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Juvita Herdianty
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INDONESIA
Strada Journal of Pharmacy
Published by Universitas Strada Indonesia
ISSN : 27763544     EISSN : 27979180     DOI : https://doi.org/10.30994/sjp
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
The journal includes various fields of pharmaceuticals sciences such as: Pharmacology and Toxicology; Pharmacokinetics; Community and Clinical Pharmacy; Pharmaceutical Chemistry; Pharmaceutical Biology; Pharmaceutics; Pharmaceutical Technology; Biopharmaceutics; Pharmaceutical Microbiology and Biotechnology; Alternative Medicines;
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 6 Documents
 1 
Search results for , issue "Vol. 7 No. 1 (2025): April" : 6 Documents clear
The Potential of Quercetin as Parkinson's Disease Therapy Assessed From Binding Affinity To Adenosine A2a Receptor Using In-Silico Adjie Wahyu Pradana; Sri Rahayu Dwi Purnaningtyas; Devita Riafinola Andaririt; Luluk Aniqoh Meliana Putri
Strada Journal of Pharmacy Vol. 7 No. 1 (2025): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i1.156

Abstract

Parkinson's disease is a degenerative disease that causes impaired mobility and muscle control caused by decreased dopamine production in the brain. Parkinson's disease therapy is dopaminergic therapy using levodopa which works by replacing the reduced dopamine, the use of levodopa has side effects such as dizziness, nausea, and excessive sleepiness. The use of istradefylline with levodopa as a non-dopaminergic therapy in parkinson's reduces side effects and increases therapeutic targets. Quercetin is thought to have activity in improving motor function in parkinson's. The aim of this study was to look at the potential of quercetin as a parkinson's therapy. Objective: Finding the activity of quercetin as Parkinson's therapy compared with istradefylline using in-silico. Method: The design of this study is in-silico, which is a study using the help of computer calculations, the method used is molecular docking based on the principle of bonding compounds to receptors. Ligand compounds obtained from PubChem and receptor clusters obtained from Protein Data Bank. The docking Software used is Pyrex, and Discovery Studio Analizer. Independent variables in this study were quercetin and istradefylline, while the dependent variable was binding affinity ligand to adenosine A2a receptor. In this study, statistical analysis was conducted using an independent sample t-test. Results: In-silico test with molecular docking method showed each 9 ligand position to the receptor, the results of data analysis with the test of independent sample t-test, at the degree of significance α = 0.05 obtained statistical results with a significance value of 0.013 which means that the quercetin ligand has stronger potential compared to istradefylline. Quercetin has a binding affinity value of -8.1 kcal/mol, while istradefylline has a binding affinity value of -6.9 kcal / mol. Conclusion: Quercetin has been shown to have potential as an alternative therapy for parkinson's disease
Antimicrobial Activity Testing of Ethyl Acetate Fraction from Mikania micrantha Leaves Against Escherichia coli and Staphylococcus aureus Ivan Junius Mesak; Mariana Kristiani
Strada Journal of Pharmacy Vol. 7 No. 1 (2025): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i1.173

Abstract

Bacterial infections remain a major global health issue, worsened by rising antibiotic resistance. This study evaluated the antimicrobial activity of the ethyl acetate fraction of Mikania micrantha leaves against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) using the disc diffusion method. Phytochemical screening identified flavonoids, tannins, saponins, and steroid/triterpenoids in the fraction. The antimicrobial test showed that this fraction inhibited the growth of both bacteria, with larger inhibition zones observed at higher extract concentrations. At 5% concentration, E. coli showed an inhibition zone of 8.43 mm, while at 15%, the zone increased to 12.26 mm. For S. aureus, the 15% concentration produced a 20.43 mm inhibition zone. Statistical analysis confirmed significant differences between concentrations (p < 0.05). These results suggest that the ethyl acetate fraction of Mikania micrantha leaves has potential as an antibacterial agent, especially effective against Escherichia. coli at 15%.
Analysis of Factors Influencing Pharmacist Compliance in Reporting Side Effects of Medications in District Health Center X Pebrian, Nggio; Hanie Kusuma Wardani; Ardhi Broto Sumanto; Hanik Maria Dewi
Strada Journal of Pharmacy Vol. 7 No. 1 (2025): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i1.174

Abstract

The occurrence of Adverse Drug Reactions (ADR) cases has resulted in an increase in the number of patients experiencing pain and death, both when patients are in the hospital and in everyday life. The purpose of this study was to analyze the factors that influence pharmacist compliance in reporting adverse drug reactions at Health Center X. This study used a quantitative research type with a cross-sectional research design. The study population was all pharmacists at Health Center X with a sample size of 25 respondents. The independent variables were knowledge, attitudes, availability and accessibility, influence of colleagues and rewards, availability of facilities and policies/regulations related to ADR reporting and the dependent variable was practices related to ADR reporting. Data collection used a questionnaire and was analyzed using the Spearman test. From the results of the study, it is known that the significance value of knowledge is 0.351>0.05, the significance value of attitude is 0.545>0.05, the significance value of availability and accessibility is 0.586>0.05, the significance value of availability of facilities is 0.413>0.05, the significance value of ADR reporting policy is 0.127>0.05, meaning that there is no influence between the variables of knowledge, attitude, availability and accessibility, availability of facilities and ADR reporting policy on pharmacist compliance at health centers in District X. While the significance value of the influence of coworkers and rewards is 0.012<0.05, meaning that there is an influence between the variables of the policy of the influence of coworkers on pharmacist compliance at health centers X.
Analysis of antibiotic costs for inpatients with urinary tract infection at hospital X in Kediri Muhammad Saddam Albiansyah Tohari; Anggi Restyana; Hanie Kusuma Wardani; Fidi Setyawan
Strada Journal of Pharmacy Vol. 7 No. 1 (2025): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i1.175

Abstract

Urinary Tract Infection (UTI) is a condition where germs grow and reproduce in the urinary tract with significant amounts of bacteriuria. UTIs are treated with antibiotics. Standardization of treatment considers more effective drugs at lower costs to reduce the number of events and health costs. The aim of this research is to determine the cost-effectiveness of using antibiotics in UTI patients at the Hospital in Kediri City, to identify the most cost-effective alternatives to achieve predetermined goals or criteria that cannot be measured in monetary terms, for example several health outcomes. The study was conducted using a retrospective method that compared the direct medical cost of antibiotics for UTI patients. The population of this study was all 44 inpatient UTI patients at the Hospital X in Kediri. The data were analyzed by calculating the Average Cost Effectiveness Ratio (ACER) and Incremental Cost Effectiveness Ratio (ICER). The results of the research showed that the average total cost effectiveness of the antibiotic Levofloxacin was lower by IDR. 2.448.854 compared to ceftriaxone with an average cost of Rp. 2.474.673. The effectiveness of the antibiotic Levofloxacin is more cost effective than Ceftriaxone because it has a lower ACER value, namely Rp. 594.382.039. The calculated ICER value for both antibiotics is Rp. -58.679.55. The conclusion in this study is that to achieve cost effectiveness of a treatment, an ICER value is needed and the calculation was obtained at Rp. -58.679.55. This shows that there is a cost reduction of Rp. -58.679.55 in the use of the antibiotic Ceftriaxone to obtain lower cost effective results
A Physical Quality and Antioxidant Test of Strawberry Leaf Fraction Lotion DPPH Method (1,1- Diphenyl-2- Picryhydrazyl) Candra Asih Setyaningrum, Candra; Arif Wijayanto; Juvita Herdianty; Devita Riafinola Andaririt
Strada Journal of Pharmacy Vol. 7 No. 1 (2025): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i1.176

Abstract

Lotion is a cosmetic preparation that functions to moisturize and protect the skin by providing a soothing effect. This research utilizes natural ingredients in the form of strawberry leaf extract (Fragaria vesca) to create a lotion formulation with high antioxidant activity. The objective of this study is to determine the effect of varying concentrations of strawberry leaf extract on the physical quality and antioxidant activity of the lotion. This experimental study involved formulating lotions with different concentrations of strawberry leaf extract at 2%, 4%, and 6%. The antioxidant activity was evaluated using the DPPH (1,1-Diphenyl-2-Picrylhydrazyl) method to measure the extract's ability to scavenge free radicals. The main active component in strawberry leaf extract is polyphenol compounds, which act as natural antioxidants in cosmetic products. The results showed that the strawberry leaf fraction lotion had a soft texture, green color, and a characteristic strawberry leaf scent. The pH test had a significance value of 0.00. The viscosity test also had a significance value of 0.00. The adhesion test results showed a significance value of 0.00, and the spreadability test also had a significance value of 0.00. The DPPH antioxidant test showed regression values of 0.932 for the positive control, 0.854 for the negative control, 0.948 for F1, 0.985 for F2, and 0.967 for F3. This study provides strong evidence that strawberry leaf fraction is suitable as an active ingredient in antioxidant cosmetic products, with the potential to compete with conventional ingredients. The SPSS test results showed a significant effect of concentration on free radical inhibition, as well as significant differences in pH, spreadability, and adhesion tests among the formulations. However, some groups did not meet the assumptions of normality and homogeneity, indicating the need for alternative analytical methods for further validation
Antibiotics Study of Antibiotic use patterns in pediatric pneumonia patients at Kediri Hospital: PENUMONIA Wardhani, Dita Kusuma; Anggi Restyana; Fidi Setyawan; Janik Kurniawati
Strada Journal of Pharmacy Vol. 7 No. 1 (2025): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i1.178

Abstract

Pneumonia is an acute infection of the lung parenchyma, consisting of alveoli and interstitial tissue on chest X-ray. The purpose of this study was to identify the pattern of antibiotic use in pneumonia patients and obtain accurate data on antibiotic use in pneumonia patients and also analyze the results of data collection on antibiotic use and the rationality of antibiotic use. This type of research is descriptive qualitative, the sample of this study were pediatric patients aged 1 year to 5 years who were diagnosed with pneumonia from 2018-2023 at the Hospital in Kediri City. The results of the study obtained the age of pneumonia patients at most at the age of 2 months - 1 year as many as 24 children, most pneumonia sufferers were male, obtaining 22 children. Overall, this study obtained rational results in the analysis of the quality of antibiotic use.

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