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International Journal of Integrated Health Sciences
Published by Universitas Padjadjaran
ISSN : 23021381     EISSN : 23384506     DOI : 10.15850/ijihs
Core Subject : Health,
Health Professions
International Journal of Integrated Health Sciences (IJIHS) is a peer-review journal which publishes original articles, medical research, clinical research and case report. This journal is supported by Faculty of Medicine Universitas Padjadjaran and was launched on September 22nd 2012 and firstly published on July 2013. The first and second publications in 2013 and 2014 were published annually. In 2015 IJIHS published twice in a year, March and September.
Arjuna Subject : -
Articles 187 Documents
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Serum Selenium Concentration in Cervical Cancer Patients: Preliminary Study and Literature Review Leri Septiani; Yudi Mulyana Hidayat; Mutakin Mutakin; Rizky Abdulah; Ahmad Faried; Hiroshi Koyama
International Journal of Integrated Health Sciences Vol 4, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To analyze the role of selenium and glutathione peroxidase (GPx) in cervical cancer.Methods: Serum selenium concentrations and GPx activities of 19 women with cervical cancer along with their healthy counterparts (control group) were obtained. Selenium concentration were measured fluorometrically and GPx activities were measured spectrophotometrically based on the quantity of NADPH used in the reduction of glutathione. Results: The mean of serum selenium concentrations in cervical cancer group was significantly lower than that in the control group, 67.24±15 ng/mL and 77.05±12 ng/mL (p=0.03), respectively. The mean GPx activity in the cervical cancer group was also significantly lower than that in the control group, 128.18±38 ∆mmol NADPH/min/L and 148.9±23 ∆mmol NADPH/min/L (p=0.04), respectively. Multivariate analysis in the cervical cancer patients showed that the Fédération Internationale de Gynécologie et d’Obstétrique (FIGO) staging score (early vs. advanced) was inversely correlated with serum selenium concentration (p=0.027).Conclusions: Serum selenium concentration and GPx activity was significantly lower in the cervical cancer patients. Our results demonstrate that selenium and GPx activity may have an important role in the carcinogenesis of cervical cancer. Keywords: Cervical cancer, glutathione peroxidase activity, selenium DOI: 10.15850/ijihs.v4n2.833
Cervical Stump Fibroidpost Supra-cervical Hysterectomy Sherman David Mathew; Betsy Abraham
International Journal of Integrated Health Sciences Vol 6, No 2 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (450.478 KB) | DOI: 10.15850/1257

Abstract

Objective: To describe of a rare case of cervical stump fibroid presenting as a late complication of supra-cervical hysterectomy.Methods: A 68-year old-female with a history of lower abdominal pain and distention for six months with increasing intensity was referred from a local clinic to the department of radio-diagnosis for evaluation. She had a history of subtotal hysterectomy previously. On ultrasonography and computerized tomography imaging studies, a large adnexal lesion was noted suggesting the possibility of a cervical stump leiomyoma. The patient underwent an elective surgery and the diagnosis was confirmed in the context of histological findings.Results: Patient was operated for the radiologically diagnosed large cervical stump leiomyoma which was laterhistologically confirmed with an uneventful recovery.Conclusions: Imaging investigations like computerized tomography and magnetic resonance imaging are valuable in the diagnosis of rare adnexal masses from cervical stump arising as late delayed complications of supra-cervical hysterectomy. Keywords: Cervical stump leiomyoma, computerized tomography, magnetic resonance imaging, supra-cervical hysterectomy DOI: 10.15850/ijihs.v6n2.1257
TYT Curve : Pilot Study on Alternatives Standards of Reference to Determine Intrauterine Growth in Low Resource Setting In Indonesia Tina Dewi Judistiani; Tetty Yuniaty; Yessika Adelwin Natalia
International Journal of Integrated Health Sciences Vol 2, No 1 (2014)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To develop a new intrauterine growth curve based on local population for accurate intrauterine growth retardation (IUGR) infant identification. Methods: An observational analytic method was applied to develop Tina-Yessika-Tetty (TYT) curve derived from 13,405 neonatal anthropometric measurements taken from the medical record database of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. The infants included in this study were born during the period of January 1st, 2005 to December 31st, 2009. The new curve was then compared to the Lubchenco and Alisjahbana curves. Only 6,814 data met the inclusion and exclusion criteria.    Results: The mean birth weight in this study was lower compared to that of the Lubchenco and Alisjahbana studies. Comparison of the three curves showed that there was a significant difference among the three curves (R=0.998, R2=0.996, p<0.001), which indicates a probability for a newborn classification.Conclusions: TYT curve may be used as an alternative to identify IUGR immediately after birth, especially when detection during pregnancy is not available in low resource setting. A prospective study with a larger population is needed; However, this study has provided an evidence to support the need for timely evaluation for such growth chart as they change over time.    Keywords: Alisjahbana curve, intrauterine growth, Lubchenco curve, TYT curveDOI: 10.15850/ijihs.v2n1.271
Loaded and Unloaded Sit-to-Stand Strengthening Exercises Effect to Gross Motor Function Measure in Spastic Diplegia Cerebral Palsy Patients Imran Safei; Marina A. Moeliono; Tertianto Prabowo
International Journal of Integrated Health Sciences Vol 4, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To examine sit-to-stand and loaded sit-to-stand exercises effect in standing, walking, and running dimensions of gross motor function measure (GMFM) in spastic diplegia cerebral palsy (SDCP) patients.Methods: This study was conducted in the period of May to October 2014 and included 24 children with SDCP as the subjects. The methods used in the study were interventional study with randomized controlled trial, and investigation of CP before and after the exercise intervention. The subjects were divided into two groups, sit-to-stand exercise group and loaded sit-to-stand exercise group. Results: The results showed that the increase of standing, walking, and running dimension scores of GMFM in the loaded group were higher (standing dimension score 12.00 vs 11.08 and walking and running dimensions 13.58 vs 13.42) compared to the unloaded group.Conclusions: Both sit-to-stand and loaded sit-to-stand exercise groups do not show significant differences in improving motor skills in standing, walking, and running dimensions of GMFM. Children with SDCP may receive the exercise to improve their motor skills in mobility aspects, such as standing, walking, and running. Keywords: Cerebral palsy, gross motor function measure, rehabilitation, sit-to-stand exercise DOI: 10.15850/ijihs.v4n1.680
Correlation between Handgrip Strength, Mobilization Function, Physical Activity Level, and Muscle Mass in Community-Dwelling Elderly in Bandung, West Java Province, Indonesia Sari Sekarsari; Vitriana Vitriana; Irma Ruslina Defi
International Journal of Integrated Health Sciences Vol 6, No 1 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.548 KB) | DOI: 10.15850/ijihs.v6n1.1047

Abstract

Objective: To investigate correlation between handgrip strength, mobilization function, and physical activity level (PAL), and muscle mass in community-dwelling Indonesian elderly.Methods: This was a cross-sectional study 193 subjects aged 60–90 years. Handgrip strength was measured using handgrip dynamometer while the mobilization function was assessed by performing gait speed test. Global Physical Activity Questionnaire (GPAQ) was used to assess the participant’s PAL and Bio Impedance Analyzer was used to measure the participant’s muscle mass based on skeletal mass index.Results: Significant positive correlations were discovered between handgrip strength and walking speed (rs. 0.501; p<0.001), PAL (rs. 0.153; p=0.003), and muscle mass (rs. 0,452; p<0.001).Conclusion: Stronger handgrip determines greater mobilization function, physical activity level, and bigger muscle mass in community-dwelling Indonesian elderly. Keywords: Gait speed, handgrip strength, muscle mass, physical activity DOI: 10.15850/ijihs.v6n1.1047
Integrating Basic Sciences into Global Health by Implementing the Translational Research Muhamad Nurhalim Shahib; Diah Dhyanawati; Elrade Rofaani
International Journal of Integrated Health Sciences Vol 1, No 1 (2013)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

An emphasize on herbal medicine in cancer therapy is also included as an example of translational research implementation. A translational research in Faculty of Medicine, Universitas Padjajaran, has been conducted to develop a novel genomic approach (herbal genomic) on herbal crude extracts. This study focuses on the effects of the extracts on specific gene expressions. In this aspect, the concept of molecular targets is slightly different from pharmaceutical approaches  that aim to find compounds that interact with a specific molecule or macromolecule with known function. In this research strategy, the herbal genomic approaches involve screening of herbal extracts that affect particular gene expression related to cell responses rather than a single proteins. The determination of herbal concentration is based on differential gene expression before and after treatment which is analyzed by real time PCR. The results are being compared to the existing small molecule (active molecule) on the gene expressions. All these academic activities require biomedical research workforce to implement the translational research which, in the Faculty of Medicine, Universitas Padjadjaran, is fulfilled by involving the postgraduate students. New crude extract formulation plus specific gene expression profile is a concept required for developing chemotherapeutic agent in Indonesia. Hopefully, this review can support increased cooperation between hospital and academic institutions in implementing translational research in Indonesia.    DOI: 10.15850/ijihs.v1n1.86
Normal Pressure Hydrocephalus Following Myodil Myelography Ezgi Akar; Mehmet Ufuk Akmil
International Journal of Integrated Health Sciences Vol 3, No 1 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: Fat-saturated contrast agent-enhanced myelography was used for the purpose of diagnosing most spinal lesions from the beginning of the 19th century until the end of the 20th century. Myodil was among the agents used for many years for this purpose.Methods: A rare long-term complication of myodil myelography is presented with a cerebrospinal fluid (CSF) absorption disorder occurring years after myelography that caused a secondary normal pressure hydrocephalus.Results: A case of normal pressure hydrocephalus with a slowly developing clinical picture that emerged years after a ventriculoperitoneal shunt for a myodil myelography 25 years ago due to suspicion of lumbar spinal stenosis was treated. Conclusions: Many acute and chronic complications of fat-saturated contrast agents were reported. Because of these complications and with the technological developments in due course, these agents are replaced by computerized tomography (CT), magnetic resonance imaging (MRI), or hydrophilic contrast agents.Keywords: Normal pressure hydrocephalus, myelography, myodil DOI: 10.15850/ijihs.v3n1.406
Cognitive Function Profile of Post-Stroke Patients Dila Larasati; Irma Ruslina Defi; Henny Anggraini Sadeli
International Journal of Integrated Health Sciences Vol 5, No 1 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To discover cognitive function profile of post-stroke patients undergoing rehabilitation to inform rehabilitation professionals in planning for a program and provide services that meet the patient’s need. Methods: This study was a descriptive cross-sectional study involving 32 post-stroke patients undergoing rehabilitation at the Physical Medicine and Rehabilitation clinic of Dr. Hasan Sadikin General Hospital Bandung in August–September 2014. An examination was conducted using the Mini Mental State Examination (MMSE) to obtain the cognitive function profile of post-stroke patients. Results: The results showed that almost all post-stroke patients undergoing rehabilitation had normal cognitive functions (93.8%), only few patients had probable cognitive impairment (6.2%). Probable cognitive impairment were found in male and female patients who were in the age range of 50–60 years who were elementary school graduates and in the sub acute phase of stroke. Conclusions: Almost all post-stroke patients undergoing rehabilitation have normal cognitive functions, only minority of patients have probable cognitive impairment, and there are no patients with definite cognitive impairment. Keywords: Cognitive function, education, rehabilitation, stroke DOI: 10.15850/ijihs.v5n1.962
Anterior Interhemispheric Approach for Olfactory Groove Meningioma Imam Hidayat; Agung Budi Sutiono; Ahmad Faried; Muhammad Zafrullah Arifin
International Journal of Integrated Health Sciences Vol 4, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To evaluate the surgical technique with bifrontal interhemispheric approach for total removal of tumor in olfactory groove meningioma (OGM). Methods: This study described a case of a 38-year-old woman with bilateral blindness, anosmia, and behaviour changes. Imaging studies show a tumor mass in midfrontal base. Surgery using a bifrontal interhemispheric approach was performed and total removal was achieved and postoperative computed tomography (CT) scan was performed to confirm the result. Histopathological findings established a diagnosis of meningioma.Results: A coronal skin incision behind the hairline was utilized. The scalp was elevated, taking care to reserve the vascularized pericranium medial to the linea temporalis of each side, and preserving the 2 supraorbital nerves. Eight burr holes were used, with the two initial holes made on each side of the orbitotemporal region, and the other four holes at the midline. A bifrontal craniotomy was performed. The tumor was first detached from its attachment with bipolar cautery and debulked. During this step, the main tumor feeder arteries from the anterior and posterior ethmoidal artery were interrupted, and the tumor devascularized. Total tumor removal through surgical intervention was achieved and confirmed by head CT-scan postoperatively.Conclusions: This case report supports the suitability of the bifrontal interhemispheric approach for OGM resection with additional radiation therapy.Keywords: Anterior interhemispheric approach, olfactory groove meningioma DOI: 10.15850/ijihs.v4n2.838
Osteoporosis Prevention Exercise Effects to Bone Density in Children with Thalassemia Andreas Arie Widiadiaksa Waluyojati; Marietta Shanti Prananta; Marina Annette Moeliono
International Journal of Integrated Health Sciences Vol 6, No 2 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (196.406 KB) | DOI: 10.15850/1349

Abstract

Objective: To discover recommendation of osteoporosis prevention exercise (OPE) for children with thalassemia.Methods: This study was conducted in the period of April–June 2017 by using quasi experimental and pretest-posttest designs. Eleven thalassemia patients who were the members of a thalassemia patient foundation and an association of parents of thalassemia patients, Yayasan Thalassaemia Indonesia and Perhimpunan Orangtua Penderita Thalassemia Indonesia, were enrolled in the study as the subjects. Sample calculation was carried out by using consecutive sampling method. The subjects were given OPE intervention 2 times per week during 12 weeks with 35 minutes of each session. BMD of spinal lumbar examination was performed before and after practicing OPE. Collected data were analyzed statistically by using paired t and Wilcoxon tests with p value <0.05.Results: After the intervention, BMD value of L1, L2, and L3 segments did not improve significantly while BMD value of L4 segment and average Z-score showed significant improvement (p<0.05).Conclusions: Osteoporosis prevention exercise can improve BMD in children with thalassemia. Continuous OPE program can be recommended for children with osteoporosis-induced thalassemia.Keywords: Bone mineral density, osteoporosis, osteoporosis prevention exercise, thalassemia, Z-score DOI: 10.15850/ijihs.v6n2.1349

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