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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 13 Documents
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Search results for , issue "Vol. 53, No. 3" : 13 Documents clear
Radiation effect of wireless fidelity (wi-fi) on oocyte number of oocyte stimulation in mice (mus musculus) Nurbayatin, Anita; Widjiati, Widjiati; Primariawan, Relly Yanuari; Poernomo, Bambang; Sulistiawati, Sulistiawati; Yudiwati, Rina
Folia Medica Indonesiana Vol. 53, No. 3
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Abstract

Infertility is a problem experienced by some women and men around the world. Most infertility problems in women is caused by impaired reproductive organs or disrupted ovulation.. One factor that causes impaired oocyte maturation is wireless fidelity (Wi-Fi) radiation which has a radio frequency field of 2.45 GHz. The radiation may increase the activity of free radical cells through the fenton reaction pathways that cause infertility because of the disrupted oocyte development. This study aimed to determine the effect of Wi-Fi radiation on the number of oocytes. This was an experimental study using control group design. The subjects were 32 female mice selected through complete random sampling and divided into two groups: control (R0) and exposure (R1). Each group consisted of 16 mice. The Wi-Fi radio frequency used was 2.5 GHz. Mice (R1) were placed closer to Wi-Fi source (± 15cm), and there were two types of laptop PCs and 3G mobile phones connected to internet placed next to mice for 15 hours/28 days. The mice underwent a simultaneous cycle with intraperitoneal injection of PMSG and HCG. Furthermore, the mice were mated with vasectomized male monomatingly to induce ovulation. The fertilization pouch in both oviducts were observed for oocyte collection. The number of oocytes was calculated using an inverted microscope. There was a difference in the number of oocytes between control and exposure group. Statistical tests were analyzed using Mann Whitney U and resulted in significant values (p value = 0.00). No oocytes count in exposure group. In other words, the group underwent anovulation. In conclusion, Wi-Fi radiation affected the number of oocyte stimulation in mice. Therefore, it was important to minimize the risk factors that trigger electromagnetic radiation on reproductive health.
Relation between length of stay and anti-filarial igg4 level in pondok gede sub-district, bekasi district, west java Susatyo, Jeffry Adijaya; Wibowo, Heri
Folia Medica Indonesiana Vol. 53, No. 3
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Filariasis is a contagious disease caused by worms of the genus Filaria which transmitted through the bite of various species of mosquitoes. In Indonesia, the existence of filariasis cases are still very concerning. Jati Sampurna and Jati Karya villages in Pondokgede Sub-district, Bekasi District, West Java have been known as filariasis endemic area. Length of stay is presumed as one of many factors that affects filariasis occurrence in those villages. This study aimed to determine the distribution of anti-filarial IgG4 on the region and its comparison with the length of stay and residence status. This study was based on secondary data. Secondary data were obtained from primary research data done by cross-sectional method. These data were used to assess the correlation of filarial infection risk factors in pregnant women living in endemic areas based on the distribution of anti-filarial IgG4 in Pondok Gede, Bekasi district, West Java. The study showed that there was an increase in anti-filarial IgG4 against residence status (p=0.017) and a positive correlation between the number of anti-filarial IgG4 with length of stay in years (p=0.003).
Impact of preparation using conventional and modified density gradient centrifugation methods on sperm concentration, motility and number of normal motile sperm recovery (nmsr) Yudiwati, Rina; Pramesti, MPBD; Agustinus, Agustinus; Pradana, E; Purwanto, Bambang
Folia Medica Indonesiana Vol. 53, No. 3
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Abstract

Some preparation techniques, either conventional or advanced, have been provided. Advanced technique may overcome the limitations of conventional techniques. Recently, not all fertility clinics in Indonesia are able to provide advanced preparation techniques. Some techniques require expensive equipments and can only be used for intracytoplasmic sperm injection (ICSI). Some fertility clinics use a modified procedure, namely the combination of density gradient centrifugation with a swim-up method for the preparation of the sperm to be used in ART. This study aimed to determine whether the modified density gradient centrifugation, which is density gradient centrifugation followed by a swim-up, is able to yield better results than conventional density gradient centrifugation. This study was a laboratory experimental pre and pos-test control group design. Population was all adult men aged 21-40 years old and the sampling unit was the man donor's semen which fulfilled inclusion criterias, collected during the periode of the study. Sample size was eight. Sperm analysis were done before and after preparation in conventional and modified group. Descriptive comparation analysis have been used. This study obtained NMSR 7.9+5.5 million/ejaculate and recovery rate (RR) 27.66+11.8 %. RR was lower compared to RR obtained conventional DGC method. RR might be lower because in modified DGC samples undergo two steps selection while conventional DGC only one step selection. But conventional DGC samples should be centrifuged twice, therefore sperms might experience more trauma. Lower RR sperm does not exclude the possibility to be used for ART, because still within the required number for all TRBs. In conclusion, modified DGC preparation method obtained lower NMSR and RR, nevertheless harvested sperms can still be used in all kind of ART.
Life quality among elderly with obesity in outpatient clinic, dr. Soetomo hospital, surabaya Kurniawati, Patricia Maria; Laswati, Hening Laswati
Folia Medica Indonesiana Vol. 53, No. 3
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Abstract

Obesity is one of the chronic diseases that may have significant impact and affect the quality of life, especially in elderly who already have multidimensional problems. This study aimed to provide information about the influence of obesity in elderly on every component of his quality of life by using the SF-36 quality of life. This study was conducted on 105 patients in outpatient Medical Rehabilitation, Geriatrics and Diabetes at Dr. Soetomo Hospital, Surabaya. Patients aged 60-75 years, consisting of 62 men and 43 women. The number of patients with obesity was 49 persons (46.7%) with an average body mass index (BMI) of 27.16 kg / m2. Whereas, non-obese patients were 56 persons (53.3%) with an average BMI of 21.23 kg/m2. In conclusion, there was no significant difference in the SF-36 life quality of obesity and non-obesity groups after being analyzed using t-test.
The effect of recombinant vascular endothelial growth factor 121 on nitride oxide level in mice (mus musculus) model of preeclampsia Soetrisno, Soetrisno; Isharyadi, Isharyadi; Sulistyowati, Sri
Folia Medica Indonesiana Vol. 53, No. 3
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Abstract

Preeclampsia is a multifactorial syndrome in pregnancy whose cause is still unknown. Several proangiogenic and antiangiogenic mediators such as Vascular Endothelial Growth Factor (VEGF) and Nitrite Oxide (NO) play important roles in preventing preeclampsia. VEGF can increase NO level that lowers maternal blood pressure, improves endothelial function and reduces placental hypoxia in preeclampsia. Recombinant VEGF 121 is expected to be an option in the prevention and treatment of preeclampsia. This experimental study used mice (Mus musculus) as the model. The objective of this study was to observe the effect of recombinant VEGF 121 in increasing the level of nitric oxide in mice (Mus musculus) model of preeclampsia. This was an experimental analytical study with Randomized Control Trial (RCT) design. The study enrolled 27 pregnant mice (Mus musculus) which met the restriction criteria divided into 3 groups. The first group (K1) were 9 normal pregnant mice. The second group (K2) were 9 pregnant mice of preeclampsia model without treatment. The third group (K3) were 9 pregnant mice of preeclampsia model receiving recombinant VEGF 121 therapy. The independent variable was the administration of recombinant VEGF 121 and the dependent variable was the serum NO level. Statistical analysis was performed by using anova statistics. NO level in the first group (K1) was 1.746±0.347, with minimum value of 1.00 µM, and maximum value of 2.28 µM, CI (1.479-2.013). NO level in second group (K2) was 1.167±0.380, with minimum value of 0.64 µM, and maximum value of 1.94 µM, CI (0.875-1.460). NO level in the third group (K3) was 2.164±0.556, with minimum value of 1.56 µM, and maximum value of 5.96 µM, CI (1.842-2.486). With anova statistical test, there were significant differences between K1 group and K2 group (p value=0.004<0.05), K1 group and K3 group (p value=0.000<0.05) as well as K2 group and K3 group (p value=0.029<0.05). In conclusion, Recombinant VEGF 121 increased the level of nitric oxide in mice (Mus musculus) model of preeclampsia significantly.
The difference of blood pressure and arterial stiffness after intake of arabica and robusta coffee in controlled hypertension Pikir, Budi S; Andrianto, Andrianto; A, Ford Ance
Folia Medica Indonesiana Vol. 53, No. 3
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Potential mechanisms of caffeine promote large artery stiffness and associated with increased morbidity and mortality of cardiovascular disease. To find the difference of blood pressure and arterial stiffness after intake of arabica and robusta coffee in controlled hypertension, a quasi-experimental study was done enrolling 24 controlled hypertension and 24 normotensive subjects collected by purposive sampling. Subjects received ± 10,6 g caffeinated coffee in 150 ml water with crossover protocol twice in 5 days. The assessment of arterial stiffness by obtaining ultrasound 2D image of common carotid artery then was calculated with beta stiffness index. Blood pressure and arterial stiffness was measured before coffee intake and again at 30 to 60 minutes thereafter. In controlled hypertension, significant differences were found between initial systolic blood pressure (SBP), 30 and 60 minutes after arabica (p 0,002) and robusta (p 0,012) intake; between diastolic blood pressure (DBP), 30 and 60 minutes after of arabica (p 0,004) and robusta (p 0,025) oral administration; and between initial beta stiffness index, 30 and 60 minutes after arabica (p 0,018) oral administration. However, no significant difference was found between initial beta stiffness index, 30 and 60 minutes after robusta (p 0,104) oral administration. No significant difference was found in all variables after arabica and robusta intake. Significant differences were found in blood pressure after arabica or robusta intake and in arterial stiffness after arabica intake. However, no significant differences were found in arterial stiffness after robusta intake and in all variables after arabica and robusta intake.
Phylogenetic analysis and anti microbial activity of streptomyces spp. Isolated from compost soil in surabaya indonesia on the basis of 16s rrna gene Kurnijasanti, R; Isnaeni, Isnaeni; AT, Poernomo; Sudjarwo, SA
Folia Medica Indonesiana Vol. 53, No. 3
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Eight isolates of Streptomyces sp. can be isolated from compost soil in Surabaya, Indonesia. The results of biochemical and morphological tests showed that the 8 isolates were new. Phylogenetic analysis was performed on the sequence of 16S rRNA gene. Nucleotide sequences of 16S rRNA gene Streptomyces sp. the compost soil isolates of Surabaya were analyzed and compared with the 16S rRNA gene sequence from the literature. Streptomyces sp. the compost soil of Surabaya based on the 16S rRNA gene showed the new species of Streptomyces. The result of phylogenetic tree diagram showed that Streptomyces Sp-D, Sp-Ep, Sp-G and Sp-I found in Bratang Surabaya compost house land were new isolates. Streptomyces Sp-Ep was a new type of Streptomyces closely related to Streptomyces indonesiasis and Streptomyces nashvillensis. Streptomyces Sp-Ea was Streptomyces olivoreticuli which was still related to Streptomyces yogyakartensis. Streptomyces Sp-F was Streptomyces levis strain NRRL B-24299. Streptomyces Sp-C was Streptomyces filamentosus. Streptomyces Sp-D was a new type of Streptomyces closely related to Streptomyces javensis and Streptomyces roseus. Streptomyces Sp-G was a new type of Streptomyces closely related to Streptomyces roseoviridis strain NBRC 12911 and Streptomyces thermocarboxydovorans strain AT52. Streptomyces Sp-I was a new streptomyces that was still closely related to Streptomyces cangkringensis and Streptomyces asiaticus. Streptomyces Sp-A was Streptomyces laurentii strain: LMG 19959.
Diabetes risk factor screening in adults using perkeni questionnaire and oral glucose tolerance test in socah county, bangkalan Kamal, Radin H; Novendrianto, Dwiki; Chadijah, Faizah; Prasetya, Galan Budi; Pratama, Gilang Satria; Ariadnya, Mentari Octarina; Larasati, Nikita Gladys; Darain, Nur Lia F; Nanda, Ovitrani; Mavita, Silvi; Usamah, Usamah; Prajitno, Jongky Hendro
Folia Medica Indonesiana Vol. 53, No. 3
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There are 8.4 million diabetes adult patients in Indonesia and most remained undiagnosed. Screening process for diabetes is very important. PERKENI has recommended the use of questionnaire and Oral Glucose Tolerance Test (OGTT) as risk factor screening tools. This study aimed to find out the use of PERKENI questionnaire and OGTT in adults as diabetes risk factor screening tools. This was a descriptive cross sectional study conducted in 2015 in Socah County Bangkalan. Participants (n=91) were interviewed regarding diabetes risk factor using PERKENI questionnaire. Anthropometric (height, weight, and abdominal circumference) measurements were also taken. The results were categorized into: very low risk, increased risk, moderate risk and high risk. Only those categorized as high risk were asked to take OGTT. Exclusion criteria were participants who had been diagnosed with diabetes by a physician and/or routinely taking anti diabetic medication, consumed drugs during the previous two weeks and does not finish the required procedures. From 91 eligible participants, only 9 (9.89%) were categorized as high risk. The result of OGTT were: 4 were within normal limit, 1 had impaired glucose tolerance (IGT) and 4 were newly diagnosed with diabetes. The use of PERKENI questionnaire and OGTT in high risk adult population as a diabetes risk factor screening tool increased new findings of diabetes cases. Our analysis may support the adoption of diabetes risk factor screening methods through questionnaires and OGTT in high risk adult population, especially in low resource setting.
Correlation between ldl, hdl, and triglyceride conditions with body fat percentage of universitas padjadjaran professors Saputra, Yosi Wailan; Miftahurachman, Miftahurachman; Lubis, Leonardo
Folia Medica Indonesiana Vol. 53, No. 3
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Elderly is a problem that may disrupt the balance of various molecules in the body, especially fat molecules, which may result in the emergence of various diseases so that blood fat and adipose level examinations need to be done regularly and periodically as an effort of early detection. This study aimed to find correlation between Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), and triglyceride with body fat percentage among professors in Universitas Padjadjaran (Unpad) who were mostly in elderly age. This study was a linear regression analytical study conducted on 52 Unpad professors (♂ 75%, ♀ 25%) based on data of LDL, HDL, and triglyceride levels obtained through laboratory examination, as well as body fat percentage data by using Bio Impedance Analysis (BIA). The correlation between low density lipoprotein (LDL), High Density Lipoprotein (HDL), and triglyceride with body fat percentage in male professors group was R2=0.072; P>0.05 and in female was R2=0.028; P>0.05. As a conclusion, there was no correlation between Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), and triglyceride with body fat percentage in Unpad professors.
Nigella sativa extract improves seminiferous tubule epithelial thickness in lead acetate-exposed balb/c mice Diana, Alis Nur; I'tishom, Reny; Sudjarwo, Sri Agus
Folia Medica Indonesiana Vol. 53, No. 3
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Lead that enters the body may lead to increased production of ROS (Reactive Oxygen Species) that may affect reproductive system. Black cumin (Nigella sativa) extract contains high antioxidant, tymoquinone, that may be used to suppress oxidative stress induced by lead in animal experiments. This study aimed to prove that black cumin (Nigella sativa) extract improves the thickness of seminiferous tubular epithelium in Balb/c mice exposed to lead (Pb) acetate. This study used post-test only control group design. The subjects in this study were 30 Balb/c male mice (Mus musculus), divided into 5 groups. K-group: control group without lead acetate and black cumin extract, K+ group: group with 50 mg/kgBW of lead acetate for 28 days, P1 group: treatment group with 50 mg/kgBW of lead acetate for 28 days + 0.3 mg/gBW of black cumin extract for 21 days, P2 group: treatment group with 50 mg/kgBW of lead acetate for 28 days + 0.6 mg/gBW of black cumin extract for 21 days, and P3 group: treatment group with 50 mg/gBW of lead acetate for 28 days + 1.2 mg/gBW black cumin extract for 21 days. The results showed that the mean ± standard deviation of the highest thickness of seminiferous tubular epithelium was 45.80 ± 2.73 in the group that was exposed to acetate + 0.6 mg/gBW of black cumin (P2), and the lowest was 32.75 ± 4.07 in the group that was exposed to lead acetate (K+). The results were then analyzed by Anova test. The results showed that there was significant differences in the thickness of seminiferous tubular epithelium between P1, P2, P3 and K+. In conclusion, black cumin extract administration was proved to improve the thickness of seminiferous tubular epithelium in lead (Pb) acetate-exposed Balb/c mice (Mus musculus).

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