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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 16 Documents
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Search results for , issue "Vol. 61, No. 1" : 16 Documents clear
DETECTION OF SEROTYPES AND KNOCKDOWN-RESISTANCE MUTATIONS IN DENGUE AND OTHER FLAVIVIRUS SAMPLES COLLECTED FROM MENGARE ISLAND, INDONESIA Dwiyanti, Tasya Amalia; Sucipto, Teguh Hari; Suhandarini, Khoirunnisa; Fathiarachman, Azizia Kanya; Nastiti, Helena Putri; Putri, Anika Rahma; Fauziyah, Shifa; Widiyanti, Prihartini; Hariyono, Hariyono; Rehman, Saifur
Folia Medica Indonesiana Vol. 61, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Dengue fever, caused by the dengue virus (DENV), poses a significant public health challenge, particularly in tropical regions. This study aimed to detect flavivirus presence, DENV serotypes, and knockdown-resistance (kdr) mutations in mosquito samples collected from Mengare Island, Gresik, Indonesia. A cross-sectional experimental design was employed, utilizing reverse transcription polymerase chain reaction (RT-PCR) for flavivirus detection and serotyping, as well as for identifying kdr mutations. Ribonucleic acid (RNA) extraction was performed using the Quick-RNA™ Miniprep Plus Kit (Zymo Research, Irvine, CA, USA), followed by RT-PCR with specific primers for DENV serotypes 1–4 and kdr mutations (V1016G and F1534C). Six adult female Aedes albopictus mosquitoes were analyzed in this study. The results revealed no evidence of flavivirus infection or DENV serotypes in the mosquito samples, as no complementary deoxyribonucleic acid (cDNA) bands corresponding to expected base pair sizes were observed on the agarose gels. Similarly, the analysis of kdr mutations showed that all samples were homozygous wildtype, with no mutations detected at the V1016G or F1534C loci. In conclusion, these findings suggest the absence of active dengue virus transmission or notable insecticide resistance in the studied mosquito population from Mengare Island. This study highlights the importance of continuous monitoring of flavivirus presence and resistance mutations. The variability in kdr mutation frequencies across regions underscores the need for sustained surveillance and effective control measures to mitigate potential outbreaks in high-risk areas such as Mengare Island.
DOUBLE BURDEN STRESS IN WOMEN AND THE ROLE OF PSYCHO-RELIGIOUS WORSHIP IN ALLEVIATING IT Putra, Fahmi Mandala; Ismah, Zata; Syahfitri, Rizky Indah; Nasution, Citra Cahyati; Putri, Az-zahra Atika; Amirah, Fitria; Helmi, Tri Amelia Rahmitha
Folia Medica Indonesiana Vol. 61, No. 1
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It has been recognized that women are twice as likely to experience depression compared to men. In addition to biological vulnerability, there is also a combined effect of bearing the burden of household responsibilities while contributing financially through employment. One coping strategy that helps women endure these challenges is meditation, which in Islam includes the practice of dhikr (remembrance of God). This study aims to analyze the phenomenon of double burden stress in women and how psychoreligious practices can help reduce stress levels. The study employed a prospective cohort design, tracking the respondents' dhikr habits over a 21-day period. On the final day, general stress levels and stress related to their professional roles were measured. The study involved 69 women participants aged 17 and above, comprising housewives as well as women who held dual roles as both teachers and students. Stress levels were assessed using the DASS-42 instrument. Respondents recorded the number of times they missed the istighfar recitation at specific times of the day on a control card. Findings indicated that women who are mothers and simultaneously hold dual roles as teachers and students are more vulnerable to stress. Further correlation tests revealed that missing istighfar after the Fajr prayer, before the Asr prayer, and after the Isha prayer was associated with increased stress levels. The predictive model showed that collectively missing istighfar at these three times (after Fajr, throughout daily activities, and the total missed times) significantly increased the likelihood of stress among women. The study concludes that women who have dual roles as mothers and teachers or students are the most vulnerable group to stress. Moreover, the more frequently istighfar is neglected at the recommended times, the higher the stress levels experienced by women.
EFFECT OF LOW INTENSITY AEROBIC EXERCISE ON VO2PEAK OF WOMEN WITH BREAST CANCER UNDERGOING CHEMOTHERAPY Novayanti, Etta; Wardhani, Indrayuni Lukitra; Narasinta, Inggar; Suprabawati, Desak Gede Agung; Pratiwi, Niken; Soebadi, Ratna Daryanti
Folia Medica Indonesiana Vol. 61, No. 1
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Abstract

Breast cancer treatments, particularly chemotherapy, have been associated with significant declines in cardiopulmonary fitness, a key determinant of functional independence and survival. VO2peak, a marker of cardiopulmonary function, is often reduced in patients undergoing chemotherapy, increasing morbidity risks. Researchers have proposed exercise interventions to mitigate these effects. However, most studies focused on moderate-to-high-intensity regimens, with limited data on the efficacy of low-intensity aerobic exercise. This study aimed to explore the impact of low-intensity cycle ergometer aerobic exercise on VO2peak in women undergoing chemotherapy for breast cancer. A randomized controlled trial with twenty participants randomly assigned to an intervention group (n = 10, low-intensity aerobic exercise twice per week for 8 weeks) or a control group (n = 10, usual care). VO2peak was estimated using the 30-Second Sit-to-Stand (30STS) test. Statistical analysis was performed using paired and independent t-tests, with effect size (Cohen’s d) calculated to assess clinical significance. The intervention group demonstrated a significant increase in VO2peak (Δ= +1.93 mL/kg/min, p < 0.001), while the control group showed a non-significant change (Δ= +0.25 mL/kg/min, p = 0.31). Between-group analysis suggested a significant difference in favour of the intervention (p = 0.02, Cohen’s d = –2.56), indicating a large effect size.
HOSPITAL LENGTH OF STAY IN SEPSIS PATIENTS ACROSS AGE, COMORBIDITY, AND INVASIVE DEVICE USE CATEGORIES Sutanto, Heri; Izzati, Alif Nurul; Mustika, Syifa
Folia Medica Indonesiana Vol. 61, No. 1
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Sepsis is a life-threatening condition caused by a dysregulated response of the body to infection. Sepsis is closely associated with high costs and prolonged length of hospitalization. The purpose of this study was to determine the correlation between sepsis risk factors and length of hospitalization for sepsis patients at Dr. Saiful Anwar Malang General Hospital. This study used a retrospective cohort approach with a sample size of 56 medical records. The study used inclusion criteria for sample selection. The analysis results in a p-value of 0.976 and an r-value of 0.004; the findings demonstrated a correlation between patient age and length of hospitalization. A p-value of 0.634 and an r-value of --0.065 indicated a correlation between comorbidities and length of hospitalization. The p-value was 0.101, and the r-value was 0.222, indicating a correlation with the use of intrusive devices. This result suggests that the length of hospitalization for sepsis patients at Dr. Saiful Anwar General Hospital in Malang was not significantly correlated with sepsis risk factors, including age, comorbidities, and the use of invasive devices. Therefore, it is also necessary to examine the admission diagnosis, the SOFA score, and the quantity and duration of invasive device use.
EXPLORING THE CORRELATION BETWEEN PUPIL DISTANCE AND MYOPIA PREVALENCE: AN OBSERVATIONAL BIOANTHROPOLOGY STUDY IN SURABAYA Kinasih, Anggitha Hayuning; Aditya, Dwi Martha Nur; Wicaksono, Y Adhimas Setyo
Folia Medica Indonesiana Vol. 61, No. 1
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Bioanthropology integrates biological and cultural perspectives, thereby enhancing our understanding of human health across populations. Myopia is a significant refractive error affecting potentially 2.5 billion people globally by the end of the decade. Bioanthropological theories suggest that pupil diameter and distance contribute to axial elongation and the progression of myopia. Nevertheless, current literature lacks empirical validation through rigorous hypothesis testing, highlighting a gap in comprehension. The research explores the relationship between pupil distance and the incidence of myopia via empirical assessments in Surabaya. An observational cross-sectional study was conducted, which involved pupil distance measurements and eye refraction assessments. Inclusion criteria required participants to provide informed consent, while those with other specific refractive disorders were excluded. The research utilized a Pupillary Distance Meter for precise measurement of the pupil distance. In addition, the refractive index was assessed using standard ocular instruments, including the Snellen Chart, Trial Lens, Trial Frame, and Occluder tool sets. The research employed a non-probability sampling method with a consecutive design. The sample size was determined using the formula for proportion estimation. The data was analyzed using the Chi-Square (CI = 95%) statistical method. The study comprised 298 individuals as participants, of which 229 were from the adult population (124 emmetropic and 105 myopic), and 69 individuals were from the elderly population (47 emmetropic and 22 myopic). Based on gender, the sample consisted of 117 males (113 emmetropic; 4 myopic) and 181 females (58 emmetropic; 123 myopic). The study statistically discovered that there was no significant association between pupil distance and myopia prevalence, with a p-value <0.05 (0.933), indicating a lack of correlation. The empirical data analysis indicates no evidence linking pupil distance to myopia incidence. The incongruence between the empirical findings of the study and the theoretical construct suggests an indirect association via axial elongation, an association that requires further inquiry.
TOWARD INDONESIA’S ZERO LEPROSY 2030: KEY LESSONS FROM EPIDEMIOLOGICAL TRENDS IN PAPUA 2020-2024 Sumolang, Inneke Viviane; Romadhon, Dimas Iqbal; Suyanto, Agnes Angelita
Folia Medica Indonesiana Vol. 61, No. 1
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Papua, the easternmost province of Indonesia, has consistently reported the highest number of new leprosy cases and leprosy-related disabilities for decades. Despite this burden, no comprehensive study in recent years has systematically examined the epidemiological trends of leprosy in Papua using large datasets. This study provides an updated analysis of leprosy elimination efforts and evaluates the province’s readiness to achieve the Zero Leprosy 2030 target. A retrospective descriptive epidemiological review was conducted using secondary data from the routine health information system of Papua Province from 2020 to 2024. Extracted variables included demographic characteristics, new case reports, diagnostic classification, disability grade, case-finding method, and clinical outcomes. Data were analyzed descriptively and presented in tables and figures to illustrate temporal trends. Between 2020 and 2024, a total of 3,909 new leprosy cases were reported, with fluctuating case detection rates. Multibacillary (MB) leprosy predominated, particularly among males, although females also contributed a substantial proportion of MB cases. Child cases showed an increasing trend, accounting for up to 20% of all new cases. Most cases were detected at Grade 0, with passive case finding as the dominant detection method. Treatment outcomes showed that approximately 70% of patients were released from treatment annually, but relapse and default remained considerable. These findings highlight that Papua is still far from reaching the Zero Leprosy 2030 goal. Strengthening active case finding, improving treatment adherence, reducing stigma, and enhancing reporting and evaluation systems are urgent priorities. Sustained political commitment from local leadership will be crucial to ensure the successful implementation of these strategies.

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