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BioHealth
Published by Institut Kesehatan dan Teknologi Al Insyirah
ISSN : 31098444     EISSN : 31105629     DOI : 10.35328
Core Subject : Science, Engineering,
Computer Science & IT Control & Systems Engineering Electrical & Electronics Engineering Engineering
Biomedical and Environmental Health Technology Journal is more than just an academic publication it is a catalyst for healthcare transformation Born from the visionary spirit of the Al Insyirah Institute of Health and Technology we stand at the forefront of innovation in the fields of Medical Electronics Biomedical Engineering Medical Informatics and Environmental Engineering bridging the gap between cutting edge research and real world healthcare solutions Our mission is revolutionizing healthcare through science In an era where healthcare challenges demand revolutionary solutions BioHealth Journal serves as the nexus where brilliant minds converge to share groundbreaking discoveries We are not just publishing research we are shaping the future of healthcare one breakthrough at a time
Arjuna Subject : Teknik (semua kategori) - Teknik Listrik dan Elektro
Articles 22 Documents
 1   2   3 
Analysis of the Potential of Bioactive Compounds in Benincasa hispida as Candidate GST-Targeting Drugs through an In Silico Study Rezka amalia; Arafah Nurfadillah
Biomedical and Environmental Health Technology Vol 3 No 1 (2026): Biomedical and Environmental Health Technology (BIOHEALTH)
Publisher : Institut Kesehatan dan Teknologi Al Insyirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35328/1hf94r52

Abstract

Gastrointestinal Stromal Tumor (GIST) merupakan jenis tumor mesenkimal yang paling sering ditemukan pada saluran pencernaan. Terapi lini kedua saat ini menggunakan Sunitinib, namun obat ini memiliki profil efek samping hematologi dan non-hematologi yang cukup luas. Oleh karena itu, pengembangan terapi alternatif berbasis bahan alam seperti Benincasa hispida yang kaya akan senyawa bioaktif sangat diperlukan. Penelitian ini bertujuan untuk mengevaluasi potensi senyawa bioaktif dari B. Hidpida sebagai kandidat obat penarget GIST melalui pendekatan in silico. Penelitian dilakukan secara komputasi (in silico) dengan tahapan meliputi prediksi aktivitas biologis menggunakan PASS Online, uji drug-likeness berbasis SwissADME, serta simulasi molecular docking menggunakan PyRx dan Biovia Discovery Studio terhadap protein target Platelet-Derived Growth Factor Receptor Alpha (PDGFRA). Hasil analisis PASS Online menunjukkan bahwa senyawa Isomultiflorenyl acetate memiliki nilai aktivitas potensial (Potential Activity/Pa) tertinggi sebesar 0,913, mengindikasikan bioaktivitas yang sangat kuat. Uji drug-likeness memperlihatkan senyawa ini memenuhi kriteria Lipinski’s Rule of Five meskipun terdapat pelanggaran pada nilai refraktivitas molar (MR 144,6). Hasil simulasi molecular docking menunjukkan Isomultiflorenyl acetate memiliki afinitas pengikatan (binding affinity) terbaik sebesar −8,7 kcal/mol, yang lebih kuat dan stabil dibandingkan obat kontrol Sunitinib (B49) dengan nilai −7,2 kcal/mol. Kestabilan kompleks ligan-reseptor ini didukung oleh pembentukan ikatan Hidrogen Konvensional dengan residu ARG585, Pi-Sigma dengan TRP586, dan Pi-Alkil dengan PHE969. Senyawa Isomultiflorenyl acetate dari B. hispida berpotensi besar untuk dikembangkan lebih lanjut sebagai kandidat agen terapi penarget Gastrointestinal Stromal Tumor (GIST) berbasis bahan alam.  
PENERAPAN METODE PROMETHEE PADA SISTEM PENDUKUNG KEPUTUSAN REKOMENDASI LOKASI PENDIRIAN FASILITAS KESEHATAN Muhammad Ikhlas; Masriadi
Biomedical and Environmental Health Technology Vol 3 No 1 (2026): Biomedical and Environmental Health Technology (BIOHEALTH)
Publisher : Institut Kesehatan dan Teknologi Al Insyirah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35328/y33n4x05

Abstract

Advancements in information technology have made significant contributions to supporting decision-making processes across various sectors, including healthcare. One of the major challenges faced by governments and related agencies is determining the most appropriate locations for healthcare facilities to ensure that healthcare services are delivered equitably, effectively, and in accordance with community needs. This study aims to implement the PROMETHEE method in a web-based Decision Support System (DSS) to assist in recommending suitable locations for healthcare facility establishment based on multiple evaluation criteria. The PROMETHEE method is employed to analyze and compare alternative locations using criteria such as distance to the health department office, population density, accessibility, establishment cost, and proximity to existing healthcare facilities. The developed system automatically calculates the leaving flow, entering flow, and net flow values, thereby generating an objective ranking of alternative locations. The results indicate that Alternative 2 (A2) achieved the highest Net Flow value of 0.56, outperforming Alternative 1 (A1) and Alternative 3 (A3). Consequently, the system successfully recommends the most appropriate location for establishing a healthcare facility based on the highest net flow value. Therefore, the proposed system effectively supports decision-making in a more objective, systematic, accurate, and efficient manner, serving as a reliable reference for planning the development of healthcare facilities in suitable locations.

Page 3 of 3 | Total Record : 22

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