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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 18 Documents
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Search results for , issue "Vol. 58, No. 1" : 18 Documents clear
Viral Load And Cd4+ among Hiv/Aids Patients Receiving Antiretroviral Therapy In Jayawijaya District, Papua Province, Indonesia Widiyanti, Mirna; Hadi, Moch. Irfan; Adiningsih, Setyo; Natalia, Evi Iriani; Purba, Dedi Ananta
Folia Medica Indonesiana Vol. 58, No. 1
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Abstract

Hightlight:• Clinical conditions, CD4+ cell counts, and the viral copies number in the blood for AIDS/HIV were given antiretroviral therapy. • The profile of CD4+ levels and plasma viral load in HIV patients receiving antiretroviral therapy • The lower CD4+ cell counts and higher viral loads happen in HIV-infected's men. Abstract: Highly active antiretroviral therapy (HAART) is expected to reduce human immunodeficiency virus (HIV) morbidity and mortality. Antiretroviral therapy in HIV patients is given based on clinical conditions, CD4+ cell counts, and the number of viral copies in the blood. This study aimed to determine the profile of CD4+ levels and plasma viral load in HIV patients receiving antiretroviral therapy. This was a cross-sectional study conducted within six months at Voluntary Counseling and Testing (VCT) in Jayawijaya Hospital, Papua, Indonesia. The CD4+ levels were measured using CD4+ counter and viral plasma was checked using Polymerase Chain Reaction (PCR) for 90 patients. The results showed more female patients had a CD4+ level <200 cells/mm3, a higher number of copies of the virus in the blood plasma, and stages of disease 3 and 4. Statistically, there was a significant relationship between CD4+ levels and gender with a p-value = 0.00. HIV-infected males were more likely to have lower CD4+ cell counts and higher viral loads than females.
Profile of Tuberculosis in Children in Taman District, Sidoarjo Regency, Indonesia Oktaviani, Ranti Dewanti; Lestari, Pudji; Maranatha, Daniel; Setyoningrum, Retno Asih
Folia Medica Indonesiana Vol. 58, No. 1
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Highlight: • Pediatric tuberculosis patients profile using the medical records was determined. • The most pediatric tuberculosis patients under five years have pulmonary tuberculosis. • Pediatric tuberculosis patients received BCG immunization had a contact with adult tuberculosis patients histories. Abstract: The prevalence of tuberculosis (TB) in Indonesia is 391 per 100,000 population with the number of deaths around 110,000 cases in 2016. This study is descriptive research that aims to determine the profile of pediatric TB patients using the medical records at Taman public health center the period 2016-2019 with a total sampling technique. The sample in this study were 31 pediatric patients aged 0-14 years with a history of TB. Pediatric TB patients aged >5 years (58.1%) and who aged ≤5 years (41.9%). Pediatric TB patients had pulmonary tuberculosis (83.9%) and those who had extrapulmonary tuberculosis (16.1%). Pediatric TB patients aged ≤5 years had good nutritional status (32%) and who had poor nutritional status (27.2%). Meanwhile, pediatric TB patients aged >5 years had poor nutritional status (22.7%) and who had good nutritional status (18.1%). Pediatric TB patients who had a history of contact with adult TB patients (86.7%) and who did not have a history of contact with adult TB patients (13.3%). Pediatric TB patients who had received BCG immunization (86.2%) and who had not received BCG immunization (13.8%). This study concludes that most pediatric TB patients are >5 years old, almost all pediatric TB patients have pulmonary tuberculosis. Pediatric TB patients aged ≤5 years are more likely to have good nutrition. Meanwhile, there were more pediatric TB patients aged >5 years who had poor nutritional status. Almost all pediatric TB patients had a history of contact with adult TB patients and had received BCG immunization.
The Prognostic Role of Neutrophil-to-Lymphocyte Ratio (NLR) in Testicular Germ Cell Tumor (GCT) Saputra, Haviv Muris; Hakim, Lukman
Folia Medica Indonesiana Vol. 58, No. 1
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Highlights: • Neutrophil to lymphocyte ratio (NLR) has been reported by several studies for its role as a biomarker in various diseases, however, the role of NLR in testicular GCT is still unclear. • The characteristics and responses of testicular GCT patients among Indonesian men show similarity to other reports worldwide. • As a parameter, NLR shows promise to be used as a potential biomarker for prognosis in testicular GCT. Abstract: The global incidence of testicular cancer is 1-2% from all cancers. The attempts to maintain high therapeutic rates while decreasing the treatment-related side effects and toxicity have become the current concern. However, the reports regarding testicular germ cell tumors (GCT) in Indonesia are limited. Thus, we aimed to evaluate the clinical characteristics of testicular GCT patients undergoing bleomycin, etoposide, and cisplatin (BEP) chemotherapy, as well as their chemotherapy response and side effects. We reported the data of patients with Testicular Germ Cell Tumor from January 2015 to December 2019. Several data were retrieved, including patient demographics, tumor characteristics, treatment, and prognosis outcome. A total of 67 patients with testicular germ cell tumors were included in this study. The mean age was 28.9 years old. The chemotherapy regimens used were four cycles of (BEP) in 36 patients (53.7%), followed by three cycles of BEP in 22 patients (32.8%). Patients with seminoma GCT mostly had a complete response (54.1%), whereas most patients with non-seminoma GCT had progressive disease (47.8%). The multiple logistic regression analysis showed that NLR and S staging were independently associated with the patient's response to chemotherapy (OR 2.14, 95% CI 1.22, 3.78, p <0.01,OR 9.43, 95% CI 1.81, 49.14, p < 0.01). The clinical characteristics and response of testicular GCT patients among Indonesian men showed similarity with the current worldwide data. The NLR could be used as a potential biomarker for prognosis.
Radiological Aspects of HR-CT Scan on Temporal Bone Ferriastuti, Widiana; Ramayuda, Ida Bagus
Folia Medica Indonesiana Vol. 58, No. 1
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Abstract

Highlight: • High-resolution computed tomography (HRCT) scan has advantage for best image reconstruction and informative in interpreting images of the temporal bone. • The essential primary aspect in HRCT of the temporal bone scan is technique and protocol. Abstract: The high-resolution computed tomography (HRCT) scan used in the 1980s offers a distinct advantage in interpreting images of the temporal bone. To obtain a right image reconstruction and to provide meaningful information, a certain degree of tilt is required so that radiologists and clinicians can get more real imaging information on structural abnormalities in the temporal bone and its soft tissue constituents. The technique or protocol in HRCT of the temporal bone becomes an essential primary aspect in presenting the analyzed structure, the assessment of the small form of the auditory bones, the soft tissue of the inner ear and the cranial nerves that pass through the temporal bone structure is much easier to analyze, of course with the help of reconstruction according to the HRCT protocol for temporal bone, however, soft tissue evaluation is preferable to MRI. In the end, the standard structure, congenital abnormalities and pathological problems in the temporal bone structure can be identified and informed to the clinician as a step to determine further treatment action.
Pre-Operative Hormonal Administration in Hypospadias Patients Undergoing Urethroplasty Ramadhani, Muhammad Zaniar; Renaldo, Johan
Folia Medica Indonesiana Vol. 58, No. 1
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Highlight: • The gold standard therapy of hypospadias is reconstructive surgery. • Glans diameter and penile length are factors influencing urethroplasty outcomes. • Many studies are being conducted to investigate various methods of increasing the size and diameter of the penis prior to the operation in order to reduce complications. • Preoperative testosterone hormonal therapy is able to reduce overall complication and urethrocutaneous fistula in hypospadias patient undergoing urethroplasty. Abstract: The gold standard of treatment for hypospadias patients is reconstructive surgery. The result and post-operative complication of urethroplasty were affected by glans diameter and penile length. Pre-operative testosterone administration, both parenterally or topically, has become one of the main interests to increase the size and diameter of penis to minimize post-operative complications. However, there has not been enough evidence to justify this recommendation. Therefore, we aimed to perform a systematic review and meta-analysis to evaluate the role of pre-operative testosterone to prevent postoperative complications after urethroplasty in hypospadias patients. Online databases of Medline, Scopus and Embase were searched until October 2021 to identify RCT studies evaluating the effect of testosterone hormone therapy in reducing post-operative complication on hypospadias patient undergoing urethroplasty. Data analysis was performed using RevMan 5.4. A total of 4 RCTs were included in the analysis of this study with the total of 211 patients. Pre-operative testosterone hormonal therapy significantly reduced the overall complications group (OR=0.17; 95% CI=0.04, 0.77; p=0.02), post-operative urethrocutaneous fistula (OR=0.4, 95% CI=0.19, 0.83, p=0.01). Finally, there was no significant effect on the incidence of dehiscence and meatal stenosis with OR of 0.59, 95% CI=0.23, 1.54, p = 0.28, and 0.277; 95% CI=0.04, 1.65; p=0.16, respectively. Pre-operative testosterone hormonal therapy could reduce overall complication and urethrocutaneous fistula in hypospadias patients undergoing urethroplasty.
Hemoglobin A1c (Hba1c) is Strongly Correlated with Mean Corpuscular Volume Among Type 2 Diabetes Mellitus (T2dm) Patients Admitted in a Tertiary Hospital in East Java, Indonesia Salim, Yusuf; Kalanjati, Viskasari P.; Prajitno, Jongky H.; Melbiarta, Rezy R.
Folia Medica Indonesiana Vol. 58, No. 1
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Highlight: • Moderate negative significant correlation between HbA1c and MCV levels in T2DM was yet reported widely. • MCV levels could mirror health indicator in adult T2DM patients. Abstract: HbA1c showed the average level of blood sugar in the recent 2-3 months. This parameter can be used to help physicians to diagnose T2DM and to plan appropriate treatment. Meanwhile, the mean corpuscular volume (MCV) is established from the erythrocytes levels as one of the blood corpuscles, in which hemoglobin is bound to. We hypothesize that MCV is correlated to the HbA1c levels and could be an indicator of blood sugar levels in adult T2DM patients. A retrospective cross-sectional study based on the medical record of patients admitted to the Outpatient Section of Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Indonesia from January to December 2019 was done. Patients under 18-years old, and incomplete medical record data were excluded. Adult patients diagnosed with T2DM and have been received initial treatment in this section were included (n=1.688). Data was analyzed using correlation test in SPSS 17.0 (USA), p-value less than 0.05 was considered significant. We found a significant negative correlation between HbA1c and MCV levels in these patients (r=-0.312; p<0.001). MCV levels showed a paradoxical pattern against the blood glucose levels in T2DM and could serve as the health indicator in these patients.
The Effect of Orlistat Administration in Change of Glycemic Control and Weight Loss of Obesity or Overweight Patients with Type 2 Diabetes Mellitus Johan, Abu Rizal Dwikatmono; Dewanti, Linda; Putri, Anandia Nafisah; Pantoro, Benny Iswanto; Albab, Chabib Fachry; Hutauruk, Maria Marind Desrianti; Novitasari, Triana
Folia Medica Indonesiana Vol. 58, No. 1
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Hightlight: • The effect of orlistat on glycemic control and weight loss in overweight or obese type 2 diabetes mellitus patients was determined • HbA1c and FPG level in overweight and obese type 2 diabetes mellitus patient can improved by orlistat as an adjuvant therapy. Abstract: Risk of Type 2 diabetes mellitus (T2DM) increases steadily with increasing overweight and obesity, and these two-health problems are emerging epidemics worldwide. Orlistat, a lipase inhibitor for weight loss drug, is often used in T2DM medication as adjuvant therapy, but effectiveness of the drug for improving glycemic control on T2DM patients is unclear. This study was to determine the effect of orlistat on glycemic control and weight loss in overweight or obese patients with T2DM. Term "Orlistat” AND "(obesity OR overweight)” AND "(HbA1c OR A1C)” AND "diabetes” were systematically searched in Pubmed and Science Direct web databases up to March 2021. Only randomized controlled study (RCT) methods studies were included in this study. Collected final samples were presented in a table with narrative review. There were 9 RCT studies with a total 2,175 subjects that met inclusion criteria. Of the sample, 360 mg/day orlistat as an adjuvant therapy, was administered to overweight or obese T2DM patients together with hypocaloric intake (8 studies) or without hypocaloric intake (1 study) intervention. They were examined for 12-52 weeks. From 2 short-term (12 weeks) studies, one study revealed that orlistat improved HbA1c and fasting plasma glucose (FPG) level significantly, while one study showed no significant effect compared to placebo. Seven other studies (long term observation) had found that orlistat significantly improved HbA1c and FPG level. All studies found that orlistat significantly reduced body weight. As an adjuvant therapy, Orlistat improved HbA1c and FPG level in overweight and obese T2DM patients.
Profile of Skin Biopsy Patients in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia Wandhita, R.A. Astrid Putri; Sandhika, Willy; Listiawan, M. Yulianto
Folia Medica Indonesiana Vol. 58, No. 1
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Highlight: • Profile of skin biopsy results which carried out the anatomical pathology examination was reviewed. • The highest skin biopsy disease group case are erythropapulosquamous, infection, skin tumor, vesiculobullous, connective tissue disease, pigmentation disorders, and vasculitis Abstract: Skin biopsy is an important tool used by dermatologists in diagnostic determination. The correlation between clinical and histological features is needed in understanding pathogenesis and formulating the diagnosis of a skin disease with a greatly varied spectrum of histopathological results, while the observable clinical symptoms are highly limited. Skin diseases are still a serious problem worldwide, especially in Indonesia. Based on the Indonesian Health Profile in 2010, skin diseases ranked third out of 10 most diseases in outpatients in hospitals throughout Indonesia. This study was a review of the profile of skin biopsy results in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia from 1 July 2014 to 31 July 2019, which were subjected to anatomic pathology examination. This study was an observational descriptive study using secondary data sources from the medical records at the Communication and Information Technology Installation (ICT) of Dr. Soetomo General Academic Hospital, Surabaya. Based on data searches, the total number of biopsy examinations performed was 1,368 cases. There were more female patients (50.3%) than males (49.7%). The most common skin disorder found was erythropapulosquamous disorder (30%), followed by infection (18%). Other cases consisted of skin tumor (15%), vesiculobullous (13%), connective tissue disease (7%), pigmentation disorders (5%), and vasculitis (5%). Diseases that could not be classified into 7 groups of the biopsy criteria were grouped separately in other diseases (7%).

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