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International Journal of Integrated Health Sciences
Published by Universitas Padjadjaran
ISSN : 23021381     EISSN : 23384506     DOI : 10.15850/ijihs
Core Subject : Health,
Health Professions
International Journal of Integrated Health Sciences (IJIHS) is a peer-review journal which publishes original articles, medical research, clinical research and case report. This journal is supported by Faculty of Medicine Universitas Padjadjaran and was launched on September 22nd 2012 and firstly published on July 2013. The first and second publications in 2013 and 2014 were published annually. In 2015 IJIHS published twice in a year, March and September.
Arjuna Subject : -
Articles 199 Documents
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Eribulin in Heavily Pre-Treated Metastatic Breast Cancer: A Case Series Kartikasari, Andini; Oehadian, Amaylia
International Journal of Integrated Health Sciences Vol 13, No 1 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v13n1.3908

Abstract

Background: Treatment options are limited for heavily pre-treated metastatic breast cancer patients, with Eribulin showing promise in improving survival outcomes.Objective: To evaluate Eribulin outcomes in patients with MBC. Metastatic or incurable diseases are observed in 4% to 10% of women despite advances in breast cancer treatment. To address this problem, EMBRACE, an important randomized phase III clinical trial was carried out by comparing eribulin to the treatment selected by physicians for individuals with previously treated locally recurrent or metastatic breast cancer (MBC). The results showed a significant and prolonged increase in median overall survival among patients treated with eribulin, compared to those who received the physician's selected treatment.Case Series: This study presents three patients who showed favorable outcomes after treatment with eribulin, despite multiple lines of previous therapy. Patient 1 was diagnosed with triple-negative breast cancer and initially achieved remission before experiencing a recurrence involving a chest lesion and enlarged lymph nodes. After two cycles of eribulin, the patient showed significant improvement. Patient 2 developed brain and liver metastases following the completion of hormonal therapy, prompting the initiation of eribulin as the next line of treatment. Patient 3 had disease progression despite undergoing multiple lines of hormonal and chemotherapy. Eribulin was administered and patient remained stable.Conclusion: Patients with MBC tend to have substantially favorable outcomes with eribulin chemotherapy even after extensive previous treatment.
AI-powered Somatic Cancer Cell Analysis for Early Detection of Metastasis: The 62 principal Cancer Types Buthelezi, Sandile; Seeletse, Solly Matshonisa; Hungwe, Taurai; Mbirimi-Hungwe, Vimbai
International Journal of Integrated Health Sciences Vol 13, No 1 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v13n1.4061

Abstract

Background: Early detection of metastasis is critical in improving survival outcomes in cancer patients, with artificial intelligence offering advanced tools for predictive analytics.Objective: To emphasize the importance of early metastasis detection in improving cancer patient outcomes, and to highlight that recent advancements in AI-powered somatic cancer cell analysis may enhance early detection and personalize treatment strategies.Methods: This study leveraged a comprehensive survival and artificial intelligence (AI) powered analysis to identify key genomic and clinical factors influencing cancer prognosis, with a focus on early metastatic detection. The AI algorithms explored the possibility of detecting tumors with a high spread risk. The study underscored the critical role of AI-powered analysis in the early detection of metastasis and the personalization of treatment strategies in cancer care.Results: By leveraging advanced AI algorithms, key predictors of cancer prognosis such as fraction genome alteration, primary tumor site, and smoking history, all of which significantly influence metastasis outcomes, were identified. Furthermore, the models demonstrated exceptional predictive accuracy, with XGBoost and Support Vector Machines achieving an accuracy of 0.95.Conclusion: Integrating AI capabilities into clinical workflows holds the promise of significantly enhancing early detection and treatment of metastatic cancer, thereby improving patient outcomes and optimizing therapeutic interventions.
Correlation between TSH, Prolactin, LH, FSH, Estrogen, and Progesterone in Women with Infertility Khambalkar, Shobha D.; Jadhav, Krishna Nitin
International Journal of Integrated Health Sciences Vol 13, No 1 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v13n1.4349

Abstract

Background: Hormonal imbalances play a pivotal role in female infertility, affecting various endocrine pathways that warrant comprehensive evaluation.Objective: To analyze correlations between thyroid-stimulating hormone (TSH), prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrogen, and progesterone in women with infertility.Methods: This retrospective observational study was conducted at the Department of Obstetrics and Gynecology of Prakash institute of Medical Sciences, India, between January 2024 and December 2024. Medical records of 140 women (90 with primary infertility and 50 with secondary infertility) aged 19–45 years were analyzed over a one-year period. Hormonal profiles including TSH, prolactin, LH, FSH, estrogen, and progesterone were analyzed. Statistical analyses were performed using the SPSS 23.0 software and  a p-value of less than 0.05 was considered statistically significant.Results: Women with primary infertility were younger and had a shorter duration since marriage compared to those with secondary infertility (p<0.001). Irregular menstrual cycles were significantly more common in primary infertility cases (p=0.002). Thyroid dysfunction was seen in 25% of cases, with hypothyroidism as the most common thyroid function abnormality (14.9%). A strong positive correlation was found between TSH and prolactin levels (r=0.821, p<0.05), whereas a significant negative correlation was present between TSH and LH (r=-0.73, p<0.05) and FSH (r=-0.41, p<0.05). Correlations between TSH and estrogen or progesterone was not found to be statistically significant (P>0.05).Conclusion: TSH levels significantly correlate with prolactin, LH, and FSH levels in women with infertility. These findings underscore the importance of comprehensive endocrine evaluation of women with infertility to optimize diagnosis and management strategies.
Role of Osteopontin in Hypothyroid Anemic Woman and Their Association with Oxidative Stress Sah, Sumesh Prasad; Sah, Sonu; Kumar, Sudeep; Arora, Manisha; Kumar, Dinesh; Kumar, Raj
International Journal of Integrated Health Sciences Vol 13, No 1 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v13n1.4099

Abstract

Background: Hypothyroidism is frequently associated with anemia and oxidative stress, necessitating exploration of biomarkers like Osteopontin to better understand disease mechanisms.Objective: To explore the association between Osteopontin, oxidative stress, and antioxidant capacity in hypothyroid woman with or without anemia.Methods: The study was conducted at the Santosh Medical College Department of Biochemistry in Ghaziabad, India, from September 2019 to October 2021. This study was cross-sectional and recruited 360 female subjects, divided into three groups: hypothyroidism with anemia, hypothyroidism without anemia, and normal healthy controls. Osteopontin, thyroid profile, malondialdehyde (MDA) and total antioxidant capacity were measured.Results: Osteopontin, T3, T4, and total antioxidant capacity levels were significantly lower (p<0.001), and the TSH and MDA levels significantly increased (p<0.001) in female subjects experiencing hypothyroidism, with or without anemia, as compared to normal healthy female control groups. Osteopontin demonstrated significant negative relationship with TSH and MDA, while showing a significant positive relationship with T3, T4, and total antioxidant status in both studied groups.Conclusion: Osteopontin and oxidative stress/antioxidant status significantly correlate in female subjects experiencing hypothyroidism, with or without anemia. In these patients, Osteopontin might be a useful biomarker for evaluating antioxidant levels and oxidative stress.
Anemia and Aggression Among Patients with Schizophrenia in Amino Gondohutomo Psychiatric Hospital Noerhidajati, Elly; Sofa, Yulia Ratna; Woroasih, Sri; Hardini, Intan Tri
International Journal of Integrated Health Sciences Vol 13, No 1 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v13n1.4029

Abstract

Background: Anemia has been identified as a potential modifiable factor influencing aggression levels in individuals with schizophrenia.Objective: To investigate the association between anemia and incidence of aggression in patients with schizophrenia in Amino Gondohutomo Psychiatric Hospital, Semarang, Indonesia.Methods: A cross-sectional study was conducted between January 2022 and December 2023 on patients with schizophrenia in Amino Gondohutomo Psychiatric Hospital, Semarang, Indonesia. Subjects were selected using consecutive sampling technique, and individuals with affective mood disorder and lost to follow-up were excluded from the study. Data were obtained through patients’ medical records, PANSS-EC scores, and hemoglobin measuring devices. Chi-square test and logistic regression were applied for statistical analyses.Results: Of 100 participants, patients with schizophrenia presented with aggression were predominantly above 40 years old (26 patients, 81.3%), women (17 patients, 51.1%), and non-anemic (17 patients, 57.1%). Gender and anemia were significantly associated with aggression in patients with schizophrenia (p <0.05). Schizophrenic patients with anemia had a 7.68-fold greater risk (95% CI: 2.70 – 21.8) of aggression. Men with schizophrenia was associated with a 2.37-fold greater risk (95% CI: 1.00 – 5.60) of aggression.Conclusion: Anemia and men seems to be risk factors of aggression in patients with schizophrenia. Further multicenter studies with larger sample size is needed to support this finding.
Impact of Chronic Smoking on Choroidal Thickness: A Comparative Analysis Using Optical Coherence Tomography Mazumdar, Ranabir; Maulik, Subhamitra; Wasim, Nazir Abdul
International Journal of Integrated Health Sciences Vol 13, No 1 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v13n1.4325

Abstract

Background: Chronic smoking has systemic vascular effects, including alterations in ocular blood flow and choroidal thickness, impacting visual health.Objective: To compare choroidal thickness (CT) in chronic smokers and nonsmokers using optical coherence tomography and to evaluate the effect of smoking duration on CT based on pack-year quartiles (PYQ).Methods: This was a case-control study conducted at the Regional Institute of Ophthalmology, Medical College, Kolkata, India between January 2023 and June 2024. Choroidal thickness was assessed in 120 cases (60 smokers and 60 nonsmokers) over a period of 18 months. Choroidal thickness was measured using Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography (EDI SD-OCT) at the sub foveal region and 1.5 mm away in the superior, inferior, nasal, and temporal directions. CT between smokers and nonsmokers was compared.  Statistical analysis was performed using the SPSS 23.0 software and a p-value of less than 0.05 was taken as statistically significant.Results: The study analyzed age distribution, ocular parameters, and choroidal thickness in 60 smokers and 60 nonsmokers. The mean age in smokers and nonsmokers was found to be 43.1 ± 7.2 and 40.8 ± 11.4 years respectively. Smokers were found to have a significantly lower sub foveal CT compared to nonsmokers (272.42 ± 13.57 µm vs. 284.94 ± 14.15 µm, p<0.05). Increased smoking exposure significantly correlated with progressive choroidal thinning (p<0.05). Other ocular parameters, such as intraocular pressure (p=0.235) and axial length (p=1.0), were found to be comparable in both groups (p>0.05).Conclusion: There significant choroidal thinning in chronic smokers as compared to nonsmokers with a dose-dependent effect linked to higher smoking exposure. These findings suggest a smoking-induced vascular compromise in the choroid.
Predictors of In-Hospital Mortality in Patients with Infective Endocarditis: A Single-Center Study Hanim, Haifany Fauziyah; Ikhsani, Rizkania; Yudharaputri, Digita Natarina; Cool, Charlotte Johanna; Hasan, Melawati
International Journal of Integrated Health Sciences Vol 13, No 1 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v13n1.3753

Abstract

Background: Infective endocarditis remains a life-threatening condition with high in-hospital mortality, necessitating identification of predictive clinical factors.Objective: To identify predictors of in-hospital mortality in infective endocarditis (IE) patients.Methods: This single-center retrospective study included 88 patients with IE aged ≥ 18 years treated at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, between September 2019 and May 2023. During hospitalization, data regarding clinical characteristics, blood cultures, and clinical outcomes were assessed to identify the predictors of in-hospital mortality. Data were analyzed using chi-square and binary logistic regression.Results: Among 88 patients with IE, the majority were male (56.8%) and aged < 60 years old (78%). More than two-thirds of patients had valvular heart disease. During treatment, 22 patients (25%) underwent cardiac surgery, and the total in-hospital mortality rate was 35.2%. Although not statistically significant, in-hospital mortality rate was lower in operated patients (22.7% vs 39.4%). In multivariate analysis, septic shock was the only significant predictor of in-hospital mortality (OR 40, 95% CI: 4.7–339, p 0.001)Conclusion: Septic shock is a strong predictor of in-hospital mortality among patients with infective endocarditis. Invasive management by cardiac surgery does not significantly decrease the mortality risk.
Electrolyte Dysregulation in Diabetic with Advanced Chronic Kidney Diseases (CKD): Comparative Analysis of CKD Stages 4 and 5 Tanjung, Asbar; Lembagus Wirawan, Riceina Javonda
International Journal of Integrated Health Sciences Vol 13, No 2 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v13n2.4197

Abstract

Background: Electrolyte imbalance is common in both diabetes mellitus (DM) and chronic kidney disease (CKD). While they may occur independently, their coexistence can exacerbate metabolic disturbances, thereby accelerating disease progression and impairing quality of life. Objective: to investigates the differences in electrolyte profiles between patients with CKD stages 4 and 5 with DM.Methods: A cross-sectional comparative design study was employed. A hundred participants (50 with CKD stage 4 and 50 with CKD stage 5 with DM) were recruited from a clinical laboratory during May to June 2024. Serum natrium, kalium, and chloride levels were measured alongside urea, creatinine, GFR, and glucose. The Mann-Whitney U test was applied to compare the electrolyte levels between these CKD stages.Results: Of 100 participants, more men participating in this study (66% vs. 34%). Pre-elderly (45-59 y.o.) was the most predominant (61%), followed by elderly (>60 years,  20%), and adult (26-45 y.o., 19%). Both groups showed elevated urea, creatinine, and glucose levels with reduced GFR, confirming advanced CKD and DM. There was no significant difference in glucose level between stage 4 and stage 5. A significant difference (p=0.001) was observed in natrium levels, with stage 5 CKD patients exhibiting lower levels compared to those in stage 4. In contrast, kalium and chloride levels showed no significant difference (p=0.71 and p=0.81, respectively) in both groups.Conclusion: This study highlights the specific vulnerability of natrium homeostasis in advanced CKD with diabetes. Natrium dysregulation observed in stage 5 CKD underscores the need for close monitoring and management of sodium levels in this population.
A Pediatric Case of Kawasaki Disease with Gastrointestinal Involvement Mimicking Acute Abdomen Patil, Prabhakar; Michael, Anwar Mousa
International Journal of Integrated Health Sciences Vol 13, No 2 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v13n2.4577

Abstract

Background: Kawasaki Disease (KD) is a childhood acute vasculitis that predominantly affects medium-sized arteries, particularly the coronaries. While classical KD is diagnosed on the basis of defined clinical criteria, atypical presentations, such as with gastrointestinal (GI) involvement, can obscure timely recognition of this disease. GI symptoms, observed in subset of cases, may mimic acute surgical abdomen.Objective: To highlight the diagnostic challenge of Kawasaki Disease with predominant gastrointestinal symptoms mimicking acute abdomen in a pediatric case, and to emphasize the importance of early recognition and timely initiation of intravenous immunoglobulin (IVIG) therapy to prevent potential cardiac complications.Case: This is the case report of a 7-year-old male who was admitted with high-grade fever, severe abdominal pain, and signs suggestive of an acute abdomen. Initial clinical assessment and abdominal ultrasound indicated mesenteric lymphadenitis. Laboratory findings revealed marked leukocytosis, anemia, thrombocytosis, and elevated inflammatory markers (ESR, CRP) along with increased NT-proBNP suggestive of systemic inflammation. Further imaging ruled out surgical pathology. The persistence of fever, along with emerging mucocutaneous signs, led to the diagnosis of KD. The patient was treated with intravenous immunoglobulin (IVIG) and supportive therapy. Fever resolved within 24 hours, and abdominal symptoms improved markedly. Patient was then discharged afebrile with no evidence of coronary artery abnormalities on echocardiography.Conclusion: This case illustrates that persistent fever and elevated inflammatory markers in the presence of GI symptoms should prompt consideration of KD, even in the absence of full diagnostic criteria. Early diagnosis and IVIG therapy are important as delayed diagnosis may lead to significant cardiac sequelae.
Arterial Blood Gas Analysis and Dyselectrolytemia in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) Reddy, Nivedita Tayamgol; Patil, Sachin; Reddy, Kailash
International Journal of Integrated Health Sciences Vol 13, No 2 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v13n2.4565

Abstract

Background: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is one of the important causes of  morbidity, mortality, and healthcare burden. Electrolyte disturbances and acid–base imbalances are frequent but under-recognized complications that may worsen outcomes in cases of AECOPD.Objective: To understand the prevalence of serum electrolyte abnormalities and arterial blood gas (ABG) parameters in patients admitted with AECOPD.Methods: This prospective observational study enrolled 200 patients with confirmed AECOPD admitted to a tertiary care hospital in Kalaburagi, India, over an 18 month period. The ABG analysis and serum electrolytes (sodium, potassium, magnesium, chloride) measurement were performed at admission. Demographic, clinical, and radiological data were also collected. Data were then analyzed using SSPS 23.0, with a P value of < 0.05 considered statistically significant.Results: Abnormalities related to sodium (91.5%), potassium (90.5%), magnesium (80.5%), and chloride (56%) were common in cases admitted with AECOPD. In 45% cases, the PaO₂ <50 mmHg  was seen whereas PaCO₂ >45 mmHg was found in 43%. Acid–base imbalance was seen  in 35% cases, with 4.5% showing severe acidosis (pH ≤7.1). Cough (72.5%) and breathlessness (60.5%) were most common symptoms. The majority were elderly males (65%) whereas 57% were smokers. Diabetes was the most common comorbidity (30.5%).Conclusion: Electrolyte abnormalities and ABG derangements are nearly universal in AECOPD and have important prognostic implications. Routine metabolic profiling should be integrated into the acute management of COPD to improve outcomes, particularly in resource-constrained settings.

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