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INDONESIA
Indonesian Journal of Global Health Research
ISSN : 27149749     EISSN : 27151972     DOI : https://doi.org/10.37287/ijghr
Core Subject :
Indonesian Journal of Global Health Research is a open access, peer reviewed and refereed international journal. Indonesian Journal of Global Health Research aim to publish original research paper devoted to various area of all health sciences. Indonesian Journal of Global Health Research provides a forum for sharing timely and up-to-date publication of scientific research, health care and promoting the development of nursing, public health, community, environmental and occupational health. The journal publishes original research papers of health sciences. High priority will be given to articles on public, nursing, adolescent, community, environmental and occupational health, pharmaceutical technology, social pharmacy, traditional medicine, pharmacology, and so on.
Arjuna Subject : -
Articles 1,005 Documents
The Role of Secukinumab in the Management of Moderate to Severe Psoroasis: A Systematic Review of Efficacy and Safety Ni Komang Sri Adelia Cahya Ningrum; Tjokorda Istri Amrita Rosvanti; Anak Agung Ari Agung Kayika Silayukti; Anak Agung Istri Saraswati Dewi; Made Hermina Laksmi
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2384

Abstract

Psoriasis is a chronic, immune-mediated inflammatory skin disease characterized by erythematous, scaly plaques. In moderate to severe psoriasis, conventional therapies often provide a suboptimal response, making biologic therapies such as secukinumab an important treatment option. Secukinumab is a human IgG1κ monoclonal antibody that targets interleukin-17A (IL-17A). To assess the efficacy and safety of secukinumab in the management of moderate to severe psoriasis. This study is a systematic review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A literature search was conducted through PubMed, Scopus, the Cochrane Library, ScienceDirect, and Google Scholar through April 2026. Included studies were randomized controlled trials (RCTs) evaluating the efficacy and safety of secukinumab in moderate to severe psoriasis. Efficacy outcomes included the Psoriasis Area and Severity Index (PASI), Investigator Global Assessment (IGA), and Dermatology Life Quality Index (DLQI), while safety outcomes included adverse events and serious adverse events. Seven studies met the inclusion criteria. Overall, secukinumab demonstrated high efficacy in improving the clinical manifestations of psoriasis, with better PASI90 and PASI100 scores compared to comparator biologics such as ustekinumab. Secukinumab also provided a rapid clinical response and improved patients' quality of life. The most frequently reported adverse events included nasopharyngitis, upper respiratory tract infection, headache, and injection site reactions, while serious adverse events were reported in low numbers. Secukinumab is an effective and safe biologic therapy for moderate to severe psoriasis.
Herbal Medicine as an Adjuvant Therapy in Experimental Traumatic Brain Injury: A Scoping Review of Types, Dosages, and Treatment Duration in Rat Models Bagaskara Yogatama; Yuriz Bakhtiar; Saekhol Bakri; Muhammad Thohar Arifin
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2400

Abstract

Traumatic brain injury (TBI) is associated with substantial neurological morbidity and mortality, and current therapeutic approaches remain limited in targeting secondary injury mechanisms. This scoping review aimed to summarize the types, dosages, treatment durations, and therapeutic effects of herbal medicine as an adjuvant therapy in experimental TBI models. A literature search was conducted in PubMed, ScienceDirect, Scopus, Springer Link, and additional sources using predefined eligibility criteria focused on rodent TBI models and herbal interventions. Thirteen studies published between 2016 and 2025 were included. Most studies were preclinical experiments using male rats or mice, while two clinical randomized controlled trials involving TBI patients were also identified. The reviewed interventions included Centella asiatica, luteolin, Pycnogenol, rhubarb, rhein, cinnamon extract, Yunnan Baiyao, TH-CD, Xuefu Zhuyu Decoction, and herbal combinations. Treatment duration typically ranged from 3 to 14 days. Overall, herbal interventions demonstrated potential neuroprotective effects by reducing neuroinflammation, oxidative stress, neuronal apoptosis, edema, and disruption of the blood–brain barrier, leading to improvements in neurological, histopathological, and selected clinical outcomes.
The Role of Nutritional Interventions in Anemia Prevention among Adolescent Girls: A Scoping Review of Quasi-Experimental Studies Dila Fatiha Sholiha; Yuliana Heri Suselo; Ika Sumiyarsi; Dono Indarto
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2402

Abstract

Anemia among adolescent girls remains a major public health problem that may compromise future maternal and child health. It is influenced by inadequate intake of iron and micronutrients, poor dietary diversity, menstrual blood loss, and low adherence to iron folic acid tablet supplementation. Although various nutritional interventions have been implemented, evidence from quasi-experimental studies needs to be comprehensively mapped because this design is widely used in school and community based settings where randomization is often limited. This article aims to review and map the scientific evidence regarding the role of nutritional interventions in preventing anemia among adolescent girls based on quasi-experimental studies. A scoping review methodology was employed, with literature searches conducted through PubMed, Scopus, and ScienceDirect, and the selection process followed the PRISMA-ScR framework. The inclusion criteria comprised quasi-experimental studies published between 2020 and 2025 involving adolescent girls as research subjects. The data indicate that interventions such as iron supplementation or iron–folic acid tablets, food fortification, and school-based nutrition education can help increase hemoglobin levels and improve anemia status among adolescent girls. However, differences in study design, intervention duration, participant adherence, and outcome indicators show variations in methods and implementation across studies. These variations may affect the magnitude of intervention effects and the consistency of the findings. Therefore, an intervention may show effective results in one study condition but may not produce the same impact in another, particularly when implementation quality, participant adherence, and evaluation methods differ. Overall, Nutritional interventions have considerable potential to prevent anemia among adolescent girls, particularly through iron folic acid supplementation, food fortification, and school-based nutrition education. However, their effectiveness depends on intervention duration, participant adherence, implementation quality, and assessment of intervention outcomes.
Balancing Tuberculosis Treatment Efficacy and Hepatotoxicity in Liver Dysfunction Muhammad Reqza Pratama; I Gede Mahatma Pratama; Asep Sukohar
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2410

Abstract

Tuberculosis (TB) remains a major global health burden. Despite the high efficacy of first-line anti-tuberculosis therapy, treatment is frequently complicated by drug-induced liver injury (DILI), particularly in patients with pre-existing liver dysfunction. This review aimed to evaluate the balance between treatment efficacy and hepatotoxicity during TB therapy in patients with liver dysfunction and to summarise current management strategies. A literature review was conducted using studies retrieved from Scopus, PubMed, and Google Scholar. Articles published between 2015 and 2025 were identified using predefined search terms. After applying inclusion and exclusion criteria, ten eligible studies were qualitatively synthesised. The findings identified baseline liver dysfunction, hepatitis C co-infection, metabolic-associated steatotic liver disease, alcohol consumption, and poor nutritional status as major risk factors for hepatotoxicity. DILI was consistently associated with treatment interruption, regimen modification, delayed recovery, and reduced therapeutic success. Regular liver function monitoring, risk stratification, individualised treatment adjustments, and selective use of hepatoprotective agents were reported to minimise hepatotoxicity while preserving treatment effectiveness. Patient-centred, risk-based management and early identification of high-risk individuals are essential to optimise clinical outcomes and safely maintain effective anti-tuberculosis therapy.
Association between Microbiological Patterns and Clinical Outcome of Pediatric Sepsis in Two Referral Hospitals Dicky Dicky; Inke Nadia Diniyanti Lubis; Aridamuriany Dwiputri Lubis; Rina Yunita; Yunnie Trisnawati; Gema Nazri Yanni
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2422

Abstract

Sepsis is a major cause of morbidity and mortality in the Pediatric Intensive Care Unit (PICU). Diverse microbiological patterns and high antibiotic resistance are thought to contribute to patient clinical outcomes. To analyze the relationship between microbiological patterns and mortality outcomes in pediatric patients with sepsis. This cross-sectional study used medical records of pediatric sepsis patients aged >28 days to <18 years hospitalized in the PICU from January 2022 to December 2024. Data collected included demographic characteristics, microbiological profiles, and mortality outcomes. Analysis was performed using SPSS Statistics v.30 using the Chi-Square or Fisher's Exact Test, followed by linear regression and multivariate logistic regression with a significance level of p<0.05. This study involved 114 patients. Ninety-nine children were in Adam Malik Hospital and 15 patients at Prof. Dr. Chairuddin Panusunan Lubis Hospital, University of North Sumatra. Higher mortality proportions were observed in the Gram-positive (53.3%), Gram-negative (44.0%), and fungal (66.7%) groups compared with the culture-negative group (30.5%). No significant association was found between microbiological patterns and mortality. Mortality in pediatric sepsis is multifactorial and may be influenced by factors beyond microbiological patterns and baseline patient characteristics alone.
Association between Adherence to Secondary Prophylaxis and the Severity of Valvular Heart Disease in Children with Rheumatic Heart Disease Ressa Hana Peranginangin; Tina Christina Lumban Tobing; Fathia Meirina; Muhammad Ichwan; Rizky Adriansyah; Gema Nazri Yani
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2428

Abstract

Rheumatic heart disease (RHD) is a complication of acute rheumatic fever that can cause progressive damage to the heart valves. Secondary prophylaxis is given to prevent recurrence of rheumatic fever and slow the progression of valve damage. However, the relationship between adherence to secondary prophylaxis and heart valve disease in children with RHD remains unclear. To determine the relationship between adherence to secondary prophylaxis medication use and the severity of heart valve disease in children with RHD. This study used a retrospective cohort design conducted at Haji Adam Malik General Hospital, Medan. Subjects were pediatric patients aged <18 years with a diagnosis of RHD who visited the Pediatric Heart Clinic between June and December 2025, had undergone routine secondary prophylaxis therapy for at least one year, and had complete echocardiographic data. Patients with congenital heart defects or other heart diseases were excluded. Data were obtained from patient registries and medical records, including age, gender, age at diagnosis, initial echocardiography results, adherence to secondary prophylaxis medication, and the severity of valve abnormalities after one year of follow-up. Data were analyzed using statistical software using univariate and bivariate analyses with a significance level of p<0.05. The most common valve lesion was severe mitral regurgitation (57,4%), and the mitral valve was the most frequently involved valve in children with RHD. Adherence to secondary prophylaxis was quite good, with 61.7% of patients compliant and 38.3% non-compliant. The analysis showed that adherence to secondary prophylaxis medication was not significantly associated with changes in heart valve severity during one year of follow-up (p>0.05). Adherence to secondary prophylaxis did not significantly correlate with changes in heart valve severity in children with RHD, although most patients maintained stable valve conditions throughout the follow-up period.
Mapping Global Research Trends and Emerging Gaps in Dysmenorrhea and Thermotherapy: A Bibliometric Analysis of Wearable Comfort-Based Interventions Eka Muzyanti; Mekar Dwi Anggraeni
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2429

Abstract

Dysmenorrhea is a common reproductive health problem that adversely affects women’s quality of life, daily activities, and productivity. Although pharmacological treatment remains the dominant management approach, interest in non-pharmacological interventions, including thermotherapy, has increased. This study aimed to map global research trends, thematic development, and emerging gaps in dysmenorrhea and thermotherapy research using a bibliometric approach. Publications were retrieved from Scopus, PubMed, Semantic Scholar, and PoPCites Crossref using predefined search terms. English-language publications from 2005 to 2026 were screened using the PRISMA framework. Of 2,207 identified records, 127 articles met the eligibility criteria and were analysed using publication trend, citation, co-authorship, keyword co-occurrence, network, overlay, and density analyses in VOSviewer. The findings showed growing research attention, particularly in recent years. Dominant themes included pain, drug therapy, quality of life, women’s health, and endometriosis, whereas comfort-based care, wearable thermotherapy, self-management, and nursing interventions remained underrepresented. This study contributes to the scientific literature by identifying an important research gap and highlighting wearable thermotherapy as a promising patient-centred, non-pharmacological intervention for menstrual pain management and future nursing research.
The Application of Evidence-Based Nursing Care for Patients after A Cesarean Section with Glaucoma Complications: A Case Report Vina Astuti; Sulastri Sulastri; Tiwuk Amini
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2431

Abstract

Preeclampsia occurring concurrently with glaucoma in pregnant women is a complex clinical condition that is rarely reported, thus requiring evidence-based nursing care to prevent maternal complications and permanent vision impairment during the perinatal period and following a section cesarean (SC). Describes the application of evidence-based nursing care for patients with preeclampsia complicated by glaucoma following a cesarean section. A descriptive case study was conducted on one patient (Mrs. S, P4A3) at PKU Muhammadiyah Delanggu General Hospital through interviews, physical examinations, review of medical records, and observation. Data analysis guided evidence-based interventions focusing on preeclampsia sign monitoring, interdisciplinary collaboration with ophthalmology for intraocular pressure management, and post-surgical care. The patient maintained clinical stability with no acute deterioration, infection, or visual worsening during hospitalization. Integrated evidence-based nursing care and multidisciplinary collaboration effectively maintain clinical stability in patients with complex preeclampsia and post-cesarean glaucoma comorbidities.
Developing A Multilevel Community Nursing Framework to Improve Self-Management among Older Adults with Hypertension: A Qualitative Meta-Synthesis Asep Iskandar; Endang Triyanto
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2444

Abstract

Hypertension is a leading cause of cardiovascular morbidity among older adults. Although community nursing interventions have improved blood pressure control, most focus on individual behaviour and overlook the interactions among individual, family, community, and healthcare system factors. To synthesize qualitative evidence on determinants of hypertension self-management among older adults and develop a Multilevel Community Nursing Framework. A qualitative evidence synthesis using a meta-synthesis approach was conducted following PRISMA 2020 and ENTREQ guidelines. Five electronic databases were searched for qualitative studies published between January 2018 and June 2026. Study quality was assessed using CASP. Data were analysed using Thomas and Harden's thematic synthesis involving line-by-line coding, descriptive theme development, and analytical theme generation. Six qualitative studies met the inclusion criteria. Six analytical themes emerged: (1) individual capability and health literacy, (2) self-efficacy and behavioural adaptation, (3) family engagement and social support, (4) community participation and social capital, (5) accessibility and responsiveness of primary healthcare services, and (6) technology-assisted community nursing interventions. These themes indicate that successful hypertension self-management is shaped by multilevel interactions extending beyond individual behaviour. The proposed Multilevel Community Nursing Framework provides an evidence-based model for integrating individual, family, community, healthcare, and technological determinants into community nursing practice to improve self-management and blood pressure control among older adults with hypertension.
Analysis of Health Human Resources Performance with HR Scorecard and AHP Mukhlis Affandy; Dewi Prihatini; Ika Barokah Suryaningsih
Indonesian Journal of Global Health Research Vol. 8 No. 5 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i5.2449

Abstract

Human resource performance is essential for ensuring hospital service quality and organisational sustainability. At the Islamic Hospital of Lumajang, several key performance indicators, including training budget realisation, new patient acquisition, medical record completeness, and medication dispensing timeliness, remained below organisational targets, highlighting the need for a comprehensive performance measurement system. Objective: To analyse healthcare human resource performance using the Human Resource Scorecard (HRSC) integrated with the Analytical Hierarchy Process (AHP). A descriptive evaluative study was conducted using the HRSC framework across four perspectives: financial, customer, internal business process, and learning and growth. Indicator priorities were weighted through AHP based on assessments from six hospital managers. Secondary KPI data from 2023–2024 were analysed to generate weighted performance scores. The learning and growth perspective received the highest priority weight (0.53), followed by internal business process (0.27), financial (0.14), and customer (0.06). The overall weighted human resource performance score increased from 4.23 in 2023 to 4.43 in 2024, both categorised as very good. High-performing indicators included compliance with the Six Patient Safety Goals, a 100% competency examination pass rate, prompt complaint handling, and effective interprofessional clinical coordination. Lower-performing indicators were training budget realisation, new patient acquisition, medication preparation timeliness, and medical record completeness. Human resource performance was categorised as very good. However, strengthening staff development, medical record documentation, medication service efficiency, and patient acquisition strategies remains necessary to sustain hospital service quality.

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