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Makassar Natural Product Journal
Published by Universitas Muslim Indonesia
ISSN : -     EISSN : 29870895     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Makassar Natural Product Journal merupakan salah satu jurnal yang dikelola oleh Fakultas Farmasi Universitas Muslim Indonesia yang terbit pertama kali pada bulan Maret 2023. Makassar Natural Product Journal merupakan jurnal ilmiah yang terbit secara on-line dan menerbitkan artikel atau karya ilmiah hasil penelitian dalam bidang obat bahan alam.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 53 Documents
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UJI TOKSISITAS EKSTRAK DAUN TALAS (Colocasia esculenta L.) TERHADAP LARVA UDANG (Artemia salina Leach) DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT) Irmawal, Nurul Azizah
Makassar Natural Product Journal (MNPJ) Juli 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i2.173

Abstract

Tanaman talas mengandung beberapa komponen kimia berupa alkaloid, flavonoid, tanin, steroid dan saponin yang diduga dapat memberikan efek toksik terhadap larva udang Artemia salina. Penelitian ini bertujuan untuk mengetahui toksisitas ekstrak daun talas terhadap larva udang Artemia salina serta menentukan nilai LC50 dengan memanfaatkan metode Brine Shrimp Lethality Test (BSLT). Penelitian ini diawali dengan melakukan ekstraksi pada daun talas menggunakan metode maserasi bertingkat dengan memakai tiga macam pelarut yang berbeda tigkat kepolaran meliputi pelarut n-heksan, etil asetat dan etanol 96%. Masing-masing ekstrak kental (n-heksan, etil asetat, etanol 96%) yang dihasilkan diidentifikasi kandungan senyawanya kemudian diuji toksisitasnya menggunakan seri konsentrasi 50, 100, 250 dan 500 ppm. Setiap konsentrasi dibagi menjadi 3 replikasi (3 vial) yang dimasukkan kedalamnya 10 ekor larva Artemia salina. Setelah 24 jam, diamati dan dihitung persen kematiannya menggunakan analisis probit. Berdasarkan hasil skrining fitokimia, ekstrak daun talas mengandung senyawa alkaloid, tanin, flavonoid, steroid dan saponin. Hasil pengujian toksisitas menunjukkan nilai LC50 dari ekstrak daun talas sebesar 555,90 pada esktrak n-heksan, 401,79 pada ekstrak etil asetat dan 57,41 pada ekstrak etanol 96%. Hal ini menunjukkan bahwa ekstrak daun talas bersifat toksik terhadap larva Artemia salina karena memiliki nilai LC50 <1000 µg/ml.
Antioxidant Activity Test of Ketapang Leaf Extract (Terminalia catappa L.) Using the B-Carotene Bleaching Method Wati, Vega
Makassar Natural Product Journal (MNPJ) Oktober 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i3.174

Abstract

Ketapang (Terminalia catappa L.) is a plant that belongs to the Combretaceae family which is spread in tropical countries, including Indonesia. Ketapang leaves (Terminalia catappa L.) contains flavonoid compounds which function as antioxidants. The purpose of this study was to determine the antioxidant activity of ketapang leaf extract (Terminalia catappa L.) using the β-carotene bleaching method. The extract was obtained through the maceration method, then the yield percentage was 20.25%. Phytochemical screening test was carried out identifiy chemical compounds and obtained namely alkaloids, flavanoids, tannins, saponins, and steroids. Antioxidant activity was performed using UV-Vis spectrophotometry with a wavelength of 538 nm. The results showed that the antioxidant activity of ketapang leaf extract (Terminalia catappa L.) of 56.5% was an intermediate antioxidant (moderate), then in a standard solution of quercetin has a strong antioxidant activity of 72.3%. Keywords : Ketapang leaves (Terminalia catappa L.), Screening Phytochemicals, Antioxidants, B-carotene bleaching, Spectrophotometry UV-Vis.
INVENTORY OF MEDICINAL PLANT FOR HYPERTENSION PATIENTS IN WATUNOHU VILLAGE, NORTH KOLAKA DISTRICT rusdam, sulisfa
Makassar Natural Product Journal (MNPJ) Juli 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i2.176

Abstract

Indonesia is an archipelagic country which is very broad as a tropical country with very diverse plants in Indonesia. Southeast Sulawesi Province is one of the 34 provinces in Indonesia which has a high level of plant species diversity. Traditional medicine using medicinal plants is still widely used by the people of Watunohu Village, North Kolaka Regency. The purpose of this study was to find out what medicinal plants are used by the people of Watunohu Village to treat hypertension and how to present them. This study used a descriptive method with a qualitative approach. Data collection was carried out by observing and interviewing informants. The sampling technique used was purposive sampling. From the results of the study, it was found that 12 types of medicinal plants were used by the people of Watunohu Village to treat hypertension with the parts used, namely fruits and leaves, by serving them boiled or mashed and then drunk.
ANTIOXIDANT ACTIVITY TEST OF TURI (Sesbania grandiflora L.) LEAF EXTRACT USING β-CAROTENE BLEACHING METHOD Lutfiah, Salsabilah
Makassar Natural Product Journal (MNPJ) Oktober 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i3.177

Abstract

Turi Leaf (Sesbania grandiflora L.) belong to the fabaceae family that contain flavonoids as an antioxidants. The antioxidants have free radical scavenging properties that can inhibit the oxidation of free radicals. It is used to protect the skin from oxidative damage and to prevent premature aging. This research aimed to determine the antioxidant activity of turi leaf extract by b-carotene bleaching method. The leaves were extracted using macerations method, the yield percentage of 16,685 %. Quantitative analysis by UV-Vis spectrophotometry at the maximum wavelength of 538 nm. The results showed that the antioxidant activity of the turi leaf extract is 50.7% which is intermediate antioxidant, then in quercetin standard solution. Keywords : Turi Leaves (Sesbania grandiflora L.), Antioxidant, β-carotene bleaching, UV-Vis spectrophotometry
STUDI ETNOFARMASI TUMBUHAN OBAT YANG BERKHASIAT SEBAGAI ANTIHIPERTENSI DI KELURAHAN GALUNG, KECAMATAN LILIRIAJA, KABUPATEN SOPPENG Sanrang, Balkis Ma’ruf
Makassar Natural Product Journal (MNPJ) Juli 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i2.212

Abstract

Medicinal plants are used as an effort to maintain health and as a treatment for a disease. Hypertension is one of the highest causes of death in Indonesia. In knowing medicinal plants which are efficacious as anti-hypertensives, an ethnopharmaceutical study was carried out. Ethnopharmacy is a science that studies the use of drugs and methods of treatment by the community. Soppeng Regency consists of 8 Districts, 21 Villages and 49 Villages, one of which is Galung Village. This research was conducted to find out what plants are used by the people of Galung Village in the treatment of hypertension and how to process them. This research was conducted by surveying people who have knowledge about medicinal plants in the treatment of hypertension with a purposive sampling method. From the results of the study, it was found that 14 medicinal plants were used by the Galung Village community for the treatment of hypertension, which were presented in single or mixed forms.
INHIBISI ENZIM α-GLUKOSIDASE PADA SENYAWA TECTOQUINONE YANG DIISOLASI DARI Syzygium oblanceolatum (C.B.ROB.) MERR Najib, Ahmad
Makassar Natural Product Journal (MNPJ) Juli 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i2.215

Abstract

Syzygium oblanceolatum (C.B.Rob.) Merr. Has several medicinal benefits, empirically its leaf decoction has been used as an antidiabetic. Several representatives of the Syzygium genus have been proposed to possess chemical compounds, nutraceutical values, and biological activities. In particular, previous studies have emphasized the abundance of bioactive chemicals, including flavonoids, phenolic acids, triterpenoids, and volatile compounds. Several representatives of the genus Syzygium have been proposed to possess chemical compounds, nutraceutical values, and biological activities. In particular, previous studies have emphasized the abundance of bioactive chemicals, including flavonoids, phenolic acids, triterpenoids, and volatile compounds. The tectoquinone compound isolated from Syzygium oblanceolatum (C.B. Rob.) Merr based on its chemical structure is a substituted anthraquinone, namely 2-methylanthraquinone. This study aims to determine the Tectoquinone compound as an α-glucosidase inhibitor and determine the IC50 value of the tectoquinone compound. The method of this research was an α-glucosidase inhibition test using ELISA reader instrument by measuring the absorbance at the maximum wavelength of 405 nm using an acarbose comparator. The results of the α-glucosidase inhibition test of the akarbosa comparator had an IC50 value of 0.258 μg/mL and the IC50 value of the tectoquinone compound was 155.184 μg/mL.
STANDARDISASI EKSTRAK ETANOL BIJI BAGORE (Caesalpinia crista L.). Ardiansa, Ardiansa; Syarif, Rezki Amriati; Waris, Risda
Makassar Natural Product Journal (MNPJ) Oktober 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i3.216

Abstract

Bagore plant (Caesalpinia crista L.) belongs to the tribe Leguminosae and grows wild on the coast. Standardization is important to guarantee potency uniformity benefits by ensuring the concentration of active ingredients through qualitative analysis of secondary metabolites, ensuring the safety and stability aspects of extracts and increasing the economic value of extracts by various analyses such as specific and non-specific parameters. This study aims to standardization bagore seed extract (Caesalpinia crista L.) and determine the value of specific and non-specific parameters of. Samples were obtained from Binuang District, Polewali Mandar Regency, West Sulawesi Province, macerated with 96% ethanol then standardized with specific and non-specific parameters. The results of the study obtained specific parameter values as follows; organoleptic tests obtained extracts in the form of viscous, light brown in color, characteristic smell and very bitter taste; The content of soluble compounds in water is 14.361%; the content of soluble compounds in ethanol is 15.708%; positively contains flavanoid compounds, alkaloids and saponins; and the value of non-specific parameters as follows: drying shrinkage which is 0.439%; specific weight of 0.859 grams; moisture content of 2.589%; total ash content of 4.216%, insoluble ash content of acid which is 0.630%; The mold number is < 1.0 x 101 colonies/ml and the yeast is < 1.0 101 colonies/ml; lead metal contamination (Pb) is 0.003 g / g and cadmium (Cd) is 0.01 g / g. Research shows bagore seed extract (Caesalpinia crista L.) provides results according to the general standard parameters of medicinal plant extracts. Keyword : Bagore seed, Caesalpinia crista L., standardization, spesific parameters, non-spesific parameters.
Studi In Silico Prediksi Sifat Fisikokimia dan Toksisitas Senyawa Tectoquinone Sebagai α-Glukosidase inhibitor Najib, Ahmad
Makassar Natural Product Journal (MNPJ) Oktober 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i3.217

Abstract

Tectoquinone is a chemical compound from natural ingredients in the Syzigium oblanceolatum (C.B.Rob) plant. Previous research has proven that Tectoquinone has antidiabetic activity by inhibiting the α-glucosidase enzyme. This research on physicochemistry and toxicity aims to determine the feasibility of tectoquinone if used as an oral drug in silico using the pKCSM Online Tool. The results obtained are that tectoquinone has fulfilled the physicochemical test with parameters based on the Lipinski Rule of Five. However, the results of the toxicity test showed that tectoquinone had ames toxicity, hepatotoxicity, and the LD50 value obtained was 468.92 g/kg.
REVIEW ARTIKEL Formulasi Sediaan Farmasi Kasumba Turate Munir, Nurul Mujahida
Makassar Natural Product Journal (MNPJ) Oktober 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i3.218

Abstract

Tanaman kasumba turate (Carthamus tinctorius L.) merupakan obat tradisional yang digunakan oleh masyarakat. Berdasarkan beberapa penelitian tanaman ini memiliki khasiat sebagai antioksidan dan imunostimulan. Kandungan kimia dari tanaman ini diantaranya adalah flavonoid, feniletanoid glikosida, kumarin, asam lemak, steroid, dan polisakarida. Karena memiliki banyak khasiat, tanaman ini telah dikembangkan menjadi sediaan-sediaan farmasi yang lebih modern. Penelitian ini bertujuan untuk mengetahui dan mengkaji informasi terkait penelitian yang telah dilakukan mengenai pengembangan formula sediaan kasumba turate (Carthamus tinctorius L.). Penelitian ini menggunakan pendekatan studi literatur dengan menggunakan Google Scholar dan Pubmed sebagai sumber data dan memilih artikel berdasarkan kriteria yang telah ditetapkan peneliti. Berdasarkan pencarian, diperoleh sebanyak 6 artikel. Terdapat beberapa rancangan formulasi bentuk sediaan farmasi tanaman kasumba turate (Carthamus tinctorius L.) diantaranya sirup (larutan), emulsi, granul, granul effervescent, mikroemulsi dan pengembangan bahan baku dalam bentuk nanopartikel.
FORMULASI DAN EVALUASI SEDIAAN BODY CREAM EKSTRAK ETANOL BUAH ALPUKAT (Persea Americana Mill) SEBAGAI PELEMBAB Maharani, Sarima Amalia
Makassar Natural Product Journal (MNPJ) Oktober 2024
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i3.222

Abstract

Moisturizers are very popular dermatological products prescribed because they have been proven effective for preventing and treating a variety of dermatological conditions. Moisturizer products have a vital role for skin health to ensure the skin remains hydrated for both normal and dry skin by increasing the water content in the stratum corneum, so that it is able to moisturize the skin. Avocado fruit (Persea americana Mill) can hydrate the skin because it contains chemicals such as vitamin A, vitamin E, fat, carbohydrates, folic acid and protein. This research aims to formulate and interpret the physical stability of avocado ethanol extract body cream preparations as a moisturizer. This type of research is laboratory experimental. The stages of this research began with extraction, formulation, and ended with evaluation of body cream preparations. This research obtained results that body cream preparations can be formulated as moisturizers by mixing the emulsion form and gel form of the formula ingredients with the effective concentration of carbopol 940 in the body cream preparation of avocado fruit ethanol extract being 0.7% (Formula 2) because this concentration is higher. physically stable and more popular with the panelists. This research can be concluded that the pH and homogeneity tests show that all formulas are stable, the viscosity test shows that there is instability due to storage temperature in formula 3, the spreadability and stickiness tests show that formula 1 is unstable to changes in storage temperature, the hedonic test shows that the panelists prefer the formula 2, and moisturizing effectiveness testing shows formula 3 provides the greatest moisturizing effect. Moisturizer adalah produk dermatologis yang sangat populer diresepkan karena terbukti efektif untuk mencegah dan mengobati berbagai kondisi dermatologis. Produk moisturizer memiliki peran yang vital bagi kesehatan kulit untuk menjamin kulit tetap terhidrasi baik untuk kulit normal maupun kering dengan cara meningkatkan kadar air dalam stratum korneum, sehingga mampu untuk melembabkan kulit. Buah Alpukat (Persea americana Mill) dapat menghidrasi kulit dikarenakan memiliki kandungan kimia seperti vitamin A, vitamin E, lemak, karbohidrat, asam folat, dan protein. Penelitian ini bertujuan untuk memformulasi dan menginterpretasi stabilitas fisik sediaan body cream ekstrak etanol buah alpukat sebagai pelembab. Jenis penelitian ini yaitu eksperimental laboratorium. Tahapan penelitian ini dimulai dengan ekstraksi, formulasi, dan diakhiri dengan evaluasi sediaan body cream. Penelitian ini memperoleh hasil bahwa sediaan body cream dapat diformulasikan sebagai pelembab dengan cara mencampurkan antara bentuk emulsi dan bentuk gel dari bahan formula dengan konsentrasi efektif karbopol 940 pada sediaan body cream ekstrak etanol buah alpukat adalah 0,7% (Formula 2) dikarenakan konsentrasi ini lebih stabil secara fisik dan lebih digemari oleh panelis. Penelitian ini dapat disimpulkan bahwa pada pengujian pH dan homogenitas menampilkan semua formula stabil, pengujian viskositas memperlihatkan adanya ketidakstabilan akibat suhu penyimpanan pada formula 3, pengujian daya sebar dan daya lekat menunjukkan formula 1 tidak stabil terhadap perubahan suhu penyimpanan, pengujian hedonik menunjukkan panelis lebih menyukai formula 2, dan pengujian efektivitas pelembab menunjukkan formula 3 memberikan efek pelembab terbesar.

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