cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Made Krisna Adi Jaya
Contact Email
jpsa@unud.ac.id
Phone
+6281293208990
Journal Mail Official
jpsa@unud.ac.id
Editorial Address
Gedung Dekanat lantai 1, Fakultas MIPA, Universitas Udayana, Jl Kampus Bukit Jimbaran No 9A, Jimbaran, Badung-Bali.
Location
Kota denpasar,
Bali
INDONESIA
Journal Pharmaceutical Science and Application (JPSA)
Published by Universitas Udayana
ISSN : 23017694     EISSN : 23017708     DOI : https://doi.org/10.24843/JPSA.2025.v01.i01
Core Subject : Health, Science, Education, Social, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other
Journal Pharmaceutical Science and Application (JPSA) publishes high-quality original research articles, review articles, and short communications that contribute substantially to the advancement of knowledge in the field of pharmaceutical sciences and their applications. The journal welcomes interdisciplinary work that integrates basic and applied research relevant to drug discovery, development, and clinical use. Areas of interest include, but are not limited to: Pharmaceutical Technology Pharmaceutics Novel Drug Delivery Systems Biopharmaceutics and Pharmacokinetics Pharmaceutical/Medicinal Chemistry Computational Chemistry and Molecular Drug Design Pharmacognosy and Natural Product Research Pharmacology and Toxicology Pharmaceutical Analysis Pharmacy Practice Clinical and Hospital Pharmacy Community Pharmacy Cell Biology and Molecular Pharmacology Genomics, Proteomics, and Pharmacogenomics Bioinformatics and Biotechnology The journal is committed to disseminating impactful findings that enhance pharmaceutical knowledge and promote the development of safe, effective, and accessible therapies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 82 Documents
 2   3   4   5   6 
MONITORING DRUG THERAPY IN X’s PHARMACY IN BADUNG REGENCY Luh Pratiwi Diva Yanti; I Made Agus Gelgel Wirasuta; Luh Rai Maduretno Asvinigita
Journal Pharmaceutical Science and Application Vol. 3 No. 1 (2021): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2021.v03.i01.p03

Abstract

Background: Monitoring drug therapy based on Permenkes RI No. 73 of 2016 is one of the pharmaceutical care standards in pharmacy practice. Monitoring drug therapy is a process that includes activities to ensure safe, effective and rational drug therapy for patients. Patients who receive drug therapy are at risk of experiencing drug-related problems. Objective: This study aims to determine the implementation of monitoring drug therapy in one pharmacy in Badung Regency. Methods: The type of research is a descriptive observational study conducted by interview session one pharmacist in X Pharmacy, then analyzed descriptively according to Permenkes RI No 73 of 2016. Results: The results showed that in January-June 2020 there were 34 patients with disease categories requiring monitoring drug therapy: 27 patients with asthma (79%), six patients with diabetes (18%), and one patient with tuberculosis (3%). Patients with the largest visits were geriatric, which were 19 out of 34 patients. Conclusion: The monitoring of drug therapy at Pharmacy X has fulfilled all the parameters in the Standard Operating Procedure (SOP) for the implementation of in Pharmacy based on Permenkes RI No.73 of 2016. Keywords: Monitoring drug therapy, Implementation, Pharmacy, Pharmacist
A REVIEW OF PHYTOCHEMICAL PROPERTIES, ANTIBACTERIAL ACTIVITY, AND TOXICITY STUDY OF Averrhoa bilimbi LEAVES AND FRUIT Intan Safitri; Ni Putu Eka Leliqia
Journal Pharmaceutical Science and Application Vol. 3 No. 1 (2021): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2021.v03.i01.p04

Abstract

Background: Averrhoa bilimbi or starfruit is a plant that is commonly found in Indonesia. A. bilimbi is widely used as herbal therapy against various diseases, especially those caused by bacteria. Objective: This article is intended to provide information regarding the chemical content of A. bilimbi, its antibacterial potential, and its safety level. Methods: The preparation of this article used a systematic literature review method of articles that have been published in both national and international scientific journal. Result: Leave and fruit of A. bilimbi is known to contain several classes of primary and secondary metabolites, namely carbohydrates, proteins, fats, flavonoids, alkaloids, glycosides, saponins, tannins, triterpenoids, and steroids. A. bilimbi also contains several macros and micro minerals including calcium (Ca), magnesium (Mg), and zinc (Zn). A. bilimbi could inhibit the growth of various Gram positive and negative bacteria which have been proven through in vitro testing with diffusion and dilution methods. Based on the acute toxicity study, it was found that 80% ethanol extract of A. bilimbi fruit had an LD50 value of above 5.000 mg/kg BW so that it is practically non-toxic. Based on sub-chronic toxicity of A. bilimbi up to a dose of 500 mg/kg BW there was no death in the test animals and shows a toxic effect. Conclusion: The leaves and fruit of A. bilimbi have antibacterial activities. The compounds contained in A. bilimbi are thought to have a role in its antibacterial activity. Based on several toxicity studies, the ethanol extract of A. bilimbi has been proven safe to use. Keywords: Averrhoa bilimbi; Starfruit; Antibacterial; Chemical Properties; Toxicity.
A REVIEW OF PHYTOCHEMICAL AND PHARMACOLOGICAL STUDIES OF Piper retrofractum Vahl. Ni Komang Sri Lumbung Artha Wardani; Ni Putu Eka Leliqia
Journal Pharmaceutical Science and Application Vol. 3 No. 1 (2021): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2021.v03.i01.p05

Abstract

Background: Javanese long pepper (Piper retrofractum Vahl.) is a plant that commonly found in Southeast Asia and is empirically used to treat various diseases. It is known that the phytochemical content in plants is one factor responsible for its pharmacology activities. The study of the pharmacological effects of herbal ingredients both pre-clinically and clinically is an attempt to prove their empirical properties. Objective: This review article aims to provide information to academics and the public regarding phytochemical studies and pharmacological activity that have been carried out regarding the Javanese long pepper plant. Methods: Article preparation was carried out through literature studies from various national scientific journals, international journals, and online reference books. Javanese long pepper data search system was based on chemical content and pharmacological activity studies either in vitro, in vivo, or clinical trials. Results: Phytochemical studies have shown that the plant parts of Javanese long pepper contain compounds such as alkaloids, saponins, tannins, flavonoids, steroids, triterpenoid, and glycosides. Based on studies of its pharmacological activity, Javanese long pepper has been reported to have antimicrobial, antioxidant, cytotoxic, analgesic, androgenic, aphrodisiac, antihyperlipidemic, antihyperuricemic, lowering leukocyte count, antileishmanial and immunostimulant effects. Conclusion: The efficacy of Javanese long pepper has been scientifically proven to have pharmacological effects either through in vitro or clinical studies which can be taken into consideration for the development of traditional medicinal products. Keywords: Javanese Long Pepper, Piper retrofractum, Phytochemical, Pharmacology activity
PHARMACIST’S ROLE IN MEDICATION RECONCILIATION TO PREVENT THE RISK OF MEDICATION ERROR AT BALI MANDARA HOSPITAL Ida Ayu Manik Partha Sutema; IBN Maharjana
Journal Pharmaceutical Science and Application Vol. 3 No. 1 (2021): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2021.v03.i01.p06

Abstract

Background: Pharmacists have an important role in implementing drug reconciliation. The implementation of drug reconciliation allows the process of identifying drug administration errors due to information gaps, which we can avoid by optimizing information as early as possible at every shift in the process of providing health services through the reconciliation process. This process is crucial, especially for groups of patients with chronic diseases who have a high risk of changing health care delivery settings. Failure to identify results in errors in administering drugs that lead to worsening clinical conditions, resulting in increased service needs and health costs. Objective: Provides information about the tendency of pharmacists who work at the UPTD Bali Mandara General Hospital to reduce drug use errors through the drug reconciliation program. Methods: Thematic analysis of structured interview results. Results: Almost all participants (6 out of 8 pharmacists) tend to be willing to be involved in the drug reconciliation process. There are three main themes of consideration that underlie the tendency of pharmacists to be willing to be involved in the drug reconciliation process, namely, related to understanding the definition, purpose, and consistency of the implementation of reconciliation. In controlling the incidence of medication errors, the biggest preventable errors through medication reconciliation are drug duplication and drug discrepancy. Conclusion: The tendency for pharmacists to be involved is good, and the tendency to control the risk of medication errors is still lacking in terms of communication and consistency in filling out by all officers. Keywords: Pharmacist’s role; drug reconciliation; risk of medication errors
REVIEW OF POTENTIAL PLANTS IN INDONESIA AS AN ANTIDIABETIC WITH HYPOGLYCEMIC ACTIVITIES Mutiarani Dasha Hanggaresty; Ni Kadek Warditiani
Journal Pharmaceutical Science and Application Vol. 3 No. 2 (2021): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2021.v03.i02.p01

Abstract

Background: Diabetes mellitus, which is characterized by hyperglycemia, is a metabolic disease due to insulin action, defects in insulin secretion, or both. Various studies have shown that herbs that have a hypoglycemic effect can be used in the treatment of diabetes mellitus. Generally, herbs can slow down the complications of diabetes mellitus and improve metabolism. The ability of plants to restore the function of pancreatic tissue to increase insulin production or make it easier for insulin to process glucose is related to the effects of hypoglycemia. Objective: Comparing plants that have a hypoglycemic activity that can be used in the treatment of diabetes mellitus in Indonesia. Methods: studying literature from various databases, websites, national journals, and relevant international journals to identify plants that have hypoglycemic activity. Results: The mechanism A. sativum as a hypoglycemic involves different fiber viscosities; A. vera involved as a hypoglycemic by protecting pancreatic β cells; Asiatic acid in C. asiatica increasing glycolysis by restoring the activity of key enzymes; G. max inhibiting α-amylase and the stigmasterol increasing the absorption of blood glucose and reducing insulin resistance; P. macrocarpa exert their antidiabetic action via α-glucosidase modulation, an extra distinctive pancreatic mechanism; S. arvensis has the potential to inhibit ɑ-amylase enzymes. Conclusions: This review article has presented 6 details of plants that have a hypoglycemic activity that can be used in the treatment of diabetes mellitus in Indonesia, and we believe it can be useful for students, researchers, or practitioners. Keywords: Diabetes mellitus; hypoglycemia; Indonesian plants
STUDY OF PHARMACEUTICAL INVENTORY CONTROL SYSTEM IN SEVERAL PHARMACIES IN KARANGASEM, BALI I Made Ari Anata; I Made Agus Gelgel Wirasuta
Journal Pharmaceutical Science and Application Vol. 3 No. 2 (2021): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2021.v03.i02.p02

Abstract

The control of pharmaceutical products is one of the pharmaceutical services at the Pharmacy that is regulated in Permenkes RI No. 73 of 2016. The pharmacy control of each pharmacy must always apply the principles stated in the Good Pharmacy Practice (GPP) guidelines. GPP is a pharmaceutical practice that responds to the needs of people who use pharmacist services to provide optimal and evidence-based care. This study aims to determine the system of one of the pharmaceutical service standards, namely the control of pharmaceutical products in several pharmacies in Karangasem, Bali. This type of research is observational descriptive. Data retrieval is carried out in a retrospective manner related to the pharmaceutical product control system in the form of an order or procurement, dispensing, and handling system. Most pharmacies are researched to apply the same control system in the procurement and spending of pharmaceutical products. Only the pharmaceutical product system for handling parts has a slight difference in each pharmacy. Keywords: forensics; control; pharmaceutical products; pharmacies; pharmacists
IDENTIFICATION OF PUBLIC MEDICINE STORAGE PROFILE IN THE COMMUNITY PHARMACY: A SYSTEMATIC REVIEW Kadek Valentina Renita Dewi; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol. 3 No. 2 (2021): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2021.v03.i02.p03

Abstract

Background: Drug is the most common form of therapy and an integral part of almost all levels of care. The conditions and proper way of storing medicines at home are important aspects of safe and effective drug treatment. Information about the knowledge of patients with appropriate storage conditions, rational drug use, appropriate drug use and management of various drugs is essential in helping pharmacists identify which medicinal products and aspects of home storage require more attention when counseling patients. Objective: The aim of this systematic review is to identify and characterize the mode of storage associated with home-stored pharmaceuticals. Methods: This systematic review analyzes the storage methods for medicines to identify and characterize the storage methods associated with medicines stored at home. The limitation of publication used, namely English and Indonesian in the last 10 years, and obtained through literature that can be considered relevant. Result: This systematic review was conducted in the period July, August, September 2020 - February 2021. As many as 20 journals were obtained. Those who met the inclusion criteria were 10 journals. Of the 10 journals that had met the inclusion criteria, 3 journals were excluded so that only 7 journals were used in literature review / systematic review.Storage of medicines in the household is based on the presence of family members who have certain diseases so that they have to consume drugs in the long term, the presence of health workers, and the education level of family members. Problems that can arise with drug storage conditions are impaired drug stability and can accelerate drug degradation prematurely. Storage of medicines in the medicine cabinet and out of reach of children is highly recommended. Placement of drugs in one place without being separated and a lack of awareness in administering specific markings can increase drug administration errors and lead to noncompliance with over-the-counter drug use. The application of drug management in the family can improve the quality of life and avoid the adverse effects of drug misuse. Conclusion: This study raises relation to medicines stored inside homes that warrant addressing that need pharmacists regarding public education in relation to drug therapy that goes beyond the dispensing process. Judging by the fnding that pharmacists were not considered primary sources of drug-related information. The good practices should be encouraged through continued health education at health institutions and medicine retail outlets. Keywords: Drugs; Storage; Household
THE IMPLEMENTATION OF INDONESIA HEALTH MINISTER REGULATION RELATED TO STERILIZED DISPENSING IN "X" HOSPITAL IN GIANYAR-BALI Ni Luh Putu Lestari Dewi; Ni Made Ari Ginarsih; I Made Agus Gelgel Wirasuta
Journal Pharmaceutical Science and Application Vol. 3 No. 2 (2021): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2021.v03.i02.p04

Abstract

The application of Regulation of the Minister of Health Number 72 of 2016 is very important to be implemented in every Pharmacy Installation in a hospital, one of which is in the clinical pharmacy service section, namely dispensing sterile preparations to avoid the possibility of medication errors. The research aimed to find out how the implementation of Regulation of the Minister of Health Number 72 of 2016 stipulated in the basic guidelines of aseptic techniques related to space, equipment, and the implementation of dispensing sterile preparations with its practice in Hospital "X" Gianyar, Bali. This research used Sequential Explanatory design by combining quantitative and qualitative methods. The results of quantitative research with a checklist found the percentage of completeness of the room and equipment by 100%, while the conformity of the practice with the guidelines of 76.48% is appropriate. The results of qualitative research with triangulation matrices that practice is by the guidelines. Dispensing sterile preparations at the Hospital "X" is following the basic guidelines of aseptic techniques that refer to Regulation of the Minister of Health Number 72 of 2016. Keywords: implementation; regulation; dispensing; sterile preparations; guidelines; medication errors
ANALYSIS OF POTENTIAL INTERACTIONS OF RAMIPRIL - AMBON BANANA (Musa paradisiaca var. sapientum (L.) Kunt.) ON HYPERKALEMIA RISK IN WHITE RATS I Gusti Ayu Sintia Dewi; Ni Putu Rutin Seciolini Agristy; Ida Ayu Gendari; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol. 3 No. 2 (2021): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2021.v03.i02.p05

Abstract

Introduction: Drug and food interaction is a condition in which nutritional factors present in food have a significant influence effect on drug therapy, both potentially increasing or decreasing the effect of drug therapy. Indonesian people have a habit of taking medicine by using food or drink. Bananas are the primadonna that is often consumed to speed up the swallowing process and reduce the bitter taste of medicine. It turns out that the consumption of bananas together with ACE inhibitors can increase the risk of hyperkalemia. Lack of information about the effects caused by drug and food interactions, so it is necessary to do related research. Objective: This study aims to determine the interaction of giving ramipril together with Ambon banana on the risk of hyperkalemia. Methods: A real experimental study while still adhering to the Covid'19 health protocol. White rats were divided into four groups, conditioned by hypertension, then intervened with ramipril and Ambon banana. Blood serum was taken and analyzed using UV spectrophotometry to obtain serum potassium levels. The levels obtained were analyzed using the One Way ANOVA Test. Results: The mean serum potassium level of the positive control group was 4.93±0.58; negative control 4.13±0.60; normal control 4.76±0.59 and treatment 5.10±0.38. The highest serum potassium level was in the ramipril treatment group together with Ambon banana, but still in the normal range of 3.60– 5.50 mmol/L. One Way Anova test results (p = 0.054). (p>0.05) showed no significant difference. Conclusion: There is no specific increase in levels of ramipril concurrently with Ambon banana so it does not have the potential to cause the risk of hyperkalemia. Keywords: Drug Interaction; Ramipril; Ambon Banana; Serum Potassium; Hyperkalemia
ANTIBACTERIAL ACTIVITY TESTING OF HAND SANITIZER GEL EXTRACT OF CORIANDER (CORIANDRUM SATIVUM L.) SEEDS AGAINST STAPHYLOCOCCUS AUREUS Kadek Sutri Ariyanthini; Elisabeth Angelina; Kadek Nanda Banyu Permana; Fiorenza Jocelyn Thelmalina; I Gusti Ngurah Jemmy Anton Prasetia
Journal Pharmaceutical Science and Application Vol. 3 No. 2 (2021): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2021.v03.i02.p06

Abstract

Background: Staphylococcus aureus is a bacterium that causes bacteremia in COVID-19 pneumonitis patients. S. aureus is responsible for 80% of suppurative disease, with the skin surface as its natural habitat. So, maintaining hand hygiene during a pandemic is very important. Currently, people prefer the use of practical hand sanitizers. Most hand sanitizers contain alcohol, which has the potential to irritate. Thus, the active substance of coriander seed extract is used as a substitute for alcohol. Objective: To determine the characteristics of the gel and the concentration of coriander seed extract which gave antibacterial effect against S. aureus. Methods: The resulting hand sanitizer gel was then tested for characteristics and antibacterial activity against Staphylococcus aureus by the Kirby-Bauer diffusion method and analyzed by the One Way Anova-LSD method. Result: The results showed that preparations with concentrations of F1(2%), F2(4%), and F3(6%) respectively had inhibition zones of 1.00 ± 0.82 mm, 5.00 ± 0.41 mm, and 5 .25 ± 1.26 mm. Conclusion: Formulas 2 and 3 were able to inhibit the growth of S. aureus with moderate inhibition category. The hand sanitizer gel meets the requirements for organoleptic tests, pH, homogeneity, dispersibility, and adhesion. However, the viscosity of the preparation did not meet the requirements. Keywords: Coriander Seed Extract; Gel Hand Sanitizer; Antibacterial

Page 4 of 9 | Total Record : 82

 2   3   4   5   6 

Filter by Year

2012 2026


Reset
Filter By Issues
All Issue Vol. 8 No. 1 (2026): Journal Pharmaceutical Science and Application (JPSA) Vol. 7 No. 2 (2025): Journal Pharmaceutical Science and Application Vol. 7 No. 1 (2025): Journal Pharmaceutical Science and Application Vol. 6 No. 2 (2024): Journal Pharmaceutical Science and Application (JPSA) Vol. 6 No. 1 (2024): Journal Pharmaceutical Science and Application (JPSA) Vol. 5 No. 2 (2023): Journal Pharmaceutical Science and Application (JPSA) Vol. 5 No. 1 (2023): Journal Pharmaceutical Science and Application (JPSA) Vol. 4 No. 2 (2022): Journal Pharmaceutical Science and Application (JPSA) Vol. 4 No. 1 (2022): Journal Pharmaceutical Science and Application (JPSA) Vol. 3 No. 2 (2021): Journal Pharmaceutical Science and Application (JPSA) Vol. 3 No. 1 (2021): Journal Pharmaceutical Science and Application (JPSA) Vol. 2 No. 2 (2020): Journal Pharmaceutical Science and Application (JPSA) Vol. 2 No. 1 (2020): Journal Pharmaceutical Science and Application (JPSA) Vol. 1 No. 1 (2012): Journal Pharmaceutical Science and Application (JPSA) More Issue