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International Journal of Integrated Health Sciences
Published by Universitas Padjadjaran
ISSN : 23021381     EISSN : 23384506     DOI : 10.15850/ijihs
Core Subject : Health,
Health Professions
International Journal of Integrated Health Sciences (IJIHS) is a peer-review journal which publishes original articles, medical research, clinical research and case report. This journal is supported by Faculty of Medicine Universitas Padjadjaran and was launched on September 22nd 2012 and firstly published on July 2013. The first and second publications in 2013 and 2014 were published annually. In 2015 IJIHS published twice in a year, March and September.
Arjuna Subject : -
Articles 187 Documents
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Rare Distal Anterior Choroidal Artery Aneurysm Muhammad Zafrullah Arifin; Julius July; Bilzardy Ferry; Ahmad Faried
International Journal of Integrated Health Sciences Vol 4, No 2 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To describe a rare patient with ruptur aneurysm case of distal anterior choroidal artery (AChA) and intraventricular hemorrhage. A 56-year old female came to our hospital with chief complaint sudden onset of severe headache and vomiting.Methods: Head computed tomography (CT)-scan and angiography on the lesion was performed at the Department of Radiology, Siloam Hospital, Tangerang, Indonesia.Results: Head CT-scan imaging revealed an intraventricular hemorrhage, primarily in the right lateral ventricle, with slight enlargement of both lateral, 3rd and 4th ventricles. Angiography examination revealed a round vascular lesion at the wall of the posterior cornu of the lateral ventricle and an occlusion of the M1 base segment of the left middle cerebral artery.Conclusions: The lesion, distal AChA aneurysm, at the posterior cornu was reached using an infratemporal lobe approach with the help of neuronavigation. Microsurgical clipping was successfully performed.Keywords: Aneurysm, distal anterior choroidal artery, neuronavigation DOI: 10.15850/ijihs.v4n2.837
Pregnancy Rate after Intrauterine Insemination with the Presence or Absence of Leukocytospermia in Sperms Prepared using Density Gradient Method Rini Widyastuti; Julius Pangayoman; Aida Riyanti; Alkaustariyah Lubis; Mas Rizky Anggun Adipurna Syamsunarno
International Journal of Integrated Health Sciences Vol 6, No 2 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6963.431 KB) | DOI: 10.15850/1318

Abstract

Objective: To examine the association between different concentrations of leukocyte and sperm recovery rate after sperms are prepared using density gradient method and pregnancy rate after intrauterine insemination (IUI). Increased leukocytes in semen have been associated with increased reactive oxygen species (ROS) that reduces sperm quality.Methods: Semen samples that were collected from 31 male partners of couples undergoing infertility investigation were analyzed for sperm concentration, motility, and leucocytes concentration. Semen samples were then divided in two groups based on their leucocytes concentrations (category A: >0 to <1 × 106/mL; category B: >1 x 106/mL. Semen samples were processed using density-gradient centrifugation technique. Results: There was a significant difference in the number of sperms harvested and sperm motility after preparation. Interestingly, pregnancy rate after IUI was higher (p<0.05) in non-leukocytospermia semen (39%) when compared to leukocytospermia semen (30%).Conclusions: Seminal leukocytes (PMNL) concentration affects pregnancy rate after intrauterine insemination. Keywords: Density gradient method, sperm recovery rate, intrauterine insemination, pregnancy rate DOI: 10.15850/ijihs.v6n2.1318
Morphometric Analysis of the Corpus, Spinal Canal and Torg Ratio Using Midsagittal Cervical Vertebrae Computed Tomography Scan: Indonesian Population Rully Hanafi Dahlan; Priandana Adya Eka Saputra; Farid Farid Yudoyono; Sevline Esthetia Ompusunggu; Muhammad Zafrullah Arifin; Agung Budi Sutiono; Ahmad Faried
International Journal of Integrated Health Sciences Vol 2, No 1 (2014)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To determine the normal ranges of cervical spinal canal morphometry in Indonesian population and to compare the acquired data collected from other populationsMethods: Computed tomography measurements on the diameter of midsagital spinal canal and corpus of cervical vertebrae and its Torg ratio from the lower cervical (C3-C7) canal from 24 normal Indonesian adults were performed at the Radiology Department of Dr. Hasan Sadikin General Hospital. Patients who had cervical spine disorders and those under 20 years old were exluded.  We used computed tomography scan midsagittal view to measure the aforementioned parameters.    Results: The average diameter for the cervical spinal canals for the Indonesian population is comparable with those of other Asian populations such as Hongkong and India, albeit with smaller Torg ratio.     Conclusions: This study reports the normal radiological anatomy of the midsagital spinal canal and corpus of cervical vertebrae as well as Torg ratio from the lower cervical vertebrae among Indonesian population. The measurements result of this study shows that, although slightly smaller, the measurement results for those parameters are identical with other Asian populations.    Keywords: Corpus cervical vertebrae, midsagittal cervical spinal canal, Torg ratio DOI: 10.15850/ijihs.v2n1.285
Correlations between Muscle Mass, Muscle Strength, Physical Performance, and Muscle Fatigue Resistance in Community-Dwelling Elderly Subjects Elizabeth Elizabeth; Vitriana Vitriana; Irma Ruslina Defi
International Journal of Integrated Health Sciences Vol 4, No 1 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To determine the correlations between muscle mass, muscle strength, physical performance, and muscle fatigue resistance in community-dwelling elderly people in order to elucidate factors which contribute to elderly’s performance of daily activities.Methods: A cross-sectional study was conducted on community-dwelling elderly in Bandung from September to December 2014. One hundred and thirty elderly, 60 years old or above, were evaluated using bioelectrical impedance analysis to measure muscle mass; grip strength to measure muscle strength and muscle fatigue resistance; habitual gait speed to measure physical performance; and Global Physical Activity Questionnaire (GPAQ) to assess physical activity. Results: There were significant positive correlations between muscle mass (r=0,27, p=0,0019), muscle strength (r=0,26, p=0,0024), and physical performance (r=0,32, p=0,0002) with muscle fatigue resistance. Physical performance has the highest correlation based on multiple regression test (p=0,0025). In association with muscle mass, the physical activity showed a significant positive correlation (r=0,42, p=0,0000). Sarcopenia was identified in 19 (14.61%) of 130 subjects. Conclusions: It is suggested that muscle mass, muscle strength, and physical performance influence muscle fatigue resistance. Keywords: Community-dwelling, elderly, muscle fatigue resistance, muscle mass, sarcopenia DOI: 10.15850/ijihs.v4n1.684
Relationship between Gymnastics Exercise and Insomnia in Elderly Fauziah Nurillah Nasa; Sharon Gondodiputro; Lina Rahmiati
International Journal of Integrated Health Sciences Vol 6, No 1 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (87.737 KB) | DOI: 10.15850/ijihs.v6n1.1132

Abstract

Objectives: To analyze the relationship between gymnastics exercise and insomnia in elderly.Methods: This study involved 60 elderly as the respondents. The respondents were divided into two groups: group 1 consisting of elderly who practiced gynmastics exercise and group 2 consisting of elderly who did not practice gymnastics exercise. The members of group 1 were enrolled from 3 gymnastic groups in 3 villages in Jatinangor, West Java, Indonesia and the members of group 2 were elderly who lived in the same villages as the elderly in group 1. The inclusion criteria were elderly women who could communicate effectively and with a Mini Mental State Examination (MMSE) score of >23. Particularly for group 1, additional criteria were applied, i.e. elderly who did gynmastics exercise minimal once a month and each exercise lasted for at least one hour. Insomnia level was determined using the insomnia severity index (ISI). This study was carried out in June 2017. Homogeneity of the groups was examined using proportion difference test and data were analyzed using chi-square test and one way ANOVA.Results: Insomnia prevalence was 56.6% but insomnia prevalence in group 2 was higher (43.3%) than that of  group 1 (13.3%). This study discovered that there was significant relationship between gymnastics exercise and insomnia in elderly (p=0.000). Referring to the  frequency of the gymnastics exercise, significant relationship between gymnastics exercise and insomnia in elderly was also found (p=0.040). Conclusions: Gymnastics exercise is a promising nonpharmacologic therapy to treat insomnia in elderly.Keywords: Elderly, insomnia, gymnastics exercise DOI: 10.15850/ijihs.v6n1.1132
Effect of Overground Walking and Treadmill Exercise on Walking Speed and Walking Ability in Elderly Theresia Chandra Tania Novy; Vitriana Vitriana; Sunaryo Barki Sastradimaja; Irma Ruslina Defi
International Journal of Integrated Health Sciences Vol 1, No 1 (2013)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To compare the effect of overground walking and treadmill exercise on walking speed and ability in elderly from week to week.  Methods: This study was conducted in 6 weeks to 18 elderly at Panti Wreda Karitas and Nazareth Bandung (September–December 2011). They were divided into two groups; overground walking exercise group and treadmill group. Walking speed and ability was measured using 10 meter walk test and 6 minute walk test consecutively. Results: Both group walking speed was improved after 1 and 2 weeks exercise (p=0.019 and p=0.050), consecutively. Walking ability in the overground and treadmill group was improved after 1 and  3 weeks  exercise (p=0.019 and p=0.009), consecutively. Overground walking group showed greater improvement in walking speed and ability after 3 weeks exercise (p=0.008 and p=0.017) consecutively. Conclusions: Three weeks overground walking exercise improves walking speed and ability better  than treadmill exercise.    Keywords: Elderly, overground walking exercise, treadmill exercise, walking ability, walking speed DOI: 10.15850/ijihs.v1n1.105
Validity of Mycobacterium tuberculosis Antigens Cocktail: ESAT-6, CFP-10 and MPT64 in Sputum and Cerebrospinal Fluid for Pulmonary Tuberculosis and Tuberculous Meningitis Diagnosis Dewi Kartika Turbawaty; Nenny Gustiani; Livia Noviani; Ida Parwati
International Journal of Integrated Health Sciences Vol 3, No 2 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: Rapid and accurate TB diagnostics play an important role in detecting the disease. Currently, antigens secreted (ESAT-6, CFP-10 and MPT64) by M. tuberculosis and encoded by genes “Region of Difference” (RD)1, RD2 and RD3 give an opportunity for rapid TB diagnosis. Genomic region RD1-RD3 was deleted in M. bovis BCG strains and absent in mycobacteria other than M. tuberculosis. This property is advantageous because it enable to create a specific diagnostic tools for M. tuberculosis infection. The aim of this study is to determine the validity of TB antigens cocktail (ESAT-6, CFP-10 and MPT64) for pulmonary tuberculosis and TB meningitis diagnosis. Methods: This is a descriptive observational study design. The study was conducted at the Clinical Pathology Laboratory of Dr. Hasan Sadikin General Hospital during September 2012 until March 2013 for the pulmonary tuberculosis study and from January 2014 to May 2014 for the TB meningitis study. The TB antigen cocktail rapid immunochromatography (ICT) test was done on all of the samples. The sputum and CSF were cultured as gold standards. Results: There were 149 pulmonary and 41 TB meningitis subjects. The sensitivity of TB antigens cocktail rapid ICT for diagnosing pulmonary tuberculosis was 95.7% with a specificity of 87.2%. Of 41 TB meningitis subjects, based on Marais criteria, there were 6 (16%) subjects with a definite TB meningitis, 26 (63%) subjects with probable TB meningitis and 9 (21%) subjects with possible TB meningitis. The sensitivity and specificity of TB antigens cocktail rapid ICT for TB meningitis diagnosis were 83.3% and 68.5% respectively. Conclusions: In this study, rapid ICT TB antigens cocktail (ESAT-6, CFP-10 and MPT64) from sputum sample has good validity for diagnosing a pulmonary tuberculosis, and from CSF sample has moderate validity to diagnose TB meningitis. Keywords: M. tuberculosis culture, pulmonary TB, TB meningitis, TB antigens cocktail (ESAT-6, CFP-10 and MPT64) rapid ICT DOI: 10.15850/ijihs.v3n2.585
Quality of Life in Thalassemia Major Patients: Reliability and Validity of Indonesian Version of TranQol Questionnaire Billy Ng Setiawan Rachmat Poengoet; Ellyana Sungkar; Tri Damiati Pandji
International Journal of Integrated Health Sciences Vol 5, No 2 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To determine the validity and reliability of TranQol questionnaire that has been translated into Indonesian to be used in Indonesian thalassemia major patients. The quality of life problems among these patients can be detected earlier because TranQol is more precise compared to the Pediatric Quality of Life Inventory (PedsQLTM), World Health Organization Quality of Life Instruments (WHOQOL), and SF-36 Questionaire.Methods: This study was conducted in Bandung, Indonesia from October 2015 to March 2016 and used a standard “forward-backward” translation procedure. It involved 60 adults and 73 children who are thalassemia major patients, and 71 parents of patients in Dr. Hasan Sadikin General Hospital. TranQol was processed through forward and backward translation approach and evaluation was conducted by the TranQol author. After the translation process, a cognitive debriefing was performed and the translated TranQol was tested to all subjects.Results: Cronbach’s alpha >0.7 was used for all TranQol categories. Front validity and content validity testing was performed. The internal validity results showed that some questions were not valid.Conclusions: TranQol reliability in Indonesian language for every category is good. Validity for TranQol in Indonesian language shows that the translated TranQol is not quite suitable that it still cannot be used. Keywords: TranQol Indonesia, validity Indonesia, reliability Indonesia DOI: 10.15850/ijihs.v5n2.1011
Morphological Changes of Cisplatin-resistant Human Breast Cancer MCF-7 Cell Line Nanda Ayu Puspita; Amy Bedford
International Journal of Integrated Health Sciences Vol 5, No 1 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (170.878 KB) | DOI: 10.15850/ijihs.v5n1.960

Abstract

Objective: To evaluate morphological changes of breast cancer cell line MCF-7 following the development of acquired resistance towards cisplatin. Resistance towards anticancer agents still plays an important role in the breast cancer chemotherapy failure.Methods: The cisplatin resistant subline MCF-7/CisR was developed in-vitro by cultivating the parental cell line cisplatin-sensitive MCF-7 with raising concentration of cisplatin (from 0.01 to 2.3 µM) for four months. The cell morphology was observed by giemsa staining. Results: The resistance was shown by the increase of IC50 by 9 folds on MCF-7/CisR compared to the initial IC50 value of MCF-7. The change in cisplatin cytotoxic potency on the resistant cell line was accompanied by the morphological modification, including the enlargement of cell size, the increase of nucleus and cytoplasm ratio, and the increase of the number of microvesicular and cytoplasmic granules.Conclusions: This result has supported the underlying mechanism of cisplatin resistance, including the ability of the cells to decrease intracellular cisplatin concentration and repair DNA damage effects.
Ultrasound Guided Fine Needle Aspiration Biopsy in Renal Tumors Tjahjodjati Tjahjodjati; Joko Pitoyo
International Journal of Integrated Health Sciences Vol 3, No 1 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

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Abstract

Objective: To assess the sensitivity and specificity of ultrasound guided fine needle aspiration biopsy (FNAB) in renal tumors.Methods: A diagnostic study was performed on 23 patients with renal tumors who visited the Urology Division, Department of Surgery, Dr. Hasan Sadikin General Hospital from January 2011 to August 2012. First time ultrasound guided was performed to the patients before nephrectomy. Renal tissues that were obtained from both procedures were examined histopathologically, and the result from nephrectomy was used as the gold standard. Analysis was conducted by measuring the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the ultrasound guided FNAB. Results: The results showed that the sensitivity value of ultrasound guided FNAB was 85.71%, with 50% specificity, 94.74% PPV and 25% NPV. From 23 patients, only 2 patients had hematoma. Conclusions: Ultrasound guided FNAB is sufficiently sensitive with a fair specificity for diagnosing renal tumors and is safe for patients.Keywords: Renal tumor, sensitivity, specificity, ultasound guided FNAB DOI: 10.15850/ijihs.v3n1.401

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