloids, flavonoids, triterpenoids, saponins, and tannins. This study aims to determine the toxicity effect and Lethal Concentration (LC50) value of ethanol extract of nutmeg stem bark (Myristica fragrans Houtt) on Artemia salina Leach larvae. The extraction method used was reflux using ethanol 96% solvent. The ethanol extract of Nutmeg bark (Myristica fragrans Houtt) was made with a concentration series of 250 ppm, 500 ppm, 1000 ppm, 1500 ppm and toxicity test was carried out using Artemia salina Leach larvae, then calculated the percent mortality of larvae using Probit analysis. The test results showed that ethanol extract of Nutmeg bark (Myristica fragrans Houtt) at concentration of 1500 ppm caused the highest larval mortality with a total of 29 larval deaths. Based on the results of the research, it can be concluded that the ethanol extract of nutmeg bark (Myristica fragrans Houtt) has a toxic effect on Artemia salina Leach larvae and the Lethal concentration (LC50) value of the ethanol extract of nutmeg bark (Myristica fragrans Houttt) is 226.986 µg/mL so it is in the toxic category. Keywords: Toxicity, Nutmeg bark (Myristica fragrans Houtt), Artemia salina Leach. ABSTRAK Tanaman pala (Myristica fragrans Houtt) merupakan tanaman multiguna yang berasal dari family Myristicaceae dan memiliki khasiat untuk mengobati gangguan pencernaan, diare, parasit wabah dan rematik. Kulit batang pala mengandung senyawa metabolit sekunder alkaloid, flavonoid, triterpenoid, saponin, dan tanin. Penelitian ini bertujuan untuk menentukan efek toksik dan nilai Lethal Concentration 50% (LC50) ekstrak etanol kulit batang pala (Myristica fragrans Houtt) terhadap larva Artemia salina Leach. Metode ekstraksi yang digunakan adalah refluks dengan menggunakan pelarut etanol 96%. Ekstrak etanol kulit batang pala (Myristica fragrans Houtt) dibuat larutan uji dengan seri konsentrasi 250 ppm, 500 ppm, 1000 ppm, 1500 ppm dan dilakukan pengujian toksisitas dengan menggunakan larva Artemia salina Leach, kemudian dihitung persen kematian larva menggunakan analisis probit. Hasil pengujian menunjukkan bahwa ekstrak etanol kulit batang pala (Myristica fragrans Houtt) pada konsentrasi 1500 ppm menyebabkan kematian larva tertinggi dengan total kematian larva sebanyak 29 ekor. Berdasarkan hasil penelitian yang telah dilakukan dapat disimpulkan bahwa ekstrak etanol kulit batang pala (Myristica fragrans Houtt) memberikan efek toksik terhadap larva Artemia salina Leach dan nilai Lethal concentration (LC50) pada ekstrak etanol kulit batang pala (Myristica fragrans Houttt) yaitu 226,986 ɥg/mL sehingga masuk kategori toksik Kata Kunci : Toksisitas; Kulit batang pala (Myristica fragrans Houtt); Artemia salina Leach.
the UJI TOKSISITAS EKSTRAK ETANOL HERBA PUTRI MALU (Mimosa pudica L.) TEHADAP Artemia salina Leac Handayani, Virsa; PRAHAYU, ADE CAHYA; rahman, safriani
Makassar Natural Product Journal (MNPJ) April 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i1.152

Abstract

ABSTRACT Mimosa pudica L. contains secondary metabolite compounds of alkaloid, flavonoid, steroid, tannin, and saponin. The content of secondary metabolites that have the potential toxicity of Mimosa pudica herbs are alkaloids, flavonoids. This study aims to determine the toxicity of Mimosa pudica L. herb against Artemia salina Leach larvae using the Brine Shrimp Lethality Test (BSLT) method. This research begins with the extraction of Mimosa pudica L. herb using ethanol 96% solvent by maceration method then phytochemical screening is carried out which shows the Mimosa pudica L. herb sample contains flavanoids, alkaloids, tannins, saponins, steroids. Toxicity test of ethanol extract of Mimosa pudica L. herb against Artemia salina Leach is divided into 6 test groups i.e 5 treatment groups (Concentration of 50 ppm, 100 ppm, 250 ppm, 500 ppm, and 750 ppm) and 1 control group. Each concentration was made in 3 vials which has inserted 10 Artemia salina Leach larvae after treatment for 24 hours. The results of the study can be seen through probit analysis by calculating LC50. The LC50 value of ethanol extract of Mimosa pudica L. herb was LC50 61.517 µg/mL. This indicates that the ethanol extract of Mimosa pudica L. herb has a toxic effect on Artemia salina Leach larvae because the LC50 value is <1000 ppm. Keywords : Toxicity Test; Mimosa pudica Herb; Artemia salina Leach; Brine Shrimp Lethality Test (BSLT) ABSTRAK Putri malu memiliki kandungan senyawa metabolit sekunder golongan alkaloid, flavonoid, steroid, tanin, dan saponin. Kandungan metabolit skunder yang memiliki potensi toksistas dari herba putri malu yaitu alkaloid, flavonoid. Penelitian ini bertujuan untuk mengetahui toksisitas dari herba putri malu (Mimosa pudica L.) terhadap larva Artemia salina Leach dengan metode Brine Shrimp Lethality Test (BSLT). Penelitian ini diawali dengan melakukan ekstraksi herba putri malu menggunakan pelarut etanol 96% dengan metode maserasi kemudian dilakukan skrining fitokimia yang menujukkan sampel herba putri malu mengandung flavanoid, alkaloid, tanin, saponin, steroid. Pengujian toksisitas ekstrak etanol herba putri malu terhadap Artemia salina Leach dibagi menjadi 6 kelompok uji yaitu 5 kelompok perlakuan (Konsentrasi 50 ppm, 100 ppm, 250 ppm, 500 ppm, dan 750 ppm) dan 1 kelompok kontrol. Masing – masing konsentrasi dibuat dalam 3 vial yang dimasukkan 10 ekor larva Artemia salina Leach setelah perlakuan selama 24 jam. Hasil penelitian dapat dilihat melalui analisa probit dengan menghitung LC50. Nilai LC50 dari ekstrak etanol herba putri malu sebesar LC50 61,517 µg/mL. Hal tersebut menujukan bahwa ekstrak etanol herba putri malu memiliki efek toksik terhadap larva Artemia salina Leach karena nilai LC50 <1000 ppm. Kata Kunci : Uji Toksisitas; Herba Putri Malu; Artemia salina Lecah; Brine Shrimp Lethality Test (BSLT).
the UJI AKTIVITAS LARVASIDA KULIT BAWANG BOMBAY (Allium sp.) TERHADAP LARVA NYAMUK Aedes Aegypti. Handayani, Virsa
Makassar Natural Product Journal (MNPJ) Juli 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i2.153

Abstract

ABSTRACT An innovation is needed by using an alternative material to replace temephos as a larvicide. One of them is onion skin (Allium sp.) which can be used as a natural larvicide where the onion skin contains flavonoids, alkaloids, and steroids. The purpose of the research is to see the ekstract larvicidal activity of onion skin against Aedes aegypti mosquito larvae and also to determine the concentration in which solvent is most capable as A. aegypti larvicidal agent. This study used onion skin extract (Allium sp.) obtained in the maceration process using ethanol solvent, ethyl acetate solvent and n-hexane solvents. Onion skin extract (Allium sp.) was tested for phytochemicals using Thin Layer Chromatography (TLC) followed by analysis using the Kruskal-Wallis test. The research results show that the ethyl acetate extract on onion skins was most effective compared to ethanol and n-hexane solvents. Keywords : Aedes aegypti; Onion Skins; larvicides; Solvent ABSTRAK Sebuah pembaruan dibutuhkan dengan membuat pengganti temefos menjadi larvasida. Salah satunya yaitu kulit bawang bombay (Allium sp.) yang bisa digunakan sebagai larvasida alami dimana pada kulit bawang bombay mengandung senyawa flavonoid, alkaloid, serta steroid. Tujuan dari penelitian yaitu untuk melihat aktivitas larvasida ekstrak kulit bawang bombay terhadap larva nyamuk A.aegypti dan juga untuk menentukan konsentrasi pada pelarut mana yang paling mampu sebagai larvasida A. aegypti. Pengujian ini memakai ekstrak kulit bawang bombay (Allium sp.) yang didapatkan pada proses maserasi pakai pelarut etanol, pelarut etil asetat dan pelarut n-heksan. Ekstrak kulit bawang bombay (Allium sp.) diuji fitokimia menggunakan KLT dan di lanjutkan dengan analisis memakai uji Kruskal-wallis. Hasil penelitian memperlihatkan bahwa ekstrak etil asetat pada kulit bawang bombay paling efektif dibandingkan dengan pelarut etanol dan n-heksan. Kata Kunci : Aedes aegypti; Kulit Bawang Bombay; Larvasida; Pelarut
UJI AKTIVITAS PENGHAMBATAN XANTIN OKSIDASE TERHADAP EKSTRAK ETANOL UMBI LOBAK (Raphanus sativus L.) SECARA IN VITRO ISRANANDA, DWI
Makassar Natural Product Journal (MNPJ) Oktober 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i3.154

Abstract

REVIEW ARTIKEL : Penggunaan Herbal Dalam Sediaan Shampo Penumbuh Rambut Yanti123, Firda
Makassar Natural Product Journal (MNPJ) Juli 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i2.160

Abstract

Kerontokan rambut merupakan salah satu masalah yang banyak menyebabkan gangguan pada kulit kepala dan rambut. Penyebab kerontokan rambut digolongkan menjadi endogen yaitu akibat penyakit sistematik, hormonal, status gizi, intoksikasi, maupun kelainan genetik, dan eksogen yaitu berupa stimulus dari lingkungan, maupun kosmetik rambut. Siklus pertumbuhan rambut normal terdiri dari 3 fase yaitu fase pertumbuhan (anagen), fase degenerasi (katagen), dan fase istirahat (telogen). Rambut mempunyai beberapa faktor berupa faktor genetik maupun pengaruh lingkungan yang akhirnya dapat mempengaruhi pertumbuhan rambut, sehingga rambut membutuhkan senyawa flavonoid dan saponin untuk memacu pertumbuhan rambut dan untuk meningkatkan aliran darah ke folikel rambut. Dalam review ini disajikan beberapa tanaman yang berbeda dari berbagai daerah yang berpotensi sebagai penyubur rambut.
Determination of Flavonoid Content of Ethanol Extract of Leaves and Bark of Ebony (Diospyros celebica Bakh) Using UV-Vis Spectrophotometry Method Hasju, Hasriyati
Makassar Natural Product Journal (MNPJ) Juli 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i2.163

Abstract

Ebony (Diospyros celebica Bakh) is a plant belonging to the Ebenaceae family which is one of the endemic plants from Sulawesi, Indonesia. Previous research has proven that ebony leaves are used as a traditional medicine to lower blood sugar levels, while the bark of ebony stems can be used as an antibacterial. Ebony leaves and bark contain secondary metabolites, namely flavonoids, alkaloids, terpenoids, steroids, tannins and saponins. This study aims to determine and determine the levels of flavonoids contained in extracts of leaves and bark of ebony stems. Flavonoid compounds have antioxidant, antibacterial, hypoallergenic, antiviral, anticancer and antidiabetic activities. The research method used to obtain the extract was the soxhletation method with 96% ethanol. The method used in the determination of flavonoid levels is using UV-Vis spectrophotometry with quercetin as a reference standard. Quercetin is a class of flavonoids belonging to the flavonol. Test results on UV-Vis Spectrophotometry with a wavelength of 430 nm, obtained flavonoid levels from ebony leaf samples, namely 7.999 mgQE/g extract, and in ebony bark, flavonoid levels obtained were 6.087 mgQE/g extract.
Aktivitas Ekstrak Daun jambu biji (psidium guajava L) sebaai antioksidan menunakan metode DPPH Ramadani, Sri Ariani
Makassar Natural Product Journal (MNPJ) Juli 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i2.164

Abstract

. Literature review Activity on Guava Leaf Extract (Psidium guajava L.) as an antioxidant Using to DPPH Method (Supervised by Faradiba and Aminah). Guava leaf (Psidium guajava L.) is one of the plants having the potential as an antioxidant. Antioxidants can donate their electrons which allow to inhibit, prevent or scavenge the reactions of free radicals and oxidants. The research aimed to determine the highest antioxidant activity on guava leaf extract using different solvents based on the value of IC50 resulted from journal review of antioxidant assay on guava leaf. The research used narrative review methods, inclusion and exclusion literature consisting of national journal/International journal of ISSN standard within the last 10-year published from 2010 to 2020. Guava leaf contains antioxidant activity proven by DPPH method, added with ethanol, and methanol. The keywords used to find the results were antioxidant test, free radicals, DPPH method, guava leaves through Google search and Google Scholar. The results confirmed that guava leaf had antioxidant activity. The strongest antioxidant activity possessed by 70% ethanol extract with IC50 0,2 μg/mL. The value of IC50 lies between <10 μg/ mL categorized as the strongest one.
Toxicity Test of Dengen fruit Ethanol Extract (Dillenia serrata Thunb.) Using the BSLT (Brine Shrimp Lethality Test) Method Pratiwi, Andi Nurul Faika
Makassar Natural Product Journal (MNPJ) Juli 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i2.169

Abstract

Dengen (Dillenia serrata Thunb.) is a plant that has various benefits. One part of the plant studied is dengen fruit. The toxic potential of dengen fruit can be known through toxicity tests. This study aims to obtain data and information on the toxicity of the fruit using the BSLT (Brine Shrimp Lethality Test) method against Artemia salina Leach larvae. The extraction method used in this study was the maceration method using 96% ethanol solvent to produce a % yield of 34.96%. The phytochemical screening test for the ethanol extract of dengen fruit was in the form of a color test which showed that the dengen fruit sample contained triterpenoid, tannin, saponin and flavonoid compounds. The toxicity test of the ethanol extract of dengen fruit used 150 Artemia salina Leach larvae which were divided into 5 concentrations (100 ppm, 200 ppm, 300 ppm, 400 ppm and 500 ppm) and 1 comparison or control group (seawater). The extract was put into the vial and 10 larvae were added each into the vial for each concentration of the test solution and also the control, then the volume was made up to 10 ml. Observations were made by looking at the mortality of Artemia salina Leach larvae after 24 hours of treatment and then analyzing the data using probit analysis by calculating the LC50 value. The LC50 value of the ethanol extract of dengen fruit is 97.274 ppm and is included in the toxic category.
Toxicity Test of Arbenan (Duchesnea indica (Jacks.) Focke) Leaf Ethanolic Extract Using the Brine Shrimp Lethality Test (BSLT) Method Nurfadhillah, Andi Zahra
Makassar Natural Product Journal (MNPJ) Juli 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i2.170

Abstract

Arbenan (Duchesnea indica (Jacks.) Focke) is a plant that has various benefits. The toxic potential of arbenan leaves is known through a toxicity test using the Brine Shrimp Lethality Test (BSLT) method. The purpose of this study was to investigale the toxicity of arbenan leaves (Duchesnea indica (Jacks.) Focke) to Artemia salina Leach larvae, and to determine the LC50 value. Arbenan leaves were extracted by maceration using 70% ethanol solvent. Then a phytochemical screening was carried out which showed the chemical content in arbenan leaves, namely tannins, flavonoids, and saponins. Toxicity testing of arbenan leaf extract against Artemia salina Leach larvae used concentration variations of 250 ppm, 300 ppm, 350 ppm, and 400 ppm. Then observed after 24 hours to see the death of Artemia salina Leach larvae. The results of the research can be seen through probit analysis by calculating the LC50 value of arbenan leaf extract is 323,593 (toxic).

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