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FIRDAYANTI
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Jurnal Analis Kesehatan Kendari
Published by Politeknik Bina Husada Kendari
ISSN : 24607967     EISSN : 27228517     DOI : https://doi.org/10.46356/jakk.v7i1.323
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology
This journal is the Journal of the D3 Medical Laboratory Technology Study Program, Politeknik Bina Husada Kendari which has a scope of knowledge including Clinical Chemistry, Hematology, Microbiology, Parasitology, Cytohistotechnology and Clinical Toxicology. Published twice a year, June and December.
Arjuna Subject : Profesi Kesehatan - Teknologi Laboratorium Medis
Articles 77 Documents
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Gambaran Indeks Aterogenik Plasma Pada Penderita Diabetes Melitus Sunaidi, Yanti; Sulfiani; Sefhia Purnama Dita; Muhammad Ihza Lisan Shidqi; Eleventi Oktarina Putri; Antoni Aldo Danendra Sawal
Jurnal Analis Kesehatan Kendari Vol. 8 No. 1 (2025): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 8 (1) Desember 2025)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

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Abstract

Diabetes mellitus is a group of metabolic disorders characterized by elevated blood glucose levels due to abnormalities in insulin secretion or insulin resistance. This condition increases the risk of cardiovascular disease by triggering dyslipidemia, which is marked by elevated cholesterol, increased levels of low-density lipoprotein (LDL), increased triglycerides, and decreased high-density lipoprotein (HDL) in the blood. Dyslipidemia in diabetic patients is associated with a higher Atherogenic Index of Plasma (AIP), which plays a role in the development of atherosclerosis, a key factor in cardiovascular disease. The logarithmic ratio of triglycerides to HDL can be used to determine the AIP, which serves as a marker for assessing atherogenicity and the risk of cardiovascular disease. This study aimed to predict cardiovascular disease in patients with diabetes mellitus through the evaluation of AIP values. The research was descriptive, involving 32 subjects selected using purposive sampling, and conducted at Dr. Tadjuddin Chalid General Hospital, Makassar, South Sulawesi. Based on the results of 32 subjects: 0 subjects (0%) were categorized as having low cardiovascular risk AIP, with an average value of 0; 1 subject (3%) was in the moderate risk category, with an average AIP of 0.19; 31 subjects (97%) were in the high cardiovascular risk category, with an average AIP of 0.82. These findings indicate that most diabetic patients tend to have a high-risk cardiovascular disease, compared to moderate or low-risk categories.
Indeks Eritrosit sebagai Indikator Prognostik Anemia pada Pasien Gagal Ginjal Kronis dengan Hemodialisa di RSUD Bahteramas Provinsi Sulawesi Tenggara Usman, Julianti Isma Sari; Anita Rosanty; Nurul Annisa Febriana Dahlan
Jurnal Analis Kesehatan Kendari Vol. 8 No. 1 (2025): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 8 (1) Desember 2025)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

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Abstract

Chronic kidney disease is a progressive and irreversible decline in kidney function, requiring hemodialysis therapy in the end stage. One of the most common complications is anemia, which can be assessed through erythrocyte indices, including MCV, MCH, and MCHC. This study aims to determine the value of the erythrocyte index as a prognostic indicator in patients with chronic kidney failure with hemodialysis. This research is a descriptive study with a cross-sectional approach. A total of 34 patients were selected using a purposive sampling technique. Blood samples were analyzed using a Sysmex XN-1000 Hematology Analyzer. The results showed normocytic normochromic in 27 patients (79%), microcytic normochromic in 4 patients (12%), and microcytic hypochromic in 3 patients (9%). The average erythrocyte index in patients with chronic renal failure with hemodialysis was found to have an average MCV value of 86.2 fL, MCH 27.5 pg, MCHC 31.8% and hemoglobin 9.1 g/dl which indicates normocytic normochromic anemia. The conclusion of this study is that chronic kidney disease patients undergoing hemodialysis predominantly have normocytic normochromic erythrocyte indices.
Hubungan Antara Hasil Grafik Scattergram Sysmex Xn-1000 Dengan Apusan Darah Tepi Pada Pasien Leukemia Di Rsup Dr. Wahidin Sudirohusodo Makassar Saputra, Agil
Jurnal Analis Kesehatan Kendari Vol. 8 No. 1 (2025): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 8 (1) Desember 2025)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

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Abstract

Leukemia is a hematological malignancy characterized by abnormal proliferation of hematopoietic precursor cells in the bone marrow and an increased number of abnormal white blood cells in peripheral circulation. Early detection is crucial to reduce morbidity and mortality rates, one of which can be achieved through the use of hematology analyzers that display scattergrams. This study aimed to analyze the relationship between scattergram patterns from the Sysmex XN-1000 Hematology Analyzer and peripheral blood smear findings in leukemia patients. A descriptive cross-sectional design with total sampling was employed, involving 13 leukemia patients who underwent complete blood count using the Sysmex XN-1000 and peripheral blood smear examination at Dr. Wahidin Sudirohusodo Hospital, Makassar, from March to May 2019. Data were analyzed descriptively based on the distribution of gender, age, type of leukemia, laboratory results, and scattergram patterns. The results showed that most patients were male (84.6%), the most common age group was 21–40 years (38.5%), and the most frequent leukemia types were Acute Lymphoblastic Leukemia (46.2%) and Chronic Myeloid Leukemia (46.2%). Scattergram analysis revealed distinct patterns for each leukemia type: predominance of high-fluorescence lymphocytes with an inverted comma pattern in ALL, variable-sized myeloid blasts overlapping with granulocytes and monocytes in AML, and granulocytic dominance with immature granulocyte values >10% in CML. These scattergram patterns were consistent with peripheral blood smear findings, supporting their role as an early indicator of hematologic abnormalities. In conclusion, scattergrams from the Sysmex XN-1000 have potential as a rapid and informative screening tool prior to microscopic confirmation in leukemia cases.
Perbedaan Kadar Tumor Necrosis Factor Alpha pada Pekerja Finishing Gitar Berdasarkan Penggunaan Alat Pelindung Diri Dan Lama Bekerja Antoni Aldo Danendra Sawal; Eleventi Oktariani Putri; Muhammad Ihza Lisan Shidqi; Yanti Sunaidi
Jurnal Analis Kesehatan Kendari Vol. 8 No. 1 (2025): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 8 (1) Desember 2025)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

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Abstract

Debu kayu dan zat kimia dari pengecatan gitar selama proses finishing yang masuk ke saluran pernapasan dapat mengaktifkan sistem imun seluler dan saat terjadinya inflamasi menyebabkan pelepasan sitokin pro-inflamasi yaitu Tumor Necrosis Factor Alpha (TNF-α). TNF-α merupakan sitokin pro-inflamasi yang memiliki efek agregasi dan stimulasi neutrofil. TNF-α disekresikan oleh makrofag, yang berperan dalam metabolisme, termasuk diferensiasi, apoptosis, proliferasi sel, koagulasi, dan metabolisme lipid. Penelitian ini merupakan penelitian observasional, dengan rancangan penelitian potong lintang di desa gitar Sukoharjo. Sampel penelitian sebanyak 30 subjek, diambil menggunakan teknik non-probability sampling dengan metode purposive sampling. Pemeriksaan TNF-α dilakukan dengan metode Enzyme-Linked Immunosorbent Assay (ELISA). Hasil penelitian menunjukkan bahwa nilai rata-rata TNF-α pada pekerja finishing gitar yang memakai APD dengan masa kerja 1-3 tahun adalah 66,66 pg/ml, sedangkan pada pekerja yang memakai APD dengan masa kerja >3 tahun adalah 70,71 pg/ml. Nilai rata-rata pada pekerja yang tidak memakai APD dengan masa kerja 1-3 tahun adalah 71,64 pg/ml, sedangkan pada pekerja yang tidak memakai APD selama >3 tahun adalah 86,10 pg/ml. Kesimpulan dari penelitian ini adalah terdapat perbedaan kadar TNF-α berdasarkan penggunaan APD yang bekerja selama 1-3 tahun maupun >3 tahun.
Analisis Retrospektif Hasil Pemeriksaan Tiroid (TSH dan FT4) dengan Metode ELFA di RSUD Dr. Doris Sylvanus Palangka Raya Eleventi Oktarina Putri; Antoni Aldo Danendra Sawal; Muhammad Ihza Lisan Shidqi; Yanti Sunaidi
Jurnal Analis Kesehatan Kendari Vol. 8 No. 1 (2025): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 8 (1) Desember 2025)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

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Abstract

Thyroid disorders are among the most prevalent endocrine conditions globally, demanding precise diagnostic methodologies for effective management. Epidemiological data on thyroid disorders in Kalimantan is still limited. This study aims to re-analyze retrospective data on .thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels measured using the Enzyme Linked Fluorescent Assay (ELFA) method in 2017 at RSUD Dr. Doris Sylvanus Palangka Raya, evaluate them with the latest guidelines, and validate the ELFA method. Data from 87 patients with suspected thyroid dysfunction were subjected to descriptive statistics, Chi-square tests, Spearman's correlation, and Receiver Operating Characteristic (ROC) curve analysis. Patients were predominantly female (n=67, 77%). Hormone distribution showed a tendency towards hyperthyroidism, with 48.3% (n=42) of patients having low TSH and 27.6% (n=24) having high FT4. Statistical analysis showed no significant association between gender and TSH (χ² = 1.277, df = 2, p = 0.528) or FT4 (χ² = 3.240, df = 2, p = 0.198) levels. However, a very strong and significant physiological relationship was found between TSH and FT4 levels, both categorically (χ² = 24.576, df = 4, p < 0.001) and correlationally (r = -0.503, p < 0.001). ROC analysis proved that the ELFA method has very good diagnostic accuracy with an Area Under Curve (AUC) of 0.915 (95% CI: 0.835–0.995, p < 0.001). The profile of thyroid disorders in this region is dominated by a hyperthyroidism pattern, and historical data from the ELFA method has been proven to remain valid and clinically relevant for epidemiological studies. These findings affirm that data generated by ELFA technology in 2017 remains robust and clinically valid when interpreted through the lens of modern guidelines. The study underscores the value of simultaneous TSH-FT4 testing and supports the sustained utility of older, yet reliable, immunoassay technologies, particularly in resource-limited settings, contributing to longitudinal epidemiological understanding of thyroid disorders in the region.
Keandalan Metode Kamar Hitung, Fonio, dan Hematology Analyzer dalam Pemeriksaan Jumlah Trombosit pada Sampel Eritropenia Purbasari, Euis; Erikardo, Oktadio; Nikmatullah, Nurul Azmah; Ardiansyah
Jurnal Analis Kesehatan Kendari Vol. 8 No. 1 (2025): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 8 (1) Desember 2025)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

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Abstract

Pemeriksaan jumlah trombosit secara manual masih menjadi metode yang dapat diandalkan, terutama untuk mengkonfirmasi hasil pemeriksaan automatic yang dicurigai kurang akurat. Namun, hasil pemeriksaan manual dapat dipengaruhi oleh berbagai faktor, termasuk kondisi penyakit pasien. Salah satu kondisi yang mungkin berpengaruh adalah eritropenia, terutama terkait metode perhitungan eritrosit tidak langsung. Meski demikian, pengaruh eritropenia terhadap keandalan pemeriksaan trombosit secara manual dan dampaknya belum banyak diteliti. Penelitian ini bertujuan untuk menganalisis perbedaan hasil hitung trombosit menggunakan metode manual langsung kamar hitung, metode manual Fonio, dan metode automatic (hematology analyzer) pada sampel eritropenia. Penelitian dilakukan pada 11 sampel darah eritropenia yang dipilih secara purposive sampling dan jumlah trombosit pada seluruh sampel dilakukan menggunakan 3 metode yang berbeda. Hasil uji One-Way ANOVA menunjukkan terdapat perbedaan yang signifikan p=<0,001, dengan rerata tertinggi pada metode automatic (302.000 sel/µL), kemudian diikuti metode langsung (254.000 sel/µL), dan jumlah terendah pada metode tidak langsung (134.032 sel/µL). Uji Post Hoc LSD menunjukkan perbedaan yang signifikan hanya terjadi antara metode manual Fonio dengan metode manual kamar hitung dan automatic. Penelitian ini menyimpulkan bahwa metode automatic dan manual secara langsung memberikan hasil yang lebih dapat diandalkan dibandingkan metode tidak langsung, karena metode tidak langsung bergantung pada jumlah eritrosit.
Uji Efektivitas Ekstrak Daun Twandokulo (Kleinhovia hospita Linn) Terhadap pertumbuhan Bakteri Streptococcus mutans ATCC 25175 Penyebab Karies Gigi Nur Awalia Putri Zainal; Ainun ayu yuniar; Angriani Fusvita; Rein Rahmat
Jurnal Analis Kesehatan Kendari Vol. 8 No. 1 (2025): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 8 (1) Desember 2025)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46356/jakk.v8i1.395

Abstract

leaf is one of the local medicinal plants of Southeast Sulawesi, which has several benefits. One of the benefits of the Kleinhovia hospita Linn plant is as an antibacterial. The purpose of this study was to determine the antibacterial effectiveness of tawandokulo leaf extract (Kleinhovia hospita Linn) on the inhibition zone of Streptcoccus mutans ATCC 25175 bacteria. This research is a laboratory experiment to see the antibacterial effectiveness test of tawandokulo leaf extract (Kleinhovia hospita Linn) against Streptcoccus mutans ATCC 25175 bacteria at various concentrations namely 20%, 40%, 60%, positive control Amoxcilin 0.001%, negative control DMSO. Tawandokulo leaf extract was obtained from maceration extraction using ethanol solvent. This study used the agar well diffusion method, incubated at 37oC for 24 hours and the inhibition was measured using a caliper, with extract samples carried out in triplicate. Based on the antibacterial effectiveness test of Tawandokulo Leaf Extract (Kleinhovia hospita Linn) against Streptcoccus mutans ATCC 25175 bacteria, the inhibition response results were obtained at concentrations of 20%, 40%, and 60%. The results obtained showed that the average diameter of the inhibition zone from the growth of Streptcoccus mutans ATCC 25175 bacteria obtained at 20% concentration had no inhibition zone, 40% concentration had no inhibition zone, 60% concentration had an average inhibition zone of 6,23 mm, positive control had an average inhibition zone of 19,13 mm, and negative control had no inhibition zone.

Page 8 of 8 | Total Record : 77

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