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Made Krisna Adi Jaya
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Journal Pharmaceutical Science and Application (JPSA)
Published by Universitas Udayana
ISSN : 23017694     EISSN : 23017708     DOI : https://doi.org/10.24843/JPSA.2025.v01.i01
Core Subject : Health, Science, Education, Social, Engineering,
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other
Journal Pharmaceutical Science and Application (JPSA) publishes high-quality original research articles, review articles, and short communications that contribute substantially to the advancement of knowledge in the field of pharmaceutical sciences and their applications. The journal welcomes interdisciplinary work that integrates basic and applied research relevant to drug discovery, development, and clinical use. Areas of interest include, but are not limited to: Pharmaceutical Technology Pharmaceutics Novel Drug Delivery Systems Biopharmaceutics and Pharmacokinetics Pharmaceutical/Medicinal Chemistry Computational Chemistry and Molecular Drug Design Pharmacognosy and Natural Product Research Pharmacology and Toxicology Pharmaceutical Analysis Pharmacy Practice Clinical and Hospital Pharmacy Community Pharmacy Cell Biology and Molecular Pharmacology Genomics, Proteomics, and Pharmacogenomics Bioinformatics and Biotechnology The journal is committed to disseminating impactful findings that enhance pharmaceutical knowledge and promote the development of safe, effective, and accessible therapies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 82 Documents
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ANTI-INFLAMMATORY ACTIVITY OF PEGAGAN LEAVES (Centella asiatica (L.) Urban) EXTRACT CREAM Siti Mardiyah
Journal Pharmaceutical Science and Application Vol. 4 No. 1 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i01.p02

Abstract

Background: Pegagan leaves (Centella asiatica (L.) Urban) is an herbal plant family of Apiaceae containing the active ingredients of the triterpenoid group glycosides (asiaticoside, Asiatic acid, madekasat acid, madikassosida) centelloside, flavonoids and Asiatic acids. Inflammation is a complex reaction in tissues that involves a response to blood vessels and leukocytes. Objective: The purpose of this study was to find out the anti-inflammatory activity that occurs in the legs of mice in the form of preparation of pegagan extract cream (Centella asiatica (L.) Urban). Methods: Pegagan extract is done by the maceration method that uses ethanol 70%. Test animals used to squeak white males as much as 10 heads with a body weight of 20-30 grams. Test animals were divided into 5 treatment groups, namely the pegagan extract group with a dose of 2 g/kg BB; 4 g/kg BB; 6 g/kg BB, positive control (Betason cream 0.1%), and negative control (pegagan extract 2 g/kg BB). 1 hour before treatment of squeaky soles is inducted with a 1% carrageenan solution subplantarically. Results: Measurement of edema volume on the soles of the feet of mice is observed every 1 hour for 6 hours. The results showed that pegagan extract cream with a dose of 6 g / kg BB showed the maximum percentage of inhibition edema that is at the 6 hour with a result of 80,2%. The results of the data analysis of the percentage of inhibition of Centella asiatica extract from the treatment group Negative Control-Formula II and Negative Control-Formula III showed significant differences (p<0.05). Conclusion: Pegagan leaves extract has an antiinflammatory effect on feet of mice. Keywords: Anti-inflammatory; Pegagan leaves; Centella asiatica (L.) Urban
THE EFFECTIVENESS TEST OF INFUSION CELERY ROOT (Apium graveolens L.) AS A DIURETIC IN WISTAR MALE WHITE RATS (Rattus Norvegicus): A LITERATURE STUDY Ida Ayu Dhea Rahnia; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol. 4 No. 1 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i01.p03

Abstract

Background: Hypertension is defined by persistently elevated arterial blood pressure. The increase in systolic blood pressure is generally>140mmHg or diastolic blood pressure> 90mmHg. The prevalence of hypertension increases with lifestyle changes. Objective: To determine the diuretic effect of celery (Apium graveolens L.) on male wistar rats (Rattus norvegicus). Methods: This research uses a literature study method, the type of the research is descriptive qualitative with literature research (library research) systematic. Results: Based on research data, there were 5 groups of mice that received different treatments. Among the five treatment groups, 0.5 % CMC suspension (KP-) showed the least mean cumulative urine volume, and furosemide suspension (KP+) showed a large mean cumulative urine volume when compared to negative controls. Conclusion: Celery root infusion can increase urine volume, because it contains flavonoids that play a role in increasing urine volume (diuresis). Keywords: Diuretic; Celery (Apium graveolens L.); Furosemide; Hypertension; Wistar rats
ACTIVITY OF BAY LEAF EXTRACT (Eugenia polyantha) AS ANTIINFLAMMATORY IN WHITE RAT (Rattus norvegicus): NARRATIVE REVIEW Ida Ayu Nadia Kusumastuti; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol. 4 No. 1 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i01.p04

Abstract

Background: Inflammation is the body's defense response against foreign body invasion, tissue injury, or both caused by microorganisms, mechanical trauma, chemical compounds, and physical factors. Anti-inflammatory agents can be used to treat inflammation. Bay leaves are one example of a plant that can be used. Ethanol extract and water extract of a bay leaf can be anti-inflammatory because they contain flavonoids. Objectives: The purpose of this study was to see how effective ethanol extract and aqueous extract of bay leaf were as antiinflammatory agents in mice. Methods: This study employs a systematic literature review approach, descriptive qualitative research, and library research. Results: The most efficacious dose was 150 mg/kg BW at a 70 percent concentration and at an 80 percent concentration for ethanol extract of bay leaves, and 50 mg/kg BW for the aqueous extract of bay leaves. Conclusion: Based on the results of this study, it can be concluded that bay leaf (Eugenia polyantha) ethanol extract and aqueous extract have anti-inflammatory activities. Keywords: Anti-inflammatory; Bay Leaf; Diclofenac sodium; Ethanol Extract; Aqueous
THE POTENTIAL OF FRANGIPANI FLOWER EXTRACT (Plumeria alba L.) AS AN ANTIBACTERIAL: A LITERATURE REVIEW Hana Yuniestica Sinaga; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol. 4 No. 1 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i01.p05

Abstract

Background: Bacteria develop naturally in the human body to aid in protecting the individual. Antibiotic resistance is quickly increasing and is becoming a global health concern. In this situation, the risk of synthetic antibiotic resistance against bacterial infections makes it critical to find alternative medications that are safe, easy to obtain, and better than synthetic antibiotic alternatives. The frangipani plant is one of the medicinal plants used in traditional medicine as an antibacterial. The frangipani plant possesses antibacterial properties comparable to broadspectrum medicines against uro-gastro pathogens. Objective: The purpose of this study was to determine the activity of the frangipani flower as an antibacterial. Methods: studying literature from various databases, websites, national journals, and relevant international journals to identify frangipani flowers with antibacterial activity. Results: Results showed that frangipani flowers have antibacterial activity against gram-positive and gram-negative bacteria because frangipani flowers contain various antibacterial chemical components, such as terpenoids, saponins, phenols, flavonoids, tannins, and essential oils. Conclusion: Frangipani flowers have the potential to an antibacterial against gram-positive and gram-negative bacteria. Keywords: Frangipani flower; Antibacterial; Bacteria
ANTI-INFLAMMATORY ACTIVITIES OF PEPEROMIA PELLUCIDA [L.] KUNTH.: A REVIEW I Gusti Agung Ayu Kartika; Ni Ketut Sinarsih; Ni Made Dwi Mara Widyani Nayaka
Journal Pharmaceutical Science and Application Vol. 4 No. 1 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i01.p06

Abstract

Background: Inflammation is a natural body response, but when it reaches the systemic chronic inflammation stage, it can cause more dangerous complications. Many natural ingredients have been developed as anti-inflammatory agents. One of them is sirih bumi (Peperomia pellucida [L.] Kunth). Objective: This study aims to summarize and examine the research results related to the anti-inflammatory activity of the sirih bumi. Methods: Research articles were collected from various online databases such as Google Scholar, Google, Medline, Pubmed, and Science Direct. Inclusion and exclusion criteria were applied to obtain original research articles relevant to the desired topic, published in the last ten years, the full text was accessible, and the research methods and results were well explained and valid. Results: In total, only six articles are eligible to be discussed. The research was conducted in Indonesia, Nigeria, and Malaysia. In vitro and in vivo methods with various models and parameters were used to test the anti-inflammatory activity. All parts of the plant are proven to have anti-inflammatory effects that can be presented in extracts or herbal teas. The activity of sirih bumi is determined by the dose or concentration of administration, processing process, and harvest time. The combination with other samples must be reconsidered to maintain the desired anti-inflammatory effect. Conclusion: Antiinflammatory activity of sirih bumi has been proven through various studies. The development of the sirih bumi product is expected to help handle inflammation and other diseases related to inflammation. Keywords: peperomia pellucida; inflammation; extract; tea
THE CORRELATION OF PHARMACEUTICAL SERVICES TO THE LEVEL OF SATISFACTION WITH COVID-19 VACCINATION PARTICIPANTS IN RS TINGKAT II UDAYANA Iwan Saka Nugraha; Wahyuni W Udi
Journal Pharmaceutical Science and Application Vol. 4 No. 2 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i02.p01

Abstract

Background: The obligation to vaccinate against Covid-19 in an effort to prevent national COVID transmission is contained in Presidential Regulation No.99 of 2020. Healthy, safe and quality COVID-19 vaccination services can be realized with pharmaceutical services. Objective: This research aims to study the correlation of pharmaceutical services to the level of satisfaction after the covid-19 vaccination at RS Tingkat II Udayana. Methods: The research design was a Cross-Sectional study which used an analytical survey. The population in the study was all participants of the COVID-19 vaccine in June at RS Tingkat II Udayana, which consisted of 500 participants. The sample in this study was obtained by using the total sampling method. Data collection in this study used primary data. Data analysis is carried out univariately and bivariate. Results: The results of the study found that vaccination participants were satisfied with pharmaceutical services, as shown from the comparison of services received and patient expectations. There is a relationship between pharmaceutical services, variables of guarantee, empathy, and physical evidence to the satisfaction of COVID vaccination participants at RS Tingkat II Udayana. Conclusions: variables of guarantee, empathy, and physical evidence have a significant correlation with the satisfaction of vaccination participants. Keywords: Pharmaceutical Services; Satisfaction; Vaccination
FIGURE OF POTENTIAL MEDICATION ERROR IN MEDICINE PRESCRIPTION FOR OUTPATIENT SERVICES OF "X" HOSPITAL IN BALI Dewa Gede Wahyu Nuryatama; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol. 4 No. 2 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i02.p02

Abstract

Background: Medication errors (ME) in health services; in this case, hospitals are supposed to have zero accidents. Evaluation of the potential ME, such as doctor's prescription writing, must still be carried out in an effort to maintain service quality, especially in maintaining patient safety or preventing medication errors. Objective: This research aimed to see the figure of potential medication errors that occur in the prescribing process, in this case, is related to the completeness of the prescription seen from the administration and pharmaceutical approach, as well as the legibility of the prescriptions originating from outpatient services at one of the hospitals in Bali. Methods: This research was observational with a qualitative descriptive approach. Data collection was carried out retrospectively through medication prescriptions for patients received by pharmaceutical installations for outpatient services at hospitals from July until October 2022, totaling 110 prescriptions. Results: Results showed that 1.8% of prescriptions still did not write down the patient's name, then 9.1% of prescriptions had not written down the patient's age, 21.8% of prescriptions had not written down the patient's gender, and as many as 93.6% of prescriptions did not include the patient's weight, 2.7 % of prescriptions did not include the name of the doctor, 75.5% of the prescriptions did not include the doctor's SIP number, 1.8% of the prescriptions still did not write down the rules for using the drug, 10.9% of the prescriptions did not write down the strength of the drug dosage and 19.1% of the prescriptions did not provide information about dosage form to be administered to the patient. This study also shows 8.9% of the prescriptions are Illegible prescription. Conclusion: The results of the research found that administratively and pharmaceutically incomplete prescriptions and also Illegible prescription writing were still found. So the results of this study show how important it is to always evaluate the potential of medication errors, especially at the prescribing and transcribing phases, to improve patient safety. Keywords: Medication error; Prescription; Hospital; Retrospective
THE EFFECT OF EDUCATIONAL LEAFLET USING BLOOD ADDED TABLETS ON THE KNOWLEDGE LEVEL OF PREGNANT MOTHER PATIENTS WITH ANEMIA AT PUSKESMAS 1 JEMBRANA I Gusti Ayu Diah Candra Dewi; Ida Ayu Manik Partha Suthema; I Gede Suasnawa
Journal Pharmaceutical Science and Application Vol. 4 No. 2 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i02.p03

Abstract

Background: Anemia in pregnancy is a condition where the hemoglobin (Hb) level is less than 11gr/dl in women who are pregnant. Providing education through leaflets to pregnant women is expected to help prevent anemia during pregnancy. Objective: The purpose of this study was to determine the effect of providing education on the use of blood supplement knowledge on the level of knowledge of pregnant women with anemia at Puskesmas I Jembrana in 2022. Methods: The research design used in this study was a quantitative study with a pre-experimental design approach of Groups Pretest-Posttest. The sampling technique used was total sampling with 67 pregnant women with anemia. Results: The results of this study revealed that there was an effect of leaflet education on the use of blood-added tablets on the knowledge level of pregnant women with anemia at Puskesmas 1 Jembrana with a pvalue of 0.000 < (0.05) and a mean difference in the pretest and posttest values of 5.43. Conclusion: There is a significant effect between the level of knowledge about the use of blood steadfast tablets and the incidence of anemia in pregnant women. It is hoped that the public, especially pregnant women, will pay more attention to their condition and always consult health workers regarding the use of blood-added tablets. Keywords: Anemia; Leaflet; Knowledge
PERCEPTION OF HYPERTENSION PATIENTS ON THE USE OF HERBAL DRUGS IN COMPLEMENTARY THERAPY OF HYPERTENSION IN DENPASAR CITY Califia Ersa Vinata; Ni Putu Aryati Suryaningsih; Made Karma Maha Wirajaya
Journal Pharmaceutical Science and Application Vol. 4 No. 2 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i02.p04

Abstract

Backgrounds: Hypertension or Silent killer is a condition when the systolic pressure is measured 140 mmHg or the diastolic pressure is measured 90 mmHg. The prevalence of hypertension in Denpasar City is still quite high, with an estimated 177,627 hypertension sufferers in Denpasar City in 2019. One alternative treatment that can be an option to lower blood pressure is herbal therapy. Herbal therapy is complementary therapy using medicinal plants. Objective: The purpose of this research is to identify the characteristics of respondents, the perception of hypertension sufferers on the use of herbal medicines in the complementary therapy of hypertension and the types of herbs used in complementary therapy of hypertension. The type of research used is descriptive research with using a quantitative approach. Methods: Sampling technique is purposive sampling. The research sample is hypertensive patients who use conventional and complementary herbal combination therapy, age >17-65 years, using a research instrument in the form of a questionnaire. Data analysis is carried out using SPSS software. Results: The majority of hypertension sufferers are in the age range of 46-65 years (elderly) as many as 71 people (71%), female as many as 57 people (57%). Respondents who have a positive perception of 55% and who have a negative perception of 45%. The types of herbs used are cucumber, melon, watermelon, celery leaves, bay leaves, moringa leaves, meniran leaves, garlic and Ginger. Conclusion: The majority of hypertensive patients perceptions of drug use herbs in the complementary therapy of hypertension has a positive value. That means, respondents believe that herbs have benefits and can help reduce treatment costs. The most widely used types of herbs are:cucumber (40%) and celery leaves (30%). Keywords: Hypertension; Perception; Complementary Therapy
ANTIBIOTICS USAGE OVERVIEW IN ORTHOPEDIC SURGERY PATIENTS AT A HOSPITAL IN BALI Putu Ary Pudak Wangi; Made Krisna Adi Jaya
Journal Pharmaceutical Science and Application Vol. 4 No. 2 (2022): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2022.v04.i02.p05

Abstract

Backgrounds: Antibiotic resistance can be prevented by controlling the use of antibiotics wisely. Based on WHO recommendations, controlling the use of antibiotics is done by grouping antibiotics with the AWaRe category. Objective: This work aims to present an overview of the use of antibiotics in orthopaedic surgery patients as an effort to monitor the use of antibiotics in a hospital in Bali. Methods: Based on the patient's medical record data, the antibiotics used for orthopaedic surgery were calculated and grouped with the AWaRe classification. Results: Results showed that the most prescribed antibiotic was ceftriaxone (84.74%). There were no antibiotics in the reserve category, but the highest percentage was 94.92% in the watch category, and the access category was 5.08%. Conclusion: There is still non-selective use of antibiotics in this hospital, so in the future, it is necessary to evaluate qualitatively and quantitatively to ensure rational use as well as efforts to prevent the occurrence of antibiotic resistance. Keywords: Antibiotics; Resistance; AwaRe; Hospital; Bali

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