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Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 14 Documents
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Search results for , issue "Vol. 32 No. 1 (2022)" : 14 Documents clear
Combination of Vitamin C and E Improves Spermatogenesis of White Male Rat Model of Paradoxical Sleep Deprivation Stress Fitranto Arjadi; Mustofa Mustofa; Yudhi Wibowo; Nur Signa Aini Gumilas; Dzicky Rifqi Fuadi
Jurnal Kedokteran Brawijaya Vol. 32 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.01.2

Abstract

Paradoxical Sleep Deprivation (PSD) elevates glucocorticoid and Reactive Oxygen Species (ROS) levels that cause oxidative stress, trigger spermatogenic cells damage, and reduce the number of sertoli cells. Vitamin C and E are antioxidants that could prevent spermatogenesis damage by preventing free radical formation. The study aimed to determine the effect of single and combined doses of vitamin C and E in improving spermatogenesis of white male rats (Rattus norvegicus) model of PSD. This is experimental research with post-test only and control group design on 28 white male rats distributed into four groups, i.e. group I (control, PSD), group II (PSD+vitamin C), group III (PSD+vitamin E), and group IV (PSD+a combination of vitamin C and E). Testicular preparations were stained using Hematoxylin-Eosin staining, quantitative scores of spermatogenic cells were measured using the Johnsen method, and the number of sertoli cells was counted in 10 seminiferous tubules in each of the three testicular sections. Group I has the lowest mean of Johnsen score (5.27±0.28), and group IV has the highest mean score (8.95±0.62), while the Mann-Whitney test showed a significant difference (p<0.05) between group II, III and IV compared to group I (control group). Mean sertoli cells number of group I is the lowest (10.66±1.04), and group IV has the highest sertoli cells number. The post-hoc LSD test showed a significant difference (p<0.05) between group IV and the other groups. Thus, the combination of vitamins C and E improves Johnsen score and sertoli cells number of male rats (Rattus norvegicus) experiencing PSD.
Validation of TWIST (Testicular Workup for Ischemia and Suspected Torsion) Score System for Differential Diagnosis in Acute Scrotum in Tertiary Teaching Hospital Nyoman Gede Prayudi; Besut Daryanto; Taufiq Nur Budaya
Jurnal Kedokteran Brawijaya Vol. 32 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.01.4

Abstract

The acute scrotum is a common urological emergency and has a broad differential diagnosis. There is no clear consensus on a particular algorithm to follow in the diagnosis of testicular torsion. Testicular Workup for Ischemia and Suspected Torsion (TWIST) Score, a risk scoring system based on signs and symptoms, can be invaluable in managing patients with the acute scrotum, specifically testicular torsion. This study aimed to evaluate the effectiveness of the TWIST scoring system for differential diagnosis of acute scrotal patients. The study was conducted using secondary data, medical records from 111 male patients diagnosed with acute scrotum in Saiful Anwar General Hospital Malang between January 2015 and December 2018. Data about the onset of pain, first contact, history, physical examination findings, any adjunct test performed, and intra-operative findings were collected. The effectiveness of the TWIST score in diagnosing testicular torsion was determined by calculating the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Of the 111 patients, 43 patients (38.7%) had testicular torsion. The mean age was 17.49 (6.69) years. A total of 39 patients were classified as high risk as per the TWIST Score with cut point 5 had 83.7% sensitivity, 95.6% specificity, 92.3% positive predictive value (PPV), and 90.3% negative predictive value (NPV). The area under the curve was 0.93. The use of the TWIST Score in clinical practice can accurately determine high-risk patients who can proceed straight to the operating theatre without the need for an ultrasound.
The Theory of Planned Behavior to Identify Out-of-Hospital Cardiac Arrest (OHCA) Bystanders' Intentions Zenita Habibatul Ilmiyah; Sri Andarini; Tony Suharsono
Jurnal Kedokteran Brawijaya Vol. 32 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.01.11

Abstract

The theory of planned behavior states that intention is the best predictor of behavior. The intention to perform a behavior is determined by a person's attitude, subjective norms, and perceived behavioral control. As volunteers in the health sector, volunteers of the Indonesian Red Cross (PMI) have been equipped with knowledge and skills regarding the role of an OHCA bystander. Besides, the intentions of PMI volunteers greatly affect a person's tendency to be willing or unwilling to become an OHCA bystander. This study aims to apply the theory of planned behavior in identifying the factors that influence the intentions of PMI volunteers in acting as OHCA bystanders and the dominant factors that affect intentions. This study used an observational research type with a cross-sectional approach. The respondents in this study were 105 PMI volunteer members in Tuban Regency, which were conducted using the purposive sampling technique. In determining the most dominant factor that influenced intention, ordinal logistic regression analysis was used in which it was shown that the variable used in the last modeling analysis stage was the subjective norm (OR= 6.19). Based on the results of the analysis, it can be concluded that subjective norms are the most predictor factor that influences intentions.
Baseline Stroke Severity as a Predictor of 30-Day Post-Ischemic Stroke Disability Outcome Diana Teresa; Rizaldy Taslim Pinzon; Sugianto Adisaputro
Jurnal Kedokteran Brawijaya Vol. 32 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.01.6

Abstract

More than 50% of patients who survived stroke have a chronic disability. The National Institute of Health Stroke Scale (NIHSS) is a scoring system to determine the neurologic deficit of a stroke patient. This study analyzed stroke severity based on baseline NIHSS score as a determinant for 30-day post-ischemic stroke disability. This study method uses a retrospective cohort design based on medical records and stroke registry of ischemic stroke patients in Bethesda Hospital Yogyakarta. During admission, the predictive factors for the disability of the study subjects were evaluated. The baseline NIHSS assessment score was measured at 1x24 hours after admission. Disability was measured using a simplified modified Rankin Scale questionnaire (smRSq) Indonesian version at 30-day post-ischemic stroke. Statistical analysis includes univariate, bivariate, and logistic regression multivariate data analysis. The subjects were 84 patients with ischemic stroke. Disability at 30-day post-ischemic stroke occurred in 22 patients (26.2%). Logistic regression multivariate analysis show that Neutrophil to Lymphocyte Ratio (NLR) (RR: 4.488, CI: 1.873–10.756, p: 0.001) and baseline NIHSS score (RR: 28.563, CI: 2.891–282.181, p: 0.004) together significantly affect the mRS of 30-day post-ischemic stroke. Patients admitted with a higher baseline NIHSS score have a 28.5 fold risk for a worse functional outcome than those with lower baseline NIHSS scores. Stroke severity based on baseline NIHSS score is a determinant factor for disability in patients at 30-day post-ischemic stroke.
Effectiveness of 0.1% Retinol Serum and Astaxanthin Gel on Skin Photoaging Boedhy Setyanto; Sinta Murlistyarini; Dea Florensia
Jurnal Kedokteran Brawijaya Vol. 32 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.01.12

Abstract

Skin photoaging is cumulative skin damage due to chronic environmental exposure, especially ultraviolet (UV) light, which interferes with the keratinocyte and fibroblast syntheses by matrix metalloproteinases (MMP). Retinol can improve wrinkles, pigmentation, elasticity, firmness, brightness, and various signs of photoaging on the skin. Astaxanthin is a powerful antioxidant that protects the skin from UV rays, inhibits MMP, and stimulates collagen production. This case report presents 2 cases of women complaining about deep skin wrinkles, dullness, and looseness. Physical examination in the facial region revealed wrinkles when resting in the first patient and wrinkles during motion in the second patient. The first patient was diagnosed Glogau III photoaging, while the second patient was diagnosed Glogau II photoaging. Both patients received astaxanthin gel therapy and SPF 33 sunscreen cream every morning, as well as 0.1% retinol serum every night. There was an improvement after six weeks. Astaxanthin and retinol 0.1% can be used as photoaging therapy. Adequate use of photoprotection is also necessary to prevent the worsening of photoaging.
Correlation between Nurse Practice and Pre-hospital Ambulance Service Satisfaction in Bali I Wayan Edi Sanjana; Titin Andri Wihastuti; Nurul Muslihah
Jurnal Kedokteran Brawijaya Vol. 32 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.01.8

Abstract

The pre-hospital emergency service was the first guard of nursing and treatment delivery. The pre-hospital ambulance service could be used to offer first aid to the patient or victim who experienced trauma or non-trauma with unpredictable condition. The improvement of service quality on emergency sector was required to assure that the health service was given and performed well. This research was aimed to analyze the correlation between nurse practice and pre-hospital ambulance service satisfaction in Bali. The correlative analytic research method and cross sectional approach were exerted to accomplish this research. The total sample was 271 respondents which were consisted of 144 patients and 127 nurses. The result of Spearman-rank referred p value 0.024; r 0.189 which it was indicated a significant relation between nurse practice and pre-hospital ambulance service satisfaction in Bali. The nurse practice was instituted through educational degree and training experience. The improvement of nurse practice value was in line with the pre-hospital ambulance service satisfaction value in Bali.
Risk Factors for Mortality Due to Covid-19: A Case Study at a Distric Hospital in March-September 2020 Luthfiana Husnaini Utami; Dyah Yulia Ariani; Oskar Renagalih Amarta
Jurnal Kedokteran Brawijaya Vol. 32 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.01.14

Abstract

The Covid-19 pandemic, which becomes a global health problem, has widely impacted not only health but also social, economic, and politics in Indonesia. Previous studies have indicated that the patient's prognosis is influenced by the degree of disease, age, gender, and comorbidities. District hospital in Bojonegoro is a Covid-19 referral hospital and 37,1 % of patients who died in march-september 2020. This study was conducted to identify risk factors for death in patients with Covid-19 in hospital so we can reduce casa fatality rate in district hospital in Bojonegoro. The independent variables in the study were age, gender, and comorbid status, while the dependent variable was the output status (recovered or deceased). The study was conducted at a private hospital in East Java in October 2020 on 104 patients as subjects. Data were analyzed using the chi-square test. The results show that all the factors studied, age p = 0.006, gender p = 0.050, and comorbid status p = 0.001, have a statistically significant relationship with mortality. In short, at this hospital, advanced age, male gender, and comorbidities are the risk factors for Covid-19 death.
Epidermoid Cyst of Sole Wuriandaru Kurniasih; Arif Widiatmoko
Jurnal Kedokteran Brawijaya Vol. 32 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.01.13

Abstract

An epidermoid cyst is benign cystic tumor coated with squamous epithelium and contains keratin. It generally appear on the body parts which have pilosebaceous follicles, such as head, neck, and body. The manifestation of the disease is a skin-colored, mobile, painless nodule with a punctum in the center. Epidermoid cyst of sole is often similar to clavus, callus, and verruca plantaris. However, epidermoid cyst of sole is rare because the area is without pilosebaceous follicles. The etiopathology is believed due to trauma that causes implantation of epidermal cells into the dermis layer, thus triggering the formation of epidermoid cysts. This case report a girl with an epidermoid cyst of sole that was initially thought as a verruca plantaris and clavus. A 14-year-old girl complained about a bump on her right foot that got bigger during nine months. The lesions surface was slippery, and the patient felt pain when walking. The patient denied any trauma or changing footwear with friends or relatives. Examination in the right lateral plantar pedis region, a nodule was found skin-colored, round, measuring 2x2 cm, and solitary. The patient was planned to undergo excochleation, but since a white cystic mass was found during the operation, it was continued with extirpation surgery. The histopathological examination results showed a stroma with keratin, which was concluded as an epidermoid cyst. In the case of epidermoid cysts with atypical clinical symptoms and unusual lesion locations, histopathological examination is required for a definite diagnosis.
The Use of PILA-Pack: Differences in Length of Stay of Hemorrhoidal Patients Fadli Robby Amsriza; Rizka Fakhriani
Jurnal Kedokteran Brawijaya Vol. 32 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.01.7

Abstract

Hemorrhoids are a common anorectal disease and can affect all ages. This research aims to specify the differences in Length of Stay (LOS) of hemorrhoidal patients who underwent a modified combined method of rubber ligation and sclerotic injection using Paran Injection Ligation for Ambeien pack (PILA pack) compared to a hemorrhoidectomy. This study consisted of 56 respondents who underwent hemorrhoidectomy, and the other 56 respondents experienced a modified combined method of rubber ligation and sclerotic injection using a PILA pack. Data showed the LOS's average of respondents who underwent hemorrhoidectomy was 47.33 hours or 1.97 days. Meanwhile, respondents' average length of stay who underwent a modified combined rubber ligation and sclerotic injection using a PILA pack was 20.44 hours or 0.85 days. Finally, the T-test results showed a p-value of 0.001 (p<0.05), indicating that there was a statistically significant difference in the average LOS between hemorrhoidal patients who underwent hemorrhoidectomy and hemorrhoidal patients who underwent a modified combined method of rubber ligation and sclerotic injection using PILA pack. Based on the result, it can be concluded that the mean LOS for hemorrhoidal patients receiving haemorrhoidectomy vs. hemorrhoidal patients undergoing a modified technique of rubber ligation and sclerotic injection utilizing the Paran Injection Ligation for Ambeien pack was significantly different.
Restraint Stress Impacts on Behavioral Changes and Adrenal and Kidney Tissue Histopathology of Adult Mice Davy Reyhanditya; Viona Faiqoh Hikmawati; Nia Kurnianingsih; Fatchiyah Fatchiyah
Jurnal Kedokteran Brawijaya Vol. 32 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.01.1

Abstract

Restraint stress causes changes in the brain parameters. Little research has been done on the impact of restraint stress on other tissues, including adrenal glands and kidneys. This study aimed to determine the effect of restraint stress on eating behaviors, depressive-like, anxiety-like behaviors, weight gain as well as histopathological changes in the kidneys and adrenal glands. Twenty adult BALB/c mice were assigned into control male, stressed male, control female, and stressed female. Restraint stress was applied two hours/day for 14 days. Tail suspension and open field tests were carried out to perform behavior analyses. Adrenal and kidney histological slides were observed under an Olympus CX-31 microscope and visualized using an Olympus E330 camera. The two-way ANOVA test was used for statistical analysis using GraphPad Prism 9.0.0 software. We found that restraint stress defeat appetite and reduces weight gain particularly in stressed female. However, depressive- and anxiety-like behavior were demonstrated in both sexes. Adrenal and kidney tissues of stressed mice demonstrated a higher number of necrotic cells than control. The pyknosis phase was more common than the karyorrhexis and karyolitic phases. Interestingly, male mice were more receptive to stress than female mice. These findings indicate that restraint stress leads to behavioral changes and cellular defects in the adrenal glands and kidneys, particularly in male mice. The sympathetic activation and hypothalamus-pituitary-axis stimulation are assumed as the underlying stress effect of the restraint procedure. The restraint stress method has the potential to be used in future research on stress-responsive target organs.

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